Selected publications

Telomerase is essential for cardiac differentiation and sustained metabolism of human cardiomyocytes.

Chatterjee S, Leach-Mehrwald M, Huang CK, Xiao K, Fuchs M, Otto M, Lu D, Dang V, Winkler T, Dunbar CE, Thum T, Bär C.

Cell Mol Life Sci. 2024 Apr 24;81(1):196. doi: 10.1007/s00018-024-05239-7. PMID: 38658440; PMCID: PMC11043037.

 

Circular RNA circZFPM2 regulates cardiomyocyte hypertrophy and survival.

Neufeldt D, Schmidt A, Mohr E, Lu D, Chatterjee S, Fuchs M, Xiao K, Pan W, Cushman S, Jahn C, Juchem M, Hunkler HJ, Cipriano G, Jürgens B, Schmidt K, Groß S, Jung M, Hoepfner J, Weber N, Foo R, Pich A, Zweigerdt R, Kraft T, Thum T, Bär C.

Basic Res Cardiol. 2024 Apr 19. doi: 10.1007/s00395-024-01048-y. Epub ahead of print. PMID: 38639887.

 

Inhibition of miR-21: cardioprotective effects in human failing myocardium ex vivo.

Abbas N, Haas JA, Xiao K, Fuchs M, Just A, Pich A, Perbellini F, Werlein C, Ius F, Ruhparwar A, Fiedler J, Weber N, Thum T.

Eur Heart J. 2024 Mar 5:ehae102. doi: 10.1093/eurheartj/ehae102. Epub ahead of print. PMID: 38442291.

 

Circulating miR-let7a levels predict future diagnosis of chronic thromboembolic pulmonary hypertension.

Kenneweg F, Hobohm L, Bang C, Gupta SK, Xiao K, Thum S, Ten Cate V, Rapp S, Hasenfuß G, Wild P, Konstantinides S, Wachter R, Lankeit M, Thum T.

Sci Rep. 2024 Feb 24;14(1):4514. doi: 10.1038/s41598-024-55223-1. PMID: 38402278; PMCID: PMC10894210.

 

Encapsulating In Vitro Transcribed circRNA into Lipid Nanoparticles Via Microfluidic Mixing.

Juchem M, Cushman S, Lu D, Chatterjee S, Bär C, Thum T.

Methods Mol Biol. 2024;2765:247-260. doi: 10.1007/978-1-0716-3678-7_14. PMID: 38381344.

 

A pilot study for risk stratification of ventricular tachyarrhythmia in hypertrophic cardiomyopathy with routine echocardiography parameters.

Derda AA, Abelmann M, Sieweke JT, Waleczek FJG, Weber N, Zehrfeld N, Bär C, Duncker D, Bavendiek U, Berliner D, Bauersachs J, Sonnenschein K, Thum T.

Sci Rep. 2024 Feb 15;14(1):3799. doi: 10.1038/s41598-024-54153-2. PMID: 38360886; PMCID: PMC10869710.

 

Macrophage-based therapeutic approaches for cardiovascular diseases.

Sansonetti M, Al Soodi B, Thum T, Jung M.

Basic Res Cardiol. 2024 Feb;119(1):1-33. doi: 10.1007/s00395-023-01027-9. Epub 2024 Jan 3. PMID: 38170281; PMCID: PMC10837257.

 

OSWG Recommended Approaches to the Nonclinical Pharmacokinetic (Absorption, Distribution, Metabolism, and Excretion) Characterization of Therapeutic Oligonucleotides

Berman CL, Antonsson M, Batkai S, Bosgra S, Chopda GR, Driessen W, Foy J, Hassan C, Hu XS, Jang HG, Meena, Sanseverino M, Thum T, Wang Y, Wild M & Wu JT.

Nucleic Acid Ther. 2023 Aug 17. doi: 10.1089/nat.2023.0011. Online ahead of print. PMID: 37590469

 

COVID-19: Insights into long-term manifestations and lockdown impacts.

Hilbold E, Bär C, Thum T.

J Sport Health Sci. 2023 Mar 2:S2095-2546(23)00019-4. doi: 10.1016/j.jshs.2023.02.006. Epub ahead of print. PMID: 36868374; PMCID: PMC9977467.

 

Circular RNAs at the intersection ofcancer and heart disease: potential therapeutic targets in cardio-oncology.

Neufeldt D, Cushman S, Bär C, Thum T.

Cardiovasc Res. 2023 Jan 18:cvad013. doi: 10.1093/cvr/cvad013. Epub ahead of print. PMID: 36651915.

