Publications 2019

  • Chatterjee S, Gupta SK, Bar C, Thum T. Noncoding RNAs: Potential regulators in cardioncology. Am J Physiol Heart Circ Physiol. 2019;316:H160-H168. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383355/
  • Polten F, Reboll MR, Widera C, Kempf T, Bethmann K, Gupta P, Miglietta J, Pekcec A, Tillmanns J, Bauersachs J, Giannitsis E, Pich A, Wollert KC. Plasma concentrations of myeloid-derived growth factor in healthy individuals and patients with acute myocardial infarction as assessed by multiple reaction monitoring-mass spectrometry. Anal Chem. 2019;91:1302-1308. https://pubmed.ncbi.nlm.nih.gov/30543396/
  • Eisen B, Ben Jehuda R, Cuttitta AJ, Mekies LN, Shemer Y, Baskin P, Reiter I, Willi L, Freimark D, Gherghiceanu M, Monserrat L, Scherr M, Hilfiker-Kleiner D, Arad M, Michele DE, Binah O. Electrophysiological abnormalities in induced pluripotent stem cell-derived cardiomyocytes generated from duchenne muscular dystrophy patients. J Cell Mol Med. 2019;23:2125-2135. https://pubmed.ncbi.nlm.nih.gov/30618214
  • Sonnenschein K, Wilczek AL, de Gonzalo-Calvo D, Pfanne A, Derda AA, Zwadlo C, Bavendiek U, Bauersachs J, Fiedler J, Thum T. Serum circular RNAs act as blood-based biomarkers for hypertrophic obstructive cardiomyopathy. Sci Rep. 2019;9:20350-019-56617-2. https://pubmed.ncbi.nlm.nih.gov/31889077
  • Nemeth A, Mozes MM, Calvier L, Hansmann G, Kokeny G. The PPARgamma agonist pioglitazone prevents TGF-beta induced renal fibrosis by repressing EGR-1 and STAT3. BMC Nephrol. 2019;20:245-019-1431. https://www.ncbi.nlm.nih.gov/pubmed/31277592
  • Hansmann G, Koestenberger M, Alastalo TP, Apitz C, Austin ED, Bonnet D, Budts W, D'Alto M, Gatzoulis MA, Hasan BS, Kozlik-Feldmann R, Kumar RK, Lammers AE, Latus H, Michel-Behnke I, Miera O, Morrell NW, Pieles G, Quandt D, Sallmon H, Schranz D, Tran-Lundmark K, Tulloh RMR, Warnecke G, Wahlander H, Weber SC, Zartner P. 2019 updated consensus statement on the diagnosis and treatment of pediatric pulmonary hypertension: The european pediatric pulmonary vascular disease network (EPPVDN), endorsed by AEPC, ESPR and ISHLT. J Heart Lung Transplant. 2019;38:879-901. https://www.ncbi.nlm.nih.gov/pubmed/31495407
  • Kokeny G, Calvier L, Legchenko E, Chouvarine P, Mozes MM, Hansmann G. PPARgamma is a gatekeeper for extracellular matrix and vascular cell homeostasis: Beneficial role in pulmonary hypertension and renal/cardiac/pulmonary fibrosis. Curr Opin Nephrol Hypertens. 2019. https://www.ncbi.nlm.nih.gov/pubmed/31815758
  • Hansmann G, Calvier L, Risbano MG, Chan SY. Activation of the metabolic master regulator PPARgamma - A potential PIOneering therapy for pulmonary arterial hypertension. Am J Respir Cell Mol Biol. 2019. https://www.ncbi.nlm.nih.gov/pubmed/31577451
  • Sallmon H, Moledina S, Albert DC, Beghetti M, Berger RMF, Bonnet D, Bukova M, Koestenberger M, Meinel K, Reinhardt Z, Tulloh RMR, de Wolf D, Hansmann G. Recommendations from the association for european paediatric and congenital cardiology for training in pulmonary hypertension. Cardiol Young. 2019;29:1323-1327. https://www.ncbi.nlm.nih.gov/pubmed/31554525
  • Bogaard HJ, Legchenko E, Chaudhary KR, Sun XQ, Stewart DJ, Hansmann G. Emphysema is-at the most-only a mild phenotype in the Sugen/Hypoxia rat model of pulmonary arterial hypertension. Am J Respir Crit Care Med. 2019;200:1447-1450. https://www.ncbi.nlm.nih.gov/pubmed/31437404
  • Bogaard HJ, Legchenko E, Ackermann M, Kuhnel MP, Jonigk DD, Chaudhary KR, Sun X, Stewart DJ, Hansmann G. The adult sprague-dawley sugen-hypoxia rat is still "the one:" A model of group 1 pulmonary hypertension: Reply to le cras and abman. Am J Respir Crit Care Med. 2019. https://www.ncbi.nlm.nih.gov/pubmed/31769697
