Publications by Dr. med. Stephan Halle, PhD

2023:

Rex, V., Stempel, M., Halle, S., & Brinkmann, M. M. (2023). The two faces of oligoadenylate synthetase-like: effective antiviral protein and negative regulator of innate immunity. Current opinion in virology, 60, 101329. https://doi.org/10.1016/j.coviro.2023.101329

Rex, V., Zargari, R., Stempel, M., Halle, S., & Brinkmann, M. M. (2023). The innate and T-cell mediated immune response during acute and chronic gammaherpesvirus infection. Frontiers in cellular and infection microbiology, 13, 1146381. https://doi.org/10.3389/fcimb.2023.1146381

2022:

Fleig, S., Kapanadze, T., Bernier-Latmani, J., Lill, J. K., Wyss, T., Gamrekelashvili, J., Kijas, D., Liu, B., Hüsing, A. M., Bovay, E., Jirmo, A. C., Halle, S., Ricke-Hoch, M., Adams, R. H., Engel, D. R., von Vietinghoff, S., Förster, R., Hilfiker-Kleiner, D., Haller, H., Petrova, T. V., … Limbourg, F. P. (2022). Loss of vascular endothelial notch signaling promotes spontaneous formation of tertiary lymphoid structures. Nature communications, 13(1), 2022. https://doi.org/10.1038/s41467-022-29701-x

2020:

Martens R, Permanyer M, Werth K, Yu K, Braun A, Halle O, Halle S, Patzer GE, Bošnjak B, Kiefer F, Janssen A, Friedrichsen M, Poetzsch J, Kohli K, Lueder Y, Gutierrez Jauregui R, Eckert N, Worbs T, Galla M, Förster R. Efficient homing of T cells via afferent lymphatics requires mechanical arrest and integrin-supported chemokine guidance. Nat Commun. 2020 Feb 28;11(1):1114. doi: 10.1038/s41467-020-14921-w. PMID: 32111837; PMCID: PMC7048855.

Rastogi A, Robert PA, Halle S, Meyer-Hermann M. Evaluation of CD8 T cell killing models with computer simulations of 2-photon imaging experiments. PLoS Comput Biol. 2020 Dec 28;16(12):e1008428. doi: 10.1371/journal.pcbi.1008428. PMID: 33370254; PMCID: PMC7793284.

2019:

Bickes MS, Pirr S, Heinemann AS, Fehlhaber B, Halle S, Völlger L, Willers M, Richter M, Böhne C, Albrecht M, Langer M, Pfeifer S, Jonigk D, Vieten G, Ure B, von Kaisenberg C, Förster R, von Köckritz-Blickwede M, Hansen G, Viemann D. Constitutive TNF-α signaling in neonates is essential for the development of tissue-resident leukocyte profiles at barrier sites. FASEB J. 2019 Oct;33(10):10633-10647. doi: 10.1096/fj.201900796R. Epub 2019 Jun 29. PMID: 31262195.

2018:

Pägelow D, Chhatbar C, Beineke A, Liu X, Nerlich A, van Vorst K, Rohde M, Kalinke U, Förster R, Halle S, Valentin-Weigand P, Hornef MW, Fulde M. The olfactory epithelium as a port of entry in neonatal neurolisteriosis. Nat Commun. 2018 Oct 15;9(1):4269. doi: 10.1038/s41467-018-06668-2. PubMed PMID: 30323282; PubMed Central PMCID: PMC6189187

Stahl FR, Jung R, Jazbutyte V, Ostermann E, Tödter S, Brixel R, Kemmer A, Halle S, Rose-John S, Messerle M, Arck PC, Brune W, Renné T. Laboratory diagnostics of murine blood for detection of mouse cytomegalovirus (MCMV)-induced hepatitis. Sci Rep. 2018 Oct 4;8(1):14823. doi: 10.1038/s41598-018-33167-7. PubMed PMID: 30287927; PubMed Central PMCID: PMC6172243

Lueder Y, Heller K, Ritter C, Keyser KA, Wagner K, Liu X, Messerle M, Stahl FR, Halle S, Förster R. Control of primary mouse cytomegalovirus infection in lung nodular inflammatory foci by cooperation of interferon-gamma expressing CD4 and CD8 T cells. PLoS Pathog. 2018 Aug 28;14(8):e1007252. doi: 10.1371/journal.ppat.1007252. eCollection 2018 Aug. PubMed PMID: 30153311; PubMed Central PMCID: PMC6112668

Georgiev, H., Ravens, I., Papadogianni, G., Halle, S., Malissen, B., Loots, G. G., Förster, R., and Bernhardt, G. (2018). Shared and unique features distinguishing follicular T helper and regulatory cells of peripheral lymph node and Peyer's Patches. Front Immunol

2017:

Halle S, Halle O, Förster R. Mechanisms and Dynamics of T Cell-Mediated Cytotoxicity In Vivo. Trends Immunol. 2017 Jun;38(6):432-443. doi: 10.1016/j.it.2017.04.002. Epub 2017 May 9. Review. PubMed PMID: 28499492.