 

Gene Therapy and Cardiovascular Diseases.

Lu D, Cushman S, Thum T, Bär C.

Adv Exp Med Biol. 2023;1396:235-254. doi: 10.1007/978-981-19-5642-3_16. PMID: 36454471.

 

Emerging epigenetic therapies of cardiac fibrosis and remodelling in heart failure: from basic mechanisms to early clinical development.

McKinsey TA, Foo R, Anene-Nzelu CG, Travers JG, Vagnozzi RJ, Weber N, Thum T.

Cardiovasc Res. 2023 Feb 3;118(18):3482-3498. doi: 10.1093/cvr/cvac142. PMID: 36004821.

 

Accelerating developments in heart failure.

Thum T, Lam CSP

Cardiovasc Res. 2023 Feb 3;118(18):3401-3402. doi: 10.1093/cvr/cvac185. PMID: 36583729

 

Chemical and mechanical activation of resident cardiac macrophages in the living myocardial slice ex vivo model.

Waleczek FJG, Sansonetti M, Xiao K, Jung M, Mitzka S, Dendorfer A, Weber N, Perbellini F, Thum T.

Basic Res Cardiol. 2022 Nov 30;117(1):63. doi: 10.1007/s00395-022-00971-2. PMID: 36449104; PMCID: PMC9712328.

 

Accelerating cardiovascular research: recent advances in translational 2D and 3D heart models.

Mohr E, Thum T, Bär C.

Eur J Heart Fail. 2022 Oct;24(10):1778-1791. doi: 10.1002/ejhf.2631. Epub 2022 Aug 4. PMID: 35867781.

 

AAV capsid engineering identified two novel variants with improved in vivo tropism for cardiomyocytes.

Rode L, Bär C, Groß S, Rossi A, Meumann N, Viereck J, Abbas N, Xiao K, Riedel I, Gietz A, Zimmer K, Odenthal M, Büning H, Thum T.

Mol Ther. 2022 Dec 7;30(12):3601-3618. doi: 10.1016/j.ymthe.2022.07.003. Epub 2022 Jul 9. PMID: 35810332; PMCID: PMC9734024.

 

A circular RNA derived from the insulin receptor locus protects against doxorubicin-induced cardiotoxicity.

Lu D, Chatterjee S, Xiao K, Riedel I, Huang CK, Costa A, Cushman S, Neufeldt D, Rode L, Schmidt A, Juchem M, Leonardy J, Büchler G, Blume J, Gern OL, Kalinke U, Wen Tan WL, Foo R, Vink A, van Laake LW, van der Meer P, Bär C, Thum T.

Eur Heart J. 2022 Nov 7;43(42):4496-4511. doi: 10.1093/eurheartj/ehac337. PMID: 35758064; PMCID: PMC9637424.

 

Neonatal injury models: integral tools to decipher the molecular basis of cardiac regeneration.

Costa A, Cushman S, Haubner BJ, Derda AA, Thum T, Bär C.

Basic Res Cardiol. 2022 May 3;117(1):26. doi: 10.1007/s00395-022-00931-w. PMID: 35503383; PMCID: PMC9064850.

 

Development and characterization of anti-fibrotic natural compound similars with improved effectivity.

Kreutzer FP, Meinecke A, Mitzka S, Hunkler HJ, Hobuß L, Abbas N, Geffers R, Weusthoff J, Xiao K, Jonigk DD, Fiedler J, Thum T.

Basic Res Cardiol. 2022 Mar 2;117(1):9. doi: 10.1007/s00395-022-00919-6. PMID: 35235052; PMCID: PMC8891108.

 

Targeted therapies in genetic dilated and hypertrophic cardiomyopathies: from molecular mechanisms to therapeutic targets. A position paper from the Heart Failure Association (HFA) and the Working Group on Myocardial Function of the European Society of Cardiology (ESC).

de Boer RA, Heymans S, Backs J, Carrier L, Coats AJS, Dimmeler S, Eschenhagen T, Filippatos G, Gepstein L, Hulot JS, Knöll R, Kupatt C, Linke WA, Seidman CE, Tocchetti CG, van der Velden J, Walsh R, Seferovic PM, Thum T.

Eur J Heart Fail. 2022 Mar;24(3):406-420. doi: 10.1002/ejhf.2414. Epub 2022 Jan 14. PMID: 34969177; PMCID: PMC9305112.

 

The long non-coding RNA NRON promotes the development of cardiac hypertrophy in the murine heart.

