• Lebenslauf

Familienstand            verheiratet, zwei Kinder

seit 09/2008

Direktor des Instituts für Biometrie an der Medizinischen Hochschule Hannover

seit 01/2019

Europäischer Experte in der „Drafting Group for ICH-E20“ des International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH)

seit 01/2007

Deutscher Vertreter in der Scientific Advice Working Party (SAWP) des Committee for Medicinal Products for Human Use (CHMP)

04/2015 - 11/2017

Europäischer Experte in der "Drafting Group for ICH-E17" des International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH)

10/2010 - 10/2018

Mitglied und (ab Dezember 2015) Vorsitzender des Wissenschaftlichen Beirats des Instituts für Qualität und Wirtschaftlichkeit im Gesundheitswesen (IQWIG)

09/2009 – 09/2018

Mitglied der Biostatistics Working Party (BSWP) des Committee for Medicinal Products for Human Use (CHMP)

04/1999 - 09/2008

Wissenschaftlicher Angestellter im Bundesinstitut für Arzneimittel und Medizinprodukte (BfArM); seit 2001 Leiter des Fachgebietes Biostatistik und Versuchsplanung; seit 2005 Leiter des Fachgebiets Biometrie, Biostatistik, Bioäquivalenz, Biowaver und Bioverfügbarkeit

07/1994

Promotion zum Dr. sc. hum. im Fach Medizinische Biometrie an der Universität Heidelberg

10/1991 - 04/1999

Wissenschaftlicher Angestellter im Institut für Medizinische Biometrie und Informatik der Universität Heidelberg

10/1988 - 09/1991

Geprüfte wissenschaftliche Hilfskraft in der Abteilung Biostatistik am Deutschen Krebsforschungszentrum in Heidelberg

11/1987 - 04/1989

Wissenschaftliche Hilfskraft in der Abteilung Biostatistik am Deutschen Krebsforschungszentrum in Heidelberg

09/1984 - 04/1988

Wissenschaftliche Hilfskraft in der Abteilung Biostatistik am Deutschen Krebsforschungszentrum in Heidelberg

09/1980 - 07/1988

Studium Mathematik und Chemie, zunächst Lehramt, dann mit Abschluss Diplom an der Universität Heidelberg

• Buchbeiträge/Zeitschriftenaufsätze

Liu, Xiaofei, Norbert Benda, Clemens Mittmann, and Armin Koch. 2024. “Combining Recurrent and Terminal Events Into a Composite Endpoint May Be Problematic.” Statistics in Biopharmaceutical Research 1–8. doi: 10.1080/19466315.2024.2395404.

Cerreta, Francesca, Ewa Balkowiec Iskra, Amelia Cupelli, Bruno Sepodes, Elina Rönnemaa, Mário Miguel Rosa, Sabine Mayrhofer, Martine Trauffler, Carla Torre, Michael Berntgen, Katarina Vucic, Priya Bahri, Armin Koch, Maria Teresa Herdeiro, Nikica Mirošević Skvrce, Julia Pallos, and Andrea Laslop. 2024. “Medicines for an Aging Population: The EMA Perspective and Policies.” Journal of the American Geriatrics Society 72(9):2921–27. doi: 10.1111/jgs.18953.

Hofner, Benjamin, Elina Asikanius, Wolfgang Jacquet, Theodor Framke, Katrien Oude Rengerink, Lukas Aguirre Dávila, Maria Grünewald, Florian Klinglmüller, Martin Posch, Finbarr P. Leacy, Thomas Lang, Armin Koch, Jörg Zinserling, and Kit Roesextra. 2023. “Vaccine Development during a Pandemic: General Lessons for Clinical Trial Design.” Statistics in Biopharmaceutical Research 1–13. doi: 10.1080/19466315.2023.2211538.

David, Sascha, Christian Bode, Klaus Stahl, Julius Schmidt, Benjamin Seeliger, Thorben Pape, Bernhard Schmidt, Marius M. Hoeper, Heiner Wedemeyer, Tobias Welte, Kai Schmidt-Ott, Pedro David Wendel Garcia, Daniel A. Hofmänner, Rea Andermatt, Reto Schuepbach, Andriyana Bankova, Hans Joerg Gillmann, Thomas Stueber, Carolin Jung, Andre Gerdes, Christian Putensen, Andrea Sauer, Lennart Wild, Felix Lehmann, Markus A. Weigand, Christian Nusshag, Judith Schenz, Sebastian O. Decker, Mascha O. Fiedler, Florian Uhle, Michael Bauer, Julia Leonhardt, Frank Bloos, Silke Rummler, Philipp Enghard, Abakar Magomedov, Daniel Zickler, Julius Kunz, Jochen Dutzmann, Alexander Vogt, Matthias Girndt, Silke Markau, Mathias Kochanek, Jan Hendrik Naendrup, Alexander Zarbock, Melanie Meersch, Thilo von Groote, Mahan Sadjadi, Carola Wempe, Steffen Mitzner, Markus Heim, Stefanie Pilge, Nicolas Bubendorfer, Gerhard Schneider, Tobias Lahmer, Sebastian Rasch, Thorsten Brenner, Marc M. Berger, Jens Brands, Florian Espeter, Julius Freytag, Stefan Kluge, Dominik Jarczak, Axel Nierhaus, Jan T. Kielstein, M. Winkler, Thomas Fühner, Jan Schmieszek, Jan Menne, Martin Sauer, Georg Richter, Ingmar Lautenschläger, David Radke, Ansgar Reising, Alexander Keil, Joern Bramstedt, Mustafa Fahham, Carsten Willam, Larissa Herbst, Karl Bihlmaier, Christoph Buettner, Peter Schellongowski, Elisabeth Lobmeyr-Längle, Gürgkan Sengölge, Thomas Staudinger, Joerg C. Schefold, Philipp Venetz, Jan Waskowski, Carmen A. Pfortmueller, Michael Joannidis, Gert Mayer, Romuald Bellmann, Armin Koch, and Xiaofei Liu. 2023. “EXCHANGE-2: Investigating the Efficacy of Add-on Plasma Exchange as an Adjunctive Strategy against Septic Shock—a Study Protocol for a Randomized, Prospective, Multicenter, Open-Label, Controlled, Parallel-Group Trial.” Trials 24(1):277. doi: 10.1186/s13063-023-07300-5.

Häckl, Sebastian, Armin Koch, and Florian Lasch. 2023. “Type-I-Error Rate Inflation in Mixed Models for Repeated Measures Caused by Ambiguous or Incomplete Model Specifications.” Pharmaceutical Statistics 22(6):1046–61. doi: 10.1002/pst.2328.

Müller-Vahl, Kirsten R., Anna Pisarenko, Natalia Szejko, Martina Haas, Carolin Fremer, Ewgeni Jakubovski, Richard Musil, Alexander Münchau, Irene Neuner, Daniel Huys, Ludger Tebartz van Elst, Christoph Schröder, Rieke Ringlstetter, Armin Koch, Eva Beate Jenz, and Anika Großhennig. 2023. “CANNA-TICS: Efficacy and Safety of Oral Treatment with Nabiximols in Adults with Chronic Tic Disorders – Results of a Prospective, Multicenter, Randomized, Double-Blind, Placebo Controlled, Phase IIIb Superiority Study.” Psychiatry Research 323. doi: 10.1016/j.psychres.2023.115135

Sievering, Esther Mw, Anika Grosshennig, Martina Kottas, Johanna Ernst, Rieke Ringlstetter, Armin Koch, Karin Weissenborn, and Gerrit M. Grosse. 2023. “Diagnostic Value of Carotid Intima-Media Thickness and Clinical Risk Scores in Determining Etiology of Ischemic Stroke.” European Stroke Journal 8(3):738–46. doi: 10.1177/23969873231182492.

