Publications 2022

  • Szaroszyk M, Kattih B, Martin-Garrido A, Trogisch FA, Dittrich GM, Grund A, Abouissa A, Derlin K, Meier M, Holler T, Korf-Klingebiel M, Volker K, Garfias Macedo T, Pablo Tortola C, Boschmann M, Huang N, Froese N, Zwadlo C, Malek Mohammadi M, Luo X, Wagner M, Cordero J, Geffers R, Batkai S, Thum T, Bork N, Nikolaev VO, Muller OJ, Katus HA, El-Armouche A, Kraft T, Springer J, Dobreva G, Wollert KC, Fielitz J, von Haehling S, Kuhn M, Bauersachs J, Heineke J. Skeletal muscle derived musclin protects the heart during pathological overload. Nat Commun. 2022;13:149-021-27634-5. https://pubmed.ncbi.nlm.nih.gov/35013221/.
  • Hansmann G, Chouvarine P, Diekmann F, Giera M, Ralser M, Mülleder M, von Kaisenberg C, Bertram H, Legchenko E, Hass R. Human umbilical cord mesenchymal stem cell-derived treatment of severe pulmonary arterial hypertension. Nature Cardiovas Res. 2022;1:568–576. https://www.nature.com/articles/s44161-022-00083-z#article-info

  • von Haehling S, Birner C, Dworatzek E, Frantz S, Hellenkamp K, Israel CW, Kempf T, Klein HH, Knosalla C, Laufs U, Raake P, Wachter R, Hasenfuss G. Travelling with heart failure: Risk assessment and practical recommendations. Nat Rev Cardiol. 2022;19:302-313. https://pubmed.ncbi.nlm.nih.gov/34992256/.

  • Ackermann M, Jonigk DD. Microvascular placental alterations in maternal COVID-19. Am J Obstet Gynecol. 2022;226:135-136. https://pubmed.ncbi.nlm.nih.gov/34228972/.

  • Ackermann M, Tafforeau P, Wagner WL, Walsh CL, Werlein C, Kuhnel MP, Langer FP, Disney C, Bodey AJ, Bellier A, Verleden SE, Lee PD, Mentzer SJ, Jonigk DD. The bronchial circulation in COVID-19 pneumonia. Am J Respir Crit Care Med. 2022;205:121-125. https://pubmed.ncbi.nlm.nih.gov/34734553/.

  • Hansmann G, Diekmann F, Chouvarine P, Ius F, Carlens J, Schwerk N, Warnecke G, Vogel-Claussen J, Hohmann D, Alten T, Jack T. Full recovery of right ventricular systolic function in children undergoing bilateral lung transplantation for severe PAH. J Heart Lung Transplant. 2022;41:187-198. https://pubmed.ncbi.nlm.nih.gov/34955331/.

  • Kamp JC, Neubert L, Stark H, Hinrichs JB, Boekhoff C, Seidel AD, Ius F, Haverich A, Gottlieb J, Welte T, Braubach P, Laenger F, Hoeper MM, Kuehnel MP, Jonigk DD. Comparative analysis of gene expression in fibroblastic foci in patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis. Cells. 2022;11 https://pubmed.ncbi.nlm.nih.gov/35203313/

  • Kreutzer FP, Meinecke A, Mitzka S, Hunkler HJ, Hobuß L, Abbas N, Geffers R, Weusthoff J, Xiao K, Jonigk DD, Fiedler J, Thum T. Development and characterization of anti-fibrotic natural compound similars with improved effectivity. Basic Res Cardiol. 2022;117. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891108/.

  • Hansmann G, Diekmann F, Chouvarine P, Ius F, Carlens J, Schwerk N, Warnecke G, Vogel-Claussen J, Hohmann D, Alten T, Jack T. Full recovery of right ventricular systolic function in children undergoing bilateral lung transplantation for severe PAH. J Heart Lung Transplant. 2022;41:187-198.  https://pubmed.ncbi.nlm.nih.gov/34955331/.

  • Calvier L, Herz J, Hansmann G. Interplay of low-density lipoprotein receptors, LRPs, and lipoproteins in Pulmonary hypertension. JACC Basic Transl Sci. 2022;7:164-180.  https://pubmed.ncbi.nlm.nih.gov/35257044/.

