Publications
Induction of cell death by sodium hexachloroplatinate (IV) in the HEI-OC1 cell line, primary rat spiral ganglion cells and rat organ of Corti explants. Berger E, Brandes G, Kaiser O, Reifenrath J, Lenarz T, Wissel K, Durisin M. PLoS One 19(7): e0307973, 2024. doi.org/10.1371/journal.pone.0307973
Regional Microglial Response in Entorhino-Hippocampal Slice Cultures to Schaffer Collateral Lesion and Metalloproteinases Modulation. Virtuoso A., Galanis Chr., Lenz M. , Papa M., Vlachos A.. Int J Mol Sci. 2024 Feb 16;25(4):2346. doi: 10.3390/ijms25042346.
Gut microbiota depletion delays somatic peripheral nerve development and impairs neuromuscular junction maturation. Cescon M*, Gambarotta G*, Calabrò S, Cicconetti C, Anselmi F, Kankowski S, Lang L, Basic M, Bleich A, Bolsega S, Steglich M, Oliviero S, Raimondo S, Bizzotto D, Haastert-Talini K* and Ronchi G*. Gut Microbes 2024, VOL. 16, NO. 1, 2363015. *authors contributed equally doi:10.1080/19490976.2024.2363015
Synaptopodin Regulates Denervation-Induced Plasticity at Hippocampal Mossy Fiber Synapses. Kruse P, Brandes G, Hemeling H, Huang Z, Wrede Ch, Hegermann J, Vlachos A, Lenz M. Cells 2024, 13, 114. doi: 10.3390/cells13020114
A dual-omics approach on the effects of fibroblast growth factor-2 (FGF-2) on ventral tegmental area dopaminergic neurons in response to alcohol consumption in miceHose L, Langenhagen A, Kefalakes E, Schweitzer T, Kubinski S, Barak S, Pich A, Grothe C. Eur J Neurosci. 2024 Apr;59(7):1519-1535. doi: 10.1111/ejn.16234.
Brain stimulation-on-a-chip: a neuromodulation platform for brain slices. Shaner S, Lu H, Lenz M, Garg S, Vlachos A, Asplund M. Lab Chip. 2023 Nov 21;23(23):4967-4985. doi: 10.1039/d3lc00492a.
The Amyloid Precursor Protein Regulates Synaptic Transmission at Medial Perforant Path Synapses. Lenz M, Eichler A, Kruse P, Galanis Ch, Kleidonas D, Andrieux G, Boerries M, Jedlicka P, Müller U, Deller T, and Vlachos A. The Journal of Neuroscience, July 19, 2023 • 43(29):5290–5304 doi: 10.1523/JNEUROSCI.1824-22.2023
Effects of the Light/Dark Phase and Constant Light on Spatial Working Memory and Spine Plasticity in the Mouse Hippocampus. Schröder J, Abdel-Hafiz L, Amira A , Cousin T, Hallenberger J, Rodrigues Almeida F, Anstötz M, Lenz M, Vlachos A , von Gall Ch and Tundo-Lavalle F. Cells 2023, 12, 1758. doi: 10.3390/cells12131758
Denervated mouse CA1 pyramidal neurons express homeostatic synaptic plasticity following entorhinal cortex lesion. Lenz M, Eichler A, Kruse P, Stöhr P, Kleidonas D, Galanis C, Lu H, Vlachos A. Front Mol Neurosci. 2023 Apr 12;16:1148219. doi: 10.3389/fnmol.2023.1148219. eCollection 2023.
Culture Conditions for Human Induced Pluripotent Stem Cell-Derived Schwann Cells: A Two-Centre Study. Huang Z., Powell R., Kankowski S., Philips J.B., Haastert-Talini K. (2023): Int. J. Mol. Sci. 2023, 24(6), 5366; https://doi.org/10.3390/ijms24065366
Chronic Voluntary Alcohol Consumption Alters Promoter Methylation and Expression of Fgf-2 and Fgfr1. Herburg L, Rhein M, Kubinski S, Kefalakes E, Levin Greenwald M, Gielman S, Barak S, Frieling H and Grothe C. Int. J. Mol. Sci. 2023, 24, 3336. https://doi.org/10.3390/ijms24043336
Decellularized porcine pericardium enhances autologous vascularized matrix as a prosthesis for left ventricular full-wall myocardial reconstruction. Meyer T, Cebotari S, Brandes G, Hartung D, Wacker F, Theis M, Kaufeld T, Tudorache I, Nolte I, Haverich A, Schilling T. Prosthesis 2023, 5, 113-29; https://doi.org/10.3390/prosthesis5010010
Stabilizing a vascularized autologous matrix with flexible magnesium scaffolds to reconstruct dysfunctional left ventricular myocardium in a large animal feasibility study. Schilling T, Cebotari S, Kaufeld T, Tudorache I, Brandes G, Hartung D, Wacker FK, Bauer M, Haverich A, Hassel T. J Funct Biomater 2023, 14, 73; https://doi.org/10.3390/jfb14020073
iPSC-Derived Striatal Medium Spiny Neurons from Patients with Multiple System Atrophy Show Hypoexcitability and Elevated α-Synuclein Release. Henkel L.M, Kankowski S, Moellenkamp T.M, Smandzich N.J, Schwarz S, Di Fonzo A, Göhring G, Höglinger G, Wegner F. (2023) Cells, 12, 223. https://doi.org/10.3390/cells12020223
In vitro impact of platinum nanoparticles on inner ear related cell culture models. Berger E, Brandes G, Reifenrath J, Lenarz T, Durisin M, Wissel K. PLoS One 18(4):e0284794, 2023. doi: 10.1371/journal.pone.0284794.
FGF2 activity regulates operant alcohol self-administration and mesolimbic dopamine transmission. Grinchii D, Levin-Greenwald M, Lezmy N, Gordon T, Paliokha R, Khoury T, Racicky M, Herburg L, Grothe C, Dremencov E, Barak S. Drug and Alcohol Dependence, Volume 248, 1 July 2023. https://doi.org/10.1016/j.drugalcdep.2023.109920
Impact of Gut Microbiota on the Peripheral Nervous System in Physiological, Regenerative and Pathological Conditions. Sonia Calabrò, Svenja Kankowski, Matilde Cescon , Giovanna Gambarotta ,Stefania Raimondo , Kirsten Haastert-Talini and Giulia Ronchi Int. J. Mol. Sci. 2023, 24, 8061. https://doi.org/10.3390/ijms24098061
Left Ventricular Wall Reconstruction with Autologous Vascularized Gastric Graft in a Porcine Pilot Model. Schilling T, Meyer T, Brandes G, Hartung D, Tudorache I, Nolte I, Wacker F, Hilfiker A, Hoeffler K, Haverich A, Cebotari S. Eur Surg Res. 2022 Feb 8;63(4):219-26. doi: 10.1159/000522478.
Specification of CNS macrophage subsets occurs postnatally in defined niches. Masuda T, Amann L, Monaco G, Sankowski R, Staszewski O, Krueger M, Del Gaudio F, He L, Paterson N, Nent E, Fernández-Klett F, Yamasaki A, Frosch M, Fliegauf M, Bosch LFP, Ulupinar H, Hagemeyer N, Schreiner D, Dorrier C, Tsuda M, Grothe C, Joutel A, Daneman R, Betsholtz C, Lendahl U, Knobeloch KP, Lämmermann T, Priller J, Kierdorf K, Prinz M. (2022) Nature. 2022, 04(7907):740-748. https://doi.org/10.1038/s41586-022-04596-2
FGF2 is an endogenous regulator of alcohol reward and consumption. Even-Chen O, Herburg L, Kefalakes E, Urshansky N, Grothe C, Barak S. (2022) Addict Biol. 2022, 27(2):e13115. https://doi.org/10.1111/adb.13115
Hetero-pentamerization determines mobility and conductance of Glycine receptor α3 splice variants. Lemmens V, Thevelein B, Vella Y, Kankowski S, Leonhard J, Mizuno H, Rocha S, Brône B, Meier J.C, Hendrix J, (2022) Cell. Mol. Life Sci. 79, 540; https://doi.org/10.1007/s00018-022-04506-9
Editorial: Schwann cells: From their development to their clinical application. Haastert-Talini K. (2022): Front Cell Neurosci. 16: 1043419, doi: 10.3389/fncel.2022.1043419
Dysregulation of Tweak and Fn14 in skeletal muscle of spinal muscular atrophy mice. Meijboom KE, Sutton ER, McCallion E, McFall E, Anthony D, Edwards B, Kubinski S, Tapken I, Bünermann I, Hazell G, Ahlskog N, Claus P, Davies KE, Kothary R, Wood MJA, Bowerman M (2022) Skelet Muscle. 2022 Jul 28;12(1):18. https://doi.org/10.1186/s13395-022-00301-z
Protein Network Analysis Reveals a Functional Connectivity of Dysregulated Processes in ALS and SMA. Kubinski S, Claus P (2022) Neuroscience Insights (2022) Volume 17: 1–10 https://doi.org/10.1177/26331055221087740
Is P-Glycoprotein Functionally Expressed in the Limiting Membrane of Endolysosomes? A Biochemical and Ultrastructural Study in the Rat Liver. Gericke B, Wienböker I, Brandes G, Löscher W (2022) Cells 2022, 11, 1556. https://doi.org/10.3390/cells11091556
The Potential Benefits of Dietary Polyphenols for Peripheral Nerve Regeneration. Muratori L., Fregnan F., Maurina M., Haastert‐Talini K and Ronchi, G. (2022), Int. J. Mol. Sci. 2022, 23(9), 5177; https://doi.org/10.3390/ijms23095177
FGF2 is an endogenous regulator of alcohol reward and consumption. Even-Chen O, Herburg L, Kefalakes E, Urshansky N, Grothe C, Barak S (2021) Addiction Biology. 2021;e13115, 1-13. doi: 10.1111/adb.13115
PVDF and P(VDF-TrFE) Electrospun Scaffolds for Nerve Graft Engineering: A Comparative Study on Piezoelectric and Structural Properties, and In Vitro Biocompatibility. Gryshkov O, AL AL Halabi F, Kuhn A. I, Leal-Marin S, Freund J, Förthmann M, Meier N, Haastert‐Talini, K, Glasmacher B. (2021), Int. J. Mol. Sci. 2021, 22(21), 11373; https://doi.org/10.3390/ijms222111373; https://www.mdpi.com/1422-0067/22/21/11373
The Role of Dietary Nutrients in Peripheral Nerve Regeneration. El Soury M., Fornasari B E, Carta G, Zen F, Haastert‐Talini K and Ronchi G. (2021), Int. J. Mol. Sci. 2021, 22(14), 7417; https://doi.org/10.3390/ijms22147417
Modified Hyaluronic Acid-Laminin-Hydrogel as Luminal Filler for Clinically Approved Hollow Nerve Guides in a Rat Critical Defect Size Model. Huang Z, Kankowski S, Ertekin E, Almog M, Nevo Z, Rochkind, S. and Haastert‐Talini K. (2021), Int. J. Mol. Sci. 2021, 22(12), 6554; https://doi.org/10.3390/ijms22126554 „We acknowledge support by the German Research Foundation (DFG) and the Open Access Publication Fund of Hannover Medical School (MHH)“
Neuropathic pain: spotlighting anatomy, experimental models, mechanisms, and therapeutic aspects. Kankowski S, Grothe C and Haastert‐Talini K (2021), European Journal of Neuroscience. doi:10.1111/ejn.15266.
