Publications by Sarina Ravens, PhD

2024

Cramer A, Yang T, Riemann L, Almeida V, Kammeyer C, Abu YE, Gluschke E, Kleiner S, León-Lara X, Janssen A, Hofmann A, Horke A, von Kaisenberg C, Förster R, Beerbaum P, Boehne M, Ravens S. Early-life thymectomy leads to an increase of granzyme-producing γδ T cells in children with congenital heart disease. Nat Commun. 2024 Nov 13;15(1):9841. doi: 10.1038/s41467-024-51673-3. PMID: 39537635.

Ravens S, Tolosa E. Expansion of human γδ T cells in periphery: Lessons learned from development, infections, and compromised thymic function. Eur J Immunol. 2024 Aug 28:e2451073. doi: 10.1002/eji.202451073. Epub ahead of print. PMID: 39194409.

León-Lara X, Fichtner AS, Willers M, Yang T, Schaper K, Riemann L, Schöning J, Harms A, Almeida V, Schimrock A, Janssen A, Ospina-Quintero L, von Kaisenberg C, Förster R, Eberl M, Richter MF, Pirr S, Viemann D, Ravens S. γδ T cell profiling in a cohort of preterm infants reveals elevated frequencies of CD83+ γδ T cells in sepsis. J Exp Med. 2024 Jul 1;221(7):e20231987. doi: 10.1084/jem.20231987. Epub 2024 May 16. PMID: 38753245; PMCID: PMC11098939.

Terzoli S, Marzano P, Cazzetta V, Piazza R, Sandrock I, Ravens S, Tan L, Prinz I, Balin S, Calvi M, Carletti A, Cancellara A, Coianiz N, Franzese S, Frigo A, Voza A, Calcaterra F, Di Vito C, Della Bella S, Mikulak J, Mavilio D. Expansion of memory Vδ2 T cells following SARS-CoV-2 vaccination revealed by temporal single-cell transcriptomics. NPJ Vaccines. 2024 Mar 20;9(1):63. doi: 10.1038/s41541-024-00853-9. PMID: 38509155; PMCID: PMC10954735.

2023

Yang, T., Barros-Martins, J., Wang, Z., Wencker, M., Zhang, J., Smout, J., Gambhir, P., Janssen, A., Schimrock, A., Georgiev, H., León-Lara, X., Weiss, S., Huehn, J., Prinz, I., Krueger, A., Foerster, R., Walzer, T., & Ravens, S. (2023). RORγt+ c-Maf+ Vγ4+ γδ T cells are generated in the adult thymus but do not reach the periphery. Cell reports, 42(10), 113230. https://doi.org/10.1016/j.celrep.2023.113230

Marzano, P., Balin, S., Terzoli, S., Della Bella, S., Cazzetta, V., Piazza, R., Sandrock, I., Ravens, S., Tan, L., Prinz, I., Calcaterra, F., Di Vito, C., Cancellara, A., Calvi, M., Carletti, A., Franzese, S., Frigo, A., Darwish, A., Voza, A., Mikulak, J., … Mavilio, D. (2023). Transcriptomic profile of TNFhigh MAIT cells is linked to B cell response following SARS-CoV-2 vaccination. Frontiers in immunology, 14, 1208662. https://doi.org/10.3389/fimmu.2023.1208662

Bufe, S., Zimmermann, A., Ravens, S., Prinz, I., Buitrago-Molina, L. E., Geffers, R., Woller, N., Kühnel, F., Talbot, S. R., Noyan, F., Manns, M. P., Wedemeyer, H., Hardtke-Wolenski, M., Jaeckel, E., & Davalos-Misslitz, A. C. (2022). PD-1/CTLA-4 Blockade Leads to Expansion of CD8+PD-1int TILs and Results in Tumor Remission in Experimental Liver Cancer. Liver cancer, 12(2), 129–144. https://doi.org/10.1159/000526899

