Publications of the Prinz Group

2023

Yang, T., Barros-Martins, J., Wang, Z., Wencker, M., Zhang, J., Smout, J., Gambhir, P., Janssen, A., Schimrock, A., Georgiev, H., León-Lara, X., Weiss, S., Huehn, J., Prinz, I., Krueger, A., Foerster, R., Walzer, T., & Ravens, S. (2023). RORγt+ c-Maf+ Vγ4+ γδ T cells are generated in the adult thymus but do not reach the periphery. Cell reports, 42(10), 113230. https://doi.org/10.1016/j.celrep.2023.113230

Marzano, P., Balin, S., Terzoli, S., Della Bella, S., Cazzetta, V., Piazza, R., Sandrock, I., Ravens, S., Tan, L., Prinz, I., Calcaterra, F., Di Vito, C., Cancellara, A., Calvi, M., Carletti, A., Franzese, S., Frigo, A., Darwish, A., Voza, A., Mikulak, J., … Mavilio, D. (2023). Transcriptomic profile of TNFhigh MAIT cells is linked to B cell response following SARS-CoV-2 vaccination. Frontiers in immunology, 14, 1208662. https://doi.org/10.3389/fimmu.2023.1208662

Song, Z., Henze, L., Casar, C., Schwinge, D., Schramm, C., Fuss, J., Tan, L., & Prinz, I. (2023). Human γδ T cell Identification from Single-cell RNA Sequencing Datasets by Modular TCR Expression. Journal of leukocyte biology, qiad069. Advance online publication. https://doi.org/10.1093/jleuko/qiad069

Bufe, S., Zimmermann, A., Ravens, S., Prinz, I., Buitrago-Molina, L. E., Geffers, R., Woller, N., Kühnel, F., Talbot, S. R., Noyan, F., Manns, M. P., Wedemeyer, H., Hardtke-Wolenski, M., Jaeckel, E., & Davalos-Misslitz, A. C. (2022). PD-1/CTLA-4 Blockade Leads to Expansion of CD8+PD-1int TILs and Results in Tumor Remission in Experimental Liver Cancer. Liver cancer, 12(2), 129–144. https://doi.org/10.1159/000526899

Klein, S., Mischke, J., Beruldsen, F., Prinz, I., Antunes, D. A., Cornberg, M., & Kraft, A. R. M. (2023). Individual Epitope-Specific CD8+ T Cell Immune Responses Are Shaped Differently during Chronic Viral Infection. Pathogens (Basel, Switzerland), 12(5), 716. https://doi.org/10.3390/pathogens12050716

Deng, L., Ly, C., Abdollahi, S., Zhao, Y., Prinz, I., & Bonn, S. (2023). Performance comparison of TCR-pMHC prediction tools reveals a strong data dependency. Frontiers in immunology, 14, 1128326. https://doi.org/10.3389/fimmu.2023.1128326

Prinz, I., & Koenecke, C. (2023). Antigen-specific γδ T cells contribute to cytomegalovirus control after stem cell transplantation. Current opinion in immunology, 82, 102303. https://doi.org/10.1016/j.coi.2023.102303

Hahn, A. M., Vogg, L., Brey, S., Schneider, A., Schäfer, S., Palmisano, R., Pavlova, A., Sandrock, I., Tan, L., Fichtner, A. S., Prinz, I., Ravens, S., & Winkler, T. H. (2023). A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages. Cell reports, 42(3), 112253. https://doi.org/10.1016/j.celrep.2023.112253

Mueller, A., Zhao, Y., Cicek, H., Paust, H. J., Sivayoganathan, A., Linke, A., Wegscheid, C., Wiech, T., Huber, T. B., Meyer-Schwesinger, C., Bonn, S., Prinz, I., Panzer, U., Tiegs, G., Krebs, C. F., & Neumann, K. (2023). Transcriptional and Clonal Characterization of Cytotoxic T Cells in Crescentic Glomerulonephritis. Journal of the American Society of Nephrology : JASN, 34(6), 1003–1018. https://doi.org/10.1681/ASN.0000000000000116

Yang T, Barros-Martins J, Janssen A, Wang Z, León-Lara X, Weiss S, Prinz I, Förster R, Ravens S (2023). Adult thymus-derived cMaf+RORγt+ γδ T cells lack Scart2 chromatin accessibility and do not reach periphery. doi: https://doi.org/10.1101/2023.02.20.529224

Picard, F. S. R., Lutz, V., Brichkina, A., Neuhaus, F., Ruckenbrod, T., Hupfer, A., Raifer, H., Klein, M., Bopp, T., Pfefferle, P. I., Savai, R., Prinz, I., Waisman, A., Moos, S., Chang, H. D., Heinrich, S., Bartsch, D. K., Buchholz, M., Singh, S., Tu, M., … Huber, M. (2023). IL-17A-producing CD8+ T cells promote PDAC via induction of inflammatory cancer-associated fibroblasts. Gut, 72(8), 1510–1522. https://doi.org/10.1136/gutjnl-2022-327855

Moos, S., Regen, T., Wanke, F., Tian, Y., Arendholz, L., Hauptmann, J., Heinen, A. P., Bleul, L., Bier, K., El Malki, K., Reinhardt, C., Prinz, I., Diefenbach, A., Wolz, C., Schittek, B., Waisman, A., & Kurschus, F. C. (2023). IL-17 signaling in keratinocytes orchestrates the defense against Staphylococcus aureus skin infection. The Journal of investigative dermatology, S0022-202X(23)00070-2. Advance online publication. https://doi.org/10.1016/j.jid.2023.01.016

Giannou, A. D., Kempski, J., Shiri, A. M., Lücke, J., Zhang, T., Zhao, L., Zazara, D. E., Cortesi, F., Riecken, K., Amezcua Vesely, M. C., Low, J. S., Xu, H., Kaffe, E., Garcia-Perez, L., Agalioti, T., Yamada, Y., Jungraithmayr, W., Zigmond, E., Karstens, K. F., Steglich, B., … Huber, S. (2023). Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22. Immunity, 56(1), 125–142.e12. https://doi.org/10.1016/j.immuni.2022.12.014

Bertram, T., Reimers, D., Lory, N. C., Schmidt, C., Schmid, J., C Heinig, L., Bradtke, P., Rattay, G., Zielinski, S., Hellmig, M., Bartsch, P., Rohde, H., Nuñez, S., Rosemblatt, M. V., Bono, M. R., Gagliani, N., Sandrock, I., Panzer, U., Krebs, C. F., Meyer-Schwesinger, C., … Mittrücker, H. W. (2023). Kidney-resident innate-like memory γδ T cells control chronic Staphylococcus aureus infection of mice. Proceedings of the National Academy of Sciences of the United States of America, 120(1), e2210490120. https://doi.org/10.1073/pnas.2210490120

2022

Mischke, J., Klein, S., Seamann, A., Prinz, I., Selin, L., Ghersi, D., Cornberg, M., Kraft, A. (2022). Cross-Reactive T Cell Response Exists in Chronic Lymphocytic Choriomeningitis Virus Infection upon Pichinde Virus Challenge. Viruses, 14(10), 2293. https://doi.org/10.3390/v14102293

Deng, L., Harms, A., Ravens, S., Prinz, I.*, Tan, L.* (2022). Systematic pattern analyses of Vδ2+ TCRs reveal that shared "public" Vδ2+ γδ T cell clones are a consequence of rearrangement bias and a higher expansion status. Frontiers in immunology, 13, 960920. https://doi.org/10.3389/fimmu.2022.960920
* These authors contributed equally to this work

Schneider J, Kuhlmann L, Xiao Y, Raha S, Bernhardt G, Stadler M, Thol F, Heuser M, Eder M, Ganser A, Ravens S, Förster R, Prinz I, Koenecke C, Schultze-Florey CR. Healthy-like CD4+ Regulatory and CD4+ Conventional T-Cell Receptor Repertoires Predict Protection from GVHD Following Donor Lymphocyte Infusion. Int J Mol Sci. 2022 Sep 18;23(18):10914. doi: 10.3390/ijms231810914. PMID: 36142824; PMCID: PMC9505302.

Ritter K, Behrends J, Rückerl D, Hölscher A, Volz J, Prinz I, Hölscher C. High-Dose Mycobacterium tuberculosis H37rv Infection in IL-17A- and IL-17A/F-Deficient Mice. Cells. 2022 Sep 14;11(18):2875. doi: 10.3390/cells11182875. PMID: 36139450; PMCID: PMC9496946.

