• Reinke, Patrick Y.A., Heiringhoff, Robin S., Reindl, Theresia, Baker, Karen, Taft, Manuel H., Meents, Alke, Mulvihill, Daniel P., Davies, Owen R., Fedorov, Roman, Zahn, Michael, Manstein, Dietmar J. (2024) Crystal structures of cables formed by the acetylated and unacetylated forms of the Schizosaccharomyces pombe tropomyosin orthologue TpmCdc8. The Journal of Biological Chemistry doi:  10.1016/j.jbc.2024.107925
   

• Greve, J. N., Marquardt, A., Heiringhoff, R., Reindl, T., Thiel, C., Di Donato , N., Taft, M. H., & Manstein, D. J. (2024) The non-muscle actinopathy-associated mutation E334Q in cytoskeletal γ-actin perturbs interaction of actin filaments with myosin and ADF/cofilin family proteins. eLife 12:RP93013. doi:  10.7554/eLife.93013.3  
   

• Greve, J. N., Schwäbe, F. V., Taft, M. H., & Manstein, D. J. (2024) Biochemical characterization of cardiac α-actin mutations A21V and D26N implicated in hypertrophic cardiomyopathy. Cytoskeleton, 1–17. doi: 10.1002/cm.21852
   

• Kengyel, A., Palarz, PM , Krohn, J., Marquardt, A., Greve, J.N., Heiringhoff, R., Manstein, D.J. (2024) Motor properties of Myosin 5c are modulated by tropomyosin isoforms and inhibited by pentabromopseudilin Frontiers in Physiology 15, 1394040. doi: 10.3389/fphys.2024.1394040
   

• Reindl T., Giese S., Greve J.N., Reinke P.Y., Chizhov I., Latham S.L., Mulvihill D.P., Taft M.H., Manstein D.J. (2022) Distinct actin-tropomyosin cofilament populations drive the functional diversification of cytoskeletal myosin motor complexes. iScience doi: 10.1016/j.isci.2022.104484
   

• Greve J.N., Schwäbe F.V., Pokrant T., Faix J., Di Donato N., Taft M.H., Manstein D.J. (2022) Frameshift mutation S368fs in the gene encoding cytoskeletal β-actin leads to ACTB-associated syndromic thrombocytopenia by impairing actin dynamics. Eur J Cell Biol. doi: 10.1016/j.ejcb.2022.151216
   

• Schwäbe, F.V., Peter, E.K., Taft, M.H., Manstein, D.J. (2021) Assessment of the Contribution of a Thermodynamic and Mechanical Destabilization of Myosin-Binding Protein C Domain C2 to the Pathomechanism of Hypertrophic Cardiomyopathy-Causing Double Mutation MYBPC3D25bp/D389V. Int.
  J.Mol. Sci. doi.10.3390/ijms222111949
   

• Peter, E.K., Manstein, D.J., Shea, J.E., Schug, A., (2021) CORE-MD II : A fast, adaptive and accurate enhanced sampling method. J. Chem. Phys. doi:10.1063/5.0063664
   

• Hennig, S., Manstein, D.J., (2021) Improvement of image resolution by combining enhanced confocal microscopy and quantum dot triexciton imaging. FEBS Open Bio. doi:10.1002/2211-5463.13246
   

• Rai, A., Klare, J.P., Reinke, P.Y.A, Englmaier, F., Fohrer, J., Fedorov, R., Taft, M.H. Chizhov, I., Curth,U., Plettenburg, O., Manstein, D.J. (2021) Structural and biochemical characterization of a dye decolorizing peroxidase from Dictyostelium discoideum. International Journal of Molecular Sciences. Accepted for publication.
   

• Pertici, I., Taft, M.H., Greve, J.N., Fedorov, R., Caremani, M., Manstein, D.J. (2021) Allosteric modulation of cardiac myosin mechanics and kinetics by the conjugated omega-7,9 trans-fat rumenic acid. The Journal of Physiology. doi.org/10.1113/JP281563
   

• Pertici I, Bianchi G, Bongini L, Cojoc D, Taft MH, Manstein D.J., Lombardi V & Bianco P. (2021). Muscle myosin performance measured with a synthetic nanomachine reveals a class-specific Ca(2+) -sensitivity of the frog myosin II isoform. J Physiol. doi: 10.1113/JP280976.
  
   
• Giese, S., Reindl, T., Reinke, P. Y. A., Zattelman, L., Fedorov, R., Henn, A., Taft, M. H., and Manstein, D.J. (2020) Mechanochemical properties of human myosin 1C are modulated by isoform-specific differences in the N-terminal extension. J Biol Chem. doi: 10.1074/jbc.RA120.015187.

• Hennig, S., and Manstein, D.J. (2020) Enhanced super-resolution microscopy by combined Airyscan and Quantum-Dot-Triexciton Imaging. bioRxiv, 2020.2005.2007.082222

• Latham, S.L., Weiss, N., Schwanke, K., Thiel, C., Croucher, D.R., Zweigerdt, R., Manstein, D.J., and Taft, M.H. (2020). Myosin-18B Regulates Higher-Order Organization of the Cardiac Sarcomere through Thin Filament Cross-Linking and Thick Filament Dynamics. Cell Rep. 32:108090. doi: 10.1016/j.celrep.2020.108090  

• Wollenberg, R. D., Donau, S. S., Taft, M. H., Balazs, Z., Giese, S., Thiel, C., Sorensen, J. L., Nielsen, T. T., Giese, H., Manstein, D.J., Wimmer, R., and Sondergaard, T. E. (2020) Undefeated-Changing the phenamacril scaffold is not enough to beat resistant Fusarium. PLoS One 15, e0235568 doi: 10.1371/journal.pone.0235568

• Bratanov D, Kovalev K, Machtens JP, Astashkin R, Chizhov I, Soloviov D, Volkov D, Polovinkin V, Zabelskii D, Mager T, Gushchin I, Rokitskaya T, Antonenko Y, Alekseev A, Shevchenko V, Yutin N, Rosselli R, Baeken C, Borshchevskiy V, Bourenkov G, Popov A, Balandin T, Büldt G, Manstein, D.J., Rodriguez-Valera F, Fahlke C, Bamberg E, Koonin E, Gordeliy V. Unique structure and function of viral rhodopsins. Nat Commun. 2019 Oct 30;10(1):4939. doi: 10.1038/s41467-019-12718-0. PMID: 31666521; PMCID: PMC6821725.