Vicente, M. M., Alves, I., Fernandes, Â., Dias, A. M., Santos-Pereira, B., Pérez-Anton, E., Santos, S., Yang, T., Correia, A., Münster-Kühnel, A., Almeida, A. R. M., Ravens, S., Rabinovich, G. A., Vilanova, M., Sousa, A. E., & Pinho, S. S. (2023). Mannosylated glycans impair normal T-cell development by reprogramming commitment and repertoire diversity. Cellular & molecular immunology, 10.1038/s41423-023-01052-7. Advance online publication. https://doi.org/10.1038/s41423-023-01052-7

Bonifacius, A., Lamottke, B., Tischer-Zimmermann, S., Schultze-Florey, R., Goudeva, L., Heuft, H. G., Arseniev, L., Beier, R., Beutel, G., Cario, G., Fröhlich, B., Greil, J., Hansmann, L., Hasenkamp, J., Höfs, M., Hundsdoerfer, P., Jost, E., Kafa, K., Kriege, O., Kröger, N., … Maecker-Kolhoff, B. (2023). Patient-tailored adoptive immunotherapy with EBV-specific T cells from related and unrelated donors. The Journal of clinical investigation, e163548. Advance online publication. https://doi.org/10.1172/JCI163548

Eiz-Vesper, B., Ravens, S., & Maecker-Kolhoff, B. (2023). αβ and γδ T-cell responses to Epstein-Barr Virus: insights in immunocompetence, immune failure and therapeutic augmentation in transplant patients. Current opinion in immunology, 82, 102305. Advance online publication. https://doi.org/10.1016/j.coi.2023.102305

Hahn, A. M., Vogg, L., Brey, S., Schneider, A., Schäfer, S., Palmisano, R., Pavlova, A., Sandrock, I., Tan, L., Fichtner, A. S., Prinz, I., Ravens, S., & Winkler, T. H. (2023). A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages. Cell reports, 42(5), 112558. https://doi.org/10.1016/j.celrep.2023.112558

Yang T, Barros-Martins J, Janssen A, Wang Z, León-Lara X, Weiss S, Prinz I, Förster R, Ravens S (2023). Adult thymus-derived cMaf+RORγt+ γδ T cells lack Scart2 chromatin accessibility and do not reach periphery. doi: https://doi.org/10.1101/2023.02.20.529224

2022

Pleuger, C., Ai, D., Hoppe, M. L., Winter, L. T., Bohnert, D., Karl, D., Guenther, S., Epelman, S., Kantores, C., Fijak, M., Ravens, S., Middendorff, R., Mayer, J. U., Loveland, K. L., Hedger, M., Bhushan, S., & Meinhardt, A. (2022). The regional distribution of resident immune cells shapes distinct immunological environments along the murine epididymis. eLife, 11, e82193. https://doi.org/10.7554/eLife.82193

Deng, L., Harms, A., Ravens, S., Prinz, I.*, Tan, L.* (2022). Systematic pattern analyses of Vδ2+ TCRs reveal that shared "public" Vδ2+ γδ T cell clones are a consequence of rearrangement bias and a higher expansion status. Frontiers in immunology, 13, 960920. https://doi.org/10.3389/fimmu.2022.960920

Schneider J, Kuhlmann L, Xiao Y, Raha S, Bernhardt G, Stadler M, Thol F, Heuser M, Eder M, Ganser A, Ravens S, Förster R, Prinz I, Koenecke C, Schultze-Florey CR. Healthy-like CD4+ Regulatory and CD4+ Conventional T-Cell Receptor Repertoires Predict Protection from GVHD Following Donor Lymphocyte Infusion. Int J Mol Sci. 2022 Sep 18;23(18):10914. doi: 10.3390/ijms231810914. PMID: 36142824; PMCID: PMC9505302.

