Contact:

Phone:                   +49 511 532-2759 (office) -3654 (lab)
Fax:                       +49 511 532-161215

Address:                Carl-Neuberg-Straße 1, 30625 Hannover, Germany
                              Building 03, level 03, room 1320

ResearchGate:       Researchgate

Career:

• Since 08/2018 doctoral student at the Institute of Molecular and Cell Physiology (MHH)
• 2015-2017 M. Sc. Animal Biology and Biomedical Sciences at the University of Veterinary Medicine Hannover
• 2011-2015 B. Sc. Biology at the University of Göttingen

Current Research Focus:

• The project of the thesis focuses on the maturation of stem cell-derived cardiomyocytes, as characterized by the expression of different sarcomeric proteins/isoforms (e.g. myosin heavy/light chain, cardiac troponin I) and other markers, and the underlying signalling pathways.

Expertise:

• Cell culture, fluorescence microscopy & immunofluorescence staining, SDS-PAGE & Western blotting, measurement of twitch contractions and Ca2+ transients of single cardiomyocytes
• Teaching practical courses of physiology for human/dental medicine students (current topic: Muscle 2)

Publication in Journals:

2025

Patient-specific hiPSC-derived cardiomyocytes indicate allelic and contractile imbalance as pathogenic factor in early-stage Hypertrophic Cardiomyopathy, Natalie Weber, Judith Montag, Kathrin Kowalsk, Bogdan Iorga, Jeanne de la Roche, Tim Holler, Daniel Wojciechowski, Meike Wendland, Ante Radocaj, Anne-Kathrin Mayer, Anja Brunkhorst, Felix Osten, Valentin Burkart, Birgit Piep, Alea Bodenschatz, Pia Gibron, Kristin Schwanke, Annika Franke, Stefan Thiemann, Anastasia Koroleva, Angelika Pfanne, Maike Konsanke, Jan Fiedler, Jan Hegermann, Christoph Wredej, Christian Mühlfeld, Boris Chichkov, Martin Fischer, Thomas Thum, Antonio Francino, Ulrich Martin, Joachim Meißner, Robert Zweigerdt, Theresia Kraft, Journal of Molecular and Cellular Cardiology (JMCC) Volume 198, January 2025, Pages 112-125, https://doi.org/10.1016/j.yjmcc.2024.11.007; PubMed

2023

Human brain microvascular endothelial cells release different types of P-glycoprotein-containing extracellular vesicles upon exposure to doxorubicin, Osten F, Löscher W, Gericke B.Toxicol Appl Pharmacol. 2023 Oct 10;479:116712. doi: 10.1016/j.taap.2023.116712. Online ahead of print.PMID: 37820772, PubMed

Myosin expression and contractile function are altered by replating stem cell–derived cardiomyocytes, Osten, F., Weber, N., Wendland, M., Holler, T., Piep, B., Kröhn, S., Teske, J., Bodenschatz, A.K., Devadas, S.B., Menge, K.S., Chatterjee, S., Schwanke, K., Kosanke, M., Montag, J., Thum, T., Zweigerdt, R., Kraft, T., Iorga, B., and Meissner, J.D. (2023), J Gen Physiol (2023) 155 (11): e202313377, https://doi.org/10.1085/jgp.202313377, Online ahead of print

2019

Continuous WNT Control Enables Advanced hPSC Cardiac Processing and Prognostic Surface Marker Identification in Chemically Defined Suspension Culture. Halloin C, Schwanke K, Löbel W, Franke A, Szepes M, Biswanath S, Wunderlich S, Merkert S, Weber N, Osten F, de la Roche J, Polten F, Wollert K, Kraft T, Fischer M Martin U, Gruh I, Kempf H, Zweigerdt R. Stem Cell Reports. 2019 Aug 13; 13(2):366-379. doi: 10.1016/j.stemcr.2019.06.004. Epub 2019 Jul 25

2018

Mechanism of drug extrusion by brain endothelial cells via lysosomal drug trapping and disposal by neutrophils. Noack A, Gericke B, von Köckritz-Blickwede M, Menze A, Noack S, Gerhauser I, Osten F, Naim HY, Löscher W. Proc Natl Acad Sci U.S.A.; 2018 Oct 08; 115 (41) E9590-E9599. doi: 10.1073/pnas.1719642115. Epub 2018 Sep 25