Spider silk nerve graft promotes axonal regeneration on long distance nerve defect in a sheep model. Kornfeld T, Nessler J, Helme C, Hannemann R, Waldmann KH, Peck C T, Hoffmann P, Brandes G, Vogt P M, Radtke C (2021) Biomaterials. 2021 Apr;271:120692. doi: 10.1016/j.biomaterials.2021.120692
Fucosylated lipid nanocarriers loaded with antibiotics efficiently inhibit mycobacterial propagation in human myeloid. Durán V, Grabski E, Hozsa C, Becker J, Yasar H, Monteiro J T, Costa B, Koller N, Lueder Y, Wiegmann B, Brandes G Kaever V, Lehr C-M, Lepenies B, Tampé R, Förste Rr, Bošnjak B, Furch M, Graalmann T, Ulrich Kalinke (2021) cells J Control Release 2021 Apr 15;S0168-3659(21)00178-4. doi: 10.1016/j.jconrel.2021.04.012.
Fibroblast growth factor signalling in the diseased nervous system. Lars Klimaschewski and Peter Claus (2021): Molecular Neurobiology, Volume 58, pages 3884–3902, (2021) doi: 10.1007/s12035-021-02367-0
What can we learn from FGF-2 isoform-specific mouse mutants? Differential insights into FGF-2 physiology in vivo. von Hövel FF, Kefalakes E, Grothe C (2021): Int J Mol Sci. 22(1):390, doi: 10.3390/ijms22010390 „We acknowledge support by the German Research Foundation (DFG) and the Open Access Publication Fund of Hannover Medical School (MHH)“
Teaching anatomy under COVID-19 conditions at German universities: recommendations of the teaching commission of the anatomical society. Böckers A.,Claassen H., Haastert-Talini K., Westermann J (2021). Annals of Anatomy - Anatomischer Anzeiger Volume 234, March 2021, 151669 https://authors.elsevier.com/c/1cNGu3LynVhSiq (use this link for open access before Feb 26, 2021) or https://doi.org/10.1016/j.aanat.2020.151669
Perspective on Schwann Cells Derived from Induced Pluripotent Stem Cells in Peripheral Nerve Tissue Engineering. Huang Z, Powell R, Philips JB, Haastert-Talini K (2020) Cells 2020, 9(11), 2497; doi: 10.3390/cells9112497
A single amino acid residue regulates PTEN-binding and stability of the Spinal Muscular Atrophy protein SMN. Rademacher S, Detering N T, Schüning T, Lindner R, Santonicola P, Wefel I-M, Dehus J, Walter L, Brinkmann H, Niewienda A, Janek K, Varela M, Bowerman M, Di Schiavi E, and Claus P (2020): Cells. 2020 Nov 3;9(11):2405. doi: 10.3390/cells9112405.
Microtubule associated protein 1B dysregulates microtubule dynamics and neuronal mitochondrial transport in Spinal Muscular Atrophy. Bora G, Hensel N, Rademacher S, Koyunoğlu D, Sunguroğlu M, Aksu-Mengeş M, Balci-Hayta B, Claus P, Erdem-Yurter H (2020): Hum Mol Genet. 2021 Feb 25;29(24):3935-3944. doi: 10.1093/hmg/ddaa275.
Low Density Lipoprotein Receptor-Related Protein-1 (LRP1) Is Involved in the Uptake of Clostridioides difficile Toxin A and Serves as an Internalizing Receptor. Schöttelndreier D, Langejürgen A, Lindner R and Genth H (2020): Frontiers in Cellular and Infection Microbiology doi.org/10.3389/fcimb.2020.565465
The proteome and secretome of cortical brain cells infected with herpes simplex virus. Hensel N, Raker V, Förthmann B, Buch A, Sodeik B, Pich A and Claus P (2020): Front. Neurol 11:844. doi.org/10.3389/fneur.2020.00844
Altered bone development with impaired cartilage formation precedes neuromuscular symptoms in Spinal Muscular Atrophy (SMA). Hensel N, Brickwedde H, Tsaknakis K, Grages A, Braunschweig L, Lüders K, Lorenz HM, Lippross S, Walter LM, Tavassol F, Lienenklaus S, Neunaber C, Claus P and Anna Kathrin Hell (2020):Human Molecular Genetics, Volume 29, Issue 16, 15 August 2020, Pages 2662–2673, https://doi.org/10.1093/hmg/ddaa145
Towards acellular xenogeneic heart valve prostheses: Histological and biomechanical characterization of decellularized and enzymatically deglycosylated porcine pulmonary heart valve matrices. Findeisen K, Morticelli L, Goecke T, Kolbeck L, Ramm R, Höffler HK, Brandes G, Korossis S, Haverich A, Hilfiker A (2020) Xenotransplantation 00: e12617. Doi:10.111/xen.12617
Stabilisation of a segment of autologous vascularised stomach as a patch for myocardial reconstruction with degradable magnesium alloy scaffolds in a swine model. Schilling T, Bauer M, Hartung D, Brandes G, Tudorache I, Cebotari S, Meyer T, Wacker F, Haverich A, Hassel T (2020) Crystals 10, 438; doi:10.3390/cryst10060438
Renal pathology in a mouse model of severe Spinal Muscular Atrophy is associated with downregulation of Glial Cell-Line Derived Neurotrophic Factor (GDNF). Allardyce H, Kuhn D, Hernandez-Gerez E, Hensel N, Huang YT, Faller K, Gillingwater TH, Quondamatteo F, Claus P, Parson SH(2020): Human Molecular Genetics, Volume 29, Issue 14, 15 July 2020, Pages 2365–2378, https://doi.org/10.1093/hmg/ddaa126
Short communication: Critical analysis of the value of the rabbit median nerve model for biomedical research on peripheral nerve grafts.Ronchi G., Gambarotta G., Morano M., Fregnan F., Pugliese P., Tos P., Geuna S., Haastert-Talini K. (2020). J Tissue Eng Regen Med. 2020. in press https://doi.org/10.1002/term.3036
Muscle overexpression of Klf15 via an AAV8-Spc5-12 construct does not provide benefits in spinal muscular atrophy mice. Ahlskog N, Hayler D, Krueger A, Kubinski S, Claus P, Hammond S M, Wood M, Yáñez-Muñoz R, Bowerman M (2020): Gene Ther. 2019 Nov;27(10-11):505-515. doi: 10.1038/s41434-020-0146-8. Epub 2020 Apr 20.
In Vivo and In Vitro Evaluation of a Novel Hyaluronic Acid–Laminin Hydrogel as Luminal Filler and Carrier System for Genetically Engineered Schwann Cells in Critical Gap Length Tubular Peripheral Nerve Graft in Rats. Dietzmeyer N., Huang Z., Schüning T., Rochkind S., Almog M., Nevo Z., Lieke T., Kankowski S., Haastert-Talini K. (2020) Cell Transplantation, 2020, Volume 29: 1–20. DOI: 10.1177/0963689720910095
The Need for SMN-Independent Treatments of Spinal Muscular Atrophy (SMA) to Complement SMN-Enhancing Drugs. Hensel N, Kubinski S and Claus P (2020): Front. Neurology 11: 45. doi: 10.3389/fneur.2020.00045
Modification of tubular chitosan-based peripheral nerve implants: applications for simple or more complex approaches. Dietzmeyer N, Förthmann M, Grothe C, Haastert-Talini K. (2020) Neural Regen Res 15(8):1421-1431. doi: 10.4103/1673-5374.271668
Original papers 2019
Gambarotta G., Raimondo S., Udina E., Phillips J.B., Haastert-Talini K. (2019): Editorial: Peripheral Nerve Regeneration. Front Cell Neurosci. 13: 464, doi: 10.3389/fncel.2019.00464
Bianca Schröder-Heurich, Sandra von Hardenberg, Lars Brodowski, Berina Kipke, Katja Borns, Constantin S. von Kaisenberg, Hella Brinkmann, Peter Claus, Frauke von Versen-Höynck (2019): Vitamin D improves endothelial barrier integrity and counteracts inflammatory effects on endothelial progenitor cells. FASEB J. 33: 9142-9153
Marc-Olivier Deguise, Giovanni Baranello, Chiara Mastella, Ariane Beauvais, Jean Michaud, Alessandro Leone, Ramona De Amicis, Alberto Battezzati, Christopher Dunham, Kathryn Selby, Jodi Warman Chardon, Hugh J McMillan, Yu-Ting Huang, Natalie L. Courtney, Alannah J. Mole, Sabrina Kubinski, Peter Claus, Lyndsay M. Murray, Melissa Bowerman, Thomas H. Gillingwater, Simona Bertoli, Simon H. Parson, and Rashmi Kothary, PhD (2019): Abnormal fatty acid metabolism is a core component of spinal muscular atrophy. Annals of Clinical and Translational Neurology 6:1519-1532.
Gamze Bora, Caren Sucularli, Niko Hensel, Peter Claus, Hayat Erdem Yurter (2019): Investigations of Microtubule-associated Protein 2 Gene Expression in Spinal Muscular Atrophy. J. Pediatr. Res. 6: 148-154.
Bursch F, Kalmbach N, Naujock M, Staege S, Eggenschwiler R, Abo-Rady M, Japtok J, Guo W, Hensel N, Reinhardt P, Boeckers TM, Cantz T, Sterneckert J, Van Den Bosch L, Hermann A, Petri S, Wegner F (2019): Altered calcium dynamics and glutamate receptor properties in iPSC-derived motor neurons from ALS patients with C9orf72, FUS, SOD1 or TDP43 mutations. Hum Mol Genet. 28:2835-2850.
Frank Brand, Alisa Förster, Anne Christians, Martin Bucher, Carina Thomé, Marc S. Raab, Manfred Westphal, Torsten Pietsch, Andreas von Deimling, Guido Reifenberger, Peter Claus, Bettina Hentschel, Michael Weller, Ruthild G. Weber (2019): FOCAD loss is associated with decreased survival in astrocytic glioma, impacts microtubules and G2/M progression. Acta Neuropathologica, doi.org/10.1007/s00401-019-02067-z.
Niko Hensel*, Verena Raker*, Benjamin Förthmann, Nora-Tula Detering, Sabrina Kubinski, Anna Buch, Georgios Katzilieris-Petras, Julia Spanier, Viktoria Gudi8, Sylvia Wagenknecht, Verena Kopfnagel, Thomas Andreas Werfel, Martin Stangel, Andreas Beineke, Ulrich Kalinke, Søren Riis Paludan, Beate Sodeik, and Peter Claus (2019): HSV-1 triggers paracrine fibroblast growth factor response from cortical brain cells via immediate-early protein ICP0. Journal of Neuroinflammation 16:248. doi: 10.1186/s12974-019-1647-5
Lisa Marie Walter, Peter Franz, Robert Lindner, Georgios Tsiavaliaris, Niko Hensel, Peter Claus (2020): Profilin2a-phosphorylation as a regulatory mechanism for actin dynamics. FASEB J. 34: 2147-2160. doi:10.1096/fj.201901883R
Niko Hensel, Nora Detering, Lisa Walter, and Peter Claus (2019): Resolution of pathogenic R-loops rescues motoneuron degeneration in Spinal Muscular Atrophy. Brain, in press.
Dietzmeyer N., Förthmann M., Grothe C., Haastert-Talini K. (2019): REVIEW: Modification of tubular chitosan-based peripheral nerve implants – applications for simple or more complex approaches. Neural Regen Res 2019 in press
Gingele S, Merkel L, Prajeeth CK, Kronenberg J, von Hoevel FF, Skripuletz T, Gudi V, Stangel M. (2019): Polarized microglia do not influence oligodendrocyte lineage cells via astrocytes. Int J Dev Neurosci. 2019 Feb 1. pii: S0736-5748(18)30279-X. doi: 10.1016/j.ijdevneu.2019.01.006.
von Hövel FF, Leiter I, Rumpel R, Langenhagen A, Wedekind A, Häger C, Bleich A, Palme R, Grothe C (2019): FGF-2 isoforms influence the development of dopaminergic neurons in the murine substantia nigra, but not anxiety-like behavior, stress susceptibility, or locomotor behavior. Behav Brain Res. 2019 Aug 2:112113. doi: 10.1016/j.bbr.2019.112113.