  • Calvier L, Chouvarine P, Legchenko E, Kokeny G, Mozes MM, Hansmann G. Chronic TGF-beta1 signaling in pulmonary arterial hypertension induces sustained canonical Smad3 pathways in vascular smooth muscle cells. Am J Respir Cell Mol Biol. 2019;61:121-123. https://www.ncbi.nlm.nih.gov/pubmed/31259625
  • Chouvarine P, Legchenko E, Geldner J, Riehle C, Hansmann G. Hypoxia drives cardiac miRNAs and inflammation in the right and left ventricle. J Mol Med (Berl). 2019;97:1427-1438. https://www.ncbi.nlm.nih.gov/pubmed/31338525
  • Chouvarine P, Geldner J, Giagnorio R, Legchenko E, Bertram H, Hansmann G. Trans-right-ventricle and transpulmonary MicroRNA gradients in human pulmonary arterial hypertension. Pediatr Crit Care Med. 2019. https://www.ncbi.nlm.nih.gov/pubmed/31876555
  • Ricke-Hoch M, Pfeffer TJ, Hilfiker-Kleiner D. Peripartum cardiomyopathy: Basic mechanisms and hope for new therapies. Cardiovasc Res. 2019. https://www.ncbi.nlm.nih.gov/pubmed/31605117
  • Pietzsch S, Ricke-Hoch M, Stapel B, Hilfiker-Kleiner D. Data on left ventricular expression of STAT3 and AKT in transgenic mouse models with B16F10 melanoma. Data Brief. 2019;26:104508. https://www.ncbi.nlm.nih.gov/pubmed/31667271
  • Pietzsch S, Ricke-Hoch M, Stapel B, Hilfiker-Kleiner D. Modulation of cardiac AKT and STAT3 signalling in preclinical cancer models and their impact on the heart. Biochim Biophys Acta Mol Cell Res. 2019:118519. https://www.ncbi.nlm.nih.gov/pubmed/31374232
  • Bauersachs J, Konig T, van der Meer P, Petrie MC, Hilfiker-Kleiner D, Mbakwem A, Hamdan R, Jackson AM, Forsyth P, de Boer RA, Mueller C, Lyon AR, Lund LH, Piepoli MF, Heymans S, Chioncel O, Anker SD, Ponikowski P, Seferovic PM, Johnson MR, Mebazaa A, Sliwa K. Pathophysiology, diagnosis and management of peripartum cardiomyopathy: A position statement from the heart failure association of the european society of cardiology study group on peripartum cardiomyopathy. Eur J Heart Fail. 2019;21:827-843. https://www.ncbi.nlm.nih.gov/pubmed/31243866
  • Borchert T, Beitar L, Langer LBN, Polyak A, Wester HJ, Ross TL, Hilfiker-Kleiner D, Bengel FM, Thackeray JT. Dissecting the target leukocyte subpopulations of clinically relevant inflammation radiopharmaceuticals. J Nucl Cardiol. 2019. https://www.ncbi.nlm.nih.gov/pubmed/31659697
  • Fiedler J, Park DH, Hobuss L, Anaraki PK, Pfanne A, Just A, Mitzka S, Dumler I, Weidemann F, Hilfiker A, Thum T. Identification of miR-143 as a major contributor for human stenotic aortic valve disease. J Cardiovasc Transl Res. 2019;12:447-458. https://www.ncbi.nlm.nih.gov/pubmed/30840186
  • Glasenapp A, Derlin K, Wang Y, Bankstahl M, Meier M, Wollert KC, Bengel FM, Thackeray JT. Multimodality imaging of inflammation and ventricular remodeling in pressure overload heart failure. J Nucl Med. 2019. https://www.ncbi.nlm.nih.gov/pubmed/31653713
  • Hess A, Nekolla SG, Meier M, Bengel FM, Thackeray JT. Accuracy of cardiac functional parameters measured from gated radionuclide myocardial perfusion imaging in mice. J Nucl Cardiol. 2019. https://www.ncbi.nlm.nih.gov/pubmed/31044402
  • Lu D, Thum T. RNA-based diagnostic and therapeutic strategies for cardiovascular disease. Nat Rev Cardiol. 2019;16:661-674. https://www.ncbi.nlm.nih.gov/pubmed/31186539
  • Moulig V, Pfeffer TJ, Ricke-Hoch M, Schlothauer S, Koenig T, Schwab J, Berliner D, Pfister R, Michels G, Haghikia A, Falk CS, Duncker D, Veltmann C, Hilfiker-Kleiner D, Bauersachs J. Long-term follow-up in peripartum cardiomyopathy patients with contemporary treatment: Low mortality, high cardiac recovery, but significant cardiovascular co-morbidities. Eur J Heart Fail. 2019;21:1534-1542. https://www.ncbi.nlm.nih.gov/pubmed/31724271
  • Perbellini F, Thum T. Living myocardial slices: A novel multicellular model for cardiac translational research. Eur Heart J. 2019. https://www.ncbi.nlm.nih.gov/pubmed/31711161
