Curriculum Vitae
1992
University entrance diploma Görres-Gymnasium, Düsseldorf
1992-1995
Academic studies-1 Biology (intermediate diploma) Heinrich-Heine-University, Düsseldorf
1995-1999
Academic studies-2 Veterinary medicine (state examination) University of Veterinary Medicine, Hannover
2000-2002
Doctorate. Clinic for Neurosurgery, Hannover Medical School and Institute for Pharmacology, Toxicology and Pharmacy, University of Veterinary, Title: “In vitro- und In vivo-Studien zur Zellvitalität und Motoneuronenfraktion in ektopen Neuroimplantaten aus embryonalem Rattenrückenmark in Abhängigkeit von Gewinnungsmethoden und pharmakologischen Einflüssen”
since 2002
Research Associate Institute of Neuroanatomy, Hannover Medical School
2005
Research stay (07-10 2005) Department of Physiological Science & Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, USA (Prof. Fernando Gomez-Pinilla, DFG-research grant)
2009
State doctorate Specialism Anatomy
2011
Associate Professor, Institute of Neuroanatomy, Hannover Medical School
Current research
Development of new therapeutic strategies to enhance peripheral nerve regeneration after massive substance loss
Selected Publications:
Huang, Z.*, Kankowski, S.*, Ertekin, E., Almog, M., Nevo, Z., Rochkind, S. and Haastert‐Talini, K. (2021), Modified Hyaluronic Acid-Laminin-Hydrogel as Luminal Filler for Clinically Approved Hollow Nerve Guides in a Rat Critical Defect Size Model Int. J. Mol. Sci. 2021, 22(12), 6554; https://doi.org/10.3390/ijms22126554 "We acknowledge support by the German Research Foundation (DFG) and the Open Access Publication Fund of Hannover Medical School (MHH)“
Ronchi G., Gambarotta G., Morano M., Fregnan F., Pugliese P., Tos P., Geuna S., Haastert-Talini K. (2020). Short communication: Critical analysis of the value of the rabbit median nerve model for biomedical research on peripheral nerve grafts. J Tissue Eng Regen Med. 2020. https://doi.org/10.1002/term.3036
Dietzmeyer N., Huang Z., Schüning T., Rochkind S., Almog M., Nevo Z., Lieke T., Kankowski S., Haastert-Talini K. (2020) In Vivo and In Vitro Evaluation of a Novel Hyaluronic Acid–Laminin Hydrogel as Luminal Filler and Carrier System for Genetically Engineered Schwann Cells in Critical Gap Length Tubular Peripheral Nerve Graft in Rats. Cell Transplantation, 2020, Volume 29: 1–20. DOI: 10.1177/0963689720910095
Dietzmeyer N, Förthmann M, Leonhard J, Helmecke O, Brandenberger C., Freier T, Haastert-Talini K (2019): Two-Chambered Chitosan Nerve Guides With Increased Bendability Support Recovery Of Skilled Forelimb Reaching Similar To Autologous Nerve Grafts In The Rat 10 mm Median Nerve Injury And Repair Model. Front. Cell. Neurosci. 10 May 2019. doi: 10.3389/fncel.2019.00149 We acknowledge support by the German Research Foundation (DFG) and the Open Access Publication Fund of Hannover Medical School (MHH).