Ataide MA, Knöpper K, Cruz de Casas P, Ugur M, Eickhoff S, Zou M, Shaikh H, Trivedi A, Grafen A, Yang T, Prinz I, Ohlsen K, Gomez de Agüero M, Beilhack A, Huehn J, Gaya M, Saliba AE, Gasteiger G, Kastenmüller W. Lymphatic migration of unconventional T cells promotes site-specific immunity in distinct lymph nodes. Immunity. 2022 Aug 17:S1074-7613(22)00354-5. doi: 10.1016/j.immuni.2022.07.019. Epub ahead of print. PMID: 36002023.

Bruni E, Cimino MM, Donadon M, Carriero R, Terzoli S, Piazza R, Ravens S, Prinz I, Cazzetta V, Marzano P, Kunderfranco P, Peano C, Soldani C, Franceschini B, Colombo FS, Garlanda C, Mantovani A, Torzilli G, Mikulak J, Mavilio D. Intrahepatic CD69+Vδ1 T cells re-circulate in the blood of patients with metastatic colorectal cancer and limit tumor progression. J Immunother Cancer. 2022 Jul;10(7):e004579. doi: 10.1136/jitc-2022-004579. PMID: 35863820.

León-Lara X, Yang T, Fichtner AS, Bruni E, von Kaisenberg C, Eiz-Vesper B, Dodoo D, Adu B, Ravens S. Evidence for an Adult-Like Type 1-Immunity Phenotype of Vδ1, Vδ2 and Vδ3 T Cells in Ghanaian Children With Repeated Exposure to Malaria. Front Immunol. 2022 Feb 17;13:807765. doi: 10.3389/fimmu.2022.807765. PMID: 35250979; PMCID: PMC8891705.

2021

Cazzetta V, Bruni E, Terzoli S, Carenza C, Franzese S, Piazza R, Marzano P, Donadon M, Torzilli G, Cimino M, Simonelli M, Bello L, Villa A, Tan L, Ravens S, Prinz I, Supino D, Colombo FS, Lugli E, Marcenaro E, Vivier E, Della Bella S, Mikulak J, Mavilio D. NKG2A expression identifies a subset of human Vδ2 T cells exerting the highest antitumor effector functions. Cell Rep. 2021 Oct 19;37(3):109871. doi: 10.1016/j.celrep.2021.109871. PMID: 34686325.

Schultze-Florey CR, Kuhlmann L, Raha S, Barros-Martins J, Odak I, Tan L, Xiao Y, Ravens S, Hambach L, Venturini L, Stadler M, Eder M, Thol F, Heuser M, Forster R, Ganser A, Prinz I, Koenecke C. Clonal expansion of CD8+ T cells reflects graft-versus-leukemia activity and precedes durable remission following DLI. Blood Adv. 2021 Sep 17:bloodadvances.2020004073. doi: 10.1182/bloodadvances.2020004073. Epub ahead of print. PMID: 34535011.

Coppin E, Sundarasetty BS, Rahmig S, Blume J, Verheyden NA, Bahlmann F, Ravens S, Schubert U, Schmid J, Ludwig S, Geissler K, Guntinas-Lichius O, von Kaisenberg C, Groten T, Platz A, Naumann R, Ludwig B, Prinz I, Waskow C, Krueger A. Enhanced differentiation of functional human T cells in NSGW41 mice with tissue-specific expression of human interleukin-7. Leukemia. 2021 May 11. doi: 10.1038/s41375-021-01259-5. Epub ahead of print. PMID: 33976371.

Tan L, Fichtner AS, Bruni E, Odak I, Sandrock I, Bubke A, Borchers A, Schultze-Florey C, Koenecke C, Förster R, Jarek M, von Kaisenberg C, Schulz A, Chu X, Zhang B, Li Y, Panzer U, Krebs CF, Ravens S, Prinz I. A fetal wave of human type 3 effector γδ cells with restricted TCR diversity persists into adulthood. Sci Immunol. 2021 Apr 23;6(58):eabf0125. doi: 10.1126/sciimmunol.abf0125. PMID: 33893173.