Ronchi G., Morano M., Fregnan F., Puigliesi P, Crosio A., Tos P., Geuna S., Haastert-Talini K, Gambarotta G. (2019): The median nerve injury model in pre-clinical research – a critical review on benefits and limitations. Front. Cell. Neurosci. doi: 10.3389/fncel.2019.00288
Muratori L.*, Fregnan F.*, Ronchi G., Haastert-Talini K. , Metzen J., Bertolo R., Porpiglia F., Geuna S. (2019): New basic insights on the potential of chitosan-based medical device for improving functional recovery after radical prostatectomy. BJU Int. 2019 May 28. doi: 10.1111/bju.14834. [Epub ahead of print]
Marcin Łyszkiewicz, Daniel Kotlarz, Natalia Ziȩtara, Gudrun Brandes, Jana Diestelhorst, Silke Glage, Elias Hobeika, Michael Reth, Lukas A. Huber, Andreas Krueger, Christoph Klein (2019) LAMTOR2 (p14) Controls B Cell Differentiation by Orchestrating Endosomal BCR Trafficking. Front Immunol. 2019 Mar 18;10:497. doi: 10.3389/fimmu.2019.00497.
Dietzmeyer N, Förthmann M, Leonhard J, Helmecke O, Brandenberger C., Freier T, Haastert-Talini K (2019): Two-Chambered Chitosan Nerve Guides With Increased Bendability Support Recovery Of Skilled Forelimb Reaching Similar To Autologous Nerve Grafts In The Rat 10 mm Median Nerve Injury And Repair Model. Accepted on 08 April 2019; Front. Cell. Neurosci. doi: 10.3389/fncel.2019.00149 We acknowledge support by the German Research Foundation (DFG) and the Open Access Publication Fund of Hannover Medical School (MHH).
Kefalakes E, Sarikidi A, Bursch F, Ettcheto M, Schmuck M, Rumpel R, Grothe C, Petri S. (2019): Isoform-selective as opposed to complete depletion of fibroblast growth factor 2 (FGF-2) has no major impact on survival and gene expression in SOD1G93A amyotrophic lateral sclerosis mice. Eur J Neurosci. 2019 Mar 18. doi: 10.1111/ejn.14405. [Epub ahead of print]
Ekaterini Kefalakes1, Sebastian Boeselt, Anastasia Sarikidi, Miren Ettcheto, Franziska Bursch, Maximilian Naujock, Nancy Stanslowsky, Martin Schmuck, Marta Barenys, Florian Wegner, Claudia Grothe, Susanne Petri (2019): Characterization of the multiple roles of FGF-2 in the SOD1G93A ALS mouse model in vivo and in vitro. J Cell Physiol. 2019 May;234(5):7395-7410. doi: 10.1002/jcp.27498
von Hövel F.F., Rumpel R., Ratzka A., Schreiner D., Grothe C. (2019): AAV2/DJ-mediated alpha-synuclein overexpression in the rat substantia nigra as early stage model of Parkinson's disease. Cell Tissue Res 2019 Apr 15. doi: 10.1007/s00441-019-03013-x. [Epub ahead of print]
Original papers 2018
Lisa M Walter, Christiane E Koch, Corinne A Betts, Nina Ahlskog, Katharina E Meijboom, Tirsa LE van Westering, Gareth Hazell, Amarjit Bhomra, Peter Claus, Henrik Oster, Matthew JA Wood, Melissa Bowerman (2018): Light modulation improves circadian dysregulation and phenotype in spinal muscular atrophy mice. Human Molecular Genetics 27: 3582-3597.
Robin Kosch, Julien Delarocque, Peter Claus, Stefanie C. Becker and Klaus Jung (2018): Gene expression profiles in neurological tissues during West Nile virus infection: a critical meta-analysis. BMC Genomics, 19(1): 530.
Wissel,K.; Brandes,G.; Pütz,N.; Angrisani,G.L.; Thieleke,J.; Lenarz,T.; Durisin,M. (2018)
Platinum corrosion products from electrode contacts of human cochlear implants induce cell death in cell culture models PLoS One, 13, 5, e0196649
Marion Bankstahl, Heike Breuer, Ina Leiter, Martin Märkel, Pablo Bascuñana, Dominik Michalski, Frank M. Bengel, Wolfgang Löscher, Martin Meier, Jens P. Bankstahl and Wolfgang Härtig (2018): Blood-Brain Barrier Leakage during Early Epileptogenesis Is Associated with Rapid Remodeling of the Neurovascular eNeuro. 2018 May 30;5(3).
P.Bascunana, M.Brackhan, I.Leiter, H.Keller, I.Jahreis, T.L.Ross, F.M.Bengel, M.Bankstahl, J.P.Bankstahl (2018): Divergent metabolic substrate utilization in brain during epileptogenesis precedes chronic hypometabolism. J Cereb Blood Flow Metab. 2018 Oct 30:271678X18809886.
Navarro X, Geuna S, Grothe C, Haastert-Talini K (2018): Introduction. Thematic Papers Issue on Peripheral Nerve Regeneration and Repair. Anat Rec (Hoboken). 2018 Oct;301(10):1614-1617.
Schöttelndreier, D., Seeger, K., Grassl, G.A., Winny, M.R., Lindner, R. and Genth, H. (2018) Expression and (lacking) internalization of cell surface receptors of Clostridioides difficile Toxin B. Front Microbiol. 2018 Jul 4;9:1483.
Saucedo L*, Rumpel R*, Sobarzo C, Schreiner D, Brandes G, Lustig L, Vazquez-Levin MH, Grothe C*, Marín-Briggiler C*. Deficiency of fibroblast growth factor 2 (FGF-2) leads to abnormal spermatogenesis and altered sperm physiology. J Cell Physiol. 2018 Dec;233(12):9640-9651. *contributed equally to this study.
Lukas Balek, Marcela Buchtova, Silvie Foldynova-Trantirkova, Jan Havlik, Miroslav Varecha, Stuart Turner, Iva Vesela, Lars Klimaschewski, Peter Claus, Lukas Trantirek, Petr Cigler, Pavel Krejci (2018): Nanodiamonds as artificial proteins: regulation of cell signaling system using picomolar solutions of inorganic nanocrystals. Biomaterials. 2018 Sep;176:106-121.
Uhde AK, Ciurkiewicz M, Herder V, Akram Khan M, Hensel N, Claus P, Beckstette M, Teich R., Floess S., Baumgärtner W, Jung K, Huehn J, Beineke A (2018): Intact interleukin-10 receptor signaling protects from hippocampal damage following experimental neurotropic virus infection of SJL mice. Scientific Reports, 8: 6106.
Lisa Marie Walter, Marc-Olivier Deguise, Katharina E Meijboom, Corinne A Betts, Nina Ahlskog, Tirsa LE van Westering, Gareth Hazell, Emily McFall, Anna Kordala, Suzan M Hammond, Frank Abendroth, Lyndsay M Murray, Hannah K Shorrock, Domenick A Prosdocimo, Saptarsi M Haldar, Mukesh K Jain, Thomas H Gillingwater, Peter Claus, Rashmi Kothary, Matthew JA Wood, Melissa Bowerman (2018): Interventions targeting glucocorticoid-Krüppel-like factor 15-branched-chain amino acid signaling improve disease phenotypes in spinal muscular atrophy mice. EBioMedicine. 2018 May;31:226-242.
Stößel M, Metzen J, Wildhagen VM, Helmecke O, Rehra L, Freier T, Haastert-Talini K, (2018): Long-term in vivo evaluation of chitosan nerve guide properties with respect to two different sterilization methods. BioMed Res Int, Volume 2018, Article ID 6982738, 11 pages, doi.org/10.1155/2018/6982738
Carvalho CR, Wrobel S, Meyer C, Brandenberger C, Cengiz IF, López-Cebral R, Silva-Correia J, Ronchi G, Reis RL, Grothe C, Oliveira JM, Haastert-Talini K (2018): Gellan Gum-based Luminal Fillers for Peripheral Nerve Regeneration. An In Vivo Study in the Rat Sciatic Nerve Repair Model. Biomater Sci. 2018 Feb 21. doi: 10.1039/c7bm01101f. [Epub ahead of print] http://pubs.rsc.org/en/content/articlepdf/2018/bm/c7bm01101f
Haastert-Talini K, Lars B. Dahlin (2018): PERSPECTIVE: Diabetes, its impact on peripheral nerve regeneration - lessons from pre-clinical rat models towards nerve repair and reconstruction. Neural Regen Res 13(1):65-66. doi:10.4103/1673-5374.224370. http://www.nrronline.org/temp/NeuralRegenRes13165-1491803_040838.pdf
Stößel M, Wildhagen VM, Helmecke O, Metzen J, Pfund CB, Freier T, Haastert-Talini K (2018): Comparative evaluation of chitosan nerve guides with regular or increased bendability for acute and delayed peripheral nerve repair – a comprehensive comparison with autologous nerve grafts and muscle-in-vein grafts. Anat Rec (Hoboken). 2018 Oct;301(10):1697-1713.
Original papers 2017
Hadler C, Wissel K, Brandes G, Dempwolf W, Reuter G, Lenarz T, Menzel H (2017)
Photochemical coating of Kapton® with hydrophilic polymers for the improvement of neural implants.
Mater Sci Eng C Mater Biol Appl. 2017 Jun 1;75:286-296. doi: 10.1016/j.msec.2017.02.020. Epub 2017 Feb 10.PMID:28415465
Rademacher S, Verheijen BM, Hensel N, Peters M, Bora G, Brandes G, Vieira de Sá R, Heidrich N, Fischer S, Brinkmann H, van der Pol WL, Wirth B, Pasterkamp RJ, Claus P (2017)Metalloprotease-mediated cleavage of PlexinD1 and its sequestration to actin rods in the motoneuron disease spinal muscular atrophy (SMA). Hum Mol Genet. 2017 Oct 15;26(20):3946-3959. doi: 10.1093/hmg/ddx282.
Haastert-Talini K, Lars B. Dahlin (2017): PERSPECTIVE: Diabetes, its impact on peripheral nerve regeneration - lessons from pre-clinical rat models towards nerve repair and reconstruction. Neural Regen Res 2017 in press
Hensel N., Baskal S., Brinkmann H., Gernert M., Claus P. (2017): ERK and ROCK functionally interact in a signaling network that is compensationally upregulated in Spinal Muscular Atrophy. Neurobiol. Dis., in press.
Stößel M, Rehra L, Haastert-Talini K (2017): Reflex-based grasping, skilled forelimb reaching, and electrodiagnostic evaluation for comprehensive analysis of functional recovery – the 7 mm rat median nerve gap repair model revisited. Brain and Behavior 2017 DOI: 10.1002/brb3.813 Link
Bradel S, Doniga-Crivat L, Besdo S, Lexow F, Fehr M, Lenarz T, Prenzler N, Brandes G (2017). Innovative 3D Model of the Human Middle Ear in High Resolution with a Histological Microgrinding Method: A Feasibility Study and Comparison with muCT. Int J Otolaryngol 2017;2017:6753604
Molumby MJ, Anderson RM, Newbold DJ, Koblesky NK, Garrett AM, Schreiner D, Radley JJ, Weiner JA (2017). gamma-Protocadherins Interact with Neuroligin-1 and Negatively Regulate Dendritic Spine Morphogenesis. Cell Rep 2017;18(11):2702-2714
Rumpel R*, Alam M*, Schwarz LM, Ratzka A, Jin X, Krauss JK, Grothe C, Schwabe K. (2017): Neuronal firing activity in the basal ganglia after striatal transplantation of dopamine neurons in hemiparkinsonian rats. Neuroscience. 2017 Sep 30;360:197-209. doi: 10.1016/j.neuroscience.2017.07.069. Epub 2017 Aug 5. *Contributed equally
Stenberg L*, Stößel M*, Ronchi G, Geuna S, Yin Y, Mommert S, Martensson L, Metzen J, Grothe C, Dahlin LB*, Haastert-Talini K* (2017): Regeneration of long-distance peripheral nerve defects after delayed reconstruction in healthy and diabetic rats is supported by immunomodulatory chitosan nerve guides. BMC Neurosci (2017) 18:53; DOI 10.1186/s12868-017-0374-z rdcu.be/uhr1 *Contributed equally
Alam M*, Rumpel R*, Jin X, von Wrangel C, Tschirner SK, Krauss JK, Grothe C, Ratzka A, Schwabe K. (2017): Altered somatosensory cortex neuronal activity in a rat model of Parkinson's disease and levodopa-induced dyskinesias. Exp Neurol. 2017 Apr 23;294:19-31. doi: 10.1016/j.expneurol.2017.04.011. [Epub ahead of print]*Contributed equally
Hensel N. & Claus P. (2017): The actin cytoskeleton in SMA and ALS: How does it contribute to motoneuron degeneration? Neuroscientist, in press.