Bavendiek, Udo, Anika Großhennig, Johannes Schwab, Dominik Berliner, Xiaofei Liu, Lars Maier, Thomas Gaspar, Andreas Rieth, Sebastian Philipp, Rainer Hambrecht, Ralf Westenfeld, Thomas Münzel, Sebastian Winkler, Martin Hülsmann, Dirk Westermann, Marja Zdravkovic, Ralf Lichtinghagen, Heiko von der Leyen, Silke Zimmermann, Christian Veltmann, Michael Böhm, Stefan Störk, Armin Koch, and Johann Bauersachs. 2023. “Simple and Safe Digitoxin Dosing in Heart Failure Based on Data from the DIGIT-HF Trial.” Clinical Research in Cardiology 112(8):1096–1107. doi: 10.1007/s00392-023-02199-z.

Großhennig, Anika, Nele Henrike Thomas, Werner Brannath, and Armin Koch. 2023. “How to Avoid Concerns with the Interpretation of Two Primary Endpoints If Significant Superiority in One Is Sufficient for Formal Proof of Efficacy.” Pharmaceutical Statistics. doi: 10.1002/pst.2314.

Großhennig, Anika, Sören Wiesner, Juliane Hellfritsch, Ulrich Thome, Matthias Knüpfer, Corinna Peter, Martin Metzelder, Christoph Binder, Ulrike Wanz, Christina Flucher, Björn O. Brands, Andreas Mollweide, Barbara Ludwikowski, Anna Koluch, Simon Scherer, Christian Gille, Till Martin Theilen, Ulrich Rochwalsky, Christian Karpinski, Annekatrin Schulze, Tobias Schuster, Florian Weber, Guido Seitz, Jens Gesche, Matthias Nissen, Maximilian Jäger, Armin Koch, Benno Ure, Omid Madadi-Sanjani, and Martin Lacher. 2023. “MUC-FIRE: Study Protocol for a Randomized Multicenter Open-Label Controlled Trial to Show That MUCous FIstula REfeeding Reduces the Time from Enterostomy Closure to Full Enteral Feeds.” Contemporary Clinical Trials Communications 32:101096. doi: 10.1016/j.conctc.2023.101096.

Müller-Vahl, Kirsten R., Ewgeni Jakubovski, Carolin Fremer, Martina Lenz-Ziegenbein, Anika Großhennig, Carolin Klages, Armin Koch, Martina Haas, and Anna Pisarenko. 2022. “Implications for Blinding in Clinical Trials with THC-Containing Cannabinoids Based on the CANNA-TICS Trial.” Frontiers in Neuroscience 16. doi: 10.3389/fnins.2022.793703.

Gwinner, Wilfried, Annika Karch, Jan H. Braesen, Abedalrazag A. Khalifa, Jochen Metzger, Maarten Naesens, Elisabet van Loon, Dany Anglicheau, Pierre Marquet, Klemens Budde, Mareen Matz, Wolfgang Arns, Michael Fischereder, Antje Habicht, Ute Eisenberger, Anja Mühlfeld, Martin Busch, Michael Wiesener, Irina Scheffner, and Armin Koch. 2022. “Noninvasive Diagnosis of Acute Rejection in Renal Transplant Patients Using Mass Spectrometric Analysis of Urine Samples: A Multicenter Diagnostic Phase III Trial.” Transplantation Direct 8(5):E1316. doi: 10.1097/TXD.0000000000001316.

Haas, Martina, Ewgeni Jakubovski, Katja Kunert, Carolin Fremer, Nadine Buddensiek, Sebastian Häckl, Martina Lenz-Ziegenbein, Richard Musil, Veit Roessner, Alexander Münchau, Irene Neuner, Armin Koch, and Kirsten Müller-Vahl. 2022. “ONLINE-TICS: Internet-Delivered Behavioral Treatment for Patients with Chronic Tic Disorders.” Journal of Clinical Medicine 11(1):250. doi: 10.3390/jcm11010250.

Haufe, Sven, Hedwig Theda Boeck, Sebastian Häckl, Johanna Boyen, Momme Kück, Clara Catharina van Rhee, Johann-Matthias Graf von der Schulenburg, Jan Zeidler, Torben Schmidt, Heiko Johannsen, Dennis Holzwart, Armin Koch, and Uwe Tegtbur. 2022. “Impact of Electrically Assisted Bicycles on Physical Activity and Traffic Accident Risk: A Prospective Observational Study.” BMJ Open Sport & Exercise Medicine 8(4):e001275. doi: 10.1136/bmjsem-2021-001275.

Burger, Hans Ulrich, Christoph Gerlinger, Chris Harbron, Armin Koch, Martin Posch, Justine Rochon, and Anja Schiel. 2021. “The Use of External Controls: To What Extent Can It Currently Be Recommended?” Pharmaceutical Statistics (January):pst.2120. doi: 10.1002/pst.2120.

Lasch, Florian, Lorenzo Guizzaro, Armin Koch, and Lukas Aguirre Dávila. 2021. “Potential Impact of COVID-19 on Ongoing Clinical Trials : A Simulation Study with the Neurological Yale Global Tic Severity Scale Based on the CANNA-TICS Study.” Pharmaceutical Statistics (January):1–17. doi: 10.1002/pst.2100.

Jakubovski, Ewgeni, Anna Pisarenko, Carolin Fremer, Martina Haas, Marcus May, Carsten Schumacher, Christoph Schindler, Sebastian Häckl, Lukas Aguirre Davila, Armin Koch, Alexander Brunnauer, Camelia Lucia Cimpianu, Beat Lutz, Laura Bindila, and Kirsten Müller-Vahl. 2020. “The CANNA-TICS Study Protocol: A Randomized Multi-Center Double-Blind Placebo Controlled Trial to Demonstrate the Efficacy and Safety of Nabiximols in the Treatment of Adults With Chronic Tic Disorders.” Frontiers in Psychiatry 11. doi: 10.3389/fpsyt.2020.575826.

Großhennig, Anika, and Armin Koch. 2020. “COVID-19 Hits a Trial: Arguments against Hastily Deviating from the Plan.” Contemporary Clinical Trials 98. doi: 10.1016/j.cct.2020.106155.Aguirre Dávila, Lukas, Armin Koch, and Florian Lasch. 2020. “Randomization versus Real-World Evidence.” New England Journal of Medicine 383(4):e21. doi: 10.1056/nejmc2020020.

Cornberg, Markus, Sven Pischke, Tobias Müller, Patrick Behrendt, Felix Piecha, Julia Benckert, Daniel Todt, Eike Steinmann, Armin Papkalla, Maria von Karpowitz, Armin Koch, Ansgar Lohse, Svenja Hardtke, Michael P. Manns, and Heiner Wedemeyer. 2020. “Sofosbuvir Monotherapy Fails to Achieve HEV RNA Elimination in Patients with Chronic Hepatitis E – The HepNet SofE Pilot Study.” Journal of Hepatology 73(3):696–99.