2020

Ravens, S.*, Fichtner, A. S.*, Willers, M., Torkornoo, D., Pirr, S., Schöning, J., Deseke, M., Sandrock, I., Bubke, A., Wilharm, A., Dodoo, D., Egyir, B., Flanagan, K. L., Steinbrück, L., Dickinson, P., Ghazal, P., Adu, B., Viemann, D.*, Prinz, I.* (2020). Microbial exposure drives polyclonal expansion of innate γδ T cells immediately after birth. Proceedings of the National Academy of Sciences of the United States of America, 117(31), 18649–18660. https://doi.org/10.1073/pnas.1922588117
* These authors contributed equally to this work

Fichtner AS, Ravens S, Prinz I. Human γδ TCR Repertoires in Health and Disease. Cells. 2020 Mar 26;9(4). pii: E800. doi: 10.3390/cells9040800. Review. PubMed PMID: 32225004

Fichtner AS, Bubke A, Rampoldi F, Wilharm A, Tan L, Steinbrück L, Schultze-Florey C, von Kaisenberg C, Prinz I, Herrmann T, Ravens S. TCR repertoire analysis reveals phosphoantigen-induced polyclonal proliferation of Vγ9Vδ2 T cells in neonates and adults. J Leukoc Biol. 2020 Feb 17. doi: 10.1002/JLB.1MA0120-427RR. [Epub ahead of print] PubMed PMID: 32064671

Janssen A, Villacorta Hidalgo J, Beringer DX, van Dooremalen S, Fernando F, van Diest E, Terrizzi AR, Bronsert P, Kock S, Schmitt-Graeff A, Werner M, Heise K, Follo M, Straetemans T, Sebestyen Z, Chudakov DM, Kasatskaya SA, Frenkel FE, Ravens S, Spierings E, Prinz I, Küppers R, Malkovsky M, Fisch P, Kuball J. γδ T-cell receptors derived from breast cancer-infiltrating T lymphocytes mediate antitumor reactivity. Cancer Immunol Res. 2020 Feb 4. pii: canimm.0513.2019. doi: 10.1158/2326-6066.CIR-19-0513. [Epub ahead of print] PubMed PMID: 32019779.

2019

Hammer SE, Leopold M, Prawits LM, Mair KH, Schwartz JC, Hammond JA, Ravens S, Gerner W, Saalmüller A. Development of a RACE-based RNA-Seq approach to characterize the T-cell receptor repertoire of porcine γδ T cells. Dev Comp Immunol. 2019 Dec 14;105:103575. doi: 10.1016/j.dci.2019.103575. [Epub ahead of print] PubMed PMID: 31846687.

Mikulak J, Oriolo F, Bruni E, Roberto A, Colombo FS, Villa A, Bosticardo M, Bortolomai I, Lo Presti E, Meraviglia S, Dieli F, Vetrano S, Danese S, Della Bella S, Carvello MM, Sacchi M, Cugini G, Colombo G, Klinger M, Spaggiari P, Roncalli M, Prinz I, Ravens S, di Lorenzo B, Marcenaro E, Silva-Santos B, Spinelli A, Mavilio D. NKp46-expressing human gut-resident intraepithelial Vδ1 T cell subpopulation exhibits high anti-tumor activity against colorectal cancer. JCI Insight. 2019 Nov 5. pii: 125884. doi: 10.1172/jci.insight.125884. [Epub ahead of print] PubMed PMID: 31689241.