Lindner, R. (2017) Invariant Chain Complexes and Clusters as Platforms for MIF Signaling. Cells. 2017 Feb 10;6(1). pii: E6. doi: 10.3390/cells6010006. F1000Prime Recommended
Original papers 2016
van Neerven SG, Haastert-Talini K, Boecker A, Schriever T, Dabhi C, Claeys K, Deumens R, Brook GA, Weis J, Pallua N and Bozkurt A (2016): Two-component collagen nerve guides support axonal regeneration in the rat peripheral nerve injury model. J Tissue Eng Regen Med. 2016 Dec 16. doi: 10.1002/term.2248. Link
Wuttke S, Zimpel A, Bein T, Braig S, Stoiber K, Vollmar A, Müller D, Haastert-Talini K, Schaeske J, Stiesch M, Zahn G, Mohmeyer A, Behrens P, Eickelberg O, Bölükbas DA and Meiners S (2016): Validating Metal-Organic Framework Nanoparticles for Their Nanosafety in Diverse Biomedical Applications. Adv Healthc Mater in press. DOI: 10.1002/adhm.201600818 Link
Stanslowsky N., Reinhardt P., Glass H., Kalmbach N., Naujock M., Hensel N., Lübben V., Pal A., Venneri A., Lupo F., De Franceschi L., Claus P., Sterneckert J., Storch A., Hermann A., Wegner F. (2016): Neuronal dysfunction in iPSC-derived medium spiny neurons from Chorea-Acanthocytosis patients is reversed by Src-kinase inhibition and F-actin stabilization. J. Neurosci., in press.
Hadler C, Aliuos P, Brandes G, Warnecke A, Bohlmann J, Dempwolf W, Menzel H, Lenarz T, Reuter G, Wissel K (2016): Polymer Coatings of Cochlear Implant Electrode Surface - An Option for Improving Electrode-Nerve-Interface by Blocking Fibroblast Overgrowth. PLoS One. 11(7):e0157710. doi: 10.1371/journal.pone.0157710. eCollection 2016. Link
Hensel N.*, Schön A.,*, Konen T.*, Lübben V., Förthmann B., Baron O., Grothe C., Leifheit-Nestler M.#, Claus P.#, Haffner D.# (2016): Fibroblast growth factor 23 acting on hippocampal neurons: Impact on neuronal morphology and synaptic density. J. Neurochem., in press. DOI: 10.1111/jnc.13585. *Contributed equally as first authors; #contributed equally as senior authors.
Ronchi G, Haastert-Talini K, Fornasari BE, Perroteau I, Geuna S, Gambarotta G (2016): The Neuregulin1/ErbB system is selectively regulated during peripheral nerve degeneration and regeneration. Eur J Neurosci. 2016 Feb;43(3):351-64. doi: 10.1111/ejn.12974. Link
Geuna S, Raimondo S, Fregnan F, Haastert-Talini K, Grothe C (2016): In vitro models for peripheral nerve regeneration. Eur J Neurosci. 2016 Feb;43(3):287-96. doi: 10.1111/ejn.13054. Link
Rumpel R*, Baron O*, Ratzka A*, Schröder ML, Hohmann M, Effenberg A, Claus P, Grothe C (2016): Increased innervation of forebrain targets by midbrain dopaminergic neurons in the absence of FGF-2. Neuroscience. 2016 Feb 9;314:134-144. doi: 10.1016/j.neuroscience.2015.11.057.
Meyer C*, Stenberg L*, Gonzalez-Perez F*, Wrobel S, Ronchi G, Udina E, Suganuma S, Geuna S, Navarro X, Dahlin LB, Grothe C, Haastert-Talini K (2016): Chitosan-film enhanced chitosan nerve guides for long-distance regeneration of peripheral nerves. Biomaterials. 2016 Jan;76:33-51. doi: 10.1016/j.biomaterials.2015.10.040., Link
Meyer C*,Wrobel S*, Raimondo S, Rochkind S, Heimann C, Shahar A, Ziv-Polat O, Geuna S, Grothe C, Haastert-Talini K (2016): Peripheral nerve regeneration through hydrogel enriched chitosan tubes containing engineered Schwann cells for drug delivery. Cell Transplant. Cell Transplant. 2016;25(1):159-82. doi: 10.3727/096368915X688010. Link
Original papers 2015
Effenberg A, Stanslowsky N, Klein A, Wesemann M, Haase A, Martin U, Dengler R, Grothe C, Ratzka A, Wegner F. (2015): Striatal transplantation of human dopaminergic neurons differentiated from induced pluripotent stem cells derived from umbilical cord blood using lentiviral reprogramming. Cell Transplant. 2015;24(10):2099-112. doi: 10.3727/096368914X685591. Epub 2014 Nov 21. www.ncbi.nlm.nih.gov/pubmed/25420114
Rohrbeck A, Stahl F, Höltje M, Hettwer T, Lindner P, Hagemann S, Pich A and Haastert-Talini K (2015): C3-induced release of neurotrophic factors from Schwann cells - potential mechanism behind its regeneration promoting activity. Neurochem Int. 2015 Sep 28. pii: S0197-0186(15)30049-8. doi: 10.1016/j.neuint.2015.09.007. [Epub ahead of print]
Hohmann M, Rumpel R, Fischer M, Donert M, Ratzka A, Klein A, Wesemann M, Effenberg A, Fahlke C, Grothe C (2015): Electrophysiological characterization of eGFP-labeled intrastriatal dopamine grafts. Cell Transplant 24(8):1451-1467
Förthmann B., Aletta J., Lee Y.-W., Terranova C., Birkaya B., Stachowiak E., Stachowiak M.K., Claus P. (2015): Coalition of nuclear receptors in the nervous system. J Cell Physiol. 2015 Dec;230(12):2875-80. doi: 10.1002/jcp.25036.
Hensel N., Rademacher S., Claus P. (2015): Chatting with the neighbors: Crosstalk between Rho-kinase (ROCK) and other signaling pathways for treatment of neurological disorders. Front. Neuroscience 9:198. doi: 10.3389/fnins.2015.00198.
Li S., Payne S., Wang F., Claus P., Su Z., Groth J., Geradts J., de Ridder G., Alvarez R., Marcom P.K., Pizzo S.V., Bachelder R.E. (2015): Nuclear basic fibroblast growth factor regulates triple-negative breast cancer chemo-resistance. Breast Cancer Research 17:91.
Förthmann B., Grothe C., Claus P. (2015): A nuclear odyssey: fibroblast growth factor-2 (FGF-2) as a regulator of nuclear homeostasis in the nervous system. Cell Mol Life Sci. 2015 May;72(9):1651-62.
Kreshuk A, Walecki R, Koethe U, Gierthmuehlen M, Plachta D, Genoud Ch, Haastert-Talini K, Hamprecht F (2015): Automated Tracing of Myelinated Axons and Detection of the Nodes of Ranvier in Serial Images of Peripheral Nerves. Microsc. 2015 Aug;259(2):143-54.
Rumpel R, Hohmann M, Klein A, Wesemann M, Baumgärtner W, Ratzka A, Grothe C. (2015): Transplantation of fetal ventral mesencephalic progenitor cells overexpressing high molecular weight fibroblast growth factor 2 isoforms in 6-hydroxydopamine lesioned rats. Neuroscience 286:293-307. http://www.ncbi.nlm.nih.gov/pubmed/25499314
Original papers 2014
Effenberg A, Klein A, Gibb R, Carroll C, Baumgärtner W, Grothe C, Ratzka A. (2014): Adult hemiparkinsonian rats do not benefit from tactile stimulation. Behav Brain Res. 261:97-105.
http://www.ncbi.nlm.nih.gov/pubmed/24342749
Pustelny C, Komor U, Pawar V, Lorenz A, Bielecka A, Moter A, Gocht B, Eckweiler D, Grothe C, Lünsdorf H, Weiss S, and Häussler S: Contribution of Veillonella parvula to Pseudomonas aeruginosa mediated pathogenicity in a murine tumor model system. Infection and Immunity, in press.
Morano M, Wrobel S, Fregnan F, Ziv-Polat O, Shahar A, Geuna S, Grothe C, Haastert-Talini K (2014): Nanotechnology versus stem cell engineering - In vitro-comparison of neurite inductive potentials. Int J Nanomedicine, 9(1):5289-5306 http://www.dovepress.com/articles.php?article_id=19161
Ziv-Polat O, Shahar A, Levy I, Skaat H, Neuman S, Fregnan F, Geuna S, Grothe C, Haastert-Talini K, Margel S. (2014): The role of neurotrophic factors conjugated to iron oxide nanoparticles in peripheral nerve regeneration - in vitro studies. BioMed Res Int, Vol 2014 (2014), Article ID 267808, 10 pages; http://dx.doi.org/10.1155/2014/267808
Van Neerven S G A, Krings L, Haastert-Talini K, Vogt M, Tolba R H, Brook G, Pallua N, Bozkurt A (2014): Human Schwann Cells Seeded on a Novel Collagen-Based Microstructured Nerve Guide Survive, Proliferate, and Modify Neurite Outgrowth. BioMed Res Int, Vol 2014 (2014), Article ID 493823, 13 pages; http://dx.doi.org/10.1155/2014/493823
Haastert-Talini K and Grothe C (2014): Comment to the paper: Acceleration of peripheral nerve regeneration using nerve conduits in combination with induced pluripotent stem cell technology and a basic fibroblast growth factor drug delivery system by M. Ikeda, T. Uemura, K. Takamatsu, M. Okada, K. Kazuki, Y. Tabata, Y. Ikada, H. Nakamura, J Biomed Mater Res A. 2013 Jun 3 doi: 10.1002/jbm.a.34816. J Biomed Mater Res A 102, 1219-1220.
Wrobel S, Serra SC, Ribeiro-Samy S, Sousa N, Heimann C, Barwig C, Grothe C, Salgado AJ, Haastert-Talini K (2014): In vitro cell-seeded chitosan filma for peripheral nerve tissue engineering. Tissue Engineering Part A; 20(17-18):2339-49. doi: 10.1089/ten.TEA.2013.0621. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161053/
Duda S, Dreyer L, Behrens P, Wienecke S, Chakradeo T, Glasmacher B, Haastert-Talini K (2014): Outer electrospun polycaprolactone shell induces massive foreign body reaction and impairs axonal regeneration through 3D multichannel chitosan nerve guides. BioMed Res Int, Vol 2014 (2014), Article ID 835269, 16 pages; http://dx.doi.org/10.1155/2014/835269
Hensel N., Stockbrügger I., Rademacher S., Broughton N., Brinkmann H., Grothe C., Claus P. (2014): Bilateral Crosstalk of Rho- and Extracellular-Signal-Regulated -Kinase (ERK) Pathways is Confined to an Unidirectional Mode in Spinal Muscular Atrophy (SMA). Cellular Signalling 26: 540-548.