• Manstein, D.J., Meiring, J. C. M., Hardeman, E. C., and Gunning, P.W. (2019). Actin–tropomyosin distribution in non‑muscle cells. J Muscle Res Cell Motil. 41:11–22. doi: 10.1007/s10974-019-09514-0

• Wollenberg, R.D., Taft, M.H., Giese, S., Thiel, C., Balazs, Z., Giese, H., Manstein, D.J., and Sondergaard, T.E. (2019). Phenamacril is a reversible and noncompetitive inhibitor of Fusarium class I myosin. J Biol Chem; 294, 1328-1337. doi: 10.1074/jbc.RA118.005408
   
• Latham, S. L., Ehmke, N., Reinke, P. Y. A., Taft, M. H., Eicke, D., Reindl, T., Stenzel, W., Lyons, M. J., Friez, M. J., Lee, J. A., Hecker, R., Fruhwald, M. C., Becker, K., Neuhann, T. M., Horn, D., Schrock, E., Niehaus, I., Sarnow, K., Grutzmann, K., Gawehn, L., Klink, B., Rump, A., Chaponnier, C., Figueiredo, C., Knofler, R., Manstein, D.J., and Di Donato, N. (2018)
  Variants in exons 5 and 6 of ACTB cause syndromic thrombocytopenia. Nat Commun.;9(1):4250, doi: 10.1038/s41467-018-06713-0
   
• Maack, C., Eschenhagen, T., Hamdani, N., Heinzel, F.R., Lyon, A.R., Manstein, D.J., et al. (2018)
  Treatments targeting inotropy. Eur Heart J., doi: 10.1093/eurheartj/ehy600
   
• Meiring, J.C.M., Bryce, N., Wang, Y., Taft, M.F., Manstein, D.J., Lau, S.L., Stear, J., Hardeman, E.C., and Gunning, P.W. (2018). Co-polymers of actin and tropomyosin account for a major fraction of the human actin cytoskeleton. Current Biology. doi: 10.1016/j.cub.2018.05.053

• Pathan-Chhatbar, S., Taft, M.H., Reindl, T., Hundt, N., Latham, S.L., and Manstein, D.J. (2018)
  Three mammalian tropomyosin isoforms have different regulatory effects on nonmuscle myosin-2B and filamentous beta-actin in vitro.
  J Biol Chem, jbc.M117.806521 doi: 10.1074/jbc.M117.806521

• Chinthalapudi, K., Heissler, S.M., Preller, M., Sellers, J.R., and Manstein, D.J. (2017)
  Mechanistic Insights into the Active Site and Allosteric Communication Pathways in Human Nonmuscle Myosin-2C.
  Elife 6, doi: 10.7554/eLife.32742
   
• Zattelman, L., Regev, R., Usaj, M., Reinke, P. Y. A., Giese, S., Samson, A. O., Taft, M. H., Manstein, D.J. and Henn, A. (2017)
  N-terminal splicing extensions of the human MYO1C gene fine-tune the kinetics of the three full-length myosin IC isoforms.
  J Biol Chem, 292, 17804-17818, doi: 10.1074/jbc.M117.794008
   
• Shevchenko, V., Mager, T., Kovalev, K., Polovinkin, V., Alekseev, A., Juettner, J., Chizhov, I., Bamann, C., Vavourakis, C., Ghai, R., Gushchin, I., Borshchevskiy, V., Rogachev, A., Melnikov, I., Popov, A., Balandin, T., Rodriguez-Valera, F., Manstein, D.J., Bueldt, G., Bamberg, E. and Gordeliy, V. (2017)
  Inward H+ pump xenorhodopsin: Mechanism and alternative optogenetic approach.
  Sci Adv. 3, doi: 10.1126/sciadv.1603187
   
• Meents, A., Wiedorn, M. O., Srajer, V., Henning, R., Sarrou, I., Bergtholdt, J., Barthelmess, M., Reinke, P. Y. A., Dierksmeyer, D., Tolstikova, A., Schaible, S., Messerschmidt, M., Ogata, C. M., Kissick, D. J., Taft, M. H., Manstein, D.J., Lieske, J., Oberthuer, D., Fischetti, R. F. and Chapman, H. N. (2017)
  Pink-beam serial crystallography.
  Nat Commun. 8, 1281, doi: 10.1038/s41467-017-01417-3
   
• Hirschmann, F., Krause, F., Baruch, P., Chizhov, I., Mueller, J. W., Manstein, D.J., Papenbrock, J. and Fedorov, R. (2017)
  Structural and biochemical studies of sulphotransferase 18 from Arabidopsis thaliana explain its substrate specificity and reaction mechanism.
  Sci Rep. 7, 4160, doi: 10.1038/s41598-017-04539-2
   
• Chinthalapudi, K., Heissler, S. M., Preller, M., Sellers, J. R. and Manstein, D.J. (2017) Mechanistic Insights Into The Active Site And Allosteric Communication Pathways In Human Nonmuscle Myosin-2C.
  bioRxiv, doi: 10.1101/138891
   
• Gateva, G., Kremneva, E., Reindl, T., Kotila, T., Kogan, K., Gressin, l., Gunning, P.W., Manstein, D.J., Michelot, A., and Lappalainen, P. (2017)
  Tropomyosin isoforms specify functionally distinct actin filament populations.
  Current Biology. doi: 10.1016/j.cub.2017.01.018
   