Ataide MA, Knöpper K, Cruz de Casas P, Ugur M, Eickhoff S, Zou M, Shaikh H, Trivedi A, Grafen A, Yang T, Prinz I, Ohlsen K, Gomez de Agüero M, Beilhack A, Huehn J, Gaya M, Saliba AE, Gasteiger G, Kastenmüller W. Lymphatic migration of unconventional T cells promotes site-specific immunity in distinct lymph nodes. Immunity. 2022 Aug 17:S1074-7613(22)00354-5. doi: 10.1016/j.immuni.2022.07.019. Epub ahead of print. PMID: 36002023.

Jarade A, Garcia Z, Marie S, Demera A, Prinz I, Bousso P, Di Santo JP, Serafini N. Inflammation triggers ILC3 patrolling of the intestinal barrier. Nat Immunol. 2022 Aug 23. doi: 10.1038/s41590-022-01284-1. Epub ahead of print. PMID: 35999393.

Bruni E, Cimino MM, Donadon M, Carriero R, Terzoli S, Piazza R, Ravens S, Prinz I, Cazzetta V, Marzano P, Kunderfranco P, Peano C, Soldani C, Franceschini B, Colombo FS, Garlanda C, Mantovani A, Torzilli G, Mikulak J, Mavilio D. Intrahepatic CD69+Vδ1 T cells re-circulate in the blood of patients with metastatic colorectal cancer and limit tumor progression. J Immunother Cancer. 2022 Jul;10(7):e004579. doi: 10.1136/jitc-2022-004579. PMID: 35863820.

Deseke M, Rampoldi F, Sandrock I, Borst E, Böning H, Ssebyatika GL, Jürgens C, Plückebaum N, Beck M, Hassan A, Tan L, Demera A, Janssen A, Steinberger P, Koenecke C, Viejo-Borbolla A, Messerle M, Krey T, Prinz I. A CMV-induced adaptive human Vδ1+ γδ T cell clone recognizes HLA-DR. J Exp Med. 2022 Sep 5;219(9):e20212525. doi: 10.1084/jem.20212525. Epub 2022 Jul 19. PMID: 35852466.

Rampoldi F, Donato E, Ullrich L, Deseke M, Janssen A, Demera A, Sandrock I, Bubke A, Juergens AL, Swallow M, Sparwasser T, Falk C, Tan L, Trumpp A, Prinz I. γδ T cells license immature B cells to produce a broad range of polyreactive antibodies. Cell Rep. 2022 May 24;39(8):110854. doi: 10.1016/j.celrep.2022.110854. PMID: 35613579.

Barros-Martins J*, Bruni E*, Fichtner AS, Cornberg M, Prinz I. OMIP-084: 28-color full spectrum flow cytometry panel for the comprehensive analysis of human γδ T cells. Cytometry A. 2022 May 6. doi: 10.1002/cyto.a.24564. Epub ahead of print. PMID: 35521651.
* These authors contributed equally to this work

Rampoldi F, Prinz I. Three Layers of Intestinal γδ T Cells Talk Different Languages With the Microbiota. Front Immunol. 2022 Mar 24;13:849954. doi: 10.3389/fimmu.2022.849954. PMID: 35422795; PMCID: PMC9004464.

Mann AO, Hanna BS, Muñoz-Rojas AR, Sandrock I, Prinz I, Benoist C, Mathis D. IL-17A-producing γδT cells promote muscle regeneration in a microbiota-dependent manner. J Exp Med. 2022 May 2;219(5):e20211504. doi: 10.1084/jem.20211504. Epub 2022 Apr 5. PMID: 35380608; PMCID: PMC8989184.

Wilharm A*, Binz C*, Sandrock I, Rampoldi F, Lienenklaus S, Blank E, Winkel A, Demera A, Hovav AH, Stiesch M, Prinz I. Interleukin-17 is disease promoting in early stages and protective in late stages of experimental periodontitis. PLoS One. 2022 Mar 17;17(3):e0265486. doi: 10.1371/journal.pone.0265486. PMID: 35298525; PMCID: PMC8929577.
* These authors contributed equally to this work

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition). Eur J Immunol. 2021 Dec;51(12):2708-3145. doi: 10.1002/eji.202170126. Epub 2021 Dec 7. PMID: 34910301.

Hu MD, Golovchenko NB, Burns GL, Nair PM, Kelly TJ 4th, Agos J, Irani MZ, Soh WS, Zeglinski MR, Lemenze A, Bonder EM, Sandrock I, Prinz I, Granville DJ, Keely S, Watson AJM, Edelblum KL. γδ Intraepithelial Lymphocytes Facilitate Pathological Epithelial Cell Shedding Via CD103-Mediated Granzyme Release. Gastroenterology. 2022 Mar;162(3):877-889.e7. doi: 10.1053/j.gastro.2021.11.028. Epub 2021 Dec 1. PMID: 34861219; PMCID: PMC8881348.

Barel O, Aizenbud Y, Tabib Y, Jaber Y, Leibovich A, Horev Y, Zubeidat K, Saba Y, Eli-Berchoer L, Heyman O, Wilensky A, Prinz I, Hovav AH. γδ T Cells Differentially Regulate Bone Loss in Periodontitis Models. J Dent Res. 2022 Apr;101(4):428-436. doi: 10.1177/00220345211042830. Epub 2021 Oct 29. PMID: 34715745.

Dywicki J, Buitrago-Molina LE, Noyan F, Davalos-Misslitz AC, Hupa-Breier KL, Lieber M, Hapke M, Schlue J, Falk CS, Raha S, Prinz I, Koenecke C, Manns MP, Wedemeyer H, Hardtke-Wolenski M, Jaeckel E. The Detrimental Role of Regulatory T Cells in Nonalcoholic Steatohepatitis. Hepatol Commun. 2022 Feb;6(2):320-333. doi: 10.1002/hep4.1807. Epub 2021 Aug 25. PMID: 34532981; PMCID: PMC8793993.

2021

Gil-Pulido J, Amézaga N, Jorgacevic I, Manthey HD, Rösch M, Brand T, Cidlinsky P, Schäfer S, Beilhack A, Saliba AE, Lorenz K, Boon L, Prinz I, Waisman A, Korn T, Cochain C, Zernecke A. Interleukin-23 receptor expressing γδ T cells locally promote early atherosclerotic lesion formation and plaque necrosis in mice. Cardiovasc Res. 2021 Dec 13:cvab359. doi: 10.1093/cvr/cvab359. Epub ahead of print. PMID: 34897380.

Ullrich L, Lueder Y, Juergens AL, Wilharm A, Barros-Martins J, Bubke A, Demera A, Ikuta K, Patzer GE, Janssen A, Sandrock I, Prinz I,* Rampoldi F.* IL-4-Producing Vγ1+/Vδ6+ γδ T Cells Sustain Germinal Center Reactions in Peyer's Patches of Mice. Front Immunol. 2021 Nov 3;12:729607. doi: 10.3389/fimmu.2021.729607. PMID: 34804014; PMCID: PMC8600568.
* These authors contributed equally to this work

Piepke M, Clausen BH, Ludewig P, Vienhues JH, Bedke T, Javidi E, Rissiek B, Jank L, Brockmann L, Sandrock I, Degenhardt K, Jander A, Roth V, Schädlich IS, Prinz I, Flavell RA, Kobayashi Y, Renné T, Gerloff C, Huber S, Magnus T, Gelderblom M. Interleukin-10 improves stroke outcome by controlling the detrimental Interleukin-17A response. J Neuroinflammation. 2021 Nov 13;18(1):265. doi: 10.1186/s12974-021-02316-7. PMID: 34772416; PMCID: PMC8590298.

Cazzetta V, Bruni E, Terzoli S, Carenza C, Franzese S, Piazza R, Marzano P, Donadon M, Torzilli G, Cimino M, Simonelli M, Bello L, Villa A, Tan L, Ravens S, Prinz I, Supino D, Colombo FS, Lugli E, Marcenaro E, Vivier E, Della Bella S, Mikulak J, Mavilio D. NKG2A expression identifies a subset of human Vδ2 T cells exerting the highest antitumor effector functions. Cell Rep. 2021 Oct 19;37(3):109871. doi: 10.1016/j.celrep.2021.109871. PMID: 34686325.

Funken D, Yu Y, Feng X, Imvised T, Gueler F, Prinz I, Madadi-Sanjani O, Ure BM, Kuebler JF, Klemann C. Lack of gamma delta T cells ameliorates inflammatory response after acute intestinal ischemia reperfusion in mice. Sci Rep. 2021 Sep 20;11(1):18628. doi: 10.1038/s41598-021-96525-y. PMID: 34545104.

