Structural Biochemistry

Director: Prof. Dr. Dietmar Manstein

Welcome to the information portal of the Research Core Unit for Structural Biochemistry at Hannover Medical School.

Address:

Research Core Unit for Structural Biochemistry

OE 8830

Building I4, Floor S0

Medizinische Hochschule Hannover

Carl-Neuberg-Str. 1

30625 Hannover

The Division for Structural Biochemistry of Hannover Medical School provides support for the following research activities:

• Initial optimization of protein sample for crystallization 
• High-Throughput screening of protein crystallization conditions
• Plate incubation and control of the crystal growth§
• Assistance during crystal optimization procedures
• Buffer optimization
• Crystal handling and preparation for cryo-crystallographic data collection
• Diffraction data collection using sealed-tube and rotating anode x-ray sources
• Calculating data collection strategies
• Initial characterization of the crystal cell parameters and Bravais lattice
• Access to our 3D graphics workstations and computing environment for complete data processing, structure determination and analysis
• Determination of oligomerization states of proteins and characterization of hydrodynamic properties and macromolecular interactions
• Finally, we help our users to apply for beamtime at synchrotron facilities. Support is provided for remote and on site access

§For High-Throughput crystallization experiment we use MRC 2 Well Crystallization plate (UVP). These plates provide adequate precision of geometric parameters for nano-dispensing and sufficient transparency in visible and UV range for imaging.