• von der Ecken, J.,  Heissler, S. M., Pathan-Chhatbar, S., Manstein, D.J., and Raunser, S. (2016)
  Cryo-EM structure of a human cytoplasmic actomyosin complex at near-atomic resolution.
  Nature 534, 724-728. http://rdcu.be/mD0X
   
• Hundt,  N., Steffen, W., Pathan-Chhatbar, S., Taft, M. H., and Manstein, D.J. (2016)
  Load-dependent modulation of non-muscle myosin-2A function by tropomyosin 4.2.
  Sci Rep 6, 20554, doi: 10.1038/srep20554
   
• Reubold, T.F., Faelber, K., Plattner, N., Posor, Y., Ketel, K., Curth, U., Schlegel, J., Anand, R., Manstein, D.J., Noe, F., Haucke, V., Daumke, O., and Eschenburg, S. (2015)
  Crystal structure of the dynamin tetramer.
  Nature 525, 404, rdcu.be/mD09, doi: 10.1038/nature14880
   
• Lohöfener,J., Steinke,N., Kay-Fedorov,P., Baruch,P., Nikulin,A., Tishchenko,S., Manstein, D.J., and Fedorov,R. (2015)
  The Activation Mechanism of 2'-5'-Oligoadenylate Synthetase Gives New Insights Into OAS/cGAS Triggers of Innate Immunity.
  Structure, doi: 10.1016/j.str.2015.03.012
   
• von der Ecken, J., Müller, M., Lehman, W., Manstein, D.J., Penczek, P.A., and Raunser, S. (2015)
  Structure of the F-actin–tropomyosin complex.
  Nature 519, 114, rdcu.be/mD01 , doi: 10.1038/nature14033
   
• Brandstaetter, H., Kishi-Itakura, C., Tumbarello, D.A., Manstein, D.J., and Buss, F. (2014)
  Loss of functional MYO1C/myosin 1c, a motor protein involved in lipid raft trafficking, disrupts autophagosome-lysosome fusion.
  Autophagy, doi: 10.4161/15548627.2014.984272
   
• Münnich, S., Pathan-Chhatbar, S., and Manstein, D.J. (2014)
  Crystal structure of the rigor-like human non-muscle myosin-2 motor domain.
  FEBS Lett, doi: 10.1016/j.febslet.2014.1011.1007
   
• Hundt, N., Preller, M., Swolski, O., Ang, A.M., Mannherz, H.G., Manstein, D.J., and Muller, M. (2014)
  Molecular mechanisms of disease-related human beta-actin mutations p.R183W and p.E364K.
  Febs J, doi: 10.1111/febs.13068
   
• Martin R, Risacher C, Barthel A, Jäger A, Schmidt AW, Richter S, Böhl M, Preller M, Chinthalapudi K, Manstein, D.J., Gutzeit HO, Knölker H-J (2014)
  Silver(I)-Catalyzed Route to Pyrroles: Synthesis of Halogenated Pseudilins as Allosteric Inhibitors for Myosin ATPase and X-ray Crystal Structures of the Protein–Inhibitor Complexes.
  Eur J Org Chem, doi: 10.1002/ejoc.201402177
   
• Stefan Münnich, Manuel H. Taft and Manstein, D.J. (2014)
  Crystal Structure of Human Myosin 1c - The Motor in GLUT4 Exocytosis: Implications for Ca2+-Regulation and 14-3-3 binding.
  J Mol Biol, doi: 10.1016/j.jmb.2014.03.004
   
• Rai, A., R. Fedorov, and Manstein, D.J. (2014)
  Expression, purification and crystallization of a dye-decolourizing peroxidase from Dictyostelium discoideum
  Acta Crystallogr Sect F Struct Biol Cryst Commun., doi: 10.1107/S2053230X14000545  (reprint, pdf)
   
• Radke, M. B., M. H. Taft, B. Stapel, D. Hilfiker-Kleiner, M. Preller, and Manstein, D.J. (2014)
  Small molecule-mediated Refolding and Activation of Myosin Motor Function
  eLife, doi: 10.7554/eLife.01603
   
• Preller, M., and Manstein, D.J. (2013)
  Myosin structure, allostery, and mechano-chemistry
  Structure, doi: 10.1016/j.str.2013.09.015
   
• Chizhov, I., B. Zorn, Manstein, D.J. and W. Gartner (2013)
  Kinetic and Thermodynamic Analysis of the Light-induced Processes in Plant and Cyanobacterial Phytochromes
  Biophys J, doi: 10.1016/j.bpj.2013.09.033
   
• Chaturvedi, A., Araujo Cruz, M.M., Jyotsana, N., Sharma, A., Yun, H., Gorlich, K., Wichmann, M., Schwarzer, A., Preller, M., Thol, F., Meyer, J., Haemmerle, R., Struys, E.A., Jansen, E.E., Modlich, U., Li, Z., Sly, L.M., Geffers, R., Lindner, R., Manstein, D.J., Lehmann, U., Krauter, J., Ganser, A., and Heuser, M. (2013)
  Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML
  Blood, doi: 10.1182/blood-2013-03-491571
   
• Heissler, S.M., and Manstein, D.J. (2013)
  Nonmuscle myosin-2: mix and match
  Cell Mol Life Sci., doi: 10.1007/s00018-012-1002-9
   
• Müller, M., Diensthuber, R.P., Chizhov, I., Claus, P., Heissler, S.M., Preller, M., Taft, M.H., and Manstein, D.J. (2013)
  Distinct Functional Interactions between Actin Isoforms and Nonsarcomeric Myosins
  PLoS One, doi: 10.1371/journal.pone.0070636
   