Di Lorenzo B, Ravens S*, Silva-Santos B.* High-throughput analysis of the human thymic Vδ1(+) T cell receptor repertoire. Sci Data. 2019 Jul 4;6(1):115. doi: 10.1038/s41597-019-0118-2. PubMed PMID: 31273218; PubMed Central PMCID: PMC6609709.
*equal contribution

Tan L, Sandrock I, Odak I, Aizenbud Y, Wilharm A, Barros-Martins J, Tabib Y, Borchers A, Amado T, Gangoda L, Herold MJ, Schmidt-Supprian M, Kisielow J, Silva-Santos B, Koenecke C, Hovav AH, Krebs C, Prinz *, Ravens S*. Single-Cell Transcriptomics Identifies the Adaptation of Scart1(+) Vγ6(+) T Cells to Skin Residency as Activated Effector Cells. Cell Rep. 2019 Jun 18;27(12):3657-3671.e4. doi: 10.1016/j.celrep.2019.05.064. PubMed PMID: 31216482.
*equal contribution

Odak I*, Raha S*, Schultze-Florey C, Tavil S, Ravens S, Ganser A, Förster R, Prinz I**, Koenecke C**. Focusing of the regulatory T cell repertoire after allogeneic stem cell transplantation indicates protection from graft-versus-host disease. Haematologica. 2019 Apr 24. pii: haematol.2019.218206. doi: 10.3324/haematol.2019.218206. [Epub ahead of print] PubMed PMID: 31018979.
*equal contribution, ** shared senior authorship

Ammer-Herrmenau C, Kulkarni U, Andreas N, Ungelenk M, Ravens S, Hübner C, Kather A, Kurth I, Bauer M, Kamradt T. Sepsis induces long-lasting impairments in CD4+ T-cell responses despite rapid numerical recovery of T-lymphocyte populations. PLoS One. 2019 Feb 7;14(2):e0211716. doi: 10.1371/journal.pone.0211716. eCollection 2019. PubMed PMID: 30730978; PubMed Central PMCID: PMC6366777

Di Lorenzo B, Simões AE, Caiado F, Tieppo P, Correia DV, Carvalho T, da Silva MG, Déchanet-Merville J, Schumacher TN, Prinz I, Norell H, Ravens S, Vermijlen D, Silva-Santos B. Broad Cytotoxic Targeting of Acute Myeloid Leukemia by Polyclonal Delta One T Cells. Cancer Immunol Res. 2019 Mar 20. doi: 10.1158/2326-6066.CIR-18-0647. [Epub ahead of print] PubMed PMID: 30894378.


2018

Bak S, Tischer S, Dragon A, Ravens S, Pape L, Koenecke C, Oelke M, Blasczyk R, Maecker-Kolhoff B, Eiz-Vesper B. Selective Effects of mTOR Inhibitor Sirolimus on Naïve and CMV-Specific T Cells Extending Its Applicable Range Beyond Immunosuppression. Front Immunol. 2018 Dec 17;9:2953. doi: 10.3389/fimmu.2018.02953. eCollection 2018. PubMed PMID: 30619313; PubMed Central PMCID: PMC6304429.

Sandrock I, Reinhardt A, Ravens S, Binz C, Wilharm A, Martins J, Oberdörfer L, Tan L, Lienenklaus S, Zhang B, Naumann R, Zhuang Y, Krueger A, Förster R, Prinz I. Genetic models reveal origin, persistence and non-redundant functions of IL-17-producing γδ T cells. J Exp Med. 2018 Nov 19. pii: jem.20181439.

Schultze-Florey RE, Tischer S, Kuhlmann L, Hundsdoerfer P, Koch A, Anagnostopoulos I, Ravens S, Goudeva L, Schultze-Florey C, Koenecke C, Blasczyk R, Koehl U, Heuft HG, Prinz I, Eiz-Vesper B, Maecker-Kolhoff B. Dissecting Epstein-Barr Virus-Specific T-Cell Responses After Allogeneic EBV-Specific T-Cell Transfer for Central Nervous System Posttransplant Lymphoproliferative Disease. Front Immunol. 2018 Jun 27;9:1475. doi: 10.3389/fimmu.2018.01475. eCollection 2018. PubMed PMID: 29997626; PubMed Central PMCID: PMC6030255

