Innate Immunity - Natural killer cells
Prof. Dr. Roland Jacobs
We are mainly working on innate immunity and particularly NK cells. These cells are of outstanding importance in defending virus infections and tumor genesis. NK cells do not require prior sensitization to efficiently kill virus-infected and tumor cells enabling them to immediately control until lymphocytes of the adopted immune system overtake and terminate infection and tumorigenesis. In addition to their cytolytic properties, NK cells can produce several cytokines such as IFN-γ, TNF-α, GM-CSF and IP10 allowing them to also control and regulate immune functions by soluble factors.
Other areas of research: innate immunity, immunodeficiencies, CD20+ T cells
NK cells
Important lymphocytes of the innate immne system
Publications
Listed on PubMed Listed on Publons (Web of Science / ResearcherID)
Jacobs, R., and R. Hass. 2018. Co-cultures. In Cell Culture Technology. C. Kasper, V. Charwat, and A. Lavrentieva, editors. Springer International Publishing, Cham. 139–153.
Weyand, B., M. Dominici, R. Hass, R. Jacobs, and C. Kasper eds. . 2013. Mesenchymal Stem Cells - Basics and Clinical Application II. 130. Springer Berlin Heidelberg, Berlin, Heidelberg.
Weyand, B., M. Dominici, R. Hass, R. Jacobs, C. Kasper, and Springer-Verlag GmbH. 2013. Mesenchymal Stem Cells - Basics and Clinical Application I. 129. B. Weyand, M. Dominici, R. Hass, R. Jacobs, and C. Kasper, editors. Springer, Berlin, Heidelberg.
Wilk, E., and R. Jacobs. 2010. NK Cells and Microarrays. In Natural Killer Cells At the Forefront of Modern Immunology. J. Zimmer, editor. Springer, Berlin, Heidelberg. 391–404.
Jacobs, R., and R.E. Schmidt. 2008. Characterization of Natural Killer Cells. In Cellular Diagnostics. KARGER, Basel. 230–260.
Jacobs, R., and R.E. Schmidt. 2006. Charakterisierung von natürlichen Killerzellen. In Zelluläre Diagnostik. KARGER, Basel. 316–350.
Jacobs, R., and R.E. Schmidt. 1999. Foundations in Immunology. In Psychoneuroimmunology. M. Schedlowski and U. Tewes, editors. Kluwer Academic/Plenum Publishers, New York. 39–62.
Jacobs, R. 1999. Methods in Immunology. In Psychoneuroimmunology. M. Schedlowski and U. Tewes, editors. Kluwer Academic/Plenum Publishers, New York. 143–165.
Link, H., L. Arseniev, O. Bähre, R. Berenson, J. Kadar, K. Battmer, R. Jacobs, J. Casper, H. Diedrich, J. Schubert, J. Kühl, and H. Poliwoda. 1997. Transplantation of Allogeneic Peripheral Blood Progenitor Cells Alone or in Addition to Bone Marrow. In Acute Leukemias VI. T. Büchner, W. Hiddemann, B. Wörmann, G. Schellong, J. Ritter, and U. Creutzig, editors. 986–988.
Schedlowski, M., R.J. Benschop, M. Rodriguez-Feuerhahn, R. Oberbeck, W. Hosch, R. Jacobs, and R.E. Schmidt. 1997. Katecholamine und Immunfunktionen. In Psychoneuroimmunologie. K.H. Schulz, J. Kugler, and M. Schedlowski, editors. Huber-Verlag, Göttingen. 243–256.
Jacobs, R. 1996. Methoden der Immunologie. In Psychoneuroimmunologie. M. Schedlowski and U. Tewes, editors. Spektrum Akademischer Verlag, Heidelberg. 187–217.
Jacobs, R., and R.E. Schmidt. 1996. Grundlagen der Immunologie. In Psychoneuroimmunologie. M. Schedlowski and U. Tewes, editors. Spektrum Akademischer Verlag, Heidelberg. 37–68.
Link, H., L. Arseniev, O. Bähre, R. Berenson, J. Kadar, K. Battmer, R. Jacobs, H. Diedrich, J. Schubert, J. Kühl, and H. Poliwoda. 1995. Transplantation of allogeneic peripheral blood progenitor cells alone or in addition to bone marrow. In Acute Leukemias VI. T. Büchner, W. Hiddemann, J. Ritter, and B. Wörmann, editors. Springer, Heidelberg.
Schmidt, R.E., R. Jacobs, T.O.F. Wagner, U. Tewes, and M. Schedlowski. 1994. Regulation of NK cells during acute psychological stress by noradrenaline.
Schedlowski, M., R. Jacobs, T. Flöge, J. Alker, F. Pröhl, G. Stratmann, S. Richter, A. Hâždicke, T.O.F. Wagner, R.E. Schmidt, and U. Tewes. 1993. Parachuting stress: Effects on endocrine and immune functions. A.J. Husband, editor. CRC Press, Boca Raton.
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This working group comprises:
Leader: Prof. Dr. Roland Jacobs
Co-worker:
Sabine Buyny, technician
Contact:
Rheumatology and Clinical Immunology
OE6830
Hannover Medical School
Carl-Neuberg-Str. 1
30625 Hannover
Tel.: 0511 532 3581
E-Mail: Prof. Dr. Roland Jacobs