2016:

Zheng X, Halle S, Yu K, Mishra P, Scherr M, Pietzsch S, Willenzon S, Janssen A, Boelter J, Hilfiker-Kleiner D, Eder M, Förster R. Cardiomyocytes display low mitochondrial priming and are highly resistant toward cytotoxic T-cell killing. Eur J Immunol. 2016 Jun;46(6):1415-26. doi: 10.1002/eji.201546080. Epub 2016 Mar 31. Erratum in: Eur J Immunol. 2016 Aug;46(8):2054. PubMed PMID: 26970349; PubMed Central PMCID: PMC5071700.

Halle S, Keyser KA, Stahl FR, Busche A, Marquardt A, Zheng X, Galla M, Heissmeyer V, Heller K, Boelter J, Wagner K, Bischoff Y, Martens R, Braun A, Werth K, Uvarovskii A, Kempf H, Meyer-Hermann M, Arens R, Kremer M, Sutter G, Messerle M, Förster R. In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity. Immunity. 2016 Feb 16;44(2):233-45. doi: 10.1016/j.immuni.2016.01.010. Epub 2016 Feb 9. PubMed PMID: 26872694; PubMed Central PMCID: PMC4846978.


2015

Schreder A, Moschovakis GL, Halle S, Schlue J, Lee CW, Schippers A, David S, Bernhardt G, Ganser A, Pabst O, Förster R, Koenecke C. Differential Effects of Gut-Homing Molecules CC Chemokine Receptor 9 and Integrin-β7 during Acute Graft-versus-Host Disease of the Liver. Biol Blood Marrow Transplant. 2015 Dec;21(12):2069-78. doi: 10.1016/j.bbmt.2015.08.038. Epub 2015 Sep 5. PubMed PMID: 26348893.

2014

Stahl FR, Keyser KA, Heller K, Bischoff Y, Halle S, Wagner K, Messerle M, Förster R. Mck2-dependent infection of alveolar macrophages promotes replication of MCMV in nodular inflammatory foci of the neonatal lung. Mucosal Immunol. 2015 Jan;8(1):57-67. doi: 10.1038/mi.2014.42. Epub 2014 Jun 4. PubMed PMID: 24894498.


2013:

Stahl FR, Heller K, Halle S, Keyser KA, Busche A, Marquardt A, Wagner K, Boelter J, Bischoff Y, Kremmer E, Arens R, Messerle M, Förster R. Nodular inflammatory foci are sites of T cell priming and control of murine cytomegalovirus infection in the neonatal lung. PLoS Pathog. 2013; 9(12):e1003828. doi: 10.1371/journal.ppat.1003828. Epub 2013 Dec 12. PubMed PMID: 24348257; PubMed Central PMCID: PMC3861546.


2011:

Braun A, Worbs T, Moschovakis GL, Halle S, Hoffmann K, Bölter J, Münk A, Förster R.; Afferent lymph-derived T cells and DCs use different chemokine receptor CCR7-dependent routes for entry into the lymph node and intranodal migration. Nat Immunol. 2011 Aug 14;12(9):879-87. doi: 10.1038/ni.2085. PMID: 21841786 [PubMed - indexed for MEDLINE] 

Marquardt A, Halle S, Seckert CK, Lemmermann NA, Veres TZ, Braun A, Maus UA, Förster R, Reddehase MJ, Messerle M, Busche A. Single cell detection of latent cytomegalovirus reactivation in host tissue. J Gen Virol. 2011 Jun;92(Pt 6):1279-91. Epub 2011 Feb 16.

Warlich E, Kuehle J, Cantz T, Brugman MH, Maetzig T, Galla M, Filipczyk AA, Halle S, Klump H, Schöler HR, Baum C, Schroeder T, Schambach A. Lentiviral vector design and imaging approaches to visualize the early stages of cellular reprogramming. Mol Ther. 2011 Apr;19(4):782-9. doi: 10.1038/mt.2010.314. Epub 2011 Feb 1. PubMed PMID: 21285961; PubMed Central PMCID: PMC3070104

2009

Halle, S., Dujardin, H. C., Bakocevic, N., Fleige, H., Danzer, H., Willenzon, S., Suezer, Y., Hammerling, G., Garbi, N., Sutter, G., et al. (2009). Induced bronchus-associated lymphoid tissue serves as a general priming site for T cells and is maintained by dendritic cells. J Exp Med 206, 2593-2601.

 

2007

Halle, S., Bumann, D., Herbrand, H., Willer, Y., Dahne, S., Forster, R., and Pabst, O. (2007). Solitary intestinal lymphoid tissue provides a productive port of entry for Salmonella enterica serovar Typhimurium. Infect Immun 75, 1577-1585.