Malaria Immunology Group

Malaria is a life-threatening parasitic disease resulting in over 1 million deaths every year. The underlying mechanisms of protective immune response against malaria are yet to be completely understood. Our group Malaria Immunology, uses murine model of malaria along with novel and established approaches to dissect the signal transduction pathways regulating the inter and intracellular communication which modulate the disease outcome. Understanding the signal transduction cascade will aid us to uncover potential candidate molecules which can be used as therapeutic options in severe malaria in combination with anti-parasitic drugs.

These research projects are supported by grants of the German Research Foundation DFG (SFB 854).

Members of the Work Group Gopala Krishna

Most important publications of the last five years (complete publication list https://orcid.org/0000-0002-7280-5663):

• Oelschlegel AM, Bhattacharjee R, Wenk P, Harit K, Rothkötter HJ, Koch SP, Boehm-Sturm P, Matuschewski K, Budinger E, Schlüter D, Goldschmidt J, Nishanth G (2024) Beyond the microcirculation: sequestration of infected red blood cells and reduced flow in large draining veins in experimental cerebral malaria. Nat Commun. 15(1):2396. doi: 10.1038/s41467-024-46617-w.
• Haage TR, Charakopoulos E, Bhuria V, Baldauf CK, Korthals M, Handschuh J, Müller P, Li J, Harit K, Nishanth G, Frey S, Böttcher M, Fischer KD, Dudeck J, Dudeck A, Lipka DB, Schraven B, Green AR, Müller AJ, Mougiakakos D, Fischer T.J (2024) Neutrophil-specific expression of JAK2-V617F or CALRmut induces distinct inflammatory profiles in myeloproliferative neoplasia. Hematol Oncol. 17(1):43. doi: 10.1186/s13045-024-01562-5.
• Zhuang Y, Fischer JB, Nishanth G, Schlüter D (2024) Cross-regulation of Listeria monocytogenes and the host ubiquitin system in listeriosis. .Eur J Cell Biol. 103(2):151401. doi: 10.1016/j.ejcb.2024.151401.
• Harit K, Bhattacharjee R, Matuschewski K, Becker J, Kalinke U, Schlüter D, Nishanth G (2023) The deubiquitinating enzyme OTUD7b protects dendritic cells from TNF-induced apoptosis by stabilizing the E3 ligase TRAF2. Cell Death Dis. 14(7):480. doi: 10.1038/s41419-023-06014-5.
• Stutz A, Nishanth G, Zenclussen AC, Schumacher A(2022) Partial otubain 1 deficiency compromises fetal well-being in allogeneic pregnancies despite no major changes in the dendritic cell and T cell compartment..BMC Res Notes. 15(1):341. doi: 10.1186/s13104-022-06230-w.
• Koschel J, Nishanth G*, Just S, Harit K, Kröger A, Deckert M, Naumann M, Schlüter D* (2021). OTUB1 prevents lethal hepatocyte necroptosis through stabilization of c-IAP1 during murine liver inflammation..Cell Death Differ.;28(7):2257-2275. doi: 10.1038/s41418-021-00752-9. * Shared senior authorship.