Hoepfner J, Leonardy J, Lu D, Schmidt K, Hunkler HJ, Biß S, Foinquinos A, Xiao K, Regalla K, Ramanujam D, Engelhardt S, Bär C, Thum T.

Mol Ther. 2022 Mar 2;30(3):1265-1274. doi: 10.1016/j.ymthe.2021.11.018. Epub 2021 Nov 29. PMID: 34856383; PMCID: PMC8899598.

 

Alternative strategies in cardiac preclinical research and new clinical trial formats.

Kreutzer FP, Meinecke A, Schmidt K, Fiedler J, Thum T.

Cardiovasc Res. 2022 Feb 21;118(3):746-762. doi: 10.1093/cvr/cvab075. PMID: 33693475; PMCID: PMC7989574.

 

LIPCAR Is Increased in Chronic Symptomatic HF Patients. A Sub-Study of the GISSI-HF Trial.

Meessen JMTA, Bär C, di Dona FM, Staszewsky LI, Di Giulio P, Di Tano G, Costa A, Leonardy J, Novelli D, Nicolis EB, Masson S, Pinet F, Thum T, Latini R.

Clin Chem. 2021 Nov 26;67(12):1721-1731. doi: 10.1093/clinchem/hvab197. PMID: 34751777.

 

COVID-19 vaccination in patients with heart failure: a position paper of the Heart Failure Association of the European Society of Cardiology.

Rosano G, Jankowska EA, Ray R, Metra M, Abdelhamid M, Adamopoulos S, Anker SD, Bayes-Genis A, Belenkov Y, Gal TB, Böhm M, Chioncel O, Cohen-Solal A, Farmakis D, Filippatos G, González A, Gustafsson F, Hill L, Jaarsma T, Jouhra F, Lainscak M, Lambrinou E, Lopatin Y, Lund LH, Milicic D, Moura B, Mullens W, Piepoli MF, Ponikowski P, Rakisheva A, Ristic A, Savarese G, Seferovic P, Senni M, Thum T, Tocchetti CG, Van Linthout S, Volterrani M, Coats AJS.

Eur J Heart Fail. 2021 Nov;23(11):1806-1818. doi: 10.1002/ejhf.2356. PMID: 34612556; PMCID: PMC8652673.

 

AntimiR-132 Attenuates Myocardial Hypertrophy in an Animal Model of Percutaneous Aortic Constriction.

Hinkel R, Batkai S, Bähr A, Bozoglu T, Straub S, Borchert T, Viereck J, Howe A, Hornaschewitz N, Oberberger L, Jurisch V, Kozlik-Feldmann R, Freudenthal F, Ziegler T, Weber C, Sperandio M, Engelhardt S, Laugwitz KL, Moretti A, Klymiuk N, Thum T, Kupatt C.

J Am Coll Cardiol. 2021 Jun 15;77(23):2923-2935. doi: 10.1016/j.jacc.2021.04.028. PMID: 34112319.

 

Cardiovascular RNA markers and artificial intelligence may improve COVID-19 outcome: a position paper from the EU-CardioRNA COST Action CA17129.

Badimon L, Robinson EL, Jusic A, Carpusca I, deWindt LJ, Emanueli C, Ferdinandy P, Gu W, Gyöngyösi M, Hackl M, Karaduzovic-Hadziabdic K, Lustrek M, Martelli F, Nham E, Potočnjak I, Satagopam V, Schneider R, Thum T, Devaux Y.

Cardiovasc Res. 2021 Jul 7;117(8):1823-1840. doi: 10.1093/cvr/cvab094. PMID: 33839767; PMCID: PMC8083253.

 

Therapeutic and Diagnostic Translation of Extracellular Vesicles in Cardiovascular Diseases: Roadmap to the Clinic.

Sahoo S, Adamiak M, Mathiyalagan P, Kenneweg F, Kafert-Kasting S, Thum T.

Circulation. 2021 Apr 6;143(14):1426-1449. doi: 10.1161/CIRCULATIONAHA.120.049254. Epub 2021 Apr 5. PMID: 33819075; PMCID: PMC8021236.

 

Telomerase therapy attenuates cardiotoxic effects of doxorubicin.

Chatterjee S, Hofer T, Costa A, Lu D, Batkai S, Gupta SK, Bolesani E, Zweigerdt R, Megias D, Streckfuss-Bömeke K, Brandenberger C, Thum T, Bär C.