  • Sallmon H, Koestenberger M, Avian A, Reiterer F, Schwaberger B, Meinel K, Cvirn G, Kurath-Koller S, Gamillscheg A, Hansmann G. Extremely premature infants born at 23–25 weeks gestation are at substantial risk for pulmonary hypertension. J Perinatol. 2022;42:781-787. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184271/.

  • Adel J, Akin M, Garcheva V, Vogel-Claussen J, Bauersachs J, Napp LC, Schäfer A. Computed-tomography as first-line diagnostic procedure in patients with out-of-hospital cardiac arrest. Front Cardiovasc Med. 2022;9:799446. https://pubmed.ncbi.nlm.nih.gov/35187123/.

  • Kirchhoff H, Ricke-Hoch M, Wohlan K, Pietzsch S, Karsli Ü, Erschow S, Zweigerdt R, Ganser A, Eder M, Scherr M, Hilfiker-Kleiner D. Chemotherapy-free targeted anti-BCR-ABL+ acute lymphoblastic leukemia therapy may benefit the heart. Cancers (Basel). 2022;14. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870618/.

  • Couch LS, Fiedler J, Chick G, Clayton R, Dries E, Wienecke LM, Fu L, Fourre J, Pandey P, Derda AA, Wang BX, Jabbour R, Shanmuganathan M, Wright P, Lyon AR, Terracciano CM, Thum T, Harding SE. Circulating microRNAs predispose to takotsubo syndrome following high-dose adrenaline exposure. Cardiovasc Res. 2022;118:1758-1770.  https://pubmed.ncbi.nlm.nih.gov/34155498/.

  • Li T, Mariani S, Bounader K, Boethig D, Schöde A, Homann K, Hanke JS, Napp LC, Merzah AS, Dogan G, Haverich A, Schmitto JD. Is there a sex gap in outcomes of comparable patients supported with left ventricular assist devices? Artif Organs. 2022. https://pubmed.ncbi.nlm.nih.gov/35686944/.

  • Reboll MR, Klede S, Taft MH, Cai C, Field LJ, Lavine KJ, Koenig AL, Fleischauer J, Meyer J, Schambach A, Niessen HW, Kosanke M, van den Heuvel J, Pich A, Bauersachs J, Wu X, Zheng L, Wang Y, Korf-Klingebiel M, Polten F, Wollert KC. Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase. Science. 2022;376:1343-1347.  https://pubmed.ncbi.nlm.nih.gov/35709278/.

  • Akin M, Sieweke J, Garcheva V, Martinez CS, Adel J, Plank P, Zandian P, Sühs K, Bauersachs J, Schäfer A. Additive impact of interleukin 6 and neuron specific enolase for prognosis in patients with out-of-hospital cardiac arrest - experience from the HAnnover COoling REgistry. Front Cardiovasc Med. 2022;9:899583.  https://pubmed.ncbi.nlm.nih.gov/35711345/.

  • Frantz S, Hundertmark MJ, Schulz-Menger J, Bengel FM, Bauersachs J. Left ventricular remodelling post-myocardial infarction: Pathophysiology, imaging, and novel therapies. Eur Heart J. 2022.  https://pubmed.ncbi.nlm.nih.gov/35511857/.

  • Pfeffer TJ, List M, Schippert C, Auber B, Ricke-Hoch M, Abou-Moulig V, Berliner D, Bauersachs J, Hilfiker-Kleiner D. High prevalence of reduced fertility and use of assisted reproductive technology in a german cohort of patients with peripartum cardiomyopathy. Clin Res Cardiol. 2022.  https://pubmed.ncbi.nlm.nih.gov/35562615/.

  • Grosse GM, Werlein C, Blume N, Abu-Fares O, Götz F, Gabriel MM, Ernst J, Leotescu A, Worthmann H, Kühnel MP, Jonigk DD, Falk CS, Weissenborn K, Schuppner R. Circulating cytokines and growth factors in acute cerebral large vessel occlusion-association with success of endovascular treatment. Thromb Haemost. 2022;122:623-632.  https://pubmed.ncbi.nlm.nih.gov/34225367/.

