Birgit Piep
Medizinischen Technologin für Veterinärmedizin (MTV /VMTA)
Contact
Tel: +49 511 532 -3604 (office), -3654 (lab)
Fax: +49 511 532-161215
address: Germany 30625 Hannover, Carl-Neuberg-Str.1
► Research Gate ► Research Network - Frontiers
Participation in the following current projects
Hypertrophic cardiomyopathyDie Erforschung von Pathomechanismen der Hypertrophen Kardiomyopathie (HCM) auf mehreren Ebenen mit Blick auf grundlegende Funktionsmechanismen der Kardiomyozyten und des Myokards.
The characterization and further development of human stem cell-derived cardiomyocytes (hPSC-CMs)Die Charakterisierung und Weiterentwicklung humaner, stammzell-abgeleiteter Kardiomyozyten (hPSC-CMs) im direkten Vergleich zu humanen, adulten Kardiomyozyten im Hinblick auf Maturierung, auf zellbasierte Krankheitsmodelle für Kardiomyopathien, und auf Entwicklung neuer pharmakologischer Interventionsmöglichkeiten bei HCM.
AG Konze AG Iorga► Research Network - Frontiers
- Patient-specific hiPSC-derived cardiomyocytes indicate allelic and contractile imbalance as pathogenic factor in early-stage Hypertrophic Cardiomyopathy, Natalie Weber, Judith Montag, Kathrin Kowalsk, Bogdan Iorga,Jeanne de la Roche,Tim Holler, Daniel Wojciechowski, Meike Wendland, Ante Radocaj, Anne-Kathrin Mayer, Anja Brunkhorst, Felix Osten, Valentin Burkart, Birgit Piep, Alea Bodenschatz, Pia Gibron, Kristin Schwanke, Annika Franke, Stefan Thiemann, Anastasia Koroleva, Angelika Pfanne, Maike Konsanke, Jan Fiedler, Jan Hegermann, Christoph Wredej, Christian Mühlfeld, Boris Chichkov, Martin Fischer, Thomas Thum, Antonio Francino, Ulrich Martin, Joachim Meißner, Robert Zweigerdt,Theresia Kraft, Journal of Molecular and Cellular Cardiology (JMCC) Volume 198, January 2025, Pages 112-125, https://doi.org/10.1016/j.yjmcc.2024.11.007; PubMed
- Myosin expression and contractile function are altered by replating stem cell–derived cardiomyocytes, Osten, F., Weber, N., Wendland, M., Holler, T., Piep, B., Kröhn, S., Teske, J., Bodenschatz, A.K., Devadas, S.B., Menge, K.S., Chatterjee, S., Schwanke, K., Kosanke, M., Montag, J., Thum, T., Zweigerdt, R., Kraft, T., Iorga, B., and Meissner, J.D. (2023), J Gen Physiol (2023) 155 (11): e202313377, https://doi.org/10.1085/jgp.202313377, Online ahead of print
- Transcriptional bursts and heterogeneity among cardiomyocytes in hypertrophic cardiomyopathy,
Valentin Burkart, Kathrin Kowalski, David Aldag-Niebling, Julia Beck, Dirk Alexander Frick, Tim Holler, Ante Radocaj, Birgit Piep, Andre Zeug, Denise Hilfiker-Kleiner, Cristobal G. dos Remedios, Jolanda van der Velden, Judith Montag and Theresia Kraft, Front. Cardiovasc. Med., August 2022, Sec. Cardiovascular Biologics and Regenerative Medicin, doi: 10.3389/fcvm.2022.987889
- Analyzing histological material to determine ajmaline and other drugs using high-performance liquid chromatography/tandem mass spectrometry., Henning K, Dziadosz M, Klintschar M, Piep B, Teske J., Drug Test Anal. 2018 Sep;10(9):1488-1490. doi: 10.1002/dta.2450. Epub 2018 Aug 1. No abstract available., PMID: 29992791, PubMed
- Differences in Contractile Function of Myofibrils within Human Embryonic Stem Cell-Derived Cardiomyocytes vs. Adult Ventricular Myofibrils Are Related to Distinct Sarcomeric Protein Isoforms., Iorga B, Schwanke K, Weber N, Wendland M, Greten S, Piep B, Dos Remedios CG, Martin U, Zweigerdt R, Kraft T, Brenner B., Front Physiol. 2018 Jan 19;8:1111. doi: 10.3389/fphys.2017.01111. eCollection 2017., PMID: 29403388, PubMed
- Stiff matrix induces switch to pure β-cardiac myosin heavy chain expression in human ESC-derived cardiomyocytes., Weber N, Schwanke K, Greten S, Wendland M, Iorga B, Fischer M, Geers-Knörr C, Hegermann J, Wrede C, Fiedler J, Kempf H, Franke A, Piep B, Pfanne A, Thum T, Martin U, Brenner B, Zweigerdt R, Kraft T., Basic Res Cardiol. 2016 Nov;111(6):68. Epub 2016 Oct 14., PMID: 27743117, PubMed
- Lipoteichoic acid from Staphylococcus aureus directly affects cardiomyocyte contractility and calcium transients., Mutig N, Geers-Knoerr C, Piep B, Pahuja A, Vogt PM, Brenner B, Niederbichler AD, Kraft T., Mol Immunol. 2013 Dec;56(4):720-8. doi: 10.1016/j.molimm.2013.07.007. Epub 2013 Aug 7., PMID: 23933512, PubMed
- Structural features of cross-bridges in isometrically contracting skeletal muscle., Kraft T, Mattei T, Radocaj A, Piep B, Nocula C, Furch M, Brenner B. Biophys J. 2002 May;82(5):2536-47., PMID: 11964242, PubMed