Clinical and epidemiological approaches in acute nephrology
Research Group Leader
- Prof. Dr. med. Michael Haase
Research Assistants
- Prof. Dr. rer. medic. Anja Haase-Fielitz
- cand. Dr. med. Martin Ernst, Wissenschaftlicher Mitarbeiter (Medical Doctor)
- cand. Dr. med. Nilüfer Tekceli (Medical Doctor)
- Julia Gleumes (cand. Dr. med.)
- Franziska Lehmanski (cand. Dr. med.)
- Gundwara Blödorn (cand. Dr. med.)
- Lena Schlesewsky (cand. Dr. med.)
Scientific profile
Anatomically, the kidney consists of functional units called nephrons. These excrete water-soluble toxins, regulate water and salt balance and blood pressure, and form hormones. The nephrons can be damaged, sometimes irreversibly, by various influences. Hypoxia, ischemia, immunological processes or (drug) toxins are often triggers of kidney damage. Concomitant diseases such as poorly controlled diabetes or arterial hypertension can contribute to the chronification of renal damage. In the transplanted kidney, additional immunological and infectious damage mechanisms play a role and limit graft survival. Our research group applies clinical and epidemiological methods to further improve early diagnosis and quality-based treatment of patients with acute kidney or kidney transplant disease. We pay special attention to the exploitation, combination and further development of existing resources. Measures at the inpatient-ambulatory interface are to be evaluated and intensified. Methodologically, we combine randomized controlled trials (parallel-group, cluster, cross-over) and an intersectoral health system approach with observational studies, reviews/meta-analyses and mixed-methods approaches. Our goal is to use the knowledge gained to improve prediction, clinical classification, and therapy in patients* with kidney disease.
Cooperation partners
Institut für Sozialmedizin, Gesundheitssystemforschung und Gesundheitsökonomie, Universitätsklinikum Magdeburg
Deutsches Herzzentrum Berlin & Deutsches Herzzentrum Bernau
Institut für Klinische Chemie und Pathobiochemie, Universitätsklinikum Leipzig
ANZICS Controlled Trials Group, Melbourne, Australia
Canadian Critical Care Trials Group, Edmonton, Canada
Department of Developmental Biology & Pediatrics, Cincinnati, US
Department of Cardiology, Veterans Affairs, San Diego, US
Department of Nephrology and Renal Transplantation, San Bartolo Hospital, Vicenza, Italy
Selected publications
Haase M#, Lesny P, Anderson M, Cloherty G, Stec M, Haase-Fielitz A, Haarhaus M, Santos-Araújo C, Veiga PM, Macario F. Humoral immunogenicity and tolerability of heterologous ChAd/BNT compared with homologous BNT/BNT and ChAd/ChAd SARS-CoV-2 vaccination in hemodialysis patients: A multicenter prospective observational study. Journal of Nephrology, 35,1467-1478, 2022.
Haarhaus M#, Santos C, Haase M, Mota Veiga P, Lucas C, Macario F. Risk prediction of COVID-19 incidence and mortality in a large multi-national haemodialysis cohort: Implications for management of the pandemic in outpatient hemodialysis settings. Clin Kidney J, 14:805-813, 2021.
Elitok S, Kuppe H, Devarajan P, Bellomo R, Isermann B, Westphal S, Kube J, Albert C, Ernst M, Kropf S, Haase-Fielitz A, Haase M#. Urinary NGAL/hepcidin-25 ratio for early identification of patients at risk for renal replacement therapy after cardiac surgery: a substudy of the BICARBONATE trial. Anesth Analg, doi: 10.1213/ANE.0000000000005741, 2021.
Elitok S, Devarajan P, Bellomo R, Isermann B, Haase M#, Haase-Fielitz A. NGAL/hepcidin-25 ratio and AKI subtypes in patients following cardiac surgery: A prospective observational study. J Nephrol, doi: 10.1007/s40620-021-01063-5, 2021.
Swolinsky S, Nerger N, Leistner D, Edelmann F, Knebel F, Tuvshinbat E, Lemke C, Roehle R, Haase M, Costanzo MR, Rauch G, Mitrovic V, Gasanin E, Meier D, McCullough PA, Eckardt KU, Molitoris BA, Schmidt-Ott KM#. Serum creatinine and cystatin C-based estimates of glomerular filtration rate are misleading in acute heart failure. ESC Heart Failure, 8:3070-3081, 2021.