Lasch, Florian, Annika Karch, Armin Koch, Thorsten Derlin, Andreas Voskrebenzev, Tawfik Moher Alsady, Marius M. Hoeper, Henning Gall, Fritz Roller, Sebastian Harth, Dagmar Steiner, Gabriele Krombach, Hossein Ardeschir Ghofrani, Fabian Rengier, Claus Peter Heußel, Ekkehard Grünig, Dietrich Beitzke, Marcus Hacker, Irene M. Lang, Jürgen Behr, Peter Bartenstein, Julien Dinkel, Kai-Helge Schmidt, Karl-Friedrich Kreitner, Thomas Frauenfelder, Silvia Ulrich, Okka W. Hamer, Michael Pfeifer, Christopher S. Johns, David G. Kiely, Andrew James Swift, Jim Wild, and Jens Vogel-Claussen. 2020. “Comparison of MRI and VQ-SPECT as a Screening Test for Patients With Suspected CTEPH: CHANGE-MRI Study Design and Rationale.” Frontiers in Cardiovascular Medicine 7:51. .doi: 10.3389/fcvm.2020.00051

Pellicer, Adelina, Ramón Fernández, Vincent Jullien, Clare Gleeson, María Carmen Bravo, Paloma López Ortego, Laura Sánchez, Marta Ybarra, Héctor Rojas-Anaya, Fernando Cabañas, Armin Koch, Andrea Smith, Heike Rabe, Philip Amess, Neil Aiton, David Crook, Ramon Fernandez-Alvarez, Liam Mahoney, Heike Rabe, Rebecca Ramsay, Héctor Rojas-Anaya, Sonia Sobowiec Kouman, Vincent Jullien, Thomas Le Saux, Gerard Pons, Sarah Zohar, Frank Biertz, Marjan Brinkhaus, Armin Koch, Andrea Smith, Yvonne Ziert, Jon Lopez Heredia, Maria Cruz Lopez Herrera, Victoria Mielgo, Wolfgang Göpel, Christoph Härtel, Charalampos Kotidis, Mark Turner, Michael Weindling, Claudia Roll, Maria del Carmen Bravo, Fernando Cabañas, Paloma López-Ortego, Marta Pavía, Adelina Pellicer, Clare Gleeson, Simon Bryson, Melinda Matyas, Gabriela Zaharie, Géza Bokodi, Miklós Szabó, Tibor Ertl, Simone Funke, Ebru Ergenekon, Kivilcim Gücüyener, Ebnem Soysal, and Christiane Dammann. 2020. “Pharmacokinetic Study (Phase I−II) of a New Dobutamine Formulation in Preterm Infants Immediately after Birth.” Pediatric Research. doi: 10.1038/s41390-020-1009-0.

Plaass, Christian, Annika Karch, Armin Koch, Vivien Wiederhoeft, Sarah Ettinger, Leif Claassen, Kiriakos Daniilidis, Daiwei Yao, and Christina Stukenborg-Colsman. 2020. “Short Term Results of Dynamic Splinting for Hallux Valgus — A Prospective Randomized Study.” Foot and Ankle Surgery 26(2):146–50. doi: 10.1016/j.fas.2019.01.002.Scheper, Verena, Melanie Schmidtheisler, Florian Lasch, Heiko Von Der Leyen, Armin Koch, Jana Schwieger, Andreas Büchner, Anke Lesinski-Schiedat, and Thomas Lenarz. 2020. “Randomized Placebo-Controlled Clinical Trial Investigating the Effect of Antioxidants and a Vasodilator on Overall Safety and Residual Hearing Preservation in Cochlear Implant Patients.” Trials 21(1). doi: 10.1186/s13063-020-04522-9.

Solbach, Philipp, Patrick Chhatwal, Sabrina Woltemate, Evelina Tacconelli, Michael Buhl, Ingo B. Autenrieth, Maria J. G. T. Vehreschild, Nathalie Jazmati, Markus Gerhard, Christoph K. Stein-Thoeringer, Jan Rupp, Kurt Ulm, Armin Ott, Florian Lasch, Armin Koch, Michael P. Manns, Sebastian Suerbaum, and Oliver Bachmann. 2020. “Microbiota-Associated Risk Factors for C. Difficile Acquisition in Hospitalized Patients: A Prospective, Multicentric Study.” Clinical Infectious Diseases. doi: 10.1093/cid/ciaa871.

Trudzinski, Franziska C., Mohamad Alqudrah, Albert Omlor, Stephen Zewinger, Danilo Fliser, Timotheus Speer, Frederik Seiler, Frank Biertz, Armin Koch, Claus Vogelmeier, Tobias Welte, Henrik Watz, Benjamin Waschki, Sebastian Fähndrich, Rudolf Jörres, and Robert Bals. 2019. “Consequences of Chronic Kidney Disease in Chronic Obstructive Pulmonary Disease.” Respiratory Research 20(1).  doi: 10.1186/s12931-019-1107-x.

Häckl, Sebastian, Armin Koch, and Florian Lasch. 2019. “Empirical Evaluation of the Implementation of the EMA Guideline on Missing Data in Confirmatory Clinical Trials: Specification of Mixed Models for Longitudinal Data in Study Protocols.” Pharmaceutical Statistics 18(6):636–44. doi: 10.1002/pst.1964. 

Bavendiek, Udo, Dominik Berliner, Lukas Aguirre Dávila, Johannes Schwab, Lars Maier, Sebastian A. Philipp, Andreas Rieth, Ralf Westenfeld, Christopher Piorkowski, Kristina Weber, Anja Hänselmann, Maximiliane Oldhafer, Sven Schallhorn, Heiko von der Leyen, Christoph Schröder, Christian Veltmann, Stefan Störk, Michael Böhm, Armin Koch, Johann Bauersachs, Udo Bavendiek, Johann Bauersachs, Armin Koch, Heiko von der Leyen, Christian Veltmann, Michael Böhm, Stefan Störk, Ulrich Tebbe, Stephan von Haehling, Markus Haass, Stefan Anker, Paul Mohacsi, Gerhard Pölzl, Helmut Trampisch, Lukas Aguirre Dávila, Kristina Weber, Silke Zimmermann, and Barbara Neuhaus. 2019. “Rationale and Design of the DIGIT-HF Trial (DIGitoxin to Improve OuTcomes in Patients with Advanced Chronic Heart Failure): A Randomized, Double-Blind, Placebo-Controlled Study.” European Journal of Heart Failure 21(5):676–84. doi: 10.1002/ejhf.1452.

Heusser, Karsten, Jens Tank, Olaf Holz, Marcus May, Julia Brinkmann, Stefan Engeli, André Diedrich, Theodor Framke, Armin Koch, Anika Großhennig, A. H. Jan Danser, Fred C. G. J. Sweep, Christoph Schindler, Katharina Schwarz, Norbert Krug, Jens Jordan, and Jens M. Hohlfeld. 2019. “Ultrafine Particles and Ozone Perturb Norepinephrine Clearance Rather than Centrally Generated Sympathetic Activity in Humans.” Scientific Reports 9(1). doi: 10.1038/s41598-019-40343-w.

Lasch, Florian, Kristina Weber, and Armin Koch. 2019. “Commentary: On the Levels of Patient Selection in Registry-Based Randomized Controlled Trials.” Trials 20(1). doi: 10.1186/s13063-019-3214-x. 

Weber, Kristina, Rob Hemmings, and Armin Koch. 2018. “How to Use Prior Knowledge and Still Give New Data a Chance?” Pp. 329–41 in Pharmaceutical Statistics. Vol. 17. John Wiley and Sons Ltd.

Weber, Kristina, Florian Lasch, and Armin Koch. 2018. “New Research Strategy with Ambiguous Implications: A Comment on ‘Planning Future Studies Based on the Conditional Power of a Meta-Analysis.’” Statistics in Medicine 37(8):1402–4.

Hasdemir, Davut B., Lukas Aguirre Dávila, Nora Schweitzer, Bernhard C. Meyer, Armin Koch, Arndt Vogel, Frank Wacker, and Thomas Rodt. 2017. “Evaluation of CT Vascularization Patterns for Survival Prognosis in Patients with Hepatocellular Carcinoma Treated by Conventional TACE.” Diagnostic and Interventional Radiology 23(3):217–22.  DOI: 10.5152/dir.2016.16006

Hasford, Joerg, and Armin Koch. 2017. “Ethische Aspekte Der Klinischen Prüfung Bei Seltenen Erkrankungen.” Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 60(5):556–62. doi: 10.1007/s00103-017-2537-6.