Schenk H, Haastert-Talini K, Jungnickel J, Grothe C, Meyer H, Rehage J, Fehr M, Bokemeyer J, Rohn K and Tipold A (2014): Morphometric parameters of peripheral nerves in calves in correlation to conduction velocity. JVet Intern Med 28, 646-655.
Original papers 2013
Hensel N., Stockbrügger I., Rademacher S., Broughton N., Brinkmann H., Grothe C., Claus P. (2013): Bilateral Crosstalk of Rho- and Extracellular-Signal-Regulated -Kinase (ERK) Pathways is Confined to an Unidirectional Mode in Spinal Muscular Atrophy (SMA). Cellular Signalling 26: 540-548. [Impact factor: 4.304]
Schenk H, Haastert-Talini K, Jungnickel J, Grothe C, Meyer H, Rehage J, Fehr M, Bokemeyer J, Rohn K and Tipold A (2013): Morphometric parameters of peripheral nerves in calves in correlation to conduction velocity. JVIM, in press.
Förthmann B, van Bergeijk J, Lee YW, Lübben V, Schill Y, Brinkmann H, Ratzka A, Stachowiak MK, Hebert M, Grothe C, Claus P (2013): Regulation of neuronal differentiation by proteins associated with nuclear bodies. PLoS One. 8(12):e82871.
Gnavi S, Barwig C, Freier T, Haastert-Talini K, Grothe C, Geuna S Chapter 1: The Use of Chitosan-Based Scaffolds to Enhance Regeneration in the Nervous System In: Int Rev Neurobiol. 2013;109C:1-62. doi: 10.1016/B978-0-12-420045-6.00001-8.
Haastert-Talini K, Grothe C Chapter 5: Electrical Stimulation for Promoting Peripheral Nerve Regeneration In: Int Rev Neurobiol. 2013;109C:111-124. doi: 10.1016/B978-0-12-420045-6.00005-5.
Behrens, P., Glasmacher, B., Duda, S., Haastert-Talini, K. (2013): Preparartion and Analysis of PCL Spun Chitosan Scaffolds as Guidance Channels for Peripheral Nerve Regeneration. Biomed Tech (Berl). 2013 Sep 7. doi:pii: /j/bmte.2013.58.issue-s1-C/bmt-2013-4062/bmt-2013-4062.xml. 10.1515/bmt-2013-4062. [Epub ahead of print]
Haastert-Talini K Ganglion Spirale Cochleae - das Schneckenganglion In: Sprache-Stimme-Gehör, 2013:37, Rubrik: Der kleine Repetitor
Geuna S, Haastert-Talini K, Navarro X (2013) Chapter 4-1: The nerve trunk in injury and during regeneration. In: Current Treatment of Nerve Injuries and Disorders (Dahlin LB, Leblebicioglu G, eds); Series: Federation of European Societies for Surgery of the Hand, Instructional Courses 2013: Palme Publications.
Haastert-Talini, K., Geuna, S., Dahlin, L. B., Meyer, C., Stenberg, L., Freier, T., Heimann, C., Barwig, C., Pinto, L. F.V., Raimondo, S., Gambarotta, G., Samy, S. R., Sousa, N., Salgado, A. J., Ratzka, A., Wrobel, S., Grothe, C. (2013): Chitosan tubes of varying degrees of acetylation for bridging peripheral nerve defects. Biomaterials 34 (2013), pp. 9886-9904 DOI information: 10.1016/j.biomaterials.2013.08.074.
Rumpel R, Alam M, Klein A, Ozer M, Wesemann M, Jin X, Krauss JK, Schwabe K, Ratzka A, Grothe C. (2013): Neuronal firing activity and gene expression changes in the subthalamic nucleus after transplantation of dopamine neurons in hemiparkinsonian rats. Neurobiol. Dis., 59, 230-243.
Förthmann B., Brinkmann H., Ratzka A., Stachowiak M.K., Grothe C., Claus P. (2013): Immobile survival of motoneuron (SMN) protein stored in Cajal bodies can be mobilized by protein interactions. Cell. Mol. Life Sci. 70: 2555–2568.
Sun H., Bénardais K., Stanslowsky N., Thau N., Hensel N., Huang D., Claus P., Dengler R., Stangel M., Petri S. (2013): Therapeutic potential of mesenchymal stromal cells and MSC conditioned medium in Amyotrophic Lateral Sclerosis (ALS) - In vitro evidence from primary motor neuron cultures, NSC-34 cells, astrocytes and microglia. PLoS One, in press.
Müller M., Diensthuber R.P., Chizhov I., Claus P., Heissler S.M., Preller M., Taft M.H., Manstein D.J. (2013): Distinct functional interactions between actin isoforms and nonsarcomeric myosins. PLoS One 8(7): e70636. doi:10.1371/journal.pone.0070636.
Gierthmuehlen M., Freiman T.M., Haastert-Talini K., Mueller A., Kaminsky J., Stieglitz T., Plachta D.T.(2013): Computational tissue volume reconstruction of a peripheral nerve using high-resolution light-microscopy and reconstruct. PLoS One. 2013 Jun 13;8(6):e66191. doi: 10.1371/journal.pone.0066191. Print 2013.
Lee Y-W., Stachowiak E. K., Birkaya B., Terranova C., Cappachietti M., Claus P., Aletta J., Stachowiak M.K. (2013): NGF-Stimulated Neurite Outgrowth and Activation of Early and Late Neuronal Genes Is Mediated by Integrative Nuclear FGF Receptor-1 (FGFR1) Signaling (INFS). PLoS One. 2013 8: e68931. doi: 10.1371/journal.pone.0068931.
Original papers 2012
Rath A, Klein A, Papazoglou A, Pruszak J, Garciaa J, Krause M, Maciaczyk J, Dunnett SB, Nikkhah G. (2012) Survival and Functional Restoration of Human Fetal Ventral Mesencephalon FollowingTransplantation in a Rat Model of Parkinson's Disease. Cell Transplant; DOI: 10.3727/096368912X654984
Klein A, Sacrey LA, Whishaw IQ, Dunnett SB. (2012) The use of rodent skilled reaching as a translational model for investigating brain damage and disease. Neurosci Biobehav Rev; 36(3):1030-1042
Klein A, Lane EL, Dunnett SB. (2012) Brain repair in a unilateral rat model of Huntington's disease: new insights into impairments and restoration of forelimb movement patterns. Cell Transplant; DOI: 10.3727/096368912X657918
Förthmann B., Brinkmann H., Ratzka R., Stachowiak M.K., Grothe C., Claus P. (2012) Immobile survival of motoneuron (SMN) protein stored in Cajal bodies can be mobilized by protein interactions. Cell Mol Life Sci; 1-14
Klein A, Whishaw IQ. (2012) Skilled motor control for the preclinical assessment of functional deficits and recovery following nigral and striatal cell transplantation. Prog Brain Res; 200:279-301
Trueman RC, Klein A, Lindgren HS, Lelos MJ, Dunnett SB. (2012) Repair of the CNS Using Endogenous and Transplanted Neural Stem Cells. Curr Top Behav Neurosci; DOI: 10.1007/7854_2012_223
Claus P. (2012) Pathogenese der Spinalen Muskelatrophie. Klin Neurophysiol; 43(3):203-205
Kirsten Haastert-Talini (2012) Chapter 17: Culture and proliferation of highly purified Schwann cells from rat, dog and man. Methods Mol Biol 2012; 846:189-200.
Mensching L, Börger AK, Wang X, Charalambous P, Unsicker K, Haastert-Talini K (2012) Local substitution of GDF-15 improves axonal and sensory recovery after peripheral nerve injury. Cell Tissue Res; 350(2):225-238
Irschick R., Trost T., Karp G., Hausott B., Auer M., Claus P., Klimaschewski L. (2012) Sorting of the FGF receptor 1 in a human glioma cell line. Histochem Cell Biol; DOI: 10.1007/s00418-012-1009-1
Bosio Y., Berto G., Camera P., Bianchi F., Ambrogio C., Claus P., Di Cunto F. (2012) PPP4R2 regulates neuronal cell differentiation and survival, functionally cooperating with SMN. European Journal of Cell Biology 91: 662-74.
Grothe C, Haastert-Talini K, Freier T, Navarro X, Dahlin LB, Salgado A, Rochkind S, Shahar A, Pinto LF, Hildebrandt M, Geuna S. (2012) BIOHYBRID - Biohybrid templates for peripheral nerve regeneration. J Peripher Nerv Syst. 17: 220-222.
Baron O, Ratzka A, Grothe C. (2012) Fibroblast growth factor 2 regulates adequate nigrostriatal pathway formation in mice. J Comp Neurol; 520(17):3949-3961
Thau N, Jungnickel J, Knippenberg S, Ratzka A, Dengler R, Petri S*, Grothe C*. (2012) Prolonged survival and milder impairment of motor function in the SOD1 ALS mouse model devoid of fibroblast growth factor 2. Neurobiol Dis. 47: 248-257. *These authors contributed equally as senior authors.
Ratzka A*, Baron O*, Stachowiak MK, Grothe C. (2012) Fibroblast growth factor 2 regulates dopaminergic neuron development in vivo. J Neurochem. 122: 94-105. * These authors contributed equally.
Baron O, Förthmann B $, Lee YW $, Terranova C $, Ratzka A, Stachowiak EK, Grothe C, Claus P #, Stachowiak MK #. (2012) Cooperation of nuclear FGFR1 and Nurr1 offers a new interactive mechanism in postmitotic development of mesencephalic dopaminergic neurons. J Biol Chem. 287: 19827-19840. $ These authors contributed equally; # These authors contributed equally as senior authors.
Lee YW, Terranova C, Birkaya B, Narla S, Kehoe D, Parikh A, Dong S, Ratzka A, Brinkmann H, Aletta JM, Tzanakakis ES, Stachowiak EK, Claus P*, Stachowiak MK*. (2012) A novel nuclear FGF Receptor-1 partnership with retinoid and Nur receptors during developmental gene programming of embryonic stem cells. J Cell Biochem. 113: 2920-2936. * These senior authors are both corresponding authors.
Hensel N, Ratzka A, Brinkmann H, Klimaschewski L, Grothe C, Claus P. (2012) Analysis of the Fibroblast Growth Factor system reveals alterations in a mouse model of Spinal Muscular Atrophy. PLoS One. 7: e31202.
Huelsenbeck SC, Rohrbeck A, Handreck A, Hellmich G, Kiaei E, Roettinger I, Grothe C, Just I, Haastert-Talini K. (2012) C3 Peptide Promotes Axonal Regeneration and Functional Motor Recovery after Peripheral Nerve Injury. Neurotherapeutics. 9: 185-198.
Ratzka A, Kalve I, Ozer M, Nobre A, Wesemann M, Jungnickel J, Köster-Patzlaff C, Baron O, Grothe C (2012): The co-layer method as an efficient way to genetically modify mesencephalic progenitor cells transplanted into 6-OHDA rat model of Parkinson's disease. Cell Transplantation 21: 479-762
Jungnickel J, Eckhardt M, Haastert-Talini K, Claus P, Bronzlik P, Lipokatic-Takacs E, Maier H, Gieselmann V, Grothe C. (2012) Polysialyltransferase-overexpression in Schwann cells mediates different effects during peripheral nerve regeneration. Glycobiology 22: 107-15.
Original papers 2011
Kreutzer M., Seehusen F., Kreutzer R., Pringproa K., Kummerfeld, M., Claus P., Deschl U., Kalkul A., Beineke A., Baumgärtner W., Ulrich R. (2011) Axonopathy is associated with complex axonal 1 transport defects 2 in a model of multiple sclerosis. Brain Pathology, in press.