  • Kamp JC, Neubert L, Ackermann M, Stark H, Plucinski E, Shah HR, Janciauskiene S, Bergmann AK, Schmidt G, Welte T, Haverich A, Werlein C, Braubach P, Laenger F, Schwerk N, Olsson KM, Fuge J, Park D, Schupp JC, Hoeper MM, Kuehnel M, Jonigk DD. A morphomolecular approach to alveolar capillary dysplasia. Am J Pathol. 2022.  https://pubmed.ncbi.nlm.nih.gov/35649494/.

  • Makarewich CA, Thum T. Exercise-induced long noncoding RNAs as new players in cardiac hypertrophy. Circulation. 2022;145:1234-1237.  https://pubmed.ncbi.nlm.nih.gov/35436132/.

  • Hamberger F, Legchenko E, Chouvarine P, Mederacke YS, Taubert R, Meier M, Jonigk D, Hansmann G, Mederacke I. Pulmonary arterial hypertension and consecutive right heart failure lead to liver fibrosis. Front Cardiovasc Med. 2022;9:862330.  https://pubmed.ncbi.nlm.nih.gov/35369312/.

  • Fleig S, Kapanadze T, Bernier-Latmani J, Lill JK, Wyss T, Gamrekelashvili J, Kijas D, Liu B, Hüsing AM, Bovay E, Jirmo AC, Halle S, Ricke-Hoch M, Adams RH, Engel DR, von Vietinghoff S, Förster R, Hilfiker-Kleiner D, Haller H, Petrova TV, Limbourg FP. Loss of vascular endothelial notch signaling promotes spontaneous formation of tertiary lymphoid structures. Nat Commun. 2022;13:2022.  https://pubmed.ncbi.nlm.nih.gov/35440634/.

  • González A, Richards AM, de Boer RA, Thum T, Arfsten H, Hülsmann M, Falcao-Pires I, Díez J, Foo RSY, Chan MY, Aimo A, Anene-Nzelu CG, Abdelhamid M, Adamopoulos S, Anker SD, Belenkov Y, Gal TB, Cohen-Solal A, Böhm M, Chioncel O, Delgado V, Emdin M, Jankowska EA, Gustafsson F, Hill L, Jaarsma T, Januzzi JL, Jhund PS, Lopatin Y, Lund LH, Metra M, Milicic D, Moura B, Mueller C, Mullens W, Núñez J, Piepoli MF, Rakisheva A, Ristić AD, Rossignol P, Savarese G, Tocchetti CG, Van Linthout S, Volterrani M, Seferovic P, Rosano G, Coats AJS, Bayés-Genís A. Cardiac remodelling - Part 1: From cells and tissues to circulating biomarkers. A review from the study group on biomarkers of the heart failure association of the european society of cardiology. Eur J Heart Fail. 2022;24:927-943.  https://pubmed.ncbi.nlm.nih.gov/35334137/.

  • Hess A, Borchert T, Ross TL, Bengel FM, Thackeray JT. Characterizing the transition from immune response to tissue repair after myocardial infarction by multiparametric imaging. Basic Res Cardiol. 2022;117:14.  https://pubmed.ncbi.nlm.nih.gov/35275268/.

  • Hansmann G, Diekmann F, Chouvarine P, Ius F, Carlens J, Schwerk N, Warnecke G, Vogel-Claussen J, Hohmann D, Alten T, Jack T. Full recovery of right ventricular systolic function in children undergoing bilateral lung transplantation for severe PAH. J Heart Lung Transplant. 2022;41:187-198.  https://pubmed.ncbi.nlm.nih.gov/34955331/.

  • Rode L, Bär C, Groß S, Rossi A, Meumann N, Viereck J, Abbas N, Xiao K, Riedel I, Gietz A, Zimmer K, Odenthal M, Büning H, Thum T. AAV capsid engineering identified two novel variants with improved in vivo tropism for cardiomyocytes. Mol Ther. 2022. https://pubmed.ncbi.nlm.nih.gov/35810332/.

  • Frantz S, Hundertmark MJ, Schulz-Menger J, Bengel FM, Bauersachs J. Left ventricular remodelling post-myocardial infarction: Pathophysiology, imaging, and novel therapies. Eur Heart J. 2022;43:2549-2561. https://pubmed.ncbi.nlm.nih.gov/35511857/.

  • Bauersachs J, Olsson KM. Targeting pulmonary hypertension in patients with heart failure and preserved ejection fraction: Rather static than DYNAMIC development? Eur Heart J. 2022.  https://pubmed.ncbi.nlm.nih.gov/35909260/.