Lasch, Florian, Kristina Weber, Mwe Mwe Chao, and Armin Koch. 2017. “A Plea to Provide Best Evidence in Trials under Sample-Size Restrictions: The Example of Pioglitazone to Resolve Leukoplakia and Erythroplakia in Fanconi Anemia Patients.” Orphanet Journal of Rare Diseases 12(1). doi: 10.1186/s13023-017-0655-8.

Karl, Florian M., Rolf Holle, Robert Bals, Timm Greulich, Rudolf A. Jörres, Annika Karch, Armin Koch, Stefan Karrasch, Reiner Leidl, Holger Schulz, Claus Vogelmeier, and Margarethe E. Wacker. 2017. “Costs and Health-Related Quality of Life in Alpha-1-Antitrypsin Deficient COPD Patients.” Respiratory Research 18(1). doi: 10.1186/s12931-017-0543-8.

Houben-Wilke, Sarah, Rudolf A. Jörres, Robert Bals, Frits M. E. Franssen, Sven Gläser, Rolf Holle, Annika Karch, Armin Koch, Helgo Magnussen, Anne Obst, Holger Schulz, Martijn A. Spruit, Margarethe E. Wacker, Tobias Welte, Emiel F. M. Wouters, Claus Vogelmeier, and Henrik Watz. 2017. “Peripheral Artery Disease and Its Clinical Relevance in Patients with Chronic Obstructive Pulmonary Disease in the COPD and Systemic Consequences-Comorbidities Network Study.” American Journal of Respiratory and Critical Care Medicine 195(2):189–97. doi: 10.1164/rccm.201602-0354OC.

Wacker, Margarethe E., Katharina Kitzing, Rudolf A. Jörres, Reiner Leidl, Holger Schulz, Stefan Karrasch, Annika Karch, Armin Koch, Claus F. Vogelmeier, and Rolf Holle. 2017. “The Contribution of Symptoms and Comorbidities to the Economic Impact of COPD: An Analysis of the German COSYCONET Cohort.” International Journal of COPD 12:3437–48. doi: 10.2147/COPD.S141852.

Karch, Annika, Armin Koch, and Viktor Grünwald. 2016. “A Phase II Trial Comparing Pazopanib with Doxorubicin as First-Line Treatment in Elderly Patients with Metastatic or Advanced Soft Tissue Sarcoma (EPAZ): Study Protocol for a Randomized Controlled Trial.” Trials 17(1). doi: 10.1186/s13063-016-1434-x.

Wacker, Margarethe E., Rudolf A. Jörres, Annika Karch, Sarah Wilke, Joachim Heinrich, Stefan Karrasch, Armin Koch, Holger Schulz, Henrik Watz, Reiner Leidl, Claus Vogelmeier, and Rolf Holle. 2016. “Assessing Health-Related Quality of Life in COPD: Comparing Generic and Disease-Specific Instruments with Focus on Comorbidities.” BMC Pulmonary Medicine 16(1). doi: 10.1186/s12890-016-0238-9.

Karch, Annika, Armin Koch, Antonia Zapf, Inga Zerr, and André Karch. 2016. “Partial Verification Bias and Incorporation Bias Affected Accuracy Estimates of Diagnostic Studies for Biomarkers That Were Part of an Existing Composite Gold Standard.” Journal of Clinical Epidemiology 78:73–82. doi: 10.1016/j.jclinepi.2016.03.022.

Deterding, Katja, Norbert Grüner, Peter Buggisch, Peter R. Galle, Ulrich Spengler, Holger Hinrichsen, Thomas Berg, Andrej Potthoff, Anika Großhennig, Armin Koch, Helmut Diepolder, Stefan Lüth, Sandra Feyerabend, Maria C. Jung, Magdalena Rogalska-Taranta, Verena Schlaphoff, Markus Cornberg, Michael P. Manns, Heiner Wedemeyer, and Johannes Wiegand. 2016. “Symptoms of Anxiety and Depression Are Frequent in Patients with Acute Hepatitis C and Are Not Associated with Disease Severity.” European Journal of Gastroenterology and Hepatology 28(2):187–92. doi: 10.1097/MEG.0000000000000517.

Bormann, Kai Hendrik, Kristina Weber, Heike Kloppenburg, Armin Koch, Peter Meiser, and Nils Claudius Gellrich. 2016. “Perioperative Bromelain Therapy after Wisdom Teeth Extraction – A Randomized, Placebo-Controlled, Double-Blinded, Three-Armed, Cross-Over Dose-Finding Study.” Phytotherapy Research 30(12):2012–19. doi: 10.1002/ptr.5707.

Rios, Nelmin, Nina Adaskina, Cornelia Frömke, Frank Papendorf, Cordula Schippert, Armin Koch, Peter Hillemanns, and Tjoung Won Park-Simon. 2016. “The Benefit of Baseline Staging-Risk Assessment of Distant Breast Cancer Metastases by Tumor Stage.” Anticancer Research 36(9):4909–14. doi: 10.21873/anticanres.11056.

Lueer, K., H. Biller, A. Casper, H. Windt, M. Mueller, P. Badorrek, D. Haefner, T. Framke, A. Koch, H. Ziehr, N. Krug, W. Koch, and J. M. Hohlfeld. 2016. “Safety, Efficacy and Repeatability of a Novel House Dust Mite Allergen Challenge Technique in the Fraunhofer Allergen Challenge Chamber.” Allergy: European Journal of Allergy and Clinical Immunology 71(12):1693–1700. doi: 10.1111/all.12947.

Scheper, Verena, Melanie Leifholz, Heiko von der Leyen, Miriam Keller, Ute Denkena, Armin Koch, Annika Karch, Josef Miller, and Thomas Lenarz. 2016. “ACEMg-Mediated Hearing Preservation in Cochlear Implant Patients Receiving Different Electrode Lengths (PROHEARING): Study Protocol for a Randomized Controlled Trial.” Trials 17(1). doi: 10.1186/s13063-016-1526-7.

Karch, Annika, Claus Vogelmeier, Tobias Welte, Robert Bals, Hans Ulrich Kauczor, Jürgen Biederer, Joachim Heinrich, Holger Schulz, Sven Gläser, Rolf Holle, Henrik Watz, Stephanie Korn, Nina Adaskina, Frank Biertz, Charlotte Vogel, Jørgen Vestbo, Emiel F. M. Wouters, Klaus Friedrich Rabe, Sandra Söhler, Armin Koch, and Rudolf A. Jörres. 2016. “The German COPD Cohort COSYCONET: Aims, Methods and Descriptive Analysis of the Study Population at Baseline.” Respiratory Medicine 114:27–37. doi: 10.1016/j.rmed.2016.03.008.

Wacker, M. E., R. A. Jörres, H. Schulz, J. Heinrich, S. Karrasch, A. Karch, A. Koch, A. Peters, R. Leidl, C. Vogelmeier, and R. Holle. 2016. “Direct and Indirect Costs of COPD and Its Comorbidities: Results from the German COSYCONET Study.” Respiratory Medicine 111:39–46. doi: 10.1016/j.rmed.2015.12.001.

Koch, Armin, and Yvonne Ziert. 2016. “Does It Help That Efficacy Has Been Proven Once We Start Discussing (Added) Benefit?” Biometrical Journal 58(1):89–103. doi: 10.1002/bimj.201400017.