Mol Ther. 2021 Apr 7;29(4):1395-1410. doi: 10.1016/j.ymthe.2020.12.035. Epub 2021 Jan 1. PMID: 33388418; PMCID: PMC8058493.

 

Reciprocal organ interactions during heart failure: a position paper from the ESC Working Group on Myocardial Function.

Ciccarelli M, Dawson D, Falcao-Pires I, Giacca M, Hamdani N, Heymans S, Hooghiemstra A, Leeuwis A, Hermkens D, Tocchetti CG, van der Velden J, Zacchigna S, Thum T.

Cardiovasc Res. 2021 Nov 1;117(12):2416-2433. doi: 10.1093/cvr/cvab009. PMID: 33483724; PMCID: PMC8562335.

 

Circulating cardiovascular microRNAs in critically ill COVID-19 patients.

Garg A, Seeliger B, Derda AA, Xiao K, Gietz A, Scherf K, Sonnenschein K, Pink I, Hoeper MM, Welte T, Bauersachs J, David S, Bär C, Thum T.

Eur J Heart Fail. 2021 Mar;23(3):468-475. doi: 10.1002/ejhf.2096. Epub 2021 Mar 5. PMID: 33421274; PMCID: PMC8014268.

 

Novel antisense therapy targeting microRNA-132 in patients with heart failure: results of a first-in-human Phase 1b randomized, double-blind, placebo-controlled study.

Täubel J, Hauke W, Rump S, Viereck J, Batkai S, Poetzsch J, Rode L, Weigt H, Genschel C, Lorch U, Theek C, Levin AA, Bauersachs J, Solomon SD, Thum T.

Eur Heart J. 2021 Jan 7;42(2):178-188. doi: 10.1093/eurheartj/ehaa898. PMID: 33245749; PMCID: PMC7954267.

 

CDR132L improves systolic and diastolic function in a large animal model of chronic heart failure.

Batkai S, Genschel C, Viereck J, Rump S, Bär C, Borchert T, Traxler D, Riesenhuber M, Spannbauer A, Lukovic D, Zlabinger K, Hašimbegović E, Winkler J, Garamvölgyi R, Neitzel S, Gyöngyösi M, Thum T.

Eur Heart J. 2021 Jan 7;42(2):192-201. doi: 10.1093/eurheartj/ehaa791. Erratum in: Eur Heart J. 2021 Oct 14;42(39):4036. PMID: 33089304; PMCID: PMC7813625.

 

Towards standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function.

Zacchigna S, Paldino A, Falcão-Pires I, Daskalopoulos EP, Dal Ferro M, Vodret S, Lesizza P, Cannatà A, Miranda-Silva D, Lourenço AP, Pinamonti B, Sinagra G, Weinberger F, Eschenhagen T, Carrier L, Kehat I, Tocchetti CG, Russo M, Ghigo A, Cimino J, Hirsch E, Dawson D, Ciccarelli M, Oliveti M, Linke WA, Cuijpers I, Heymans S, Hamdani N, de Boer M, Duncker DJ, Kuster D, van der Velden J, Beauloye C, Bertrand L, Mayr M, Giacca M, Leuschner F, Backs J, Thum T.

Cardiovasc Res. 2021 Jan 1;117(1):43-59. doi: 10.1093/cvr/cvaa110. PMID: 32365197.

 

Groß S, Jahn C, Cushman S, Bär C, Thum T. SARS-CoV-2 receptor ACE2-dependent

implications on the cardiovascular system: From basic science to clinical

implications. J Mol Cell Cardiol. 2020 Apr 30;144:47-53. doi:

10.1016/j.yjmcc.2020.04.031. Epub ahead of print. PMID: 32360703; PMCID:

PMC7191280.

 

Zacchigna S, Paldino A, Falcão-Pires I, Daskalopoulos EP, Dal Ferro M, Vodret

S, Lesizza P, Cannatà A, Miranda-Silva D, Lourenço AP, Pinamonti B, Sinagra G,

Weinberger F, Eschenhagen T, Carrier L, Kehat I, Tocchetti CG, Russo M, Ghigo A,

Cimino J, Hirsch E, Dawson D, Ciccarelli M, Oliveti M, Linke WA, Cuijpers I,

Heymans S, Hamdani N, de Boer M, Duncker D, Kuster D, van der Velden J, Beauloye

C, Bertrand L, Mayr M, Giacca M, Leuschner F, Backs J, Thum T; Working Group on

Myocardial Function of the European Society of Cardiology.. Toward

standardization of echocardiography for the evaluation of left ventricular

function in adult rodents: a position paper of the ESC Working Group on

Myocardial Function. Cardiovasc Res. 2020 May 4:cvaa110. doi:

10.1093/cvr/cvaa110. Epub ahead of print. PMID: 32365197.

