Contact

► Dr. Tianbang Wang

Tel:  +49 511 532 -2754 (office), -3654 (lab)

Fax: +49 511 532-161215

address: 30625 Hannover, Carl-Neuberg-Str.1, Germany

Building J03, level 03, room 1330

► Profil bei ResearchGate

Career

• since 07.2018 Postdoc im Institut für Molekular- und Zellphysiologie an der Medizinischen Hochschule Hannover (MHH)
• 10.2013 to 02.2018 Promotion im Institut für Molekular- und Zellphysiologie an der Medizinischen Hochschule Hannover (MHH)

Current Research Focus

• Characterizing the mechanical and kinetic properties of β-cardiac and skeletal muscle myosin II
• In vitro studies involving modulatory roles of sub-components of motor proteins
• Single molecule analysis of mutant myosin motors implicated in human hypertrophic cardiomyopathy using optical trap and TIRF microscopy 

Expertise

• Optical trapping, TIRF Mikroskopie, Rekombinantes Protein mittels gentechnischer Methoden, Proteinherstellung und – aufreinigung.
• Matlab und Labview

Publication and Abstructs

2024

• Single-Molecule Investigation of Load-Dependent Actomyosin Dissociation Kinetics for Cardiac and Slow Skeletal Myosin, Wang T, Nayak A, Kraft T, Amrute-Nayak M., Nano Micro Small. 2024 Oct 7:e2406865.doi: 10.1002/smll.202406865. Online ahead of print., Pubmed, Journal Link

2022

• Myosin essential light chain 1sa decelerates actin and thin filament gliding on β-myosin molecules, Jennifer Osten, Maral Mohebbi, Petra Uta, Faramarz Matinmehr, Tianbang Wang, Theresia Kraft, Mamta Amrute-Nayak and Tim Scholz, J Gen Physiol . 2022 Oct 3;154(10):e202213149. doi: 10.1085/jgp.202213149. Epub 2022 Sep 2,  PubMed
   
• Cardiac ventricular myosin and slow skeletal myosin exhibit dissimilar chemomechanical properties despite bearing the same myosin heavy chain isoform, Tianbang Wang, Emrulla Spahiu, Jennifer Osten, Florentine Behrens, Fabius Grünhagen, Tim Scholz, Theresia Kraft, Arnab Nayak, Mamta Amrute-Nayak J Biol Chem . 2022 May 24;102070.  doi: 10.1016/j.jbc.2022.102070. [Online ahead of print] PubMed

2020

• Acto-Myosin Cross-Bridge Stiffness Depends on the Nucleotide State of Myosin II. Wang T, Brenner B, Nayak A, and Amrute-Nayak M. Nano Letters, 2020 Sep 15. doi: 10.1021/acs.nanolett.0c02960. [Online ahead of print] PubMed
   
• Single-molecule analysis reveals that regulatory light chains fine-tune skeletal myosin-II function, Nayak A, Wang T, Franz P, Steffen W, Chizhov I, Tsiavaliaris G, Amrute-Nayak M, J Biol Chem. 2020 Apr 9. pii: jbc.RA120.012774. doi: 10.1074/jbc.RA120.012774, PMID: 32273340, Artikel, PubMed

2019

• Mg²⁺ -free ATP regulates the processivity of native cytoplasmic dynein; Behrens VA, Walter WJ, Peters C, Wang T, Brenner B, Geeves MA, Scholz T, Steffen W.; FEBS Lett. 2019 Feb;593(3):296-307. doi: 10.1002/1873-3468.13319. Epub 2019 Jan 3.

2013

• Difference in F-actin depolymerization induced by toxin B from the Clostridium difficile strain VPI 10463 and toxin B from the variant Clostridium difficile serotype F strain 1470; May M, Wang T, Müller M, Genth H. Toxins (Basel). 2013 Jan 11;5(1):106-19. doi: 10.3390/toxins5010106.

2012

• Increased Cell-Matrix Adhesion upon Constitutive Activation of Rho Proteins by Cytotoxic Necrotizing Factors from E. Coli and Y. Pseudotuberculosis. May M, Kolbe T, Wang T, Schmidt G, Genth H. J Signal Transduct. 2012;2012:570183. doi: 10.1155/2012/570183. Epub 2012 Jul 5.