Nölle A., Zeug A., van Bergeijk J., Tönges L., Gerhard R., Brinkmann H., Al Rayes S., Hensel N., Schill Y., Apkhazava D., Jablonka S., O´mer J., Srivastav R.K., Baasner A., Lingor P., Wirth B., Ponimaskin E., Niedenthal R., Grothe C., Claus P. (2011) The Spinal Muscular Atrophy disease protein SMN is linked to the Rho-kinase pathway via profilin. Hum Mol Genet. 2011 Dec 15;20(24):4865-78. Epub 2011 Sep 14.
Kirsten Haastert-Talini (2011) Chapter 9: Experimental Approaches on Tissue engineering Repair of Peripheral Nerve Gaps. In: The Sciatic Nerve: Blocks, Injuries and Regeneration (Fonseca DJ, Martins JL, eds); Series: Neuroscience Research Progress: Nove Science Publishers Link
Kirsten Haastert-Talini Editorial for special issue: Gene Therapy approaches for Neuroregeneration Curr Gene Ther 2011 in press (Vol 11 No 2, April 2011)
Ratzka A, Baron O, Grothe C. (2011) FGF-2 Deficiency Does Not Influence FGF Ligand and Receptor Expression during Development of the Nigrostriatal System. PLoS One 6(8):e23564. [Epub 2011 Aug 18]
Korte N, Schenk HC, Grothe C, Tipold A, Haastert-Talini K. (2011) Evaluation of periodic electrodiagnostic measurements to monitor motor recovery after different peripheral nerve lesions in the rat. Muscle & Nerve 44(1):63-73. [Epub 2011 Jun 14]
Heurich B, el Idrissi NB, Donev RM, Petri S, Claus P, Neal J, Morgan BP, Ramaglia V. (2011) Complement upregulation and activation on motor neurons and neuromuscular junction in the SOD1 G93A mouse model of familial amyotrophic lateral sclerosis. J Neuroimmunol. 235(1-2):104-109. [Epub 2011 Apr 17]
Seitz M, Grosheva M, Skouras E, Angelova SK, Ankerne J, Jungnickel J, Grothe C, Klimaschewski L, Hübbers CU, Dunlop SA, Angelov DN. (2011) Poor functional recovery and muscle polyinnervation after facial nerve injury in fibroblast growth factor-2-/- mice can be improved by manual stimulation of denervated vibrissal muscles. Neuroscience 182:241-247. [Epub 2011 Mar 31]
Haastert-Talini K, Schmitte R, Korte N, Klode D, Ratzka A, Grothe C. (2011) Electrical stimulation accelerates axonal and functional peripheral nerve regeneration across long gaps. J Neurotrauma 28(4):661-674. [Epub 2011 Mar 24]
Meixner M, Jungnickel J, Grothe C, Gieselmann V, Eckhardt M. (2011) Myelination in the absence of UDP-galactose:ceramide galactosyl-transferase and fatty acid 2 -hydroxylase. BMC Neurosci. 2011 Mar 2; 12:22
Jungnickel J, Kalve I, Reimers L, Nobre A, Wesemann M, Ratzka A, Halfer N, Lindemann C, Schwabe K, Töllner K, Gernert M, Grothe C. (2011) Topology of intrastriatal dopaminergic grafts determines functional and emotional outcome in neurotoxin-lesioned rats. Behav Brain Res 216(1):129-135. [Epub 2010 Jul 22]
Original papers 2010
Haastert-Talini K, Schaper-Rinkel J, Schmitte R, Bastian R, Mühlenhoff M, Schwarzer D, Draeger G, Su Y, Scheper T, Gerardy-Schahn R, Grothe C. (2010) In vivo evaluation of polysialic acid as part of tissue-engineered nerve transplants. Tissue Eng Part A 16(10):3085-3098. [Epub 2010 Jun 24]
Jungnickel J, Haastert K, Grzybek M, Thau N, Lipokatic-Takacs E, Ratzka A, Nölle A, Claus P, Grothe C. (2010) Mice lacking basic fibroblast growth factor showed faster sensory recovery. Exp Neurol. 223(1):166-172. [Epub 2009 Jun 9]
Ratzka A, Mundlos S, Vortkamp A. (2010) Expression patterns of sulfatase genes in the developing mouse embryo. Dev Dyn 239(6):1779-1788. [Epub 2010 Apr 9]
Haastert K, Joswig H, Jäschke KA, Samii M, Grothe C. (2010) Nerve repair by end-to-side nerve coaptation: histologic and morphometric evaluation of axonal origin in a rat sciatic nerve model. Neurosurgery 66(3):567-577.
Nobre A, Kalve I, Cesnulevicius K, Ragancokova D, Ratzka A, Halfer N, Wesemann M, Krampfl K, Claus P, Grothe C. (2010) Characterization and differentiation potential of rat ventral mesencephalic neuronal progenitor cells immortalized with SV40 large T antigen. Cell Tissue Res 340(1):29-43. [Epub 2010 Feb 23]
Steinhaus S, Stark Y, Bruns S, Haile Y, Scheper T, Grothe C, Behrens P. (2010) Polysialic acid immobilized on silanized glass surfaces: a test case for its use as a biomaterial for nerve regeneration. J Mater Sci Mater Med 21(4):1371-1378. [Epub 2010 Jan 30]
Schmitte R, Tipold A, Stein VM, Schenk H, Flieshardt C, Grothe C, Haastert K. (2010) Genetically modified canine Schwann cells--In vitro and in vivo evaluation of their suitability for peripheral nerve tissue engineering. J Neurosci Methods 186(2):202-208. [Epub 2009 Dec 3]
Original papers 2009
Haastert K, Grosheva M, Angelova S, Guntinas-Lichius O, Skouras E, Joern M, Grothe C, Dunlop S, Angelov DN. (2009) Schwann cells over-expressing FGF-2 alone or combined with manual stimulation do not promote functional recovery after facial nerve injury. J Biomed Biotechnol, 2009:408794, 11 pages, doi:10. 1155/2009/408794. [Epub 2009 Oct 8]
Bruns AF, Bergeijk JV, Lorbeer C, Nölle A, Jungnickel J, Grothe C, Claus P. (2009) Fibroblast growth factor-2 regulates the stability of nuclear bodies. Proc Natl Acad Sci USA 106(31):12747-12752. [Epub 2009 Jul 17]
Schiff M, Weinhold B, Grothe C, Hildebrandt H. (2009) NCAM and polysialyltransferase profiles match dopminergic marker gene expression but polysialic acid is dispensable for development of the midbrain dopamine system. J Neurochem 110(5):1661-1673. [Epub 2009 Jul 8]
Ragancokova D, Jahn K, Kotsiari A, Schlesinger F, Haastert K, Stangel M, Petri S, Krampfl K. (2009) Analysis of neuroprotective effects of valproic acid on primary motor neurons in monoculture or co-cultures with astrocytes or Schwann cells. Cell Mol Neurobiol 29(6-7):1037-1043. [Epub 2009 Mar 28]
Dunham-Ems SM, Lee Y-W, Stachowiak EK, Pudavar H, Claus P, Prasad PN, Stachowiak MK. (2009) Fibroblast Growth Factor Receptor-1 (FGFR1) nuclear dynamics reveal a novel mechanism in transcription control. Mol Biol Cell 20(9):2401-2412. [Epub 2009 Mar 4]
Haastert K, Seef P, Stein VM, Tipold A, Grothe C. (2009) A new cell culture protocol for enrichment and genetic modification of adult canine Schwann cells suitable for peripheral nerve tissue engineering. Res Vet Sci 87(1):140-142. [Epub 2009 Feb. 18]
Jungnickel J, Brämer C, Bronzlik P, Lipokatic-Takacs E, Weinhold B, Gerardy-Schahn R, Grothe C. (2009) Level and localization of polysialic acid is critical for early peripheral nerve regeneration. Mol Cell Neurosci 40(3):374-381 [Epub 2008 Dec 24]
Bruns AF, Grothe C, Claus P. (2009) Fibroblast growth factor 2 (FGF-2) is a novel substrate for arginine methylation by PRMT5. Biol Chem 390(1):59-65. [Epub 2008 Oct 21]
Original papers 2008
Stark Y, Bruns, S, Stahl F, Kasper C, Wesemann M, Grothe C, Scheper T. A study on polysialic acid as a biomaterial for cell culture applications. J Biomed Mater Res A. 2008 Apr;85(1):1-13. Erratum in: J Biomed Mater Res A. 2008 Apr; 85(1):284
Petri S, Krampfl K, Kuhlemann K, Dengler R, Grothe C Preserved expression of fibroblast growth factor (FGF)-2 and FGF receptor 1 in brain and spinal cord of amyotrophic lateral sclerosis patients Histochem Cell Biol 2008 Dec 19 [Epub ahead of print]
Claudia Grothe, Julia Jungnickel, Kirsten Haastert Physiological role of basic FGF in peripheral nerve development and regeneration: potential for reconstruction approaches Future Neurol 2008; 5:605-12
Sarlette A, Krampfl K, Grothe C, Neuhoff N, Dengler R, Petri S. Nuclear erythroid 2-related factor 2-antioxidative response element signaling pathway in motor cortex and spinal cord in amyotrophic lateral sclerosis J Neuropathol Exp Neurol. 2008 Nov;67(11):1055-62.
Haastert K, Ying Z, Grothe C, Gómez-Pinillabr F The effects of FGF-2 gene therapy combined with voluntary exercise on axonal regeneration across peripheral nerve gaps Neuroscience Lett. 2008 Oct 10;443(3):179-83.
Berski S, van Bergeijk J, Schwarzer D, Stark Y, Kasper C, Scheper T, Grothe C, Gerardy-Schahn R, Kirschning A, Dräger G. Synthesis and biological evaluation of a polysialic acid-based hydrogel as enzymatically degradable scaffold material for tissue engineering. Biomacromolecules. 2008 Sep;9(9):2353-9.
Knop E, Knop N, Claus P Local Production of Secretory IgA in the Eye-Associated Lymphoid Tissue (EALT) of the Normal Human Ocular Surface. Invest Ophthalmol Vis Sci. 2008; 49(6):2322-9.
Koehler NK, Roebbert M, Dehghani K, Ballmaier M, Claus P, von Hoersten S, Shing M, Odin P, Strehlau J, Heidenreich F. Up-regulation of platelet-derived growth factor by peripheral-blood leukocytes during experimental allergic encephalomyelitis. J Neurosci Res. 2008 Feb 1;86(2):392-402.
Grothe C, Claus P, Haastert K, Lutwak E, Ron D. Expression and regulation of Sef, a novel signalling inhibitor of receptor tyrosine kinases mediated signalling in the nervous system. Acta Histochem. 2008;110(2):155-62.
Lindner M, Heine S, Haastert K, Garde N, Fokuhl J, Linsmeier F, Grothe C, Baumgärtner W, Stangel M. Sequential myelin protein expression during remyelination reveals fast and efficient repair after central nervous system demyelination. Neuropathol Appl Neurobiol. 2008 Feb;34(1):105-14.
Haile Y, Berski S, Dräger G, Nobre A, Stummeyer K, Gerardy-Schahn R, Grothe C. The effect of modified polysialic acid based hydrogels on the adhesion and viability of primary neurons and glial cells. Biomaterials. 2008 Apr; 29(12):1880-91
Original papers 2007
Bridger PS, Haupt S, Klisch K, Leiser R, Tinneberg HR, Pfarrer C. Validation of primary epitheloid cell cultures isolated from bovine placental caruncles and cotyledons. Theriogenology. 2007 Sep 1; 68(4):592-603
Klisch K, Mess A Evolutionary differentiation of cetartiodactyl placentae in the light of the viviparity-driven conflict hypothesis. Placenta 2007;28(4):353-60.