 

Garg A, Foinquinos A, Jung M, Janssen-Peters H, Biss S, Bauersachs J, Gupta

SK, Thum T. MiRNA-181a is a novel regulator of aldosterone-mineralocorticoid

receptor-mediated cardiac remodelling. Eur J Heart Fail. 2020 Apr 18. doi:

10.1002/ejhf.1813. Epub ahead of print. PMID: 32304626.

 

Huang CK, Kafert-Kasting S, Thum T. Preclinical and Clinical Development of

Noncoding RNA Therapeutics for Cardiovascular Disease. Circ Res. 2020 Feb

28;126(5):663-678. doi: 10.1161/CIRCRESAHA.119.315856. Epub 2020 Feb 27. PMID:

32105576; PMCID: PMC7043728.

 

Foinquinos A, Batkai S, Genschel C, Viereck J, Rump S, Gyöngyösi M, Traxler

D, Riesenhuber M, Spannbauer A, Lukovic D, Weber N, Zlabinger K, Hašimbegović E,

Winkler J, Fiedler J, Dangwal S, Fischer M, de la Roche J, Wojciechowski D,

Kraft T, Garamvölgyi R, Neitzel S, Chatterjee S, Yin X, Bär C, Mayr M, Xiao K,

Thum T. Preclinical development of a miR-132 inhibitor for heart failure

treatment. Nat Commun. 2020 Jan 31;11(1):633. doi: 10.1038/s41467-020-14349-2.

PMID: 32005803; PMCID: PMC6994493.

 

Schimmel K, Jung M, Foinquinos A, José GS, Beaumont J, Bock K, Grote-Levi L,

Xiao K, Bär C, Pfanne A, Just A, Zimmer K, Ngoy S, López B, Ravassa S, Samolovac

S, Janssen-Peters H, Remke J, Scherf K, Dangwal S, Piccoli MT, Kleemiss F,

Kreutzer FP, Kenneweg F, Leonardy J, Hobuß L, Santer L, Do QT, Geffers R,

Braesen JH, Schmitz J, Brandenberger C, Müller DN, Wilck N, Kaever V, Bähre H,

Batkai S, Fiedler J, Alexander KM, Wertheim BM, Fisch S, Liao R, Diez J,

González A, Thum T. Natural Compound Library Screening Identifies New Molecules

for the Treatment of Cardiac Fibrosis and Diastolic Dysfunction. Circulation.

2020 Mar 3;141(9):751-767. doi: 10.1161/CIRCULATIONAHA.119.042559. Epub 2020 Jan

17. PMID: 31948273; PMCID: PMC7050799.

 

Stojanović SD, Fiedler J, Bauersachs J, Thum T, Sedding DG. Senescence-

induced inflammation: an important player and key therapeutic target in

atherosclerosis. Eur Heart J. 2020 Jan 3:ehz919. doi: 10.1093/eurheartj/ehz919.

Epub ahead of print. PMID: 31898722.

 

Kenneweg F, Bang C, Xiao K, Boulanger CM, Loyer X, Mazlan S, Schroen B,

Hermans-Beijnsberger S, Foinquinos A, Hirt MN, Eschenhagen T, Funcke S,

Stojanovic S, Genschel C, Schimmel K, Just A, Pfanne A, Scherf K, Dehmel S,

Raemon-Buettner SM, Fiedler J, Thum T. Long Noncoding RNA-Enriched Vesicles

Secreted by Hypoxic Cardiomyocytes Drive Cardiac Fibrosis. Mol Ther Nucleic

Acids. 2019 Dec 6;18:363-374. doi: 10.1016/j.omtn.2019.09.003. Epub 2019 Sep 13.

PMID: 31634682; PMCID: PMC6807307.

 

Santer L, Bär C, Thum T. Circular RNAs: A Novel Class of Functional RNA

Molecules with a Therapeutic Perspective. Mol Ther. 2019 Aug 7;27(8):1350-1363.

doi: 10.1016/j.ymthe.2019.07.001. Epub 2019 Jul 9. PMID: 31324392; PMCID:

PMC6697450.

 

Lu D, Thum T. RNA-based diagnostic and therapeutic strategies for

cardiovascular disease. Nat Rev Cardiol. 2019 Nov;16(11):661-674. doi:

10.1038/s41569-019-0218-x. Epub 2019 Jun 11. PMID: 31186539.