  • Hasan H, Chouvarine P, Diekmann F, Diedrich N, Koestenberger M, Hansmann G. Validation of the new paediatric pulmonary hypertension risk score by CMR and speckle tracking echocardiography. Eur J Clin Invest. 2022:e13835. Available from: https://pubmed.ncbi.nlm.nih.gov/35844040/.

  • Schweintzger S, Kurath-Koller S, Burmas A, Grangl G, Fandl A, Noessler N, Avian A, Gamillscheg A, Chouvarine P, Hansmann G, Koestenberger M. Normal echocardiographic reference values of the right ventricular to left ventricular endsystolic diameter ratio and the left ventricular endsystolic eccentricity index in healthy children and in children with pulmonary hypertension. Front Cardiovasc Med. 2022;9:950765. https://pubmed.ncbi.nlm.nih.gov/35911557/.

  • Hansmann G, Sabiniewicz A, Sabiniewicz R. Atrial flow regulator for postcapillary pulmonary hypertension: First-in-human transcatheter AFR device implantations in RCM. JACC Case Rep. 2022;4:878-884.  https://pubmed.ncbi.nlm.nih.gov/35912333/.

  • Heimerl M, Gausepohl T, Mueller JH, Ricke-Hoch M. Neuraminidases-key players in the inflammatory response after pathophysiological cardiac stress and potential new therapeutic targets in cardiac disease. Biology (Basel). 2022;11:1229.

  • Hasan H, Hysko K, Jack T, Dingemann J, Wetzke M, Hansmann G. Case report: Rescue treatment with add-on selexipag in a preterm infant with suprasystemic pulmonary hypertension, pulmonary capillary hemangiomatosis, and isolated pulmonary vein stenosis. Front Cardiovasc Med. 2022;9:984698.

  • van der Velden J, Asselbergs FW, Bakkers J, Batkai S, Bertrand L, Bezzina CR, Bot I, Brundel BJJM, Carrier L, Chamuleau S, Ciccarelli M, Dawson D, Davidson SM, Dendorfer A, Duncker DJ, Eschenhagen T, Fabritz L, Falcão-Pires I, Ferdinandy P, Giacca M, Girao H, Gollmann-Tepeköylü C, Gyongyosi M, Guzik TJ, Hamdani N, Heymans S, Hilfiker A, Hilfiker-Kleiner D, Hoekstra AG, Hulot J, Kuster DWD, van Laake LW, Lecour S, Leiner T, Linke WA, Lumens J, Lutgens E, Madonna R, Maegdefessel L, Mayr M, van der Meer P, Passier R, Perbellini F, Perrino C, Pesce M, Priori S, Remme CA, Rosenhahn B, Schotten U, Schulz R, Sipido KR, Sluijter JPG, van Steenbeek F, Steffens S, Terracciano CM, Tocchetti CG, Vlasman P, Yeung KK, Zacchigna S, Zwaagman D, Thum T. Animal models and animal-free innovations for cardiovascular research: Current status and routes to be explored. consensus document of the ESC working group on myocardial function and the ESC working group on cellular biology of the heart. Cardiovasc Res. 2022;118:3016-3051.

  • Diekmann J, Koenig T, Thackeray JT, Derlin T, Czerner C, Neuser J, Ross TL, Schäfer A, Tillmanns J, Bauersachs J, Bengel FM. Cardiac fibroblast activation in patients early after acute myocardial infarction: Integration with MR tissue characterization and subsequent functional outcome. J Nucl Med. 2022;63:1415-1423.

  • Hermanns N, Wroblewski V, Bascuñana P, Wolf B, Polyak A, Ross TL, Bengel FM, Thackeray JT. Molecular imaging of the brain-heart axis provides insights into cardiac dysfunction after cerebral ischemia. Basic Res Cardiol. 2022;117:52.

  • Verleden SE, Kvasnicka HM, Kreipe HH, Haverich A, Black SM, Walch A, Tafforeau P, Lee PD, Hoeper MM, Welte T, Seeliger B, David S, Schuppan D, Mentzer SJ, Jonigk DD. The fatal trajectory of pulmonary COVID-19 is driven by lobular ischemia and fibrotic remodelling. EBioMedicine. 2022;85:104296.