ACT-COVID19-Study

A Phase I/ Randomized Phase II Trial To Analyse Safety And Efficacy Of Human SARS-COV-2-Specific T Lymphocyte Transfer In Patients With COVID-19 In Need Of Treatment Or At Risk Of Severe COVID-19

Sponsor:

University of Cologne
Albertus-Magnus-Platz
50923 Cologne
Germany

Principal Coordinating Investigator:

Priv.-Doz. Dr. med. Philipp Köhler
Department I for Internal Medicine
University Hospital of Cologne
Kerpener Strasse 62
50937 Cologne
Germany

Trial protocol code: Uni-Köln-4480

Clinical Trials.gov: NCT04762186

EudraCT number: 2021-000417-16

Publications:

Long-Lasting Immunity Against SARS-Cov-2: Dream or Reality?
Gussarow D, Bonifacius A, Cossmann A, Stankov MV, Mausberg P, Tischer-Zimmermann S, Gödecke N, Kalinke U, Behrens GMN, Blasczyk R, Eiz-Vesper B.Front Med (Lausanne). 2021 Nov 25;8:770381. doi: 10.3389/fmed.2021.770381. eCollection 2021.PMID: 34901085 Free PMC article.

COVID-19 immune signatures reveal stable antiviral T cell function despite declining humoral responses
Bonifacius A, Tischer-Zimmermann S, Dragon AC, Gussarow D, Vogel A, Krettek U, Gödecke N, Yilmaz M, Kraft ARM, Hoeper MM, Pink I, Schmidt JJ, Li Y, Welte T, Maecker-Kolhoff B, Martens J, Berger MM, Lobenwein C, Stankov MV, Cornberg M, David S, Behrens GMN, Witzke O, Blasczyk R, Eiz-Vesper B.Immunity. 2021 Feb 9;54(2):340-354.e6. doi: 10.1016/j.immuni.2021.01.008.

Rapid manufacturing of highly cytotoxic clinical-grade SARS-CoV-2-specific T cell products covering SARS-CoV-2 and its variants for adoptive T cell therapy
Agnes Bonifacius, Sabine Tischer-Zimmermann, Maria M. Santamorena, Philip Mausberg, Josephine Schenk, Stephanie Koch, Johanna Barnstorf-Brandes, Nina Gödecke, Jörg Martens, Lilia Goudeva, Murielle Verboom, Jana Wittig, Britta Maecker-Kolhoff, Herrad Baurmann, Caren Clark, Martina Simon, Peter Lang, Oliver A. Cornely, Michael Hallek, Rainer Blasczyk, Dominic Seiferling, Philipp Koehler and Britta Eiz-Vesper