 

miR-212/132 Cluster Modulation Prevents Doxorubicin-Mediated Atrophy and Cardiotoxicity.

Gupta SK, Garg A, Avramopoulos P, Engelhardt S, Streckfuss-Bömeke K, Batkai S, Thum T (2018).

Mol Ther. 2019 Jan 2;27(1):17-28. Epub 2018 Nov 13

 

Quaking inhibits Doxorubicin-mediated cardiotoxicity through regulation of cardiac circular RNA expression.

Gupta SK, Garg A, Bär C, Chatterjee S, Foinquinos A, Milting H, Streckfuß-Bömeke K, Fiedler J, Thum T (2018)

Circ Res. 122(2):246-254. [Epub 2017 Nov 13]

 

Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling.

Sassi Y, Avramopoulos P, Ramanujam D, Grüter L, Werfel S, Giosele S, Brunner AD, Esfandyari D, Papadopoulou AS, De Strooper B, Hübner N, Kumarswamy R, Thum T, Yin X, Mayr M, Laggerbauer B, Engelhardt S (2017).

Nat Commun. 8(1):1614.

 

A large shRNA library approach identifies lncRNA Ntep as an essential regulator of cell proliferation.

Beermann J, Kirste D, Iwanov K, Lu D, Kleemiß F, Kumarswamy R, Schimmel K, Bär C, Thum T (2017).

Cell Death Differ. 25(2):307-318. [Epub 2017 Nov 3]

 

Circulating microRNA-132 levels improve risk prediction for heart failure hospitalization in patients with chronic heart failure.

Masson S, Batkai S, Beermann J, Bär C, Pfanne A, Thum S, Magnoli M, Balconi G, Nicolosi GL, Tavazzi L, Latini R, Thum T (2017).

Eur J Heart Fail. 20(1):78-85 [Epub 2017 Oct 12]

 

Antagonism of profibrotic microRNA-21 improves outcome of murine chronic renal allograft dysfunction.

Schauerte C, Hübner A, Rong S, Wang S, Shushakova N, Mengel M, Dettling A, Bang C, Scherf K, Koelling M, Melk A, Haller H, Thum T, Lorenzen JM (2017).

Kidney Int. 92(3):646-656.

 

Inhibition of the Cardiac Fibroblast-Enriched lncRNA Meg3 Prevents Cardiac Fibrosis and Diastolic Dysfunction.

Piccoli MT, Gupta SK, Viereck J, Foinquinos A, Samolovac S, Kramer FL, Garg A, Remke J, Zimmer K, Batkai S, Thum T.

Circ Res. 2017 Aug 18;121(5):575-583. doi: 10.1161/CIRCRESAHA.117.310624. Epub 2017 Jun 19.

 

Therapeutic miR-21 Silencing Ameliorates Diabetic Kidney Disease in Mice.

Kölling M, Kaucsar T, Schauerte C, Hübner A, Dettling A, Park JK, Busch M, Wulff X, Meier M, Scherf K, Bukosza N, Szénási G, Godó M, Sharma A, Heuser M, Hamar P, Bang C, Haller H, Thum T, Lorenzen JM (2017).

Mol Ther. 25(1):165-180.

 

Circulating long-non coding RNAs as biomarkers of left ventricular diastolic function and remodelling in patients with well-controlled type 2 diabetes.

de Gonzalo-Calvo D, Kenneweg F, Bang C, Toro R, van der Meer RW, Rijzewijk LJ, Smit JW, Lamb HJ, Llorente-Cortes V, Thum T.

Sci Rep. 2016 Nov 22;6:37354. doi: 10.1038/srep37354.

 

Long Noncoding RNAs in Cardiovascular Pathology, Diagnosis, and Therapy.

Bär C, Chatterjee S, Thum T.

Circulation. 2016 Nov 8; 134(19):1484-1499.

 

MicroRNA-based Therapy of Gata2-deficient Vascular Disease.

Hartmann D, Fiedler J, Sonnenschein K, Just A, Pfanne A, Zimmer K, Remke J, Foinquinos A, Butzlaff M, Schimmel K, Maegdefessel L, Hilfiker-Kleiner D, Lachmann N, Schober A, Froese N, Heineke J, Bauersachs J, Batkai S, Thum T.

Circulation. 2016 Oct 25. pii: CIRCULATIONAHA.116.022478. [Epub ahead of print]

 

Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches.

