Contact:

Emrulla Spahiu

Tel:                        +49 511 532-2094 (office) -3654 (lab)
Fax:                       +49 511 532-161215

address:                Carl-Neuberg-Straße 1, MHH Campus,
                              Building J03, level 03, room 1320

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Career Summary

• 2020 – 2025: Dr. rer. nat. degree at Hannover Medical School (MHH)

           Thesis: Functional investigations of cardiac tissue-specific myosin and thin filaments
                        in physiological and cardiomyopathy conditions

• 2012 – 2015: Master of Science in Biology at the Middle East Technical University
• 2008 – 2012: Bachelor's degree in Biology at the Middle East Technical University

Main Research Focus

• Functional investigation of Hypertrophic Cardiomyopathy causing mutations.
• Investigation of the modulatory role of myosin light chains.

Experience:

• Recombinant protein expression and purification, cell culture, in vitro motility, western blotting, laboratory animal handling, immunofluorescence.
• Scientific illustration using Inkscape and Blender, image analysis automation using ImageJ, ChimeraX, Python, HTML.
• Teaching practical courses for human medicine and dentistry students.

Publication:

2024

• Spahiu, E., Uta, P., Kraft, T., Nayak, A., & Amrute-Nayak, M. (2024). Influence of native thin filament type on the regulation of atrial and ventricular myosin motor activity. Journal of Biological Chemistry. https://doi.org/10.1016/j.jbc.2024.107854
• Spahiu, E., Kastrati, E. & Amrute-Nayak, M. PyChelator: a Python-based Colab and web application for metal chelator calculations. BMC Bioinformatics 25, 239 (2024). https://doi.org/10.1186/s12859-024-05858-8

2022

• Wang, T., Spahiu, E., Osten, J., Behrens, F., Grünhagen, F., Scholz, T., Kraft, T., Nayak, A., Amrute-Nayak, M., 2022. Cardiac ventricular myosin and slow skeletal myosin exhibit dissimilar chemo-mechanical properties despite bearing the same myosin heavy chain isoform. Journal of Biological Chemistry 7. https://doi.org/10.1016/j.jbc.2022.102070
• Dogan, S., Spahiu, E., Cilic, A., 2022. Structural Analysis of microRNAs in Myeloid Cancer Reveals Consensus Motifs. Genes 13, 1152. https://doi.org/10.3390/genes13071152

2020

• Karatas, M., Dogan, S., Spahiu, E., Ašić, A., Bešić, L., Turan, Y., 2020. Enzyme kinetics and inhibition parameters of human leukocyte glucosylceramidase. Heliyon 6, e05191. https://doi.org/10.1016/j.heliyon.2020.e05191

Awards:

• 2024: Marcus Schaub Young Investigator Award at the 51st European Muscle Conference in Ljubljana (Slovenia)