• Münnich, S., and Manstein, D.J. (2013)
  Expression, purification, crystallization and preliminary X-ray crystallographic analysis of human myosin 1c in complex with calmodulin
  Acta Crystallogr Sect F Struct Biol Cryst Commun., doi: 10.1107/S1744309113020988
   
• Rai A, Tzvetkov N, and Manstein, D.J. (2013)
  Functional Dissection of the Dictyostelium discoideum Dynamin B Mitochondrial Targeting Sequence
  PloS one, doi: 10.1371/journal.pone.0056975
   
• Taft, M.H., Behrmann, E., Munske-Weidemann, L.C., Thiel, C., Raunser, S., and Manstein, D.J. (2013)
  Functional Characterization of Human Myosin-18A and its Interaction with F-actin and GOLPH3
  J Biol Chem., doi: 10.1074/jbc.M113.497180
   
• Müller, M., Mazur, A.J., Behrmann, E., Diensthuber, R.P., Radke, M.B., Qu, Z., Littwitz, C., Raunser, S., Schoenenberger, C.A., Manstein, D.J., Mannherz, H.G. (2012)
  Functional characterization of the human alpha-cardiac actin mutations Y166C and M305L involved in hypertrophic cardiomyopathy.
  Cell Mol Life Sci 69:3457–3479, rdcu.be/mD3P, doi: 10.1007/s00018-012-1030-5
   
• Heissler, S.M., Selvadurai, J., Bond, L.M., Fedorov, R., Kendrick-Jones, J., Buss, F. and Manstein, D.J. (2012)
  Kinetic properties and small-molecule inhibition of human myosin-6. 
  FEBS Lett., doi: 10.1016/j.febslet.2012.07.014
   
• Heissler SM, Manstein, D.J. (2012)
  Functional characterization of the human myosin-7a motor domain.
  Cell Mol Life Sci., doi: 10.1007/s00018-011-0749-8, rdcu.be/mD3m  
   
• Behrmann E, Müller M, Penczek PA, Mannherz HG, Manstein, D.J., Raunser S (2012)
  Structure of the Rigor Actin-Tropomyosin-Myosin Complex.
  Cell, doi: 10.1016/j.cell.2012.05.037
   
• Rai A, Nöthe H, Tzvetkov N, Korenbaum E, Manstein, D.J. (2011)
  Dictyostelium dynamin B modulates cytoskeletal structures and membranous organelles.
  Cell Mol Life Sci. 68:2751-2767, rdcu.be/mD4t, doi: 10.1007/s00018-010-0590-5
   
• Preller M, Chinthalapudi K, Martin R, Knölker H-J, Manstein, D.J. (2011)
  Inhibition of Myosin ATPase Activity by Halogenated Pseudilins: A Structure-Activity Study.
  J Med Chem., doi: 10.1021/jm200259f
   
• Preller M, Bauer S, Adamek N, Fujita-Becker S, Fedorov R, Geeves MA, Manstein, D.J. (2011)
  Structural basis for the allosteric interference of myosin function by reactive thiol region mutations G680A and G680V.
  J Biol Chem., doi: 10.1074/jbc.M111.265298
   
• Polonais V, Javier Foth B, Chinthalapudi K, Marq JB, Manstein, D.J., Soldati-Favre D, Frenal K (2011)
  Unusual anchor of a motor complex (MyoD-MLC2) to the plasma membrane of Toxoplasma gondii.
  Traffic., doi: 10.1111/j.1600-0854.2010.01148.x
   
• Naue N, Fedorov R, Pich A, Manstein, D.J., Curth U (2011)
  Site-directed mutagenesis of the chi subunit of DNA polymerase III and single-stranded DNA-binding protein of E. coli reveals key residues for their interaction.
  Nucleic Acids Res., doi: 10.1093/nar/gkq988
   
• Heissler SM, Manstein, D.J. (2011)
  Comparative kinetic and functional characterization of the motor domains of human nonmuscle myosin-2C isoforms.
  J Biol Chem., doi: 10.1074/jbc.M110.212290
   
• Diensthuber RP, Muller M, Heissler SM, Taft MH, Chizhov I, Manstein, D.J. (2011)
  Phalloidin perturbs the interaction of human non-muscle myosin isoforms 2A and 2C1 with F-actin.
  FEBS Lett., doi: 10.1016/j.febslet.2011.01.042
   
• Chinthalapudi K, Taft MH, Martin R, Heissler SM, Preller M, Hartmann FK, Brandstaetter H, Kendrick-Jones J, Tsiavaliaris G, Gutzeit HO, Fedorov R, Buss F, Knölker H-J, Coluccio LM, Manstein, D.J. (2011)
  Mechanism and specificity of pentachloropseudilin-mediated inhibition of myosin motor activity.
  J Biol Chem., doi: 10.1074/jbc.M111.239210
   
• Al-Omari M, Korenbaum E, Ballmaier M, Lehmann U, Jonigk D, Manstein, D.J., Welte T, Mahadeva R, Janciauskiene S (2011)
  The acute phase protein, alpha1-antitrypsin, inhibits neutrophil calpain I and induces random migration. 
  Mol Med., doi: 10.2119/molmed.2011.00089
   
• Montessuit S, Somasekharan SP, Terrones O, Lucken-Ardjomande S, Herzig S, Schwarzenbacher R, Manstein, D.J., Bossy-Wetzel E, Basanez G, Meda P, Martinou JC (2010)
  Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization.
  Cell., doi: 10.1016/j.cell.2010.08.017
   
• Amrute-Nayak, M., Diensthuber, R.P., Steffen, W., Kathmann, D., Hartmann, F.K., Fedorov, R., Urbanke, C., Manstein, D.J., Brenner, B. and Tsiavaliaris, G. (2010)
  Targeted optimization of a protein nanomachine for operation in biohybrid devices.
  Angew Chem Int Ed Engl., doi: 10.1002/anie.200905200
   