Heidrich, Benjamin, Hans Jörg Cordes, Hartwig Klinker, Bernd Möller, Uwe Naumann, Martin Rössle, Michael R. Kraus, Klaus H. Böker, Christoph Roggel, Marcus Schuchmann, Albrecht Stoehr, Andreas Trein, Svenja Hardtke, Andrea Gonnermann, Armin Koch, Heiner Wedemeyer, Michael P. Manns, and Markus Cornberg. 2015. “Treatment Extension of Pegylated Interferon Alpha and Ribavirin Does Not Improve SVR in Patients with Genotypes 2/3 without Rapid Virological Response (OPTEX Trial): A Prospective, Randomized, Two-Arm, Multicentre Phase IV Clinical Trial.” PLoS ONE 10(6). doi: 10.1371/journal.pone.0128069.

Zapf, Antonia, Wilfried Gwinner, Annika Karch, Jochen Metzger, Hermann Haller, and Armin Koch. 2015. “Non-Invasive Diagnosis of Acute Rejection in Renal Transplant Patients Using Mass Spectrometry of Urine Samples - A Multicentre Phase 3 Diagnostic Accuracy Study.” BMC Nephrology. doi: 10.1186/s12882-015-0146-x.

Tiddens, Harm A. W. M., Stephen M. Stick, Jim M. Wild, Pierluigi Ciet, Geoffrey J. M. Parker, Armin Koch, and Jens Vogel-Claussen. 2015. “Respiratory Tract Exacerbations Revisited: Ventilation, Inflammation, Perfusion, and Structure (VIPS) Monitoring to Redefine Treatment.” Pediatric Pulmonology 50:S57–65.

Gonnermann, A., M. Kottas, and Armin Koch. 2015. “Biometrische Entscheidungsunterstützung in Zulassung Und Nutzenbewertung Am Beispiel Der Implikationen von Heterogenen Ergebnissen in Untergruppen Der Studienpopulation.” Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 58(3):274–82. doi: 10.1007/s00103-014-2105-2.

Gonnermann, Andrea, Theodor Framke, Anika Großhennig, and Armin Koch. 2015. “No Solution yet for Combining Two Independent Studies in the Presence of Heterogeneity.” Statistics in Medicine 34(16):2476–80. doi: 10.1002/sim.6473.

Budde, S., Y. Noll, V. Zieglschmid, C. Schroeder, A. Koch, and H. Windhagen. 2015. “Determination of the Efficacy of EVICELTM on Blood Loss in Orthopaedic Surgery after Total Knee Replacement: Study Protocol for a Randomised Controlled Trial.” Trials 16(1). doi: 10.1186/s13063-015-0822-y.

Grünwald, Viktor, U. Keilholz, A. Boehm, O. Guntinas-Lichius, B. Hennemann, H. J. Schmoll, P. Ivanyi, M. Abbas, U. Lehmann, A. Koch, A. Karch, A. Zörner, and T. C. Gauler. 2015. “TEMHEAD: A Single-Arm Multicentre Phase II Study of Temsirolimus in Platin- and Cetuximab Refractory Recurrent and/or Metastatic Squamous Cell Carcinoma of the Head and Neck (SCCHN) of the German SCCHN Group (AIO).” Annals of Oncology 26(3):561–67. doi: 10.1093/annonc/mdu571.

Tiede, Andreas, Robert Klamroth, Rüdiger E. Scharf, Ralf U. Trappe, Katharina Holstein, Angela Huth-Kühne, Saskia Gottstein, Ulrich Geisen, Joachim Schenk, Ute Scholz, Kristina Schilling, Peter Neumeister, Wolfgang Miesbach, Daniela Manner, Richard Greil, Charis Von Auer, Manuela Krause, Klaus Leimkühler, Ulrich Kalus, Jan Malte Blumtritt, Sonja Werwitzke, Eva Budde, Armin Koch, and Paul Knöbl. 2015. “Prognostic Factors for Remission of and Survival in Acquired Hemophilia A (AHA): Results from the GTH-AH 01/2010 Study.” Blood 125(7):1091–97. doi: 10.1182/blood-2014-07-587089.

Rohde, Gernot G. U., Armin Koch, Tobias Welte, M. Dreher, C. Cornelissen, W. Knüppel, S. Dressel, T. Bauer, T. Sabha, W. Pankow, A. Lies, A. de Roux, N. Dallwitz, O. Pociuli, P. Zierock, B. Hauptmeier, D. Wehde, C. Herzmann, C. Lange, B. Schaaf, C. Teipel, G. Höffken, M. Kolditz, M. Idzko, B. Seuthe, S. Gläser, R. Ewert, G. Nilius, K. J. Franke, C. Weiss, T. Zelniker, T. Köhnlein, J. Freise, S. Andreas, P. Hammerl, M. Pletz, S. Hagel, K. Dalhoff, D. Drömann, H. Buschmann, R. Kröning, T. Schaberg, C. Göbel, W. Randerath, C. Priegnitz, S. Stieglitz, S. Hagmeyer, K. Rasche, M. Leidag, G. Barten, W. Kröner, J. Naim, M. Abrahamczik, A. Koch, A. Gonnermann, D. Stichtenoth, H. Von Der Leyen, D. Breuer, M. Craul, T. Welte, N. Suttorp, S. Stenger, G. Rohde, M. Pletz, H. Schütte, J. Rupp, T. Illmann, M. Wallner, T. Illig, N. Klopp, and S. Bauer. 2015. “Randomized Double Blind Placebo-Controlled Study to Demonstrate That Antibiotics Are Not Needed in Moderate Acute Exacerbations of COPD - The ABACOPD Study.” BMC Pulmonary Medicine. doi: 10.1186/1471-2466-15-5.

Manolis, Efthymios, Armin Koch, Dieter Deforce, and Spiros Vamvakas. 2015. “The European Medicines Agency Experience with Biomarker Qualification.” Methods in Molecular Biology 1243:255–72. doi: 10.1007/978-1-4939-1872-0_15.

Wonnemann, Meinolf, Cornelia Frömke, and Armin Koch. 2015. “Inflation of the Type i Error: Investigations on Regulatory Recommendations for Bioequivalence of Highly Variable Drugs.” Pharmaceutical Research 32(1):135–43. doi: 10.1007/s11095-014-1450-z.

Kreuzer, Martin, Jenny Prüfe, Dirk Bethe, Charlotte Vogel, Anika Großhennig, Armin Koch, Martina Oldhafer, Marie-Luise Dierks, Urs-Vito Albrecht, Silvia Müther, Reinhard Brunkhorst, and Lars Pape. 2014. “The TRANSNephro-Study Examining a New Transition Model for Post-Kidney Transplant Adolescents and an Analysis of the Present Health Care: Study Protocol for a Randomized Controlled Trial.” Trials 15(1):505. doi: 10.1186/1745-6215-15-505..

Schrem, Harald, Anna Luise Platsakis, Alexander Kaltenborn, Armin Koch, Courtney Metz, Marc Barthold, Christian Krauth, Volker Amelung, Felix Braun, Thomas Becker, Jürgen Klempnauer, and Benedikt Reichert. 2014. “Value and Limitations of the BAR-Score for Donor Allocation in Liver Transplantation.” Langenbeck’s Archives of Surgery 399(8):1011–19. doi: 10.1007/s00423-014-1247-x.

Schaumann, Frank, Cornelia Frömke, Dorothea Dijkstra, Francesca Alessandrini, Horst Windt, Erwin Karg, Meike Müller, Carla Winkler, Armin Braun, Armin Koch, Jens M. Hohlfeld, Heidrun Behrendt, Otmar Schmid, Wolfgang Koch, Holger Schulz, and Norbert Krug. 2014. “Effects of Ultrafine Particles on the Allergic Inflammation in the Lung of Asthmatics: Results of a Double-Blinded Randomized Cross-over Clinical Pilot Study.” Particle and Fibre Toxicology 11(1). doi: 10.1186/s12989-014-0039-3.