Schultze-Florey CR, Kuhlmann L, Raha S, Barros-Martins J, Odak I, Tan L, Xiao Y, Ravens S, Hambach L, Venturini L, Stadler M, Eder M, Thol F, Heuser M, Forster R, Ganser A, Prinz I, Koenecke C. Clonal expansion of CD8+ T cells reflects graft-versus-leukemia activity and precedes durable remission following DLI. Blood Adv. 2021 Sep 17:bloodadvances.2020004073. doi: 10.1182/bloodadvances.2020004073. Epub ahead of print. PMID: 34535011.

Binz C, Bubke A, Sandrock I, Prinz I. αβ T cells replacing dermal and epidermal γδ T cells in Tcrd-/- mice express an MHC-independent TCR repertoire. Eur J Immunol. 2021 Aug 16. doi: 10.1002/eji.202149243. Epub ahead of print. PMID: 34398456.

Ritter K, Behrends J, Erdmann H, Rousseau J, Hölscher A, Volz J, Prinz I, Lindenstrøm T, Hölscher C. Interleukin-23 instructs protective multifunctional CD4 T cell responses after immunization with the Mycobacterium tuberculosis subunit vaccine H1 DDA/TDB independently of interleukin-17A. J Mol Med (Berl). 2021 Aug 5. doi: 10.1007/s00109-021-02100-3. Epub ahead of print. PMID: 34351501.

Schultze-Florey CR, Chukhno E, Goudeva L, Blasczyk R, Ganser A, Prinz I, Förster R, Koenecke C, Odak I. Distribution of major lymphocyte subsets and memory T-cell subpopulations in healthy adults employing GLP-conforming multicolor flow cytometry. Leukemia. 2021 Jul 21. doi: 10.1038/s41375-021-01348-5. Epub ahead of print. PMID: 34290358.

Coppin E, Sundarasetty BS, Rahmig S, Blume J, Verheyden NA, Bahlmann F, Ravens S, Schubert U, Schmid J, Ludwig S, Geissler K, Guntinas-Lichius O, von Kaisenberg C, Groten T, Platz A, Naumann R, Ludwig B, Prinz I, Waskow C, Krueger A. Enhanced differentiation of functional human T cells in NSGW41 mice with tissue-specific expression of human interleukin-7. Leukemia. 2021 May 11. doi: 10.1038/s41375-021-01259-5. Epub ahead of print. PMID: 33976371.

Tan L, Fichtner AS, Bruni E, Odak I, Sandrock I, Bubke A, Borchers A, Schultze-Florey C, Koenecke C, Förster R, Jarek M, von Kaisenberg C, Schulz A, Chu X, Zhang B, Li Y, Panzer U, Krebs CF, Ravens S,* Prinz I.* A fetal wave of human type 3 effector γδ cells with restricted TCR diversity persists into adulthood. Sci Immunol. 2021 Apr 23;6(58):eabf0125. doi: 10.1126/sciimmunol.abf0125. PMID: 33893173.
* These authors contributed equally to this work

Elfaki Y, Robert PA, Binz C, Falk CS, Bruder D, Prinz I, Floess S, Meyer-Hermann M, Huehn J. Influenza A virus-induced thymus atrophy differentially affects dynamics of conventional and regulatory T cell development in mice. Eur J Immunol. 2021 Feb 26. doi: 10.1002/eji.202048981. Epub ahead of print. PMID: 33638148.

Regen T, Isaac S, Amorim A, Núñez NG, Hauptmann J, Shanmugavadivu A, Klein M, Sankowski R, Mufazalov IA, Yogev N, Huppert J, Wanke F, Witting M, Grill A, Gálvez EJC, Nikolaev A, Blanfeld M, Prinz I, Schmitt-Kopplin P, Strowig T, Reinhardt C, Prinz M, Bopp T, Becher B, Ubeda C, Waisman A. IL-17 controls central nervous system autoimmunity through the intestinal microbiome. Sci Immunol. 2021 Feb 5;6(56):eaaz6563. doi: 10.1126/sciimmunol.aaz6563. PMID: 33547052.

Wald S, Leibowitz A, Aizenbud Y, Saba Y, Zubeidat K, Barel O, Koren N, Heyman O, Wilharm A, Sandrock I, Fleissig O, Tal Y, Prinz I, Aizenbud D, Chaushu S, Hovav AH. γδT Cells Are Essential for Orthodontic Tooth Movement. J Dent Res. 2021 Jan 21:22034520984774. doi: 10.1177/0022034520984774. Epub ahead of print. PMID: 33478315.

Koren N, Zubeidat K, Saba Y, Horev Y, Barel O, Wilharm A, Heyman O, Wald S, Eli-Berchoer L, Shapiro H, Nadler C, Elinav E, Wilensky A, Prinz I, Bercovier H, Hovav AH. Maturation of the neonatal oral mucosa involves unique epithelium-microbiota interactions. Cell Host Microbe. 2021 Jan 6:S1931-3128(20)30668-5. doi: 10.1016/j.chom.2020.12.006. Epub ahead of print. PMID: 33412104.

2020

Möhn N, Bruni E, Schröder A, Frömmel S, Gueler F, Vieten G, Prinz I, Kuebler JF, Petersen C, Klemann C. Synthetic retinoid AM80 inhibits IL-17 production of gamma delta T cells and ameliorates biliary atresia in mice. Liver Int. 2020 Dec;40(12):3031-3041. doi: 10.1111/liv.14639. Epub 2020 Sep 14. PMID: 33463083.

Déchanet-Merville J, Prinz I. From basic research to clinical application of γδ T cells. Immunol Rev. 2020 Nov;298(1):5-9. doi: 10.1111/imr.12931.

Helmke, A., Hüsing, A. M., Gaedcke, S., Brauns, N., Balzer, M. S., Reinhardt, M., Hiss, M., Shushakova, N., de Luca, D., Prinz, I., Haller, H., & von Vietinghoff, S. (2020). Peritoneal dialysate-range hypertonic glucose promotes T-cell IL-17 production that induces mesothelial inflammation. European journal of immunology, 10.1002/eji.202048733. Advance online publication. https://doi.org/10.1002/eji.202048733

Wilharm, A.*, Brigas, H. C.*, Sandrock, I., Ribeiro, M., Amado, T., Reinhardt, A., Demera, A., Hoenicke, L., Strowig, T., Carvalho, T., Prinz, I.*, Ribot, J. C.* (2020). Microbiota-dependent expansion of testicular IL-17-producing Vγ6+ γδ T cells upon puberty promotes local tissue immune surveillance. Mucosal immunology, 10.1038/s41385-020-0330-6. Advance online publication. https://doi.org/10.1038/s41385-020-0330-6
* These authors contributed equally to this work

Deseke, M., Prinz, I. (2020). Ligand recognition by the γδ TCR and discrimination between homeostasis and stress conditions. Cellular & molecular immunology, 10.1038/s41423-020-0503-y. Advance online publication. https://doi.org/10.1038/s41423-020-0503-y

Ravens, S.*, Fichtner, A. S.*, Willers, M., Torkornoo, D., Pirr, S., Schöning, J., Deseke, M., Sandrock, I., Bubke, A., Wilharm, A., Dodoo, D., Egyir, B., Flanagan, K. L., Steinbrück, L., Dickinson, P., Ghazal, P., Adu, B., Viemann, D.*, Prinz, I.* (2020). Microbial exposure drives polyclonal expansion of innate γδ T cells immediately after birth. Proceedings of the National Academy of Sciences of the United States of America, 117(31), 18649–18660. https://doi.org/10.1073/pnas.1922588117
* These authors contributed equally to this work

Odak, I., Barros-Martins, J., Bošnjak, B., Stahl, K., David, S., Wiesner, O., Busch, M., Hoeper, M. M., Pink, I., Welte, T., Cornberg, M., Stoll, M., Goudeva, L., Blasczyk, R., Ganser, A., Prinz, I., Förster, R., Koenecke, C., & Schultze-Florey, C. R. Reappearance of effector T cells is associated with recovery from COVID-19 [published online ahead of print, 2020 Jul 7]. EBioMedicine. 2020;57:102885. doi:10.1016/j.ebiom.2020.102885

Klein S, Ghersi D, Manns MP, Prinz I, Cornberg M, Kraft ARM. PD-L1 checkpoint inhibition narrows the antigen-specific T cell receptor repertoire in chronic LCMV infection [published online ahead of print, 2020 Jul 8]. J Virol. 2020;JVI.00795-20. doi:10.1128/JVI.00795-20