• Martin, R., Jäger, A., Böhl, M., Richter, S., Fedorov, R., Manstein, D.J., Gutzeit, H.O. and Knölker, H.J. (2009)
  Total synthesis of pentabromo- and pentachloropseudilin,
  and synthetic analogues--allosteric inhibitors of myosin ATPase.
  Angew Chem Int Ed Engl., doi: 10.1002/anie.200903743
   
• Knoth, T., Warburg, K. ,Katzka, C. ,Rai, A. ,Wolf, A. Brockmeyer, A. Janning, P.  Reubold, T.F., Eschenburg, S., Manstein, D.J., Hubel, K. Kaiser, M. and Waldmann, H. (2009)
  The Ras Pathway Modulator Melophlin A Targets Dynamins.
  Angew Chem Int Ed Engl., doi: 10.1002/anie.200902023
   
• Fedorov, R., Böhl, M., Tsiavaliaris, G., Hartmann, F. K., Taft, M. H., Baruch, P., Brenner, B., Martin, R., Knölker, H.-J., Gutzeit, H. O., and Manstein, D.J. (2009).
  The mechanism of pentabromopseudilin inhibition of myosin motor activity.
  Nat. Struct. Mol. Biol. 16, 80-88, rdcu.be/mD13 , doi: 10.1038/nsmb.1542
   
• Tsiavaliaris, G., Fujita-Becker, S., Dürrwang, U., Diensthuber, R. P., Geeves, M. A., and Manstein, D.J. (2008).
  Mechanism, Regulation, and Functional Properties of Dictyostelium Myosin-1B.
  J Biol Chem 283, 4520-4527. (Abstract) (pdf, 350 kB)
   
• Taft, M. H., Hartmann, F. K., Rump, A., Keller, H., Chizhov, I., Manstein, D.J., and Tsiavaliaris, G. (2008).
  Dictyostelium Myosin-5b is a conditional processive motor.
  J Biol. Chem 283, 26902-26910. (Abstract) (pdf, 390 kB)
   
• Stolboushkina, E., Nikonov, S., Nikulin, A., Blasi, U., Manstein, D.J., Fedorov, R., Garber, M., and Nikonov, O. (2008).
  Crystal structure of the intact archaeal translation initiation factor 2 demonstrates very high conformational flexibility in the alpha- and beta-subunits.
  J Mol. Biol. 382, 680-691. (Abstract)  (pdf, 3.2 MB)
   
• Nikonov, O., Stolboushkina, E., Nikulin, A., Hasenohrl, D., Blasi, U., Manstein, D.J., Fedorov, R., Garber, M., and Nikonov, S. (2007).
  New insights into the interactions of the translation initiation factor 2 from archaea with guanine nucleotides and initiator tRNA.
  J Mol Biol 373, 328-336. (Abstract) (pdf, 2.5 MB)
   
• Hachikubo, Y., Ito, K., Schiefelbein, J., Manstein, D.J., and Yamamoto, K. (2007).
  Enzymatic activity and motility of recombinant Arabidopsis myosin XI. MYA1
  Plant Cell Physiol 48, 886-891. (Abstract) (pdf, 174 kB)
   
• Fujita-Becker, S.,Tsiavaliaris, G., Ohkura, R., Shimada, T., Manstein, D.J., and Sutoh, K. (2006).
  Functional characterization of the N-terminal region of myosin-2.
  J Biol Chem 281, 36102-36109. (Abstract)(pdf)
   
• Fedorov, R., Witte, G., Urbanke, C., Manstein, D.J., and Curth, U. (2006).
  3D structure of Thermus aquaticus single-stranded DNA-binding protein gives insight into the functioning of SSB proteins.
  Nucleic Acids Res 34, 6708-6717. (Abstract) (pdf 5.7 MB)
   
• Ulrike Dürrwang, Setsuko Fujita-Becker, Muriel Erent, F. Jon Kull, Georgios Tsiavaliaris, Michael A. Geeves, and Manstein, D.J. (2006)
  Dictyostelium myosin-IE is a fast molecular motor involved in phagocytosis
  J. Cell Science 119, 550-558 (Abstract) (pdf)
   
• Reubold, T. F., Eschenburg, S., Becker, A., Leonard, M., Schmid, S. L., Vallee, R. B., Kull, F. J. and Manstein, D.J. (2005)
  Crystal structure of the GTPase domain of rat dynamin 1
  Proc. Natl. Acad. Sci. U.S.A. 102, 13093-13098 (pdf)
   
• Fujita-Becker, S., Dürrwang, U., Erent, M., Clark, R. J., Geeves, M. A. and Manstein, D.J. (2005)
  Changes in Mg2+ ion concentration and heavy chain phosphorylation regulate the motor activity of a class I myosin
  J. Biol. Chem. 280, 6064-6071 (pdf)
   
• Van Dijk, J., Lafont, C., Knetsch, M. L., Derancourt, J., Manstein, D.J., Long, E. C. and Chaussepied, P. (2004)
  Conformational changes in actin-myosin isoforms probed by Ni(II).Gly-Gly-His reactivity
  J. Muscle Res. Cell Motil. 25, 527-537 (pdf)
   
• Tsiavaliaris, G., Fujita-Becker, S. & Manstein, D.J. (2004)
  Molecular engineering of a backwards moving myosin motor
  Nature 427, 558-561, rdcu.be/mD1F, (Abstract)(pdf)
   
• Schlosser, A., Klockow, B., Manstein, D.J., & Lehmann, W.D. (2003)
  Analysis of post-translational modification and characterization of the domain structure of dynamin A from Dictyostelium discoideum.
  J. Mass. Spectrom. 38 (3) 277-282 (Abstract)(pdf)
   