Beermann J, Piccoli MT, Viereck J, Thum T.

Physiol Rev. 2016 Oct; 96(4):1297-325. doi: 10.1152/physrev.00041.2015.

 

Preclinical Development of a MicroRNA-Based Therapy for Elderly Patients With Myocardial Infarction.

Gupta SK, Foinquinos A, Thum S, Remke J, Zimmer K, Bauters C, de Groote P, Boon RA, de Windt LJ, Preissl S, Hein L, Batkai S, Pinet F, Thum T.

J Am Coll Cardiol. 2016 Oct 4;68(14):1557-71. doi: 10.1016/j.jacc.2016.07.739.

 

Identification of miR-126 as a new regulator of skin aging.

Fiedler J, Grönniger E, Pfanne A, Brönneke S, Schmidt K, Falk CS, Wenck H, Terstegen L, Thum T, Winnefeld M.

Exp Dermatol. 2016 Aug 30. doi: 10.1111/exd.13173. [Epub ahead of print]

 

Long noncoding RNA Chast promotes cardiac remodeling.

Viereck J, Kumarswamy R, Foinquinos A, Xiao K, Avramopoulos P, Kunz M, Dittrich M, Maetzig T, Zimmer K, Remke J, Just A, Fendrich J, Scherf K, Bolesani E, Schambach A, Weidemann F, Zweigerdt R, de Windt LJ, Engelhardt S, Dandekar T, Batkai S, Thum T.

Sci Transl Med. 2016 Feb 17;8(326):326ra22. doi: 10.1126/scitranslmed.aaf1475.

 

Enabling [(18)F]-bicyclo[6.1.0]nonyne for oligonucleotide conjugation for positron emission tomography applications: [(18)F]-anti-microRNA-21 as an example.

Li XG, Roivainen A, Bergman J, Heinonen A, Bengel F, Thum T, Knuuti J.

Chem Commun (Camb). 2015 Jun 2;51(48):9821-4.

 

Osteopontin is indispensible for AP1-mediated angiotensin II-related miR-21 transcription during cardiac fibrosis.

Lorenzen JM, Schauerte C, Hübner A, Kölling M, Martino F, Scherf K, Batkai S, Zimmer K, Foinquinos A, Kaucsar T, Fiedler J, Kumarswamy R, Bang C, Hartmann D, Gupta SK, Kielstein J, Jungmann A, Katus HA, Weidemann F, Müller OJ, Haller H, Thum T.

Eur Heart J. 2015 Apr 21. pii: ehv109.

 

Long noncoding RNAs in cardiac development and ageing.

Devaux Y, Zangrando J, Schroen B, Creemers EE, Pedrazzini T, Chang CP, Dorn GW 2nd, Thum T, Heymans S; Cardiolinc network.

Nat Rev Cardiol. 2015 Apr 7. doi: 10.1038/nrcardio.2015.55

 

Impairment of Wound Healing in Patients With Type 2 Diabetes Mellitus Influences Circulating MicroRNA Patterns via Inflammatory Cytokines.

Dangwal S, Stratmann B, Bang C, Lorenzen JM, Kumarswamy R, Fiedler J, Falk CS, Scholz CJ, Thum T, Tschoepe D.

Arterioscler Thromb Vasc Biol. 2015 Jun;35(6):1480-8.

 

MicroRNA signatures differentiate preserved from reduced ejection fraction heart failure.

Watson CJ, Gupta SK, O'Connell E, Thum S, Glezeva N, Fendrich J, Gallagher J, Ledwidge M, Grote-Levi L, McDonald K, Thum T.

Eur J Heart Fail. 2015 Apr;17(4):405-15.

 

Long noncoding RNAs and microRNAs in cardiovascular pathophysiology.

Thum T, Condorelli G.

Circ Res. 2015 Feb 13;116(4):751-62.

 

Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy.

Bang C, Batkai S, Dangwal S, Gupta SK, Foinquinos A, Holzmann A, Just A, Remke J, Zimmer K, Zeug A, Ponimaskin E, Schmiedl A, Yin X, Mayr M, Halder R, Fischer A, Engelhardt S, Wei Y, Schober A, Fiedler J, Thum T. 

J Clin Invest. 2014;124:2136-2146.

 

Functional MicroRNA library screening identifies the HypoxaMiR MiR-24 as a potent regulator of smooth muscle cell proliferation and vascularization.