Bagshaw S, Al-Khafaji A, Artigas A, Davison D, Haase M, Lissauer M, Zacharowski K, Chawla L, Kwan T, Kampf P, McPherson P, Kellum J#. External Validation of Urinary C-C motif Chemokine Ligand 14 (CCL14) for Prediction of Persistent Acute Kidney Injury. Critical Care, 25:185, 2021
Albert C#, Zapf A, Haase M, Röver C, Pickering JW, Albert A, Bellomo R, Breidthardt T, Camou F, Chen Z, Chocron S, Cruz D, de Geus HRH, Devarajan P, Di Somma S, Doi K, Endre ZH, Garcia-Alvarez M, Hjortrup PB, Hur M, Karaolanis G, Kavalci C, Kim H, Lentini P, Liebetrau C, Lipcsey M, Mårtensson J, Müller C, Nanas S, Nickolas TL, Pipili C, Ronco C, Rosa-Diez GJ, Ralib A, Soto K, Braun-Dullaeus RC, Heinz J, Haase-Fielitz A. Neutrophil Gelatinase-Associated Lipocalin Measured on Clinical Laboratory Platforms for the Prediction of Acute Kidney Injury and the Associated Need for Dialysis Therapy: A Systematic Review and Meta-analysis. The NGAL Meta-Analysis Investigator Group. Am J Kidney Dis, 76:826-841.e1, 2020.
Elitok S*, Haase-Fielitz A*, Schostak M, Ernst M, Isermann B, Albert C, Robra BP, Kribben A, Haase M#. Effekte einer intensivierten Versorgung im Vergleich zur üblichen Versorgung bei akuter Nierenschädigung: Eine explorative, randomisierte, kontrollierte Studie. Dtsch Arztebl Int, 117:289-296, 2020.
Hoste E, Bihorac A, Al-Khafaji A, Ortega LM, Ostermann M, Haase M, Zacharowski K, Wunderink R, Heung M, Lissauer M, Self WH, Koyner JL, Honore PM, Prowle JR, Joannidis M, Forni LG, Kampf JP, McPherson P, Kellum JA, Chawla LS#; RUBY Investigators. Identification and validation of biomarkers of persistent acute kidney injury: the RUBY study. Intensive Care Med, 46:943-953, 2020.
Joannidis M, Forni LG, Haase M, Koyner J, Shi J, Kashani K, Chawla LS, Kellum JA#; Sapphire Investigators. Use of Cell Cycle Arrest Biomarkers in Conjunction With Classical Markers of Acute Kidney Injury. Crit Care Med, 47:e820-e826, 2019.
Koyner JL, Shaw AD, Chawla LS, Hoste EA, Bihorac A, Kashani K, Haase M, Shi J, Kellum JA#; on behalf of the Sapphire Investigators. Tissue Inhibitor Metalloproteinase-2 (TIMP-2)⋅IGF-Binding Protein-7 (IGFBP7) Levels Are Associated with Adverse Long-Term Outcomes in Patients with AKI. J Am Soc Nephrol, 26:1747-1754, 2015.
Haase M*#, Haase-Fielitz A*, Plass M, Kuppe H, Hetzer R, Hannon C, Murray PT, Bailey MJ, Bellomo R, Bagshaw SM. Prophylactic perioperative sodium bicarbonate to prevent acute kidney injury following open heart surgery: a multicenter double-blinded randomized controlled trial. PLoS Med, 10:e1001426, 2013.
Haase M*#, Devarajan P*, Haase-Fielitz A*, Bellomo R, Cruz DN, Wagener G, Krawczeski CD, Koyner JL, Murray P, Zappitelli M, Goldstein SL, Makris K, Ronco C, Martensson J, Martling CR, Venge P, Siew E, Ware LB, Ikizler TA, Mertens PR. The Outcome of Neutrophil Gelatinase-Associated Lipocalin (NGAL)-positive Subclinical Acute Kidney Injury: A Multicenter Pooled Analysis of Prospective Studies. J Am Coll Cardiol, 57:1752-1761, 2011.
*equal contribution | #corresponding author
Current third-party funding
Else Kröner Fresenius-Stiftung, Effect of sodium bicarbonate on the kidney during and after cardiopulmonary bypass
Deutsche Stiftung für Herzforschung, Biomarkers of acute kidney injury (AKI)
Fritz-Scheler-Grant of the German Society of Nephrology (DGfN) and KfH Foundation of Preventive Medicine, Pathophysiological importance of catecholamine-resistant vasodilatory shock
Open positions and PhD projects
Wir rekrutieren derzeit wissenschaftliche Mitarbeiter:innen, naturwissenschaftliche und medizinische Doktorand:innen und studentische Mitarbeiter:innen. Bei Interesse bewerben Sie sich bitte unter Vorlage von Motivationsschreiben, Lebenslauf und Zeugnissen bei Nephrologie@mh-hannover.de. Eine Einbindung in strukturierte Programme wird dabei angestrebt.
Contact
Prof. Dr. med. Michael Haase
Klinik für Nieren- und Hochdruckerkrankungen
Zentrum Innere Medizin
Medizinische Hochschule Hannover
OE6840, Carl-Neuberg-Str. 1, 30625 Hannover
Tel: +49 511 532 6320, Fax: +49 511 532-18515