Odak I, Depkat-Jakob A, Beck M, Jarek M, Yu Y, Seidler U, David S, Ganser A, Förster R*, Prinz I*, Koenecke C*. Donor-derived IL-17A and IL-17F deficiency triggers Th1 allo-responses and increases gut leakage during acute GVHD. PLoS One. 2020 Apr 6;15(4):e0231222. doi: 10.1371/journal.pone.0231222. eCollection 2020. PubMed PMID: 32251446.
* These authors contributed equally to this work

Fichtner AS, Ravens S, Prinz I. Human γδ TCR Repertoires in Health and Disease. Cells. 2020 Mar 26;9(4). pii: E800. doi: 10.3390/cells9040800. Review. PubMed PMID: 32225004

Moyé S, Bormann T, Maus R, Sparwasser T, Sandrock I, Prinz I, Warnecke G, Welte T, Gauldie J, Kolb M, Maus UA. Regulatory T Cells Limit Pneumococcus-Induced Exacerbation of Lung Fibrosis in Mice. J Immunol. 2020 Mar 25. pii: ji1900980. doi: 10.4049/jimmunol.1900980. [Epub ahead of print] PubMed PMID: 32213566.

Rampoldi F, Ullrich L, Prinz I. Revisiting the Interaction of γδ T-Cells and B-Cells. Cells. 2020 Mar 18;9(3). pii: E743. doi: 10.3390/cells9030743. Review. PubMed PMID: 32197382.

Jirmo AC, Busse M, Happle C, Skuljec J, Dalüge K, Habener A, Grychtol R, DeLuca DS, Breiholz OD, Prinz I, Hansen G. IL-17 regulates dendritic cell migration to the peribronchial lymph nodes and allergen presentation in experimental allergic asthma. Eur J Immunol. 2020 Mar 6. doi: 10.1002/eji.201948409. [Epub ahead of print] PubMed PMID: 32142593.

Hovav AH, Wilharm A, Barel O, Prinz I. Development and Function of γδT Cells in the Oral Mucosa. J Dent Res. 2020 Feb 24:22034520908839. doi: 10.1177/0022034520908839. [Epub ahead of print] PubMed PMID: 32091949

Fichtner AS, Bubke A, Rampoldi F, Wilharm A, Tan L, Steinbrück L, Schultze-Florey C, von Kaisenberg C, Prinz I, Herrmann T, Ravens S. TCR repertoire analysis reveals phosphoantigen-induced polyclonal proliferation of Vγ9Vδ2 T cells in neonates and adults. J Leukoc Biol. 2020 Feb 17. doi: 10.1002/JLB.1MA0120-427RR. [Epub ahead of print] PubMed PMID: 32064671

Janssen A, Villacorta Hidalgo J, Beringer DX, van Dooremalen S, Fernando F, van Diest E, Terrizzi AR, Bronsert P, Kock S, Schmitt-Graeff A, Werner M, Heise K, Follo M, Straetemans T, Sebestyen Z, Chudakov DM, Kasatskaya SA, Frenkel FE, Ravens S, Spierings E, Prinz I, Küppers R, Malkovsky M, Fisch P, Kuball J. γδ T-cell receptors derived from breast cancer-infiltrating T lymphocytes mediate antitumor reactivity. Cancer Immunol Res. 2020 Feb 4. pii: canimm.0513.2019. doi: 10.1158/2326-6066.CIR-19-0513. [Epub ahead of print] PubMed PMID: 32019779.

Prinz I, Sandrock I, Mrowietz U. Interleukin-17 cytokines: Effectors and targets in psoriasis-A breakthrough in understanding and treatment. J Exp Med 217 (1) 2020 Jan 6 PMID: 31727784 DOI: 10.1084/jem.20191397

2019

Prinz I, Sandrock I, Mrowietz U. Interleukin-17 cytokines: Effectors and targets in psoriasis-A breakthrough in understanding and treatment. J Exp Med. 2019 Nov 14. pii: jem.20191397. doi: 10.1084/jem.20191397.

Soon CF, Zhang S, Suneetha PV, Antunes DA, Manns MP, Raha S, Schultze-Florey C, Prinz I, Wedemeyer H, Sällberg Chen M, Cornberg M. Hepatitis E Virus (HEV)-Specific T Cell Receptor Cross-Recognition: Implications for Immunotherapy. Front Immunol. 2019 Sep 4;10:2076. doi: 10.3389

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). Eur J Immunol. 2019 Oct;49(10):1457-1973. doi: 10.1002/eji.201970107.

Mikulak J, Oriolo F, Bruni E, Roberto A, Colombo FS, Villa A, Bosticardo M, Bortolomai I, Lo Presti E, Meraviglia S, Dieli F, Vetrano S, Danese S, Della Bella S, Carvello MM, Sacchi M, Cugini G, Colombo G, Klinger M, Spaggiari P, Roncalli M, Prinz I, Ravens S, di Lorenzo B, Marcenaro E, Silva-Santos B, Spinelli A, Mavilio D. NKp46-expressing human gut-resident intraepithelial Vδ1 T cell subpopulation exhibits high anti-tumor activity against colorectal cancer. JCI Insight. 2019 Nov 5. pii: 125884. doi: 10.1172/jci.insight.

Sebestyen Z, Prinz I, Déchanet-Merville J, Silva-Santos B, Kuball J. Translating gammadelta (γδ) T cells and their receptors into cancer cell therapies. Nat Rev Drug Discov. 2019 Sep 6. doi: 10.1038/s41573-019-0038-z. [Epub ahead of print] Review. PubMed PMID: 31492944.

Prinz I, Sandrock I. Dangerous γδ T cells in aged mice. EMBO Rep. 2019 Jul 9:e48678. doi: 10.15252/embr.201948678. [Epub ahead of print] PubMed PMID: 31286651.

Tan L, Sandrock I, Odak I, Aizenbud Y, Wilharm A, Barros-Martins J, Tabib Y, Borchers A, Amado T, Gangoda L, Herold MJ, Schmidt-Supprian M, Kisielow J, Silva-Santos B, Koenecke C, Hovav AH, Krebs C, Prinz *, Ravens S*. Single-Cell Transcriptomics Identifies the Adaptation of Scart1(+) Vγ6(+) T Cells to Skin Residency as Activated Effector Cells. Cell Rep. 2019 Jun 18;27(12):3657-3671.e4. doi: 10.1016/j.celrep.2019.05.064. PubMed PMID: 31216482.
*equal contribution

Odak I*, Raha S*, Schultze-Florey C, Tavil S, Ravens S, Ganser A, Förster R, Prinz I**, Koenecke C**. Focusing of the regulatory T cell repertoire after allogeneic stem cell transplantation indicates protection from graft-versus-host disease. Haematologica. 2019 Apr 24. pii: haematol.2019.218206. doi: 10.3324/haematol.2019.218206. [Epub ahead of print] PubMed PMID: 31018979.
*equal contribution, ** shared senior authorship

Di Lorenzo B, Simões AE, Caiado F, Tieppo P, Correia DV, Carvalho T, da Silva MG, Déchanet-Merville J, Schumacher TN, Prinz I, Norell H, Ravens S, Vermijlen D, Silva-Santos B. Broad Cytotoxic Targeting of Acute Myeloid Leukemia by Polyclonal Delta One T Cells. Cancer Immunol Res. 2019 Mar 20. doi: 10.1158/2326-6066.CIR-18-0647. [Epub ahead of print] PubMed PMID: 30894378.

Mangare C, Tischer-Zimmermann S, Riese SB, Dragon AC, Prinz I, Blasczyk R, Maecker-Kolhoff B, Eiz-Vesper B. Robust Identification of Suitable T-Cell Subsets for Personalized CMV-Specific T-Cell Immunotherapy Using CD45RA and CD62L Microbeads. Int J Mol Sci. 2019 Mar 20;20(6). pii: E1415. doi: 10.3390/ijms20061415. PubMed PMID: 30897843.

Sparber F, De Gregorio C, Steckholzer S, Ferreira FM, Dolowschiak T, Ruchti F, Kirchner FR, Mertens S, Prinz I, Joller N, Buch T, Glatz M, Sallusto F, LeibundGut-Landmann S. The Skin Commensal Yeast Malassezia Triggers a Type 17 Response that Coordinates Anti-fungal Immunity and Exacerbates Skin Inflammation. Cell Host Microbe. 2019 Mar 13;25(3):389-403.e6. doi: 10.1016/j.chom.2019.02.002. PubMed PMID: 30870621.

