The Role of Purinergic Immune Regulation in the Peritoneal Tumor Microenvironment

Purinergic signaling pathways, which include the ectonucleotidases ENTPD1 (CD39) and ENTPD3, are critically involved in the formation of a microenvironment conducive to tumor growth and are expressed not only on tumor cells but also on tumor-associated immune cells such as T cells, macrophages, and myeloid-derived suppressor cells (MDSCs). The goal of our research is to characterize the role of CD39 and ENTPD3 expressing immune cells in the context of metastasis of various tumor entities.

Team

PD Dr. med. Linda Feldbrügge

Vincent Wolf

Felix Gronau

Prof. Dr. med. Beate Rau