Ahlenstiel-Grunow, Thurid, Armin Koch, Anika Großhennig, Cornelia Frömke, Martina Sester, Urban Sester, Christoph Schröder, and Lars Pape. 2014. “A Multicenter, Randomized, Open-Labeled Study to Steer Immunosuppressive and Antiviral Therapy by Measurement of Virus (CMV, ADV, HSV)-Specific T Cells in Addition to Determination of Trough Levels of Immunosuppressants in Pediatric Kidney Allograft Recip.” Trials 15(1). doi: 10.1186/1745-6215-15-324.

Gillmann, Hans Jörg, Antje Meinders, Anika Grohennig, Jan Larmann, Christoph Bünte, Simone Calmer, Bianca Sahlmann, Saad Rustum, Thomas Aper, Ralf Lichtinghagen, Armin Koch, Omke E. Teebken, and Gregor Theilmeier. 2014. “The Authors Reply.” Critical Care Medicine 42(9).

Gillmann, Hans Jörg, Antje Meinders, Anika Großhennig, Jan Larmann, Christoph Bünte, Simone Calmer, Bianca Sahlmann, Saad Rustum, Thomas Aper, Ralf Lichtinghagen, Armin Koch, Omke E. Teebken, and Gregor Theilmeier. 2014. “Perioperative Levels and Changes of High-Sensitivity Troponin T Are Associated with Cardiovascular Events in Vascular Surgery Patients.” Critical Care Medicine 42(6):1498–1506. doi: 10.1097/CCM.0000000000000249.

Koch, Armin, and Theodor Framke. 2014. “Reliably Basing Conclusions on Subgroups of Randomized Clinical Trials.” Journal of Biopharmaceutical Statistics 24(1):42–57. doi: 10.1080/10543406.2013.856020.

Calle Serrano, B., A. Großhennig, M. Homs, B. Heidrich, A. Erhardt, K. Deterding, J. Jaroszewicz, B. Bremer, A. Koch, M. Cornberg, M. P. Manns, M. Buti, and H. Wedemeyer. 2014. “Development and Evaluation of a Baseline-Event-Anticipation Score for Hepatitis Delta.” Journal of Viral Hepatitis 21(11):e154–63. doi: 10.1111/jvh.12251.

Schober, Tilmann, Theodor Framke, Hans Kreipe, Thomas F. Schulz, Anika Grohennig, Kais Hussein, Ulrich Baumann, Lars Pape, Stephan Schubert, Anne Margret Wingen, Thomas Jack, Armin Koch, Christoph Klein, and Britta Maecker-Kolhoff. 2013. “Characteristics of Early and Late PTLD Development in Pediatric Solid Organ Transplant Recipients.” Transplantation 95(1):240–46. doi: 10.1097/TP.0b013e318277e344.

Deterding, Katja, Norbert Grüner, Peter Buggisch, Johannes Wiegand, Peter R. Galle, Ulrich Spengler, Holger Hinrichsen, Thomas Berg, Andrej Potthoff, Nisar Malek, Anika Großhennig, Armin Koch, Helmut Diepolder, Stefan Lüth, Sandra Feyerabend, Maria Christina Jung, Magdalena Rogalska-Taranta, Verena Schlaphoff, Markus Cornberg, Michael P. Manns, and Heiner Wedemeyer. 2013. “Delayed versus Immediate Treatment for Patients with Acute Hepatitis C: A Randomised Controlled Non-Inferiority Trial.” The Lancet Infectious Diseases 13(6):497–506. doi: 10.1016/S1473-3099(13)70059-8.

Großhennig, A., N. Benda, and A. Koch. 2013. “Die Bedeutung von Biomarkern Für Eine Personalisierte Medizin.” Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 56(11):1480–88. doi: 10.1007/s00103-013-1828-9.

Koch, Armin. 2006. “Rejoinder.” Biometrical Journal 48(4):616–22.

Koch, Armin. 2006. “Confirmatory Clinical Trials with an Adaptive Design.” Biometrical Journal 48(4):574–85.

Koch, Armin. 2005. “Discussion on ‘establishing Efficacy of a New Experimental Treatment in the “gold Standard” Design.’” Biometrical Journal 47(6):792–93.

Röhmel, Joachim, D. Hauschke, A. Koch, and I. Pigeot. 2005. “Biometrische Verfahren Zum Wirksamkeitsnachweis Im Zulassungsverfahren. Nicht-Unterlegenheit in Klinischen Studien.” Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 48(5):562–71. doi: 10.1007/s00103-005-1042-5.

Koch, A. 2005. “Biostatistische Methoden Zum Wirksamkeitsnachweis Im Zulassungsverfahren. Ein Erkenntnistheoretischer Zugang Zu Adaptiven Designs.” Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 48(5):572–79. doi: 10.1007/s00103-005-1031-8.

Koch, Armin. 2005. “How Much Do We Have to Pay for How Many Interim Analyses?” Contemporary Clinical Trials 26(1):113–16.

Koch, Armin, and Joachim Röhmel. 2004. “Hypothesis Testing in the ‘Gold Standard’ Design for Proving the Efficacy of an Experimental Treatment Relative to Placebo and a Reference.” Journal of Biopharmaceutical Statistics 14(2):315–25.

Koch A, Röhmel J (2003): Meta-analysis of randomised clinical trials in the evaluation of medical treatments – a partly regulatory perspective. In: Schulze R, Holling H and Böhning D: Meta-analysis: new developments and applications in medical and social sciences. Hogrefe & Huber. Göttingen, p. 99-112.

Koch, Armin, and Joachim Röhmel. 2002. “The Impact of Sloppy Study Conduct on Noninferiority Studies.” Therapeutic Innovation & Regulatory Science 36(1):3–6. doi: 10.1177/009286150203600102.

Sillem, Martin, Sophia Prifti, Armin Koch, Markus Neher, Julia Jauckus, and Benno Runnebaum. 2001. “Regulation of Matrix Metalloproteinases and Their Inhibitors in Uterine Endometrial Cells of Patients with and without Endometriosis.” European Journal of Obstetrics and Gynecology and Reproductive Biology 95(2):167–74. doi: 10.1016/S0301-2115(00)00415-2.

Ziegler, S., A. Koch, and N. Victor. 2001. “Deficits and Remedy of the Standard Random Effects Methods in Meta-Analysis.” Pp. 148–55 in Methods of Information in Medicine. Vol. 40.

Koch, Armin, and Joachim Röhmel. 2001. “Why Are Some Meta-Analyses More Credible than Others?” Therapeutic Innovation & Regulatory Science 35(3):1019–30. doi: 10.1177/009286150103500341.

Koch, Armin, Sandra Ziegler, Heike Breitschwerdt, and Norbert Victor. 2001. “Low Molecular Weight Heparin and Unfractionated Heparin in Thrombosis Prophylaxis: Meta-Analysis Based on Original Patient Data.” Thrombosis Research 102(4):295–309. doi: 10.1016/S0049-3848(01)00251-1.

Windeler, Jürgen, and Armin Koch. 2000. “CONSORT - Was Eine Ordentliche Wissenschaftliche Publikation Leisten Muss.” Medizinische Klinik 95(3):171–77. doi: 10.1007/PL00002102.

Koch A, Ziegler S (2000): Metaanalyse als Werkzeug zum Erkenntnisgewinn. Medizinische Klinik (95), S. 109-116. Nachdruck in: Grundlagen der Biometrie und Klinischen Pharmakologie für Internisten. Medizinische Klinik (95, Sonderheft 1), S. 83-90.

Schuster, S., A. Koch, U. Burczyk, R. Schiele, H. G. Glunz, T. Voigtländer, P. Limbourg, K. Stuby, G. Berg, U. Gieseler, M. Jakob, P. Hauptmann, and J. Senges. 1999. “Indikationsstellung Zur Herzkatheteruntersuchung Nach Akutem Myokardinfarkt in Deutschland: Klinische Praxis vs. Richtlinien - MITRA- Studie.” Zeitschrift Fur Kardiologie 88(10):795–801. doi: 10.1007/s003920050354.