Stößel M, Wildhagen VM, Helmecke O, Metzen J, Pfund CB, Freier T, Haastert-Talini K (2018): Comparative evaluation of chitosan nerve guides with regular or increased bendability for acute and delayed peripheral nerve repair – a comprehensive comparison with autologous nerve grafts and muscle-in-vein grafts. Anat Rec (Hoboken). 301:1697-1713, 2018. doi: 10.1002/ar.23847. doi.org/10.1002/ar.23847
Stößel M, Rehra L, Haastert-Talini K (2017): Reflex-based grasping, skilled forelimb reaching, and electrodiagnostic evaluation for comprehensive analysis of functional recovery – the 7 mm rat median nerve gap repair model revisited. Brain and Behavior 2017 DOI: 10.1002/brb3.813 onlinelibrary.wiley.com/doi/10.1002/brb3.813/epdf
Stenberg L*, Stößel M*, Ronchi G, Geuna S, Yin Y, Mommert S, Martensson L, Metzen J, Grothe C, Dahlin LB*, Haastert-Talini K* (2017): Regeneration of long-distance peripheral nerve defects after delayed reconstruction in healthy and diabetic rats is supported by immunomodulatory chitosan nerve guides. *Contributed equally, BMC Neurosci (2017) 18:53; DOI 10.1186/s12868-017-0374-z rdcu.be/uhr1
Meyer C*, Stenberg L*, Gonzalez-Perez F*, Wrobel S, Ronchi G, Udina E, Suganuma S, Geuna S, Navarro X, Dahlin LB, Grothe C, Haastert-Talini K (2016): Chitosan-film enhanced chitosan nerve guides for long-distance regeneration of peripheral nerves. Biomaterials. 2016 Jan;76:33-51. doi: 10.1016/j.biomaterials.2015.10.040., authors.elsevier.com/a/1RxprWWN0R~xz
Wrobel, S., Serra, S.C., Ribeiro-Samy, S., Sousa, N., Heimann, C., Barwig, C., Grothe, C., Salgado, A.J., Haastert-Talini, K. (2014): In vitro cell-seeded chitosan films for peripheral nerve tissue engineering. Tissue Engineering Part A 20(17-18):2339-49.
Haastert-Talini, K., Geuna, S., Dahlin, L. B., Meyer, C., Stenberg, L., Freier, T., Heimann, C., Barwig, C., Pinto, L. F.V., Raimondo, S., Gambarotta, G., Samy, S. R., Sousa, N., Salgado, A. J., Ratzka, A., Wrobel, S., Grothe, C. (2013): Chitosan tubes of varying degrees of acetylation for bridging peripheral nerve defects. Biomaterials 34(38):9886-904
Schmitte R, Tipold A, Stein VM, Schenk H, Flieshardt C, Grothe C, Haastert K (2010): Genetically modified canine Schwann cells - in vitro and in vivo evaluation of their suitability for peripheral nerve tissue engineering. J Neurosci Methods 2010 Feb;186(2):202-208
Haastert K, Mauritz C, Chaturvedi S, Grothe C (2007): Adult human and rat Schwann cell cultures - fast and efficient enrichment and highly effective non-viral transfection protocol. Nature Protocols 2 (1), 99-104.
Books and Book Chapters:
Haastert-Talini, Kirsten, Assmus, Hans, Antoniadis, Gregor (Eds.): Modern Concepts of Peripheral Nerve Repair. Springer-Verlag GmbH, Heidelberg, 2017 http://www.springer.com/de/book/9783319523187
Ahmet Bozkurt, Kirsten Haastert-Talini (2014) Kapitel 10: Bioartifizielle Nervenimplantate und alternative Rekonstruktionsverfahren. In: Nervenchirurgie: Trauma, Tumor, Kompression (Kretschmer, Antoniadis, Assmus,eds), Springer Verlag Berlin Heidelberg http://www.springer.com/de/book/9783642368943#otherversion=9783642368950
Stefano Geuna, Kirsten Haastert-Talini, Xavier Navarro (2013) Chapter 4-1: The Nerve Trunk in Injury and During Regeneration. In: Current Treatment of Nerve Injuries and Disorders (Dahlin LB, Leblebicioglu G, eds), Federation of European Societies for Surgery of the Hand, Instructional Courses 2013, Palme Publications
Kirsten Haastert-Talini (2012) Chapter 17: Culture and proliferation of highly purified Schwann cells from rat, dog and man. Methods Mol Biol 2012; 846:189-200. http://www.springer.com/de/book/9781617795350
Kirsten Haastert-Talini (2011) Chapter 10: Experimental Approaches on Tissue engineering Repair of Peripheral Nerve Gaps. In: The Sciatic Nerve: Blocks, Injuries and Regeneration (Fonseca DJ, Martins JL, eds); Series: Neuroscience Research Progress: Nove Science Publishers Link
Contact
Prof. Dr. med. vet. Kirsten Haastert-Talini
Institute of Neuroanatomy and Cell Biology, OE 4140
Building I3, Level H, Room 3110
Hannover Medical School
Carl-Neuberg-Str. 1
30625 Hannover, Germany
Phone: +49-511-532-2891
Fax: +49-511-532-2880
Mail: Haastert-Talini.Kirsten@mh-hannover.de