Clinical epidemiology in nephrology
Research Group Leader
- Prof. Dr. med. Bernhard Schmidt
Post-Docs and doctoral students
- Dr. med. Clara Vollmer-Barbosa
- Dr. med. Hannah Lang
- Dr. med. Janis Casper
- Zhejia Tian
- cand.med. Mikal Obed
- Nesrin Stock
- cand. med. Fabian Büttner
- cand. med. Sören Becker
- cand. med. Alexander Kuhnt
- cand. med. Leonora Lara Hornjak
- cand. med. Tayefeh Babak
Scientific profile
The research group of Prof. Schmidt uses methods of clinical epidemiology to address questions in the field of nephrology, transplantation medicine and hypertensiology.
The spectrum of methods includes the performance of own prospective and retrospective cohort studies (e.g. in cooperation with Prof. A. Melk, Pediatric Nephrology), the analysis of secondary data (health insurance data of the AOK Lower Saxony in cooperation with Prof. S. Geyer and Dr. J. Epping, Medical Sociology), the processing of own questions in existing large databases (e.g. NHANES, ANZ-Data) and the analysis of these data with modern regression models.
As it is a characteristic of our field that there are only small studies on many clinically relevant questions - but often several of them - the evidence according to criteria of "evidence based medicine" is often low. We try to counteract this by conducting meta-analyses on important topics in nephrology, transplantation medicine and hypertensiology. The performance of meta-analyses and network meta-analyses represents a further focus of the working group.
The substantive focus of research is in the area of cardiovascular risk, particularly after renal transplantation, progression reduction of chronic renal failure, acute renal failure, and hypertension, as well as gender-related differences in these areas of interest.
Selected publications
Obed M, Gabriel MM, Dumann E, Vollmer Barbosa C, Weißenborn K, Schmidt BMW. Risk of acute kidney injury after contrast-enhanced computerized tomography: a systematic review and meta-analysis of 21 propensity score-matched cohort studies. Eur Radiol. 2022. doi: 10.1007/s00330-022-08916-y
Eden G*, Schmidt JJ*, Büttner S, Kümpers P, Hafer C, Rovas A, Koch BF, Schmidt BMW, Kielstein JT. Safety and efficacy of the Seraph® 100 Microbind® Affinity Blood Filter to remove bacteria from the blood stream: results of the first in human study. Crit Care. 2022 Jun 17;26(1):181. *Authors contributed equally.
Vollmer Barbosa C, Lang H, Melk A, Schmidt BMW. Renal events in patients receiving Neprilysin inhibitors: a systematic review and meta-analysis. Nephrol Dial Transplant. 2022 Jan 11:gfac001. doi: 10.1093/ndt/gfac001.
Sugianto RI, Memaran N, Schmidt BMW, Doyon A, Thurn-Valsassina D, Alpay H, Anarat A, Arbeiter K, Azukaitis K, Bayazit AK, Bulut IK, Caliskan S, Canpolat N, Duzova A, Gellerman J, Harambat J, Homeyer D, Litwin M, Mencarelli F, Obrycki L, Paripovic D, Ranchin B, Shroff R, Tegtbur U, Born JV, Yilmaz E, Querfeld U, Wühl E, Schaefer F, Melk A. Insights from the 4C-T Study suggest increased cardiovascular burden in girls with end stage kidney disease before and after kidney transplantation. Kidney Int. 2021 Dec 21:S0085-2538(21)01163-7
Kraemer TD, Soerensen-Zender I, Memaran N, Haller H, Melk A, Schmidt BMW*, Schmitt R*. Changes in AZGP1 Serum Levels and Correlation With Pulse Wave Velocity After Kidney Transplantation. Front Cardiovasc Med. 2021;8:692213. doi: 10.3389/fcvm.2021.692213 *Authors contributed equally.
Stocklassa T, Borchert-Mörlins B, Memaran N, Einecke G, Schmitt R, Richter N, Vondran FW, Bauer E, Markefke S, Melk A*, Schmidt BMW*. Sex Differences in Subclinical Cardiovascular Organ Damage After Renal Transplantation: A Single-Center Cohort Study. J Womens Health (Larchmt). 2021;30:1352-61. *Authors contributed equally.
Melk A*, Schmidt BMW*, Geyer S, Epping J. Sex disparities in dialysis initiation, access to waitlist, transplantation and transplant outcome in German patients with renal disease-A population based analysis. PLoS One. 2020;15(11):e0241556. *Authors contributed equally.
Menne J*, Dumann E*, Haller H, Schmidt BMW Effect of SGLT-2 inhibition on acute kidney injury: A systematic review and meta-analysis. Plos Med 2019;16:e1002983 *Authors contributed equally.
Scurt FG, Ewert L, Mertens PR, Haller H, Schmidt BMW, Chatzikyrkou C Clinical outcomes after ABO incompatible renal transplantation – a systematic review and meta-analysis. Lancet. 2019;393:1059-72
Current third-party funding
Geschlecht – Macht – Wissen in der Transplantation: Vom Mythos zur biomedizinischen Realität
Förderer: Niedersächsisches Ministerium für Wissenschaft und Kultur
Antragsteller: A. Melk, C. Falk, S. Geyer, B.M.W. Schmidt
Cardiovascular Disease after Transplantation – Causes and Prevention
Förderer: BMBF (IFB Transplantation, Projekt CORE_1)
Antragsteller: A. Melk, B.M.W. Schmidt, G. Beutel
Cardiovascular risk profile in children and young adults after renal transplantation”
Förderer: ROTRF (ID 365520785)
Antragsteller: B.M.W. Schmidt
Open positions and PhD projects
Promotionsprojekte:
Sex differences in the efficacy of antihypertensive drug treatment - a systematic review and metaanalysis.
Predictors of adverse events during and after therapeutic plasma exchange - a retrospective cohort study.