Hepatocyte Transplantation

Hepatocyte transplantation (HCTx) is a promising therapy option for the treatment of numerous inborn and acquired liver diseases. HCTx is much more cost efficient and a less invasive procedure than conventional liver transplantation. Furthermore, the method of cell transplantation enables the opportunity of pre-Tx modification of hepatocytes by technologies such as gene therapy. Unfortunately, the promising results obtained in animal models could not be successfully transferred into clinical application in man, yet. The aim of our project is to evaluate the immunological aspects of HCTx in murine and porcine models in order to establish new strategies for efficient cell transplantation with optimized long-term outcome.

Team

PD Dr. med. Oliver Beetz

PD Dr. med. Felix Oldhafer