Koch, Armin, and Jürgen Windeler. 1999. “Statistische Modelle Und Die Auswertung von Beobachtungsstudien.” Medizinische Klinik 94(10):587–93. doi: 10.1007/BF03044958.

Koch A, Abel U (1999): Randomisierte klinische Studien und Beobachtungsstudien: Probleme der Durchführbarkeit und Interpretation. In: Günther H, Ehninger G: Tradition und Fortschritt in der Onkologie. Roderer Verlag, Regensburg, S. 63-79.

Koch, Armin, and Jürgen Windeler. 2000. “Testen, Schatzen, ‘Signifikanz’ - Konzept Und Sprache Der Medizinischen Biometrie.” Medizinische Klinik 95(SUPPL. 1):41–46.

Hänsch, Gertrud Maria, Markus Radsak, Christof Wagner, Bettina Reis, Armin Koch, Andreas Breitbart, and Konrad Andrassy. 1999. “Expression of Major Histocompatibility Class II Antigens on Polymorphonuclear Neutrophils in Patients with Wegener’s Granulomatosis.” Kidney International 55(5):1811–18. doi: 10.1046/j.1523-1755.1999.00446.x.

Abel U, Koch A (1999): Commentary: The role of randomization in clinical studies: myths and beliefs. Journal of Clinical Epidemiology (52), p. 487-497.

Schuster, Stefan, Armin Koch, Rudolf Schiele, Udo Burczyk, Stefan Wagner, Ralf Zahn, Jörg Rustige, Peter Limbourg, Hartmut Gülker, and Jochen Senges. 1998. “Impact of Early Risk Stratification on the Length of Hospitalization in Patients with Acute Q-Wave Myocardial Infarction. The 60-Minutes Myocardial Infarction Project.” Cardiology 90(3):212–19. doi: 10.1159/000006846.

Koch, Armin, and Ulrich Abel. 1998. “Die Rolle Der Randomisation in Klinischen Studien.” Forschende Komplementarmedizin Und Klassische Naturheilkunde 5(SUPPL.):121–24. doi: 10.1159/000057331.

Koch A (1998): Verfahren 6/13/7: Zusammenfassung mehrerer Studien (Meta-Analyse). In: Rasch D, Herrendörfer G, Bock J, Victor N und Guiard V (Hrsg.): Verfahrensbibliothek – Versuchsplanung und – auswertung, Band II. R. Oldenbourg Verlag, München, p. 738-762.

Koch A (1998): Einführung: Logistische Regression. Konferenzbeiträge der 2. Konferenz der SAS-Benutzer in Forschung und Entwicklung (KSFE) an der Friedrich Schiller-Universität Jena. 26. -27. Februar 1998. Rechenzentrum der Universität Jena.

Feichtenbeiner M, Ziegler S, Koch A (1998): Meta-Analyse mit ordinaler Zielgröße. In: Greiser E und Wischnewsky M (Hrsg.): Methoden der Medizinischen Informatik, Biometrie und Epidemiologie in der modernen Informationsgesellschaft. MMV Medien & Medizin Verlag, München, S. 377-380.

Ziegler S, Koch A,Victor N (1998): Meta-Analyse: Zum Fehler 1. Art im Modell mit zufälligen Effekten. In: Greiser E und Wischnewsky M (Hrsg.): Methoden der Medizinischen Informatik, Biometrie und Epidemiologie in der modernen Informationsgesellschaft. MMV Medien & Medizin Verlag, München, S. 381-384.

Koch A, Victor N (1997): The need for meta-analysis in clinical research. Biocybernetics and Biomedical Engineering (17), p. 135-167.

Abel U, Koch A (Eds) (1998): Nonrandomized comparative clinical studies. Symposion Publishing, Düsseldorf.

Koch A, Hörmann A, Löwel H, Senges J (1998): "The 60-Minutes-Myocardial Infarction Project": comparison with a registry and a randomized clinical trial. In: Abel U und Koch A (Eds.): Nonrandomized comparative clinical studies. Symposion Publishing, Düsseldorf, p. 149-160.

Abel U, Koch A (1998): The mythology of randomisation. In: Abel U und Koch A (Eds.): Nonrandomized comparative clinical studies. Symposion Publishing, Düsseldorf, p. 27-40.

Haller, C., M. Meyer, T. Scheele, A. Koch, W. G. Forssmann, and W. Kübler. 1998. “Radiocontrast-Induced Natriuresis Associated with Increased Urinary Urodilatin Excretion.” Journal of Internal Medicine 243(2):155–62. doi: 10.1046/j.1365-2796.1998.00260.x.

Abel U, Koch A (1998): Spezielle Forschungsprobleme, Teil 5: Nichtrandomisierte vergleichende Therapiestudien. In: Bühring M, Kemper FH (Hrsg.): Naturheilverfahren und unkonventionelle Medizinische Richtungen (Loseblattwerk Abschnitt 01.08, Ausgabe April '98). Springer, Berlin.

Koch, A. 1998. “Meta-Analysis of Homoeopathy Trials.” The Lancet 351(9099):366–67. doi: 10.1016/s0140-6736(05)78309-4.

Koch A, Windeler J (1998): Kommentar zu: Meta-Analyse zur Homöopathie (von K. Linde et al. (1997), Lancet (350), p. 834-843), Forsch. Komplementärmed. (5), S. 36-37.

Koch, Armin, and Allmut. Hörmann. 1997. “Rapid Communications Section.” Computational Statistics & Data Analysis 25(1):109. doi: 10.1016/s0167-9473(97)89201-8.

Zahn, Ralf, Jörg Rustige, Armin Koch, Rudolf Schiele, Udo Burczyk, Stefan Schuster, Dietrich Harmjanz, Dietrich Boppert, Martin Gottwik, Karl Ludwig Neuhaus, and Jochen Senges. 1997. “Influence of the Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries (GUSTO-1) Trial on the Use of Thrombolytics Germany.” American Journal of Cardiology 80(10):1339–43. doi: 10.1016/S0002-9149(97)00677-2.

Abel U, Koch A (1997): Randomisation in klinischen Studien: Empirisch begründet oder nur ein Dogma? In: Köbberling, J. (Hrsg.): Zeitfragen der Medizin. Springer, Berlin, S. 79-90.

Burczyk U, Schuster S, Schiele R, Wagner S, Koch A, Glunz HG, Heinrich F, Stuby K, Gieseler U, Senges J (1997): Klinische Praxis in der Frühbehandlung des akuten Myokardinfarkts: Ergebnisse der MITRA-Pilotphase in Südwestdeutschland. Medizinisches Forum (1), S. 22-25.

Rustige, J., R. Schiele, U. Burczyk, A. Koch, M. Gottwik, K. L. Neuhaus, U. Tebbe, R. Uebis, and J. Senges. 1997. “The 60 Minutes Myocardial Infarction Project. Treatment and Clinical Outcome of Patients with Acute Myocardial Infarction in Germany.” European Heart Journal. doi: 10.1093/oxfordjournals.eurheartj.a015470.

Ziegler S, Kuss O, Koch A (1997): Meta-Analyse in einem Modell mit festen und mit zufälligen Effekten. In: Medizinische Informatik, Biometrie und Epidemiologie - GMDS'97: 42. Jahrestagung der GMDS, Ulm, September 1997. MMV Medizin-Verlag, München, S. 361-365.

Koch A, Abel U (1997): Zur Aussagekraft nichtrandomisierter Studien. In: Muche R, Büchele G, Harder D, Gaus W (Hrsg): Medizinische Informatik, Biometrie und Epidemiologie - GMDS '97: 42. Jahrestagung der GMDS, Ulm, September 1997. MMV Medizin-Verlag, München, S. 391-395.

