Transplantation and Regeneration
Liver transplantation and normothermic machine perfusion Ex-vivo liver-xenoperfusion for the treatment of acute liver failure Stimulatory and inhibitory receptor/ligand interactionsStimulatory and inhibitory receptor/ligand interactions as targets for reducing human immune responses to porcine xenoantigen
Infrastructure: Primary Human Hepatocyte (MHH) / Humanized Mouse (UKE) Core Facility Hepatocyte transplantation Isolation, culture and cryopreservation of primary human hepatocytes Isolation and cultivation of primary cholangiocytes from different species Models of ischemia-/reperfusion induced cholangiopathy in small and large animal models In vivo imaging of organs via endoscopic, fiber based fluorescence and hyperspectral microscopy Longitudinal imaging and laser manipulation in vivo using an abdominal imaging window Hyperspectral imaging Sterile inflammation and innate immune responses in acute-on-chronic liver failure