Ravens S*, Hengst J*, Schlapphoff V, Deterding K, Dhingra A, Schultze-Florey C, Koenecke C, Cornberg M, Wedemeyer H, Prinz I. Human γδ T Cell Receptor Repertoires in Peripheral Blood Remain Stable Despite Clearance of Persistent Hepatitis C Virus Infection by Direct-Acting Antiviral Drug Therapy. Front Immunol. 2018 Mar 16;9:510. doi: 10.3389/fimmu.2018.00510. eCollection 2018. PubMed PMID: 29616028; PubMed Central PMCID: PMC5864898.
* equal contribution

2017

Edelblum KL, Sharon G, Singh G, Odenwald MA, Sailer A, Cao S, Ravens S, Thomsen I, El Bissati K, McLeod R, Dong C, Gurbuxani S, Prinz I, Mazmanian SK, Turner JR. The Microbiome Activates CD4 T-cell-mediated Immunity to Compensate for Increased Intestinal Permeability. Cell Mol Gastroenterol Hepatol. 2017 Jun 10;4(2):285-297. doi: 10.1016/j.jcmgh.2017.06.001. eCollection 2017 Sep. PubMed PMID: 28795125; PubMed Central PMCID: PMC5540699

Ravens S, Schultze-Florey C, Raha S, Sandrock I, Drenker M, Oberdörfer L, Reinhardt A, Ravens I, Beck M, Geffers R, von Kaisenberg C, Heuser M, Thol F, Ganser A, Förster R, Koenecke C*, Prinz I*. Human γδ T cells are quickly reconstituted after stem-cell transplantation and show adaptive clonal expansion in response to viral infection. Nat Immunol. 2017 Feb 20. doi: 10.1038/ni.3686. [Epub ahead of print] PubMed PMID: 28218745
*equal contribution


2015

Ravens S, Yu C, Ye T, Stierle M, Tora L. Tip60 complex binds to active Pol II  promoters and a subset of enhancers and co-regulates the c-Myc network in mouse embryonic stem cells. Epigenetics Chromatin. 2015 Nov 6;8:45.


2014

Ravens S, Fournier M, Ye T, Stierle M, Dembele D, Chavant V, Tora L. Mof-associated complexes have overlapping and unique roles in regulating pluripotency in embryonic stem cells and during differentiation. Elife. 2014 Jun  4;3.

Ye T, Ravens S, Krebs AR, Tora L. Interpreting and visualizing ChIP-seq data with the seqMINER software. Methods Mol Biol. 2014;1150:141-52.

Fleige H1, Ravens S, Moschovakis GL, Bölter J, Willenzon S, Sutter G, Häussler S, Kalinke U, Prinz I, Förster R. IL-17-induced CXCL12 recruits B cells and induces follicle formation in BALT in the absence of differentiated FDCs. J Exp Med. 2014 Apr 7;211(4):643-51. doi: 10.1084/jem.20131737. Epub 2014 Mar 24.

Reinhardt A, Ravens S, Fleige H, Haas JD, Oberdörfer L, Lyszkiewicz M, Förster R, Prinz I. CCR7-mediated migration in the thymus controls γδ T-cell development. Eur J Immunol. 2014 Feb 5. doi: 10.1002/eji.201344330. [Epub ahead of print] PMID: 24500801 [PubMed - as supplied by publisher]


2012

Haas JD*, Ravens S*, Düber S, Sandrock I, Oberdörfer L, Kashani E, Chennupati V, Föhse L, Naumann R, Weiss S, Krueger A, Förster R, Prinz I. Development of Interleukin-17-Producing γδ T Cells Is Restricted to a Functional Embryonic Wave. Immunity. 2012 Jul 3. [Epub ahead of print] PMID: 22770884
* equal contribution

2010

Giusti C, Luciani MF, Ravens S, Gillet A, Golstein P. Autophagic cell death in Dictyostelium requires the receptor histidine kinase DhkM. Mol Biol Cell. 2010 Jun 1;21(11):1825-35. doi: 10.1091/mbc.E09-11-0976.