Fu H, Jangani M, Parmar A, Wang G, Coe D, Spear S, Sandrock I, Capasso M, Coles M, Cornish G, Helmby H, Marelli-Berg FM. A Subset of CCL25-Induced Gut-Homing T Cells Affects Intestinal Immunity to Infection and Cancer. Front Immunol. 2019 Feb 25;10:271. doi: 10.3389/fimmu.2019.00271. eCollection 2019. PubMed PMID: 30863398; PubMed Central PMCID: PMC6400137.

Łyszkiewicz M, Winter SJ, Witzlau K, Föhse L, Brownlie R, Puchałka J, Verheyden NA, Kunze-Schumacher H, Imelmann E, Blume J, Raha S, Sekiya T, Yoshimura A, Frueh JT, Ullrich E, Huehn J, Weiss S, Gutierrez MG, Prinz I, Zamoyska R, Ziętara N, Krueger A. miR-181a/b-1 controls thymic selection of Treg cells and tunes their suppressive capacity. PLoS Biol. 2019 Mar 11;17(3):e2006716. doi: 10.1371/journal.pbio.2006716. [Epub ahead of print] PubMed PMID: 30856173

Wilharm A, Sandrock I, Marotel M, Demera A, Naumann R, Walzer T, Prinz I. Styk1 is specifically expressed in NK1.1(+) lymphocytes including NK, γδ T and iNKT cells in mice, but is dispensable for their ontogeny and function. Eur J Immunol. 2019 Feb 13. doi: 10.1002/eji.201848033. [Epub ahead of print] PubMed PMID: 30758858

Wilharm A*, Tabib Y*, Nassar M, Reinhardt A, Mizraji G, Sandrock I, Heyman O, Barros-Martins J, Aizenbud Y, Khalaileh A, Eli-Berchoer L, Elinav E, Wilensky A, Förster R, Bercovier H, Prinz I**, Hovav AH**. Mutual interplay between IL-17-producing γδT cells and microbiota orchestrates oral mucosal homeostasis. Proc Natl Acad Sci U S A. 2019 Jan 28. pii: 201818812. doi: 10.1073/pnas.1818812116. [Epub ahead of print] PubMed PMID: 30692259
*equal contribution, ** shared senior authorship

Ronkina N, Schuster-Gossler K, Hansmann F, Kunze-Schumacher H, Sandrock I, Yakovleva T, Lafera J, Baumgärtner W, Krueger A, Prinz I, Gossler A, Kotlyarov A, Gaestel M. Germline deletion reveals a non-essential role of the atypical MAPK6/ERK3. Mol Cell Biol. 2019 Jan 14. pii: MCB.00516-18. doi: 10.1128/MCB.00516-18. [Epub ahead of print] PubMed PMID: 30642948

2018

Sandrock I, Reinhardt A, Ravens S, Binz C, Wilharm A, Martins J, Oberdörfer L, Tan L, Lienenklaus S, Zhang B, Naumann R, Zhuang Y, Krueger A, Förster R, Prinz I. Genetic models reveal origin, persistence and non-redundant functions of IL-17-producing γδ T cells. J Exp Med. 2018 Nov 19. pii: jem.20181439.

Schultze-Florey RE, Tischer S, Kuhlmann L, Hundsdoerfer P, Koch A, Anagnostopoulos I, Ravens S, Goudeva L, Schultze-Florey C, Koenecke C, Blasczyk R, Koehl U, Heuft HG, Prinz I, Eiz-Vesper B, Maecker-Kolhoff B. Dissecting Epstein-Barr Virus-Specific T-Cell Responses After Allogeneic EBV-Specific T-Cell Transfer for Central Nervous System Posttransplant Lymphoproliferative Disease. Front Immunol. 2018 Jun 27;9:1475. doi: 10.3389/fimmu.2018.01475. eCollection 2018. PubMed PMID: 29997626; PubMed Central PMCID: PMC6030255

Lessel D, Gehbauer C, Bramswig NC, Schluth-Bolard C, Venkataramanappa S, van Gassen KLI, Hempel M, Haack TB, Baresic A, Genetti CA, Funari MFA, Lessel I, Kuhlmann L, Simon R, Liu P, Denecke J, Kuechler A, de Kruijff I, Shoukier M, Lek M, Mullen T, Lüdecke HJ, Lerario AM, Kobbe R, Krieger T, Demeer B, Lebrun M, Keren B, Nava C, Buratti J, Afenjar A, Shinawi M, Guillen Sacoto MJ, Gauthier J, Hamdan FF, Laberge AM, Campeau PM, Louie RJ, Cathey SS, Prinz I, Jorge AAL, Terhal PA, Lenhard B, Wieczorek D, Strom TM, Agrawal PB, Britsch S, Tolosa E, Kubisch C. BCL11B mutations in patients affected by a neurodevelopmental disorder with reduced type 2 innate lymphoid cells. Brain. 2018 Jul 9. doi: 10.1093/brain/awy173. [Epub ahead of print] PubMed PMID: 29985992

Reinhardt A, Prinz I. Whodunit? The Contribution of Interleukin (IL)-17/IL-22-Producing γδ T Cells, αβ T Cells, and Innate Lymphoid Cells to the Pathogenesis of Spondyloarthritis. Front Immunol. 2018 Apr 25;9:885. doi: 10.3389/fimmu.2018.00885. eCollection 2018. Review. PubMed PMID: 29922283; PubMed Central PMCID: PMC5996894.

Kamradt T, Amling M, Dankbar B, Dudeck A, Gunzer M, Ignatius A, Krönke G, Kubatzky K, Pap T, Prinz I, Schett G, Schinke T, Tuckermann J, Waisman A. Mutual influence of immune system and bones. Z Rheumatol. 2018 Apr 19. doi: 10.1007/s00393-018-0454-1. [Epub ahead of print] Review. German. PubMed PMID: 29675686.

Hammer Q, Rückert T, Borst EM, Dunst J, Haubner A, Durek P, Heinrich F, Gasparoni G, Babic M, Tomic A, Pietra G, Nienen M, Blau IW, Hofmann J, Na IK, Prinz I, Koenecke C, Hemmati P, Babel N, Arnold R, Walter J, Thurley K, Mashreghi MF, Messerle M, Romagnani C. Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells. Nat Immunol. 2018 Apr 9. doi: 10.1038/s41590-018-0082-6. [Epub ahead of print] PubMed PMID: 29632329.

Ravens S, Hengst J, Schlapphoff V, Deterding K, Dhingra A, Schultze-Florey C, Koenecke C, Cornberg M, Wedemeyer H, Prinz I. Human γδ T Cell Receptor Repertoires in Peripheral Blood Remain Stable Despite Clearance of Persistent Hepatitis C Virus Infection by Direct-Acting Antiviral Drug Therapy. Front Immunol. 2018 Mar 16;9:510. doi: 10.3389/fimmu.2018.00510. eCollection 2018. PubMed PMID: 29616028; PubMed Central PMCID: PMC5864898.

Burstein VL, Guasconi L, Beccacece I, Theumer MG, Mena C, Prinz I, Cervi L, Herrero M, Masih DT, Chiapello LS. Interleukin-17 (IL-17)-mediated immunity controls skin infection and T helper 1 response during experimental Microsporum canis dermatophytosis. J Invest Dermatol. 2018 Mar 20. pii: S0022-202X(18)31735-4. doi: 10.1016/j.jid.2018.02.042. [Epub ahead of print] PubMed PMID: 29571944

2017

Renz H, Adkins BD, Bartfeld S, Blumberg RS, Farber DL, Garssen J, Ghazal P, Hackam DJ, Marsland BJ, McCoy KD, Penders J, Prinz I, Verhasselt V, von Mutius E, Weiser JN, Wesemann DR, Hornef MW. The neonatal window of opportunity - early priming for life. J Allergy Clin Immunol. 2017 Dec 13. pii: S0091-6749(17)31895-X. doi: 10.1016/j.jaci.2017.11.019. [Epub ahead of print] PubMed PMID: 29247715.

Papotto PH, Reinhardt A, Prinz I, Silva-Santos B. Innately versatile: γδ17 T cells in inflammatory and autoimmune diseases. J Autoimmun. 2017 Dec 1. pii: S0896-8411(17)30768-0. doi: 10.1016/j.jaut.2017.11.006. [Epub ahead of print] Review. PubMed PMID: 29203226.