Kirsten Haastert, Claudia Grothe Gene Therapy in Peripheral Nerve Reconstruction Approaches Curr Gene Ther, 2007 Jun, 7:221-228
Grothe C and Timmer M The physiological and pharmacological role of basic fibroblast growth factor in the dopaminergic nigrostriatal system. Brain Res. Rev. 2007, 54: 80-91.
Ma X, Dang X,Claus P, Hirst C, Fandrich RR, Jin Y, Grothe C, Kirshenbaum LA, Cattini PA, Kardami E. Chromation compaction and cell death by high molecular weight FGF-2 depend on ist nuclear localization, intracrine ERK activation and engagement of Mitochondria. J Cell Physiol. 2007 Dec;213(3):690-8
Haastert K., Mauritz C., Chaturvedi S. and Grothe C. Human and Rat adult Schwann cell cultures - fast and efficient enrichment plus highly effective non-viral transfection protocol. Nature Protocols, 2007, Volume 2 No.1, pp 99-104
Grosskreutz J, Haastert K, Dewil M, Van Damme P, Callewaert G, Robberecht W, Dengler R. and Van Den Bosch L. Role of mitochondria in kainate-induced fast Ca(2+) transients in cultured spinal motor neurons. Cell Calcium 2007 Jul;42(1):59-69
Timmer,M., Cesnulevicius,K., Winkler,C., Kolb,J., Lipokatic-Takacs,E., Jungnickel,J., Grothe,C. FGF-2 and FGFR3 are required for the development of the substantia nigra and FGF-2 plays a crucial role for the rescue of dopaminergic neurons after 6-OHDA lesion. J Neurosci 2007; 27: 459-471.
Haile, Y., Haastert, K., Cesnulevicius, K., Stummeyer, K., Timmer, M., Berski, S., Dräger, G., Gerardy-Schahn, R., Grothe, C. Culturing of glial and neuronal cells on polysialic acid. Biomaterials 2007; 28: 1163-1173
van Bergeijk J, Rydel-Könecke K, Grothe C, Claus P. The spinal muscular atrophy gene product regulates neurite outgrowth: importance of the C-terminus. FASEB J. 2007 May 21(7): 1492-1502.
Original papers 2006
Petri S, Kollewe K, Grothe C, Hori A, Dengler R, Bufler J, Krampfl K GABA(A)-receptor mRNA expression in the prefrontal and temporal cortex of ALS patients. J Neurol Sci. 2006 Dec 1;250(1-2):124-32
Klisch K, Boos A, Friedrich M, Herzog K, Feldmann M, Sousa NM, Beckers JF The glycosylation of pregnancy-associated glycoproteins and prolactin-related protein-I in bovine binucleate trophoblast giant cells changes before parturition. Reproduction; 2006 Nov; 132:791-798
K. Jahn, J.Grosskreutz, K.Haastert, E.Ziegler, Schlesinger, C.Grothe, R.Dengler, J.Bufler Temporospatial coupling of networked synaptic activation of ampa-type glutamate receptor channels and calcium transients in cultured motoneurons. Neuroscience 2006 Nov. 3;142(4):1019-1029
Kirsten Haastert, Nicole Semmler, Maike Wesemann, Martin Rücker, Nils-Claudius Gellrich, Claudia Grothe Establishment of co-cultures of osteoblasts, Schwann cells and neurons towards a tissue-engineered approach for orofacial reconstruction. Cell Transplant. 2006;15(8-9):733-44.
Cesnulevicius,K., Timmer,M., Wesemann,M., Thomas,T., Barkhausen,T., Grothe,C. Nucleofection is the most efficient non-viral transfection method for neuronal stem cells derived from ventral mesencephali with no changes in cell composition or dopaminergic fate. Stem Cells. 2006 Dec;24(12):2776-91.
Grothe, C., Haastert, K., Jungnickel, J. Physiological function and putative therapeutic impact of the FGF-2 system in peripheral nerve regeneration - lessons from in vivo studies in mice and rats Brain Res Rev. 2006 Aug;51(2):293-9
Berens v. Rautenfeld D., Claus P. (2006) Terminal Vascular System (Microcirculation), Interstitial Connective Tissue, Lymph Capillaries and Precollectors. In: Földi/Földi/Kubik (Ed.): Földi's Textbook of Lymphology. Elsevier, München. 2nd ed.
Weinberg A.M., Hofmann A., Claus P. (2006): Molekulare, physiologische und anatomische Grundlagen der Knochenentwicklung. In: Weinberg/Tscherne (Ed.): Tscherne Unfallchirurgie. Springer, Heidelberg.
Jungnickel J, Haase K, Konitzer J, Timmer M, Grothe C. Faster nerve regeneration after sciatic nerve injury in mice over-expressing basic fibroblast growth factor. J Neurobiol. 2006 Aug; 66(9):940-8
Haastert, K., Mauritz, C., Matthies, C., Grothe, C. Autologous adult human Schwann cells genetically modified to provide alternative cellular transplants in peripheral nerve regeneration J Neurosurg 104:778-786, 2006
Timmer, M.; Grosskreutz, J.; Schlesinger, F.; Krampfl, K.; Wesemann, M.; Just, L.; Bufler, J.; Grothe, C. Dopaminergic properties and function after grafting of attached neural precursor cultures. Neurobiol. Dis. 2006 Mar 21;(3):587-606
Haastert K., Lipokatic E., Fischer M., Timmer M., Grothe C. Differentially promoted peripheral nerve regeneration by grafted Schwann cells over-expressing different FGF-2 isoforms. Neurobiol Dis. 2006 Jan;21(1):138-53.
Jeroen van Bergeijk, Kirsten Haastert, Claudia Grothe, Peter Claus Valproic acid promotes neurite outgrowth in PC12 cells independent from regulation of the survival of motoneuron protein. Chem Biol Drug Des. 2006 Mar; 67(3): 244-7
Wesche J, Malecki J, Wiedlocha A, Skiple Skjerpen C, Claus P, Olsnes S. FGF-1 and FGF-2 require the cytosolic chaperone HSP90 for translocation into the cytosol and the cell nucleus. J Biol Chem 2006 Apr 21;281(16):11405-12
Schuler G, Teichmann U, Kowalewski MP, Hoffmann B, Fortier MA, Madore E, Klisch K Expression of cyclooxygenase II (COX-II) and 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD)/prostaglandin F-synthase (PGFS) in bovine placentomes: implications for the initiation of parturition in cattle. Placenta 2006; 27(9-10):1022-9
Fink C, Tatar M, Failing K, Hospes R, Kressin M, Klisch K Serotonin-containing cells in the gastrointestinal tract of newborn foals and adult horses. Anatomia Histologia Embryologia 2006; 35:23-27.
Carvalho AF, Klisch K, Miglino MA, Pereira FTV, Bevilacqua E Binucleate trophoblast giant cells in the water buffalo (Bubalus bubalis) placenta. Journal of Morphology 2006; 2671:50-6
Hahnen E, Eyupoglu IY, Brichta L, Haastert K, Trankle C, Siebzehnrubl FA, Riessland M, Holker I, Claus P, Romstock J, Buslei R, Wirth B, Blumcke I In vitro and ex vivo evaluation of second-generation histone deacetylase inhibitors for the treatment of spinal muscular atrophy." J Neurochem. 2006 Jul;98(1):193-202.
Original papers 2005
Petri S, Schmalbach S, Grosskreutz J, Krampfl K, Grothe C, Dengler R, Van Den Bosch L, Robberecht W, Bufler J. The cellular mRNA expression of GABA and glutamate receptors in spinal motor neurons of SOD1 mice. J Neurol Sci. 2005 Nov 15; 238(1-2):25-30 Epub 2005 Aug 8.
Jungnickel J, Klutzny A, Guhr S, Meyer K, Grothe C. Regulation of neuronal death and calcitonin gene-related peptide by fibroblast growth factor-2 and FGFR3 after peripheral nerve injury: Evidence from mouse mutants. Neuroscience. 2005;134(4):1343-50.
Haastert K., Grosskreutz J., Jaeckel M., Laderer C., Bufler J., Grothe C., Claus P. Rat embryonic motoneurons in long-term co-culture with Schwann cells - a system to investigate motoneuron diseases on a cellular level in vitro. J. Neurosci. Methods 2005; 142(2): 275-84
Berens v. Rautenfeld D., Claus P. (2005) Terminale Strombahn, interstitieller Bindegewebsraum, initiale Lymphgefäße und Präkollektoren. In: Földi/Kubik (Hrsg.): Lymphologie. Elsevier, München. 6. Aufl.
Original papers 2004
Gringel S., van Bergeijk J., Haastert K., Grothe C., Claus P. Nuclear Fibroblast Growth Factor-2 Interacts Specifically with the Splicing Factor SF3a66. Biol Chem. 2004 Dec; (12):1203-8.
C.Grothe, M.Timmer, T.Scholz, C.Winkler, G.Nikkhah, P.Claus, N.Itoh, E.Arenas Fibroblast growth factor-20 promotes the differentiation of Nurr1-overexpressing neural stem cells into tyrosine hydroxylase-positive neurons. Neurobiol. Dis. 2004,17(2):163-170.
Mauritz C, Grothe C, Haastert K. Comparative study of cell culture and purification methods to obtain highly enriched cultures of proliferating adult rat Schwann cells. J Neurosci Res. 2004 Aug 1;77(3):453-61.
Claus P, Bruns AF, Grothe C. Fibroblast growth factor-2 (23) is binding directly to the survival of motoneuron protein and is associated with small nuclear RNAs. Biochem J. 2004 Dec 15;384(Pt 3): 559-65
Petri S, Krampfl K, Hashemi F, Schmalbach S, Grothe C, Hori A, Dengler R, Bufler J. The mRNA expression of AMPA type glutamate receptors in the primary motor cortex of patients with amyotrophic lateral sclerosis: an in situ hybridization study. Neurosci Lett. 2004 Apr 29;360(3):170-4.
Timmer M, Muller-Ostermeyer F, Kloth V, Winkler C, Grothe C*CA, Nikkhah G*. Enhanced survival, reinnervation, and functional recovery of intrastriatal dopamine grafts co-transplanted with Schwann cells overexpressing high molecular weight FGF-2 isoforms. Exp Neurol. 2004 May;187(1):118-36. CA: Corresponding Author; *contributed equally
Nindl, W., Kavakebi, P., Claus, P., Grothe, C., Pfaller, K., Klimaschewski, L. Expression of basic fibroblast growth factor isoforms in postmitotic sympathetic neurons: synthesis, intracellular localization and involvement in karyokinesis. Neuroscience. 2004;124(3):561-72.
Claus, P., Werner, S., Timmer, M., Grothe, C. Expression of the fibroblast growth factor-2 isoforms and the FGF receptor 1 – 4 transcripts in the rat model system of Parkinson`s disease. Neurosci Lett. 2004 Apr 29;360(3):117-20.
Jungnickel,J., Claus,P., Gransalke, K., Timmer, M., Grothe,C. Targeted disruption of the FGF-2 gene affects the response to peripheral nerve injury. Mol. Cell. Neurosci., 2004 Mar;25(3):444-52.
Jungnickel,J., Gransalke, K., Timmer, M., Grothe,C. Fibroblast growth factor receptor 3 signaling regulates injury-related effects in the peripheral nervous system. Mol. Cell. Neurosci., 2004 Jan;25(1):21-9.
Original papers 2003
Petri, S., Krampfl, K., Hashemi, F., Grothe, C., Hori, A., Dengler, R., Bufler, J. Distribution of GABAA receptor mRNA in the motor cortex of ALS patients. J Neuropathol Exp Neurol. 2003 Oct;62(10):1041-51.