Koch A, Schmitt J, Dinkel H (1997): Herzinfarkt - Zeit ist Überleben. Biometrischer Abschlußbericht. Bericht aus der Abteilung Medizinische Biometrie Nr. 28. Ruprecht-Karls-Universität Heidelberg, Institut für Medizinische Biometrie und Informatik.

Koch, A., S. Bouges, S. Ziegler, H. Dinkel, J. P. Daures, and N. Victor. 1997. “Low Molecular Weight Heparin and Unfractionated Heparin in Thrombosis Prophylaxis after Major Surgical Intervention: Update of Previous Meta-Analyses.” British Journal of Surgery 84(6):750–59.

Koch A, Chiroleu F (1997): Diagnostische Tests und die Schätzung des Therapieeffektes in der Vierfeldertafel. In: Baur MP, Fimmers R, Blettner M (Hrsg): Medizinische Informatik, Biometrie und Epidemiologie: 41. Jahrestagung der GMDS Bonn, September 1996. MMV-Verlag, München, S. 456-460.

Schuster, S., A. Koch, U. Burczyk, R. Schiele, S. Wagner, R. Zahn, H. G. Glunz, F. Heinrich, K. Stuby, G. Berg, T. Voigtländer, U. Gieseler, M. Jakob, P. Hauptmann, and J. Senges. 1997. “Fruhbehandlung Des Akuten Myokardinfarktes: Umsetzung von Therapierichtlinien in Den Klinischen Alltag, MITRA-Pilotphase.” Zeitschrift Fur Kardiologie 86(4):273–83. doi: 10.1007/s003920050059.

Abel U, Koch A (1997): Randomisation in klinischen Studien: Empirisch begründet oder nur ein Dogma? Der Internist (38), S. 318-324.

Koch A, Haag U (eds) (1997): The Statistical Software Guide ´96/97. Computational Statistics & Data Analysis (24), p. 105-136.

Koch A, Holle R (1997): Einsatz von Statistik - Software in der Biometrie - Ausbildung der Medizinstudenten. Informatik, Biometrie und Epidemiologie in Medizin und Biologie (28), S. 14-24.

Zahn, Ralf, Armin Koch, Jörg Rustige, Rudolf Schiele, Alexander Wirtzfeld, Karl Ludwig Neuhaus, Horst Kuhn, Hartmut Gülker, and Jochen Senges. 1997. “Primary Angioplasty versus Thrombolysis in the Treatment of Acute Myocardial Infarction.” American Journal of Cardiology 79(3):264–69. doi: 10.1016/S0002-9149(96)00745-X.

Kuss, Oliver, and Armin Koch. 1996. “Meta-Analysis Macros for SAS.” Computational Statistics & Data Analysis 22(3):325–33. doi: 10.1016/0167-9473(96)81456-3.

Koch A, Dinkel H (1996): Das 60-Minuten-Herzinfarktprojekt. Biometrischer Abschlußbericht. Bericht aus der Abteilung Medizinische Biometrie Nr. 26. Ruprecht-Karls-Universität Heidelberg, Institut für Medizinische Biometrie und Informatik.

Koch, A., and U. Haag. 1996. “The Statistical Software Guide ’95/96.” Computational Statistics & Data Analysis 21(2):231–56. doi: 10.1016/s0167-9473(96)90303-5.

Koch, Armin, Jürgen Windeler, and Ulrich Abel. 1996. “Anwendungsbeobachtungen: Zu Begriff Und Nutzen.” Medizinische Klinik 91(2):103–5.

Koch A, Callier P (1995): Meta-Analyse zum Vergleich von niedermolekularem Heparin mit Standardheparin in der Thromboseprophylaxe: Untersuchung eines Modells für die Entstehung von Heterogenität. In: Trampisch HJ und Lange S: Medizinische Forschung - Ärztliches Handeln. MMV Medizin Verlag, München, S. 170-174.

Koch A, Haag U (eds) (1995): The Statistical Software Guide ´94/95. Computational Statistics & Data Analysis (19), p. 237-261.

Koch A (1994): Intervallzensierte Beobachtungen in klinischen Studien. Dissertation, Fakultät für Theoretische Medizin der Universität Heidelberg.

Koch A (1994): Interval censored observations in clinical trials. In: Dirschedl P and Ostermann R (Eds.): Computational statistics. Physica Verlag Heidelberg, p. 451-467.

Koch, Armin, and Uwe Haag. 1994. “The Statistical Software Guide ’93/94.” Computational Statistics & Data Analysis 17(2):215–38. doi: 10.1016/0167-9473(94)90112-0.

Koch A, Haag U (eds) (1993): Statistical Software Guide ´92/93. Informacní Bulletin. Ceské Statistické Spolecnosti. Mimorádné cislo, listopad 1993, rocník 4, p. 1-36.

Haag, Uwe, Armin Koch, and Werner VACH. 1993. “Why and How to Build a Simple Statistical Computing System.” Computational Statistics and Data Analysis 16(2):237–44. doi: 10.1016/0167-9473(93)90118-D.

Koch A (1993): Announcing The Statistical Software Guide '93/94. Computational Statistics & Data Analysis (16), p. 133.

Koch A, Haag U (eds) (1993): The Statistical Software Guide ´92/93. Computational Statistics & Data Analysis (15), p. 241-264.

Shahin, Manal, Detlef Schuppan, Rüdiger Waldherr, Juha Risteli, Leila Risteli, Eeva‐Riitta ‐R Savolainen, Christine Oesterling, Hosna M. Abde. Rahman, Abdul M. E. Sahly, Samia M. Abde. Razek, Omar El Ruby, Armin Koch, and Helmut K. Seitz. 1992. “Serum Procollagen Peptides and Collagen Type VI for the Assessment of Activity and Degree of Hepatic Fibrosis in Schistosomiasis and Alcoholic Liver Disease.” Hepatology 15(4):637–44. doi: 10.1002/hep.1840150414..

Koch, Armin. 1991. “Software Presentations at Statistical Computing ’90.” Computational Statistics & Data Analysis 11(2):225–27. doi: 10.1016/0167-9473(91)90074-c.

Seitz, Helmut K., Ulrich A. Simanowski, Felix T. Garzon, James M. Rideout, Timothy J. Peters, Armin Koch, Martin R. Berger, Henner Einecke, and Matthias Maiwald. 1990. “Possible Role of Acetaldehyde in Ethanol-Related Rectal Cocarcinogenesis in the Rat.” Gastroenterology 98(2):406–13. doi: 10.1016/0016-5085(90)90832-L.

Koch A (1990): Book review for: Lochner HA (1989): APL2-Handbuch. Springer, Berlin. Meth. Inform. Med. (29), p. 77.

Hörmann A, Dirschedl P, Haag U, Koch A, Himmelmann W (eds) (1990): Comparing Statistical Analysis Systems - A Proposal for a List of Comparison Criteria with Descriptions of BMDP (by G. Fitzgerald), P-STAT (by E.J. Zimmermann), SAS (by G. Held), SPSS (by C. Schmidtner) and comments by Members of the Working Group "Statistical Evaluation Systems" of the German Society for Medical Documentation, Informatics and Statistics. Statistical Software Newsletter (16), p. 90-127.

Koch, Armin. 1989. “Reading DBase III Files from Withing A STSC APL Workspace.” ACM SIGAPL APL Quote Quad 19(3):27. doi: 10.1145/379217.379231.

Moller, P., T. Mattfeldt, C. Gross, P. Schlosshauer, A. Koch, K. Koretz, G. Moldenhauer, M. Kaufmann, and H. F. Otto. 1989. “