Dr. Hans Bakker

Phone.: +49(0)511/532-5214

FAX: +49(0)511/532-8801

E-Mail: Bakker.Hans@mh-hannover.de

Mailing Address:

Medizinische Hochschule Hannover, MHH

Institut für Klinische Biochemie, OE 4340

Carl-Neuberg-Strasse 1

30625 Hannover

Campus Address:

Building J03, Level 04, Room 1290 (Office), Room 1250 (Lab)

C-mannosylated tryptophans in thrombospondin type 1 repeats are part of the tryptophan-arginine ladder that forms the heart of the repeat. The mannoses are transferred by specific endoplasmic reticulum localized C-mannosyltransferases of the DPY-19 family. The name DPY-19 comes from the worm C. elegans, where mutations in the C-mannosyltransferase gene lead to a temperature-sensitive DumPY phenotype.
In humans there are four homologs of DPY-19, which are called DPY19L1, DPY19L2, DPY19L3, and DPY19L4.