Claus,P., Döring,F., Gringel,S., Müller-Ostermeyer,F., Fuhlrott,J., Kraft,T., and Grothe,C. Differential intranuclear localization of fibroblast growth factor - 2 (FGF-2) isoforms and specific interaction with the survival of motoneuron protein (SMN) J. Biol. Chem. 2003; 278(1):479-85, [Full Text]
Timmer,M., Robben,S., Mueller-Ostermeyer,F., Nikkhah,G., Grothe,C. Axonal regeneration across long gaps in silicone chambers filled with Schwann cells over-expressing high molecular weight FGF-2 Cell Transplant. 2003; 12(3): 265-77
Kretschmann HJ, Weinrich W. Cranial Neuroimaging and Clinical Neuroanatomy. Atlas of MR Imaging and Computed Tomography. 3. Auflage. ISBN 3136726030, Stuttgart, New York: Thieme; 2003.
Original papers 2002
Plischke,M., Wolf,K.-H., Krofczik,S., Rinkwitz,S., Grothe,C., Pretschner,D.P., Seidl,K. 4D-Atlas der embryonalen Mausentwicklung. Proc. of Workshop Bildverarbeitung in der Medizin, 295-298, 2002.
Streppel,M., Azzolin,N., Dohm,S., Guntinas-Lichius,O., Tomov,T.L., Haas,C., Grothe,C., Wevers,A., Neiss,W.F., Angelov,D.N. Focal application of neutralizing antibodies to soluble neurotrophic factors improves the quality of axonal pathfinding after peripheral nerve lesion. Eur. J. Neurosci. 15, 1327-1342, 2002.
Guntinas-Lichius, O., Wewetzer, K., Tomov, T.L., Azzolin, N., Kazemi, S.H., Streppel, M., Neiss, W.F., Angelov, D.N. Transplantation of olfactory mucosa minimizes the axonal branching and promotes the recovery of vibrissae motor performance after facial nerve repair in rats. J. Neurosci. 15: 7121-7131, 2002.
Jedrusik M.A., Vogt S., Claus P., Schulze E. A novel type of linker histone is a cytoplasmic filament associated protein in Caenorhabditis elegans. J. Cell Sci. 115: 2881-2891, 2002.
Kretschmann HJ, Weinrich W. Klinische Neuroanatomie und kranielle Bilddiagnostik Atlas der Computertomographie und Magnetresonanztomographie 3. Auflage. ISBN 3136152034, 2002.
Wewetzer, K., Verdu, E., Angelov, D.N., Navarro, X. Olfactory ensheathing glia and Schwann cells: two of a kind? Cell Tissue Res. 309:337-345, 2002.
Original papers 2001
Üner A., Weinberg A.-M., Poulsen Nautrup C., Kassianoff I., Lüdemann W., Schier F., Claus P., Berens v. Rautenfeld D. Spontaneous lymphvascular reanastomosis between lymphatic vessels following syngeneic transplantation of the small intestine in rat. Surg. Radiol. Anat. 23: 383-387, 2001.
Wewetzer, K., Dilmaghani, K. Exposure to dimethyl sulfoxide at 37°C prior to freezing significantly improves the recovery of cryopreserved hybridoma cells. Cryobiology 43, 288-92, 2001.
Müller-Ostermeyer F*., Claus P*., Grothe C. Distinctive effects of rat fibroblast growth factor-2 isoforms on PC12 and Schwann cells. Growth factors, 19: 175-191, 2001. [* These authors contributed equally to this work].
Wewetzer,K., Grothe, C. Claus, P. In vitro expression and regulation of ciliary neurotrophic factor and its alpha-receptor unit in neonatal rat olfactory ensheathing cells. Neurosci. Lett. 306, 165-168, 2001.
Klinge, P.M., Groos, S., Wewetzer, K., Haastert, K., Rosahl, S., Vafa, M.A., Hosseini, H., Samii, M. Brinker, T. Regeneration of a transected peripheral nerve by transplantation of spinal cord encapsulated in a vein. NeuroReport 12, 1271-1275, 2001.
Guntinas-Lichius, O., Angelov, D.N., Tomov, T.L., Dramiga, J., Neiss, W.F., Wewetzer, K. Transplantation of olfactory ensheathing cells stimulates the collateral sprouting from axotomized adult rat facial motoneurons. Exp. Neurol. 172, 70-80, 2001.
Klinge, P., Vafa, M.A., B., Brinker, T., Brandis, A., Walter, G.F., Stieglitz, T., Samii, M., Wewetzer, K. Immunohistochemical characterization of axonal sprouting and reactive tissue changes after long-term implantation of a polyimide sieve electrode to the transected adult rat sciatic nerve. Biomaterials 22, 2333-2343, 2001.
Claus,P. and Grothe,C. Molecular cloning and developmental expression of rat fibroblast growth factor receptor 3. Histochem. Cell Biol. 115, 147-155, 2001.
Grothe,C., Meisinger,C. and Claus,P. In vivo expression and localization of the fibroblast growth factor system in the intact and lesioned rat peripheral nerve and spinal ganglia. J. Comp. Neurol. 434, 342-357, 2001.
Grothe,C. and Nikkhah,G. The role of basic fibroblast growth factor (FGF-2) in peripheral nerve regeneration. Anat. Embryol., 204, 171-177, 2001.
Original papers 2000
Böhlandt, S., von Kaisersberg, C.S., Wewetzer, K., Christ, B., Nicolaides, K.H., Brand-Saberi, B. Hyaluronan in the nuchal skin of chromosomally abnormal fetuses. Hum.Reprod. 15, 1155-1158, 2000.
Grothe,C., Heese,K., Meisinger,C., Wewetzer,K., Kunz,D., Cattini,P. and Otten,W. Expression of interleukin-6 and its receptor in sciatic nerve and Schwann cells: relation to 18kD fibroblast growth factor-2. Brain Res. 885, 172-181, 2000.
Grothe,C., Schulze,A., Semkova,I., Müller-Ostermeyer,F, Rege,A., Wewetzer,K. The high molecular weight FGF-2 isoforms (21,000 mol.wt and 23,000 mol.wt) mediate neurotrophic activity on rat embryonic mesencephalic dopaminergic neurons in vitro. Neuroscience 100, 73-86, 2000.
Original papers 1999
Wewetzer, K., Lausch, M., Christ, B. Macrowell cultures identify a subpopulation of neonatal rat dorsal root ganglionic neurons displaying NGF-idependent survival. Neurosci. Lett. 276:9-12, 1999.
Wewetzer, K., Archelos, J. J., Seilheimer, B., Hartung, H.-P., Christ, B. The monoclonal antibody 23E9 recognizes a novel developmentally regulated Schwann cell surface antigen. Int. J. Dev. Neurosci. 17: 715-725, 1999.
Klimaschewski,L., Meisinger,C., Grothe,C. Axotomy-induced regulation of FGF-2 and FGF receptors in the rat superior cervical ganglion. J. Neurobiol. 38, 499-506, 1999.
Kretschmann, H.-J. Zentralnervensystem In: Schiebler, T.H., Schmidt, W., Zilles, K. (Hrsg.) Anatomie. Achte, vollständig überarbeitete Auflage, Springer-Verlag, Berlin, Heidelberg 1999
Kretschmann, H.-J., Weinrich, W., Fresen, T., Gerke, M., Wesemann, M. Neurofunctional Systems - 3D Reconstructions with Correlated Neuroimaging CD-ROM for Microsoft Windows 95, 98 and NT, Thieme, Stuttgart, New York 1999
Grothe,C., Meisinger,C., Wewetzer,K. Fibroblast Growth Factors. In: M. Berry, A. Logan (eds.), CNS injuries. Cellular responses and pharmacological strategies. CRC Press, Boca Raton, New York, 201-218, 1999.
Original papers 1998
Wewetzer, K. Single-step cloning under microscopic control using an automated cell selection and transfer system (QuixellTM). Elsevier Trend Journals. Technical Tips Online (1998). http://tto.trends.com
Steger,K., Tetens,F., Seitz,J., Grothe,C., Bergmann,M. Localization of fibroblast growth factor 2 (FGF-2) protein and receptors FGFR 1-4 in normal human seminiferous epithelium. Histochem. Cell Biol. 110, 57-62, 1998.
Peschen,M., Grenz,H., Grothe,C., Schöpf,E., Vanscheidt,W. Patterns of epidermal growth factor receptor, basic fibroblast growth factor and transforming growth factor-ß3 expression in skin with chronic venous insufficiency. Eur. J. Dermatol. 8, 334-338, 1998.
Lausch, M., Christ, B., Wewetzer, K. Cell death of neonatal rat sensory neurons is prevented by culture at clonal density. NeuroReport 9:1735-1739, 1998.
Grothe,C., Meisinger,C., Holzschuh,J., Wewetzer,K., Cattini,P. Over-expression of the 18kD and 21/23kD fibroblast growth factor-2 isoforms in PC12 cells and Schwann cells results in altered cell morphology and growth. Mol. Brain Res. 57, 97-105, 1998.
Erck,C., Meisinger,C., Grothe,C., Seidl,K. Regulation of nerve growth factor (NGF) and its low affinity receptor (p75NGFR) during myogenic differentiation. J. Cell. Physiol. 176, 22-31, 1998.
Buhmann, C., Kretschmann, H.-J. Computer-assisted three-dimensional reconstruction of the corticospinal system as a reference for CT and MRI. Neuroradiology 1998; 40: 549-557
Kretschmann, H.-J., Weinrich, W., Fresen, T., Gerke, M., Wesemann, M. Dreidimensionale Computergraphik neurofunktioneller Systeme - Grundlagen für die neurologisch-topische Diagnostik und die kranielle Bilddiagnostik Interaktive CD-ROM für Microsoft Windows 95, 98 und NT, Thieme, Stuttgart 1998
Kretschmann, H.-J., Weinrich, W., Fiekert, W., Gerke, M., Vogt, H., Weirich, D., Wesemann, M. Neurofunctional Systems - 3D Reconstructions with Correlated Neuroimaging Thieme, Stuttgart 1998
Original papers 1997
Wisniewski J.R., Hessler K., Claus P., Zechel K. Structural and functional consequences of mutations within the hydrophobic cores of the HMG1-box domain of the insect protein cHMG1a. Eur. J. Biochem. 243: 151-159, 1997
Wewetzer,K., Grothe,C., Christ,B., Seilheimer,B. Identification and characterization of differentiation-dependent Schwann cell surface antigens by novel monoclonal antibodies: introduction of a marker common to the non-myelin-forming phenotype. Glia 19, 213-226, 1997.
Meisinger,C., Grothe,C. Differential stimulation of FGF-2 isoforms in the rat adrenal medulla during postnatal development in vivo. Brain Res. 757, 291-294, 1997.
Meisinger,C., Grothe,C. Differential regulation of FGF-2 and FGF receptor 1 mRNAs and FGF-2 isoforms in spinal ganglia and sciatic nerve after peripheral nerve lesion. J. Neurochem. 68, 1150-1158, 1997.
Huber,K., Meisinger,C., Grothe,C. Expression of fibroblast growth factor-2 in hypoglossal motoneurons is stimulated by peripheral nerve injury. J. Comp. Neurol. 382, 189-198, 1997.
Heyduk E., Heyduk T., Claus P., Wisniewski J.R. Conformational changes of DNA induced by binding of Chironomus high mobility group protein 1a: regions flanking an HMG-box domain do not influence the bend angle of the DNA. J. Biol. Chem. 272: 19763-70, 1997
Sauerbier I. Neuroanatomie In: Schumacher, G.-H. (Hrsg.), Anatomie für Zahnmediziner. Hüthig, Heidelberg 1997
Grothe,C., Meisinger,C. The multifunctionality of FGF-2 in the adrenal medulla. Anat. Embryol. 195, 103-111, 1997.
Claus, P. (1996) Primärstruktur, Expression und DNA-Interaktion eines Chromatin-Proteins der High-Mobility-Group (cHMGI). VWF Verlag für Wissenschaft und Forschung, Berlin. ISBN: 3-930324-91-1.