• Reubold, T.F., Eschenburg, S., Becker, A., Kull, F.J. & Manstein, D.J. (2003)
  A structural model for actin-induced nucleotide release in myosin
  Nature Struct. Biol., 10, 826-830. rdcu.be/mD2y , (Abstract)(pdf)
   
• Krylyshkina, O., Anderson, K.I., Kaverina, I., Upmann, I., Manstein, D.J., Small, J.V. & Toomre, D.K.
  Nanometer targeting of microtubules to focal adhesions
  J. Cell Biol., 161, 853-859. (Abstract)(pdf)
   
• Ito K., Kashiyama T., Shimada K, Yamaguchi A., Awata J, Hachikubo Y., Manstein, D.J., Yamamoto K. (2003)
  Recombinant motor domain constructs of Chara corallina myosin display fast motility and high ATPase activity
  Biochem. Biophys. Res. Commun. 312, 958-64. (Abstract) (pdf)
   
• Ballweber, E., Kiessling, P., Manstein, D.J., & Mannherz, H.G. (2003)
  Interaction of Myosin subfragment 1 with forms of monomeric actin
  Biochemistry 42 (10) 3060-3069 (Abstract)
   
• Tsiavaliaris, G., Fujita-Becker, S., Batra, R., Levitsky, D.I., Kull, F.J., Geeves, M.A. & Manstein, D.J. (2002)
  Mutations in the relay loop region result in dominant-negative inhibition of myosin II function in Dictyostelium
  EMBO Reports, 3, 1099-1105 (Abstract) (pdf)
   
• Linke, W.A., Kulke, M., Li, H., Fujita-Becker S., Neagoe C., Manstein, D.J., Gautel, M., Fernandez, J.M. (2002)
  PEVK Domain of Titin: An Entropic Spring with Actin-Binding Properties
  J. Struct. Biol. 137, 194-205. (Abstract)
   
• Kollmar, M. Dürrwang, U., Kliche, W., Manstein, D.J., & Kull, F.J. (2002)
  Crystal structure of the motor domain of a class-I myosin
  EMBO J. 21, 2517-25 (Abstract)
   
• Knetsch, M.L.W., Tsiavaliaris, G., Zimmermann, S., Rühl, S., &. Manstein, D.J. (2002)
  Expression vectors for studying cytoskeletal proteins in Dictyostelium discoideum
  J. Mus. Res. Cell Motil. 23, 605-611 (Abstract)
   
• Klockow, B., Tichelaar, W., Madden, D., Niemann, H.H., Akiba, T., Hirose, K., & Manstein, D.J. (2002)
  The dynamin a ring complex: molecular organization and nucleotide-dependent conformational changes
  EMBO J. 21, 240-250. (Abstract) (pdf, 500 kB)
   
• Herm-Gotz, A., Weiss, S., Fujita-Becker, S., Ruff, C., Meyhöfer, E., Soldati, T., Manstein, D.J., Geeves, M.A., & Soldati, D. (2002)
  Toxoplasma gondii class XIV myosin is a fast, single-headed, plus-end directed motor
  EMBO J. 21, 2149-2158. (Abstract) (pdf, 400 kB) 
   
• Ruff, C., Furch, M., Brenner, B., Manstein, D.J. & Meyhöfer, E. (2001)
  Single-molecule tracking of myosins with genetically engineered amplifier domains
  Nature Struct. Biol., 8, 226-229. (Abstract) (pdf, 590 kB)
   
• Niemann, H.H., Knetsch, M.L.W. Scherer, A., Manstein, D.J., & Kull, F.J. (2001)
  Crystal structure of a dynamin GTPase domain
  EMBO J., 21, 5813-5821. (Abstract) (pdf, 400 kB)
   
• Kulke, M., Fujita-Becker, S., Rostkova, E., Neagoe, C., Labeit, D., Manstein, D.J., Gautel, M., & Linke, W.A. (2001)
  Interaction between PEVK-titin and actin filaments: origin of a viscous force component in cardiac myofibrils
  Circ. Res., 89, 874-881. (Abstract)
   
• Knetsch, M.L.W., Schäfers, N., Horstmann, H. & Manstein, D.J. (2001)
  A Bcr/Abr-related protein controls the organization of a tubolocisternal organelle, F-Actin dynamics, and cytokinesis in Dictyostelium
  EMBO J., 20, 1620-1629. (Abstract) (pdf, 350 kB)
   
• Kliche, W., Fujita-Becker, S., Kollmar, M., Manstein, D.J. & Kull, F.J. (2001)
  Structure of a genetically engineered molecular motor
  EMBO J., 20, 40-46. (Abstract) (pdf)
   
• Ponomarev, M.A., Furch, M., Levitsky, D.I. & Manstein, D.J. (2000)
  Charge changes in loop 2 affect the thermal unfolding of the myosin motor domain bound to F-actin
  Biochemistry, 39, 4527-4532. (Abstract) (pdf)
   
• Furch, M., Remmel, B., Geeves, M.A. & Manstein, D.J. (2000)
  Stabilization of the actomyosin complex by negative charges on myosin
  Biochemistry 39, 11602-11608. (Abstract) (pdf)
   
• Wienke, D.C., Knetsch, M.L.W., Neuhaus, E.M., Reedy, M.C. & Manstein, D.J. (1999)
  Disruption of a dynamin homologue affects en­docytosis, organelle morphology and cytokinesis in Dictyostelium discoideum
  Mol. Biol. Cell 10, 225-243. (Abstract) (pdf, 966 kB)
   
• Van Dijk, J., Furch, M., Lafont, C., Manstein, D.J., & Chaussepied, P. (1999)
  Functional characterization of the secondary actin binding site of myosin II
  Biochemistry, 38, 15078-15085. (Abstract) (pdf, 160 kB)
   
