Chronic low-grade sterile inflammation is a hallmark of aging and has been shown to be associated with functional decline and age-related diseases in different organ systems. However, for the vast majority of age associated diseases, we have little understanding of the functional effect of certain immune cell subsets and their context-specificity. This challenge will be addressed by this proposed research, focusing on pathological aging of the peripheral sensory nervous system and associated symptoms of neuropathy including neuropathic itch and pain. The overarching aim is to determine the impact of immune cells on neuronal function during lifetime and identify mechanism of pathologic neuro-immune – interactions that are drivers of sensory neuron aging. This will advance our understanding of disease-associated transcriptional programs underlying sensory neuron aging and answer questions of sensory neuron function that is shaped by immune cell-environment interactions.