Alnahas S, Hagner S, Raifer H, Kilic A, Gasteiger G, Mutters R, Hellhund A, Prinz I, Pinkenburg O, Visekruna A, Garn H, Steinhoff U. IL-17 and TNF-α Are Key Mediators of Moraxella catarrhalis Triggered Exacerbation of Allergic Airway Inflammation. Front Immunol. 2017 Nov 14;8:1562. doi: 10.3389/fimmu.2017.01562. eCollection 2017. PubMed PMID: 29184554; PubMed Central PMCID: PMC5694487.

Shalaby KH, Lyons-Cohen MR, Whitehead GS, Thomas SY, Prinz I, Nakano H, Cook DN. Pathogenic Th17 inflammation is sustained in the lungs by conventional dendritic cells and TLR4 signaling. J Allergy Clin Immunol. 2017 Nov 14. pii: S0091-6749(17)31753-0. doi: 10.1016/j.jaci.2017.10.023. [Epub ahead of print] PubMed PMID: 29154958.

Van Hede D, Polese B, Humblet C, Wilharm A, Renoux V, Dortu E, de Leval L, Delvenne P, Desmet CJ, Bureau F, Vermijlen D, Jacobs N. Human papillomavirus oncoproteins induce a reorganization of epithelial-associated γδ T cells promoting tumor formation. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E9056-E9065. doi: 10.1073/pnas.1712883114. Epub 2017 Oct 10. PubMed PMID: 29073102; PubMed Central PMCID: PMC5664550.

Edelblum KL, Sharon G, Singh G, Odenwald MA, Sailer A, Cao S, Ravens S, Thomsen I, El Bissati K, McLeod R, Dong C, Gurbuxani S, Prinz I, Mazmanian SK, Turner JR. The Microbiome Activates CD4 T-cell-mediated Immunity to Compensate for Increased Intestinal Permeability. Cell Mol Gastroenterol Hepatol. 2017 Jun 10;4(2):285-297. doi: 10.1016/j.jcmgh.2017.06.001. eCollection 2017 Sep. PubMed PMID: 28795125; PubMed Central PMCID: PMC5540699

Arunachalam P, Ludewig P, Melich P, Arumugam TV, Gerloff C, Prinz I, Magnus T, Gelderblom M. CCR6 (CC Chemokine Receptor 6) Is Essential for the Migration of Detrimental Natural Interleukin-17-Producing γδ T Cells in Stroke. Stroke. 2017 Jun 13. pii: STROKEAHA.117.016753. doi: 10.1161/STROKEAHA.117.016753. [Epub ahead
of print] PubMed PMID: 28611085.

Lino CN, Barros-Martins J, Oberdörfer L, Walzer T, Prinz I. Eomes expression reports the progressive differentiation of IFN-γ-producing Th1-like γδ T cells. Eur J Immunol. 2017 Apr 6. doi: 10.1002/eji.201646753. [Epub ahead of print] PubMed PMID: 28386934

Pezoldt J, Pisano F, Heine W, Pasztoi M, Rosenheinrich M, Nuss AM, Pils MC, Prinz I, Förster R, Huehn J, Dersch P. CCR7 deficiency modulates T cell response and increases susceptibility to Yersinia pseudotuberculosis infection. J Infect Dis. 2017 Jan 27. doi: 10.1093/infdis/jix037. [Epub ahead of print] PubMed PMID: 28329174.

Ravens S, Schultze-Florey C, Raha S, Sandrock I, Drenker M, Oberdörfer L, Reinhardt A, Ravens I, Beck M, Geffers R, von Kaisenberg C, Heuser M, Thol F, Ganser A, Förster R, Koenecke C*, Prinz I*. Human γδ T cells are quickly reconstituted after stem-cell transplantation and show adaptive clonal expansion in response to viral infection. Nat Immunol. 2017 Feb 20. doi: 10.1038/ni.3686. [Epub ahead of print] PubMed PMID: 28218745
*equal contribution

Reinhardt A, Prinz I. Speculating about human entheseal γδ T cells. Arthritis Rheumatol. 2017 Jan 24. doi: 10.1002/art.40050. [Epub ahead of print] PubMed PMID: 28118535

Vachharajani N, Joeris T, Luu M, Hartmann S, Pautz S, Jenike E, Pantazis G, Prinz I, Hofer MJ, Steinhoff U, Visekruna A. Prevention of colitis-associated cancer by selective targeting of immunoproteasome subunit LMP7. Oncotarget. 2017 Jan 10. doi: 10.18632/oncotarget.14579. [Epub ahead of print] PubMed PMID: 28086242

Hassane M, Demon D, Soulard D, Fontaine J, Keller LE, Patin EC, Porte R, Prinz I, Ryffel B, Kadioglu A, Veening JW, Sirard JC, Faveeuw C, Lamkanfi M, Trottein F, Paget C. Neutrophilic NLRP3 inflammasome-dependent IL-1β secretion regulates the γδT17 cell response in respiratory bacterial infections. Mucosal Immunol. 2017 Jan 4. doi: 10.1038/mi.2016.113. [Epub ahead of print] PubMed PMID: 28051086

2016

Raha S*, Raud B*, Oberdörfer L, Castro CN, Schreder A, Freitag J, Longerich T, Lochner M, Sparwasser T, Berod L*, Koenecke C*, Prinz I*. Disruption of de novo fatty acid synthesis via acetyl-CoA carboxylase 1 inhibition prevents acute graft-versus-host disease. Eur J Immunol. 2016 Jun 24. doi: 10.1002/eji.201546152. [Epub ahead of print] PubMed PMID: 27338930.
*equal contribution

Reinhardt A, Yevsa T, Worbs T, Lienenklaus S, Sandrock I, Oberdörfer L, Korn T, Weiss S, Förster R, Prinz I. IL-23-dependent γδ T cells produce IL-17 and accumulate in enthesis, aortic valve, and ciliary body. Arthritis Rheumatol. 2016 Apr 25. doi: 10.1002/art.39732. [Epub ahead of print] PubMed PMID: 27111864.

Motrich RD, Breser ML, Sánchez LR, Godoy GJ, Prinz I, Rivero VE. IL-17 is not essential for inflammation and chronic pelvic pain development in an experimental model of chronic prostatitis/chronic pelvic pain syndrome. Pain. 2016 Mar;157(3):585-97. doi: 10.1097/j.pain.0000000000000405. PubMed PMID: 26882345

Auger JL, Cowan HM, Engelson BJ, Kashem SW, Prinz I, Binstadt BA. Arthritis in KRN T cell receptor transgenic mice does not require interleukin-17 or Th17 cells. Arthritis Rheumatol. 2016 Feb 16. doi: 10.1002/art.39646. [Epub ahead of print] PubMed PMID: 26882006


2015

Sandrock I, Ziętara N, Łyszkiewicz M, Oberdörfer L, Witzlau K, Krueger A*, Prinz I*. MicroRNA-181a/b-1 Is Not Required for Innate γδ NKT Effector Cell Development. PLoS One. 2015 Dec 16;10(12):e0145010. doi: 10.1371/journal.pone.0145010. eCollection 2015. PubMed PMID: 26673421. *equal contribution

Klemann C, Schröder A, Dreier A, Möhn N, Dippel S, Winterberg T, Wilde A, Yu Y, Thorenz A, Gueler F, Jörns A, Tolosa E, Leonhardt J, Haas JD, Prinz I, Vieten G, Petersen C, Kuebler JF. Interleukin-17, Produced by γδ-T Cells, Contributes to Hepatic Inflammation in a Mouse Model of Biliary Atresia and is Increased in Livers of Patients. Gastroenterology. 2015 Sep 21. pii: S0016-5085(15)01352-9. doi: 10.1053/j.gastro.2015.09.008. [Epub ahead of print] PubMed PMID: 26404950

Prinz I, Sandrock I. γδ T cells come to stay: innate skin memory in the Aldara model. Eur J Immunol. 2015 Sep 21. doi: 10.1002/eji.201546033. [Epub ahead of print] PubMed PMID: 26389517

Ziętara N, Łyszkiewicz M, Puchałka J, Witzlau K, Reinhardt A, Förster R, Pabst O, Prinz I, Krueger A. Multicongenic fate mapping quantification of dynamics of thymus colonization. J Exp Med. 2015 Sep 7. pii: jem.20142143. [Epub ahead of print] PMID: 26347471

Yang BH, Hagemann S, Mamareli P, Lauer U, Hoffmann U, Beckstette M, Föhse L, Prinz I, Pezoldt J, Suerbaum S, Sparwasser T, Hamann A, Floess S, Huehn J, Lochner M. Foxp3+ T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation. Mucosal Immunol. 2015 Aug 26. doi: 10.1038/mi.2015.74. [Epub ahead of print] PMID: 26307665

Kashani E, Föhse L, Raha S, Sandrock I, Oberdörfer L, Koenecke C, Suerbaum S, Weiss S, Prinz I. A clonotypic Vγ4Jγ1/Vδ5Dδ2Jδ1 innate γδ T-cell population restricted to the CCR6(+)CD27(-) subset. Nat Commun. 2015 Mar 13;6:6477. doi: 10.1038/ncomms7477. PubMed PMID: 25765849.