  • Ricke-Hoch M, Hoes MF, Pfeffer TJ, Schlothauer S, Nonhoff J, Haidari S, Bomer N, Scherr M, Stapel B, Stelling E, Kiyan Y, Falk C, Haghikia A, Binah O, Arany Z, Thum T, Bauersachs J, van der Meer P, Hilfiker-Kleiner D. In peripartum cardiomyopathy plasminogen activator inhibitor-1 is a potential new biomarker with controversial roles. Cardiovasc Res. 2019. https://www.ncbi.nlm.nih.gov/pubmed/31711127
  • Riehle C, Bauersachs J. Small animal models of heart failure. Cardiovasc Res. 2019;115:1838-1849. https://www.ncbi.nlm.nih.gov/pubmed/31243437
  • Sarkozy M, Gaspar R, Zvara A, Kiscsatari L, Varga Z, Kovari B, Kovacs MG, Szucs G, Fabian G, Dioszegi P, Cserni G, Puskas LG, Thum T, Kahan Z, Csont T, Batkai S. Selective heart irradiation induces cardiac overexpression of the pro-hypertrophic miR-212. Front Oncol. 2019;9:598. https://www.ncbi.nlm.nih.gov/pubmed/31380269
  • Tongers J, Flierl U, Sieweke JT, Bauersachs J, Schafer A, Napp LC. Safe exchange of a transfemoral impella pump. Cardiovasc Revasc Med. 2019;20:827-828. https://www.ncbi.nlm.nih.gov/pubmed/30651215
  • Kempf T, Wollert KC. Iron and atherosclerosis: Too much of a good thing can be bad. Eur Heart J. 2019. https://www.ncbi.nlm.nih.gov/pubmed/31324916
  • Ius F, Hoeper MM, Fegbeutel C, Kuhn C, Olsson K, Koigeldiyev N, Tudorache I, Warnecke G, Optenhofel J, Puntigam JO, Schafer A, Meyer BC, Hinrichs JB, Bauersachs J, Haverich A, Cebotari S. Extracorporeal membrane oxygenation and surgical embolectomy for high-risk pulmonary embolism. Eur Respir J. 2019.  https://www.ncbi.nlm.nih.gov/pubmed/30728206
  • Muller D, Hagenah D, Biswanath S, Coffee M, Kampmann A, Zweigerdt R, Heisterkamp A, Kalies SMK. Femtosecond laser-based nanosurgery reveals the endogenous regeneration of single Z-discs including physiological consequences for cardiomyocytes. Sci Rep. 2019;9:3625-019-40308-z.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403391/
  • Stahl K, Schenk H, Seeliger B, Wiesner O, Schmidt JJ, Bauersachs J, Welte T, Kuhn C, Haverich A, Hoeper MM, David S. Extracorporeal membrane oxygenation for ARDS due to pneumocystis pneumonia. Eur Respir J. 2019.  https://www.ncbi.nlm.nih.gov/pubmed/31151957
  • Koestenberger M, Sallmon H, Avian A, Cantinotti M, Gamillscheg A, Kurath-Koller S, Schweintzger S, Hansmann G. Ventricular-ventricular interaction variables correlate with surrogate variables of clinical outcome in children with pulmonary hypertension. Pulm Circ. 2019;9:2045894019854074.  https://www.ncbi.nlm.nih.gov/pubmed/31099302
  • Koestenberger M, Avian A, Cantinotti M, Hansmann G, European Pediatric Pulmonary Vascular Disease Network. Tricuspid annular plane systolic excursion (TAPSE) in pediatric pulmonary hypertension: Integrating right ventricular ejection efficiency (RVEe) into advanced multi-parametric imaging. Int J Cardiol. 2019;274:296-298.  https://www.ncbi.nlm.nih.gov/pubmed/30454722
  • Calvier L, Boucher P, Herz J, Hansmann G. LRP1 deficiency in vascular SMC leads to pulmonary arterial hypertension that is reversed by PPARgamma activation. Circ Res. 2019;124:1778-1785. https://www.ncbi.nlm.nih.gov/pubmed/31023188
  • Prasse A, Binder H, Schupp JC, Kayser G, Bargagli E, Jaeger B, Hess M, Rittinghausen S, Vuga L, Lynn H, Violette S, Jung B, Quast K, Vanaudenaerde B, Xu Y, Hohlfeld JM, Krug N, Herazo-Maya JD, Rottoli P, Wuyts WA, Kaminski N. BAL cell gene expression is indicative of outcome and airway basal cell involvement in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2019;199:622-630. https://www.ncbi.nlm.nih.gov/pubmed/30141961
  • Bar C, Thum T, de Gonzalo-Calvo D. Circulating miRNAs as mediators in cell-to-cell communication. Epigenomics. 2019;11:111-113. https://www.ncbi.nlm.nih.gov/pubmed/30638052