Fiedler J, Stohr A, Gupta SK, Hartmann D, Holzmann A, Just A, Hansen A, Hilfiker-Kleiner D, Eschenhagen T, Thum T. 

Antioxid Redox Signal. 2014;21:1167-1176.

 

Circulating long noncoding RNA, LIPCAR, predicts survival in patients with heart failure.

Kumarswamy R, Bauters C, Volkmann I, Maury F, Fetisch J, Holzmann A, Lemesle G, de Groote P, Pinet F, Thum T. 

Circ Res. 2014;114:1569-1575.

 

MicroRNA-24 antagonism prevents renal ischemia reperfusion injury.

Lorenzen JM, Kaucsar T, Schauerte C, Schmitt R, Rong S, Hubner A, Scherf K, Fiedler J, Martino F, Kumarswamy R, Kolling M, Sorensen I, Hinz H, Heineke J, van Rooij E, Haller H, Thum T.

 J Am Soc Nephrol. 2014.

 

MicroRNA-22 increases senescence and activates cardiac fibroblasts in the aging heart.

Jazbutyte V, Fiedler J, Kneitz S, Galuppo P, Just A, Holzmann A, Bauersachs J, Thum T. 

Age (Dordr). 2013;35:747-762.

 

The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy.

Ucar A, Gupta SK, Fiedler J, Erikci E, Kardasinski M, Batkai S, Dangwal S, Kumarswamy R, Bang C, Holzmann A, Remke J, Caprio M, Jentzsch C, Engelhardt S, Geisendorf S, Glas C, Hofmann TG, Nessling M, Richter K, Schiffer M, Carrier L, Napp LC, Bauersachs J, Chowdhury K, Thum T. 

Nat Commun. 2012;3:1078.

 

MicroRNA-24 regulates vascularity after myocardial infarction.

Fiedler J, Jazbutyte V, Kirchmaier BC, Gupta SK, Lorenzen J, Hartmann D, Galuppo P, Kneitz S, Pena JT, Sohn-Lee C, Loyer X, Soutschek J, Brand T, Tuschl T, Heineke J, Martin U, Schulte-Merker S, Ertl G, Engelhardt S, Bauersachs J, Thum T. 

Circulation. 2011;124:720-730.

 

miRNA screening reveals a new miRNA family stimulating iPS cell generation via regulation of Meox2.

Pfaff N, Fiedler J, Holzmann A, Schambach A, Moritz T, Cantz T, Thum T. 

EMBO Rep. 2011;12:1153-1159.

 

Comparison of different miR-21 inhibitor chemistries in a cardiac disease model.

Thum T, Chau N, Bhat B, Gupta SK, Linsley PS, Bauersachs J, Engelhardt S. 

J Clin Invest. 2011;121:461-2; author reply 462-3.

 

Impairment of endothelial progenitor cell function and vascularization capacity by aldosterone in mice and humans.

Thum T, Schmitter K, Fleissner F, Wiebking V, Dietrich B, Widder JD, Jazbutyte V, Hahner S, Ertl G, Bauersachs J.

Eur Heart J. 2011;32:1275-1286.

 

miR-212 and miR-132 are required for epithelial stromal interactions necessary for mouse mammary gland development.

Ucar A, Vafaizadeh V, Jarry H, Fiedler J, Klemmt PA, Thum T, Groner B, Chowdhury K.

Nat Genet. 2010;42:1101-1108.

 

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts.

Thum T, Gross C, Fiedler J, Fischer T, Kissler S, Bussen M, Galuppo P, Just S, Rottbauer W, Frantz S, Castoldi M, Soutschek J, Koteliansky V, Rosenwald A, Basson MA, Licht JD, Pena JT, Rouhanifard SH, Muckenthaler MU, Tuschl T, Martin GR, Bauersachs J, Engelhardt S.

Nature. 2008;456:980-984.

 

MicroRNAs in the human heart: A clue to fetal gene reprogramming in heart failure.

Thum T,  Galuppo P, Wolf C, Fiedler J, Kneitz S, van Laake LW, Doevendans PA, Mummery CL, Borlak J, Haverich A, Gross C, Engelhardt S, Ertl G, Bauersachs J.

Circulation. 2007;116:258-267.

 

Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulin-like growth-factor-1.

Thum T, Hoeber S, Froese S, Klink I, Stichtenoth DO, Galuppo P, Jakob M, Tsikas D, Anker SD, Poole-Wilson PA, Borlak J, Ertl G, Bauersachs J.

Circ Res. 2007;100:434-443.

 

 

For a complete list of publications please go to PubMed.