• Van Dijk, J., Furch, M., Derancourt, J., Batra, R., Knetsch, M.L.W., Manstein, D.J., & Chaussepied, P.(1999)
  Differences in the interaction of actin with the motor domains of non-muscle and muscle myosin II
  Europ. J. Biochem. 260, 672-683. (Abstract) (pdf, 844 kB)
   
• Knetsch, M.L.W., Uyeda, T.Q.P., & Manstein, D.J. (1999)
  Disturbed communication between actin- and nucleotide binding sites in a myosin II with truncated 50K/20K junction
  J. Biol. Chem. 274, 20133-20138. (Abstract) (pdf, 122 kB)
   
• Furch, M., Fujita-Becker, S., Geeves, M.A., Holmes, K.C. & Manstein, D.J. (1999)
  Role of the salt-bridge between switch-1 and switch-2 of Dictyostelium myosin
  J. Mol. Biol. 290, 797-809. (Abstract) (pdf, 330 kB)
   
• Batra, R. & Manstein, D.J. (1999)
  Functional characterisation of Dictyostelium myosin II with conserved tryptophanyl residue 501 mutated to tyrosine
  Biol. Chem. 380, 1017-1023. (Abstract) (pdf)
   
• Batra, R., Geeves, M.A., &. Manstein, D.J. (1999)
  Kinetic analysis of myosin motor domains with glycine-to-alanine mutations in the reactive thiol region 
  Biochemistry 38, 6126-6134 (Abstract) (pdf)
   
• Levitsky, D.I., Ponomarev, M.A., Geeves, M.A., Shnyrov, V.L. & Manstein, D.J. (1998)
  Differential scanning calorimetric study of the thermal unfolding of the motor domain fragments of Dictyostelium discoideum myosin II
  Europ. J. Biochem. 251, 275-280. (Abstract) (pdf, 11 MB)
   
• Furch, M., Geeves, M.A. & Manstein, D.J. (1998)
  Modulation of actin affinity and actomyosin ATPase by charge changes in the myosin motor domain
  Biochemistry 37, 6317-6326. (Abstract)
   
• Friedman, A. L., Geeves, M. A., Manstein, D.J. & Spudich, J.A. (1998)
  Kinetic Characterization of myosin head fragments with long-lived myosin.ATP states
  Biochemistry 37, 9679-9687. (Abstract) (pdf)
   
• Kurzawa, S.E., Manstein, D.J. & Geeves, M.A. (1997)
  Dictyostelium discoideum myosin II: characterization of functional motor fragments
  Biochemistry 36, 317-323. (Abstract) (pdf, 163 kB)
   
• Anson, M. Geeves, M.A., Kurzawa, S. & Manstein, D.J. (1996)
  Myosins with artificial lever arms
  EMBO J. 15, 6069-6074. (Abstract) (pdf, 15 MB)
   
• Woodward, S.K.A., Geeves, M.A. & Manstein, D.J. (1995)
  Kinetic characterization of the catalytic domain of Dictyostelium discoideum myosin
  Biochemistry 34, 16056-16064. (Abstract)
   
• Manstein, D.J. & Hunt, D.M. (1995)
  Overexpression of myosin motor domains in Dictyostelium discoideum: Screening of transformants and pu­rification of the affinity tagged protein
  J. Mus. Res. Cell Motil. 16, 325-332. (Abstract) (pdf, 13 MB)
   
• Manstein, D.J., Schuster, H.-P., Morandini, P. & Hunt, D.M. (1995)
  Cloning vectors for the production of proteins in Dictyostelium discoideum
  Gene 162, 129-134. (Abstract) (pdf, 436 kB)
   
• Schröder, R.R., Manstein, D.J., Jahn, W., Holden, H.M., Rayment, I., Holmes, K.C. & Spudich, J.A. (1993)
  Three-dimensional atomic model of F-actin decorated with Dictyostelium myosin S1
  Nature 364, 171-174. rdcu.be/mD1p, (Abstract)
   
• Ritchie, M.D., Geeves, M.A., Woodward, S.K.A. & Manstein, D.J. (1993)
  Kinetic characterization of a cytoplasmic motor domain expressed in Dictyostelium discoideum
  Proc. Natl. Acad. Sci. USA 90, 8619-8623. (Abstract) (pdf)
   
• Manstein, D.J., Ruppel, K.M., Kubalek, L. & Spudich, J.A. (1991)
  Manipulation and expression of molecular motors in Dictyostelium discoideum
  J. Cell Science, 14s, 63-65. (Abstract) (pdf)
   
• Egelhoff, T.T., Manstein, D.J. & Spudich, J.A. (1990)
  Complementation of myosin null mutants in Dictyostelium discoideum by direct functional selection
  Develop. Biol. 137, 359-367. (Abstract)
   
• Manstein, D.J., Titus, M.A., De Lozanne, A. & Spudich, J.A. (1989)
  Gene replacement in Dictyostelium: generation of myosin null mutants
  EMBO J. 8, 923-932. (Abstract) (pdf)
   
• Manstein, D.J., Ruppel, K.M. & Spudich, J.A. (1989)
  Expression and cha­racterization of a functional myosin head fragment in Dictyostelium discoideum
  Science 246, 656-658. (Abstract) (pdf, 5.6 MB)
   
• Egelhoff, T.T., Brown, S.S., Manstein, D.J. & Spudich, J.A. (1989)
  Hygromycin resistance as a selectable marker in Dictyostelium
  Mol. Cell. Biol. 9, 1965-1968. (Abstract) (pdf,15 MB)
   
• Manstein, D.J., Massey, V., Ghisla, S. & Pai, E.F., (1988)
  Stereochemistry and accessibility of prosthetic groups in flavoproteins
  Biochemistry 27, 2300-2305. (Abstract) (pdf, 17 MB)
   
• Manstein, D.J., Pai, E.F., Schopfer, L.M., & Massey, V. (1986)
  Absolute stereochemistry of flavins in enzyme catalyzed reactions
  Biochemistry 25, 6807-6816. (Abstract) (pdf)
   