Schwinge D, Carambia A, Quaas A, Krech T, Wegscheid C, Tiegs G, Prinz I, Lohse AW, Herkel J, Schramm C. Testosterone Suppresses Hepatic Inflammation by the Downregulation of IL-17, CXCL-9, and CXCL-10 in a Mouse Model of Experimental Acute Cholangitis. J Immunol. 2015 Mar 15;194(6):2522-30. doi: 10.4049/jimmunol.1400076. Epub 2015 Feb 11. PubMed PMID: 25672751.


2014

Łyszkiewicz M, Ziętara N, Föhse L, Puchałka J, Diestelhorst J, Witzlau K, Prinz I, Schambach A, Krueger A. Limited niche availability suppresses murine intrathymic dendritic-cell development from non-committed progenitors. Blood, published online Nov 19 2014, doi: 10.1182/blood-2014-07-592667.

Vermijlen D, Prinz I. Ontogeny of Innate T Lymphocytes - Some Innate Lymphocytes are More Innate than Others. Front Immunol. 2014 Oct 10;5:486. doi: 10.3389/fimmu.2014.00486. Collection 2014. Review. PubMed PMID: 25346734; PubMed Central PMCID: PMC4193329

Blink SE, Caldis MW, Goings GE, Harp CT, Malissen B, Prinz I, Xu D, Miller SD. γδ T cell subsets play opposing roles in regulating experimental autoimmune encephalomyelitis. Cell Immunol. 2014 May 10;290(1):39-51. doi: 10.1016/j.cellimm.2014.04.013. [Epub ahead of print]

Fleige H1, Ravens S, Moschovakis GL, Bölter J, Willenzon S, Sutter G, Häussler S, Kalinke U, Prinz I, Förster R. IL-17-induced CXCL12 recruits B cells and induces follicle formation in BALT in the absence of differentiated FDCs. J Exp Med. 2014 Apr 7;211(4):643-51. doi: 10.1084/jem.20131737. Epub 2014 Mar 24.

Daussy C, Faure F, Mayol K, Viel S, Gasteiger G, Charrier E, Bienvenu J, Henry T, Debien E, Hasan UA, Marvel J, Yoh K, Takahashi S, Prinz I, de Bernard S, Buffat L, Walzer T. T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow. J Exp Med. 2014 Feb 10. [Epub ahead of print]

Reinhardt A, Ravens S, Fleige H, Haas JD, Oberdörfer L, Lyszkiewicz M, Förster R, Prinz I. CCR7-mediated migration in the thymus controls γδ T-cell development. Eur J Immunol. 2014 Feb 5. doi: 10.1002/eji.201344330. [Epub ahead of print] PMID: 24500801 [PubMed - as supplied by publisher]

Winter M, Kashani E, Chennupati V, Föhse L, Prinz I. Visualization and quantification of monoallelic TCRα gene rearrangement in αβ T cells. Immunology and Cell Biology advance online publication 14 January 2014; doi: 10.1038/icb.2013.105


2013

Huang YJ, Haist V, Baumgärtner W, Föhse L, Prinz I, Suerbaum S, Floess S, Huehn J. Induced and thymus-derived Foxp3(+) regulatory T cells share a common niche. Eur J Immunol. 2013 Oct 8. doi: 10.1002/eji.201343463. [Epub ahead of print] PubMed PMID: 24170313

Hammerich L, Bangen JM, Govaere O, Zimmermann HW, Gassler N, Huss S, Liedtke C, Prinz I, Lira SA, Luedde T, Roskams T, Trautwein C, Heymann F, Tacke F. Chemokine receptor CCR6-dependent accumulation of γδ T-cells in injured liver restricts hepatic inflammation and fibrosis. Hepatology. 2013 Aug 19. doi: 10.1002/hep.26697. [Epub ahead of print] PubMed PMID: 23959575

Prinz I, Silva-Santos B, Pennington DJ. Functional development of γδ T cells. Eur J Immunol. 2013 Aug;43(8):1988-94. doi: 10.1002/eji.201343759. PubMed PMID: 23928962

Föhse L, Reinhardt A, Oberdörfer L, Schmitz S, Förster R, Malissen B, Prinz I. Differential Postselection Proliferation Dynamics of αβ T Cells, Foxp3+ Regulatory T Cells, and Invariant NKT Cells Monitored by Genetic Pulse Labeling. J Immunol. 2013 Jul 26. [Epub ahead of print] PubMed PMID: 23894200

Prinz I, Thamm K, Port M, Weissinger EM, Stadler M, Gabaev I, Jacobs R, Ganser A, Koenecke C. Donor Vdelta1+ gammadelta T cells expand after allogeneic hematopoietic stem cell transplantation and show reactivity against CMV-infected cells but not against progressing B-CLL. Exp Hematol Oncol. 2013 May 11;2(1): 14. pub ahead of print] PubMed PMID: 23663319.

Ziętara N, Łyszkiewicz M, Witzlau K, Naumann R, Hurwitz R, Langemeier J, Bohne J, Sandrock I, Ballmaier M, Weiss S, Prinz I*, and Krueger A* (2013). Critical role for miR-181a/b-1 in agonist selection of invariant NKT cells. Proc. Natl. Acad. Sci. USA, published ahead of print April 15, 2013, doi:10.1073/pnas.1221984110.* Equal contribution.

Chien YH, Zeng X, Prinz I. The natural and the inducible: interleukin (IL)-17-producing γδ T cells. Trends Immunol. 2012 Dec 21. doi:pii: S1471-4906(12)00198-6. 10.1016/j.it.2012.11.004. [Epub ahead of print] PubMed PMID: 23266231 

2012
 

Gelderblom M, Weymar A, Bernreuther C, Velden J, Arunachalam P, Steinbach K,Orthey E, Arumugam TV, Leypoldt F, Simova O, Thom V, Friese M, Prinz I, Hölscher C, Glatzel M, Korn T, Gerloff C, Tolosa E, Magnus T. Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke. Blood.2012 Sep 13. [Epub ahead of print] PubMed PMID: 22976954.

Koenecke C, Lee CW, Thamm K, Föhse L, Schafferus M, Mittrücker HW, Floess S, Huehn J, Ganser A, Förster R, Prinz I. IFN-γ Production by Allogeneic Foxp3+
Regulatory T Cells Is Essential for Preventing Experimental Graft-versus-Host
Disease. J Immunol. 2012 Aug 6. [Epub ahead of print] PubMed PMID: 22869903.

Turner JE, Krebs C, Tittel AP, Paust HJ, Meyer-Schwesinger C, Bennstein SB, Steinmetz OM, Prinz I, Magnus T, Korn T, Stahl RA, Kurts C, Panzer U., IL-17A Production by Renal γδ T Cells Promotes Kidney Injury in Crescentic GN. J Am Soc Nephrol. 2012 Jul 12. [Epub ahead of print], PMID: 22797181

Haas JD, Ravens S, Düber S, Sandrock I, Oberdörfer L, Kashani E, Chennupati V, Föhse L, Naumann R, Weiss S, Krueger A, Förster R, Prinz I. Development of Interleukin-17-Producing γδ T Cells Is Restricted to a Functional Embryonic Wave. Immunity. 2012 Jul 3. [Epub ahead of print] PMID: 22770884

Koenecke C, Prinz I, Bubke A, Schreder A, Lee CW, Pabst O, Förster R.;  Shift of graft-versus-host-disease target organ tropism by dietary vitamin a. PLoS One. 2012;7(5):e38252. Epub 2012 May 30.

Edelblum KL, Shen L, Weber CR, Marchiando AM, Clay BS, Wang Y, Prinz I,
Malissen B, Sperling AI, Turner JR. Dynamic migration of γδ intraepithelial
lymphocytes requires occludin. Proc Natl Acad Sci U S A. 2012 Apr 17. [Epub ahead of print] PubMed PMID: 22511722.

Prinz I, Koenecke C. ; Therapeutic potential of induced and natural FoxP3+ regulatory T cells for the treatment of graft-versus-host disease.  Arch Immunol; Ther Exp (Warsz). 2012 Apr 5. [Epub ahead of print] PubMed PMID: 22476537 

Cornelia Lindner, Benjamin Wahl, Lisa Föhse, Sebastian Suerbaum, Andrew J. Macpherson, Immo Prinz, and Oliver Pabst, Age, microbiota, and T cells shape diverse individual IgA repertoires in the intestine; J. Exp. Med. 2012;0 201119801-20111980, Published online Jan 16 2012, 10.1084/jem.20111980.

2011

Fleige H, Haas JD, Stahl FR, Willenzon S, Prinz I.*, Förster R.* Induction of BALT in the absence of IL-17. Nat Immunol. 2011 Dec 16;13(1):1. doi: 10.1038/ni.2167. PMID: 22179267 * Equal contribution

Moschovakis GL, Bubke A, Dittrich-Breiholz O, Braun A, Prinz I, Kremmer E, Förster R. Deficient CCR7 signaling promotes T(H) 2 polarization and B-cell activation in vivo. Eur J Immunol. 2011 Oct 4. doi: 10.1002/eji.201141753. [Epub ahead of print] PubMed PMID: 21969271.

Föhse L, Suffner J, Suhre K, Wahl B, Lindner C, Lee CW, Schmitz S, Haas JD, Lamprecht S, Koenecke C, Bleich A, Hämmerling GJ, Malissen B, Suerbaum S, Förster R, Prinz I. High TCR Diversity ensures optimal Function and Homeostasis of FoxP3+ Regulatory T Cells, Eur J Immunol. 2011 Nov;41(11):3101-13. doi: 10.1002/eji.201141986. Epub 2011 Oct 18. PubMed PMID: 21932448.

Prinz I, Föhse L, γδ T cells are not alone. Immunol Cell Biol. 2011 Jul 12. doi: 10.1038/icb.2011.61. [Epub ahead of print]

Haas JD, Nistala K, Petermann F, Saran N, Chennupati V, Schmitz S, Korn T, Wedderburn LR, Förster R, Krueger A.*, Prinz I.* PLoS One. 2011;6(5):e20171. Epub 2011 May 26. Expression of miRNAs miR-133b and miR-206 in the Il17a/f Locus Is Co-Regulated with IL-17 Production in αβ and γδ T Cells.* Equal contribution

Prinz I. Dynamics of the interaction of γδ T cells with their neighbors in vivo. Cell Mol Life Sci. 2011 Jul;68(14):2391-8. Epub 2011 May 17. Review. PubMed PMID: 21584813.

Busche A , Schmitz S, Fleige F, Robbins SH, Walzer T, Stewart CA, Forster R, Messerle M, Prinz I Genetic labeling reveals altered turnover and stability of innate lymphocytes in latent mouse cytomegalovirus infection, J Immunol. 2011 Mar 1;186(5):2918-25. Epub 2011 Jan 26

2010

Pils MC, Bleich A, Prinz I, Fasnacht N, Bollati-Fogolin M, Schippers A, Rozell B, Müller W. Commensal gut flora reduces susceptibility to experimentally induced colitis via T-cell-derived interleukin-10. Citation: Inflamm Bowel Dis. 2010 Dec 22. [Epub ahead of print] PMID: 21182023

Malinarich FH, Grabski E, Worbs T, Chennupati V, Haas JD, Schmitz S, Candia E, Quera R, Malissen B, Förster R, Hermoso M, Prinz I. Constant TCR triggering suggests that the TCR expressed on intestinal intraepithelial γδ T cells is functional in vivo. Eur J Immunol. 2010 Dec;40(12):3378-88. doi: 10.1002/eji.201040727. Epub 2010 Nov 11.PMID: 21108461

Chennupati, V., Worbs, T., Liu, X., Malinarich, F. H., Schmitz, S., Haas, J. D., Malissen, B., Forster, R., and Prinz, I. (2010). Intra- and Intercompartmental Movement of gammadelta T Cells: Intestinal Intraepithelial and Peripheral gammadelta T Cells Represent Exclusive Nonoverlapping Populations with Distinct Migration Characteristics. J Immunol. Sep 24. [Epub ahead of print]

Petermann, F., Rothhammer, V., Claussen, M. C., Haas, J. D., Blanco, L. R., Heink, S., Prinz, I., Hemmer, B., Kuchroo, V. K., Oukka, M., and Korn, T. (2010). gammadelta T cells enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism. Immunity 33, 351-363.

2009

Haas, J. D., Malinarich, F. H., Schmitz, S., Chennupati, V., Fohse, L., Kremmer, E., Forster, R., and Prinz, I. (2009). CCR6 and NK1.1 distinguish between IL-17A and IFN-gamma-producing gammadelta effector T cells. Eur J Immunol 39, 3488-3497.

Koenecke, C., Chennupati, V., Schmitz, S., Malissen, B., Forster, R., and Prinz, I. (2009a). In vivo application of mAb directed against the gammadelta TCR does not deplete but generates "invisible" gammadelta T cells. Eur J Immunol 39, 372-379.

Koenecke, C., Czeloth, N., Bubke, A., Schmitz, S., Kissenpfennig, A., Malissen, B., Huehn, J., Ganser, A., Forster, R., and Prinz, I. (2009b). Alloantigen-specific de novo-induced Foxp3+ Treg revert in vivo and do not protect from experimental GVHD. Eur J Immunol 39, 3091-3096.

2007

Stewart, C. A., Walzer, T., Robbins, S. H., Malissen, B., Vivier, E., and Prinz, I. (2007). Germ-line and rearranged Tcrd transcription distinguish bona fide NK cells and NK-like gammadelta T cells. Eur J Immunol 37, 1442-1452.

Vanura, K., Montpellier, B., Le, T., Spicuglia, S., Navarro, J. M., Cabaud, O., Roulland, S., Vachez, E., Prinz, I., Ferrier, P., et al. (2007). In vivo reinsertion of excised episomes by the V(D)J recombinase: a potential threat to genomic stability. PLoS Biol 5, e43.

2006

Prinz, I., Sansoni, A., Kissenpfennig, A., Ardouin, L., Malissen, M., and Malissen, B. (2006). Visualization of the earliest steps of gammadelta T cell development in the adult thymus. Nat Immunol 7, 995-1003.

2005

Prinz, I., Gregoire, C., Mollenkopf, H., Aguado, E., Wang, Y., Malissen, M., Kaufmann, S. H., and Malissen, B. (2005a). The type 1 cysteinyl leukotriene receptor triggers calcium influx and chemotaxis in mouse alpha beta- and gamma delta effector T cells. J Immunol 175, 713-719.

Prinz, I., Kursar, M., Mittrucker, H. W., Aguado, E., Steinhoff, U., Kaufmann, S. H., and Malissen, B. (2005b). Autistic effector T cells in mice with a point mutation in the LAT adaptor fail to respond to Listeria monocytogenes infection. Int Immunol 17, 951-957.

Vor 2005

Prinz, I., Klemm, U., Kaufmann, S. H., and Steinhoff, U. (2004). Exacerbated colitis associated with elevated levels of activated CD4+ T cells in TCRalpha chain transgenic mice. Gastroenterology 126, 170-181.

Kuckelkorn, U., Ruppert, T., Strehl, B., Jungblut, P. R., Zimny-Arndt, U., Lamer, S., Prinz, I., Drung, I., Kloetzel, P. M., Kaufmann, S. H., and Steinhoff, U. (2002). Link between organ-specific antigen processing by 20S proteasomes and CD8(+) T cell-mediated autoimmunity. J Exp Med 195, 983-990.

Prinz, I., Zerrahn, J., Kaufmann, S. H., and Steinhoff, U. (2002). Promiscuous peptide recognition of an autoreactive CD8(+) T-cell clone is responsible for autoimmune intestinal pathology. J Autoimmun 18, 281-287.

Yuan, H., Mutomba, M., Prinz, I., and Gottlieb, R. A. (2001). Differential processing of cytosolic and mitochondrial caspases. Mitochondrion 1, 61-69.

Steinhoff, U., Brinkmann, V., Klemm, U., Aichele, P., Seiler, P., Brandt, U., Bland, P. W., Prinz, I., Zugel, U., and Kaufmann, S. H. (1999). Autoimmune intestinal pathology induced by hsp60-specific CD8 T cells. Immunity 11, 349-358.