• Manstein, D.J. & Pai, E.F. (1986)
  Purification and characterization of FAD synthetase from Brevibacterium ammoniagenes
  J. Biol. Chem. 261, 16169-16973. (Abstract) (pdf, 9 MB)
   
• Manstein, D.J., Berriman, J., Leonard, K. & Rosenbusch, J.P. (1986)
  Ultrastructure of native lipoprotein from Escherichia coli envelopes
  J. Mol. Biol. 189, 701-707. (Abstract) (pdf, 14 MB)

Manstein, D.J. and Preller, M. (2020)
Small Molecule Effectors of Myosin Function
Myosins. A Superfamily of Molecular Motors. Coluccio, L.M. (Ed.); Adv Exp Med Biol 1239, 61-84; ISBN 978-3-030-38061-8; DOI: 10.1007/978-3-030-38062-5_5

 

Preller, M. and Manstein, D.J. (2017)
Myosin Motors: Structural Aspects and Functionality.
In Reference Module in Life Sciences, (Egelman, E. H., ed.) Elsevier, Amsterdam dx.doi.org/10.1016/B978-0-12-809633-8.08058-4

 

Manstein, D.J. and Mulvihill D. P. (2016)
Tropomyosin-mediated Regulation of Cytoplasmic Myosins.
Traffic,  (2016). doi: 10.1111/tra.12399

 

Preller, M. and Manstein, D.J. (2012) 
4.8 Myosin Motors: Structural Aspects and Functionality.
In Comprehensive Biophysics. (Editor-in-Chief: Edward, H.E., ed.), pp. 118-150. Elsevier, Amsterdam. PDF.

 

Heissler, S.M. and Manstein, D.J. (2012). 
Nonmuscle myosin-2: mix and match.
in Cell Mol Life Sci 70: 1-21. rdcu.be/mD3v

 

Martin, R. et al. (2010)
Biomolecular Chemistry Directed Towards Drug Development.
in Med Chem Res 19, S23-S26. PDF.

 

Oiwa, K. and Manstein, D.J. (2007)
How linear motor proteins work
in Lecture Notes in Physics, 711, Controlled Nanoscale Motion – Nobel Symposium 131, H. Linke, A. Mansson (eds.) Springer, Berlin, Heidelberg, New York, pp. 41-59. (pdf, 880 kB)

Geeves, M.A., Fedorov, R. and Manstein, D.J. (2005)
Molecular mechanism of actomyosin-based motility.
in Cell Mol Life Sci 62, 1462-77. (pdf) http://rdcu.be/mD36

 

Manstein, D.J. (2004)
Molecular engineering of myosin.
in Philos Trans R Soc Lond B Biol Sci 359, 1907-12. (Abstract)

 

Toomre, D. & Manstein, D.J. (2001)
Lighting up the cell surface with evanescent wave microscopy
Trends Cell Biol., 11, 298-303. (Abstract) (pdf, 2.5 MB)
Manstein, D.J. (1993)

 

Myosin function in the motile behaviour of cells
in Cell Behaviour: Adhesion & Motility, Jones, G., Wigley, C., Warn, R. (eds.), The company of Biologists Limited, Cambridge UK, pp. 375-381. (pdf, 11 MB)

 

Forke, R., Gruner, K.K., Knott, K.E., Auschill, S., Agarwal, S., Martin, R.,Böhl, M., Richter, S., Tsiavaliaris, G., Fedorov, R., Manstein, D.J., Gutzeit, H.O. and Knölker, H.-J. (2010)
Total Synthesis of Biologically Active Alkaloids Using Transition Metals
Pure Appl. Chem. 82:1975-1991.

 

Schröder, R.R., Manstein, D.J., Jahn, W., & Spudich, J.A. (1993)
Energy filtering and correction for the contrast transfer function (CTF) of frozen hydrated objects as illustrated by a reconstruction of Dictyostelium S1 decorated Actin
in Proc. 51st Annual Meeting of the Microscopy Society of America; Bailey, G.W. and Rieder C.L. (eds.), MSA, San Francisco Press, San Francisco, CA, pp. 118-119.

 

Egelhoff, T.T., Titus, M.A., Manstein, D.J., Ruppel, K.M. & Spudich, J.A. (1991)
Molecular genetic tools for the study of the cytoskeleton in Dictyostelium
Meth. Enzymol. 196, 319-334. (Abstract) (pdf, 14 MB)

 

Manstein, D.J., Massey, V. & Pai E.F. (1987)
Absolute stereochemistry of flavins
in Flavins & Flavoproteins, Edmondson, D.E., McCormick, D.B.(eds.) Walter de Gruyter & Co., Berlin, New York, pp. 3-12. (Abstract)

 

Manstein, D.J. & Pai, E.F. (1987)
Purification and characterization of the bifunctional enzyme FAD synthetase from Brevibacterium ammoniagenes
in Flavins & Flavoproteins, Edmondson, D.E., McCormick, D.B.(eds.) Walter de Gruyter & Co., Berlin, New York, pp. 455-458. (Abstract)

Patents

• Manstein, D.J., Preller, M., Furch, M., Kalesse, M. and Diaz-Gomez, N. (2016) Biphenyl compounds for use in treating malaria and other parasitic disorders. US9499471 B2, published on 22. Nov. 2016
   
• Manstein, D.J., Preller, M., Kalesse, M. Novel means and methods for treating malaria and other parasitic disorders. EP 2727911 B1, published 21. Dec. 2016
   
• Manstein, D.J., Fedorov, R., Tsiavaliaris, G., KNÖLKER, H. J., Martin, R., Kirst, J., Gutzeit, H. and BÖHL, M. (2016) Means for treating myosin-related diseases. EP2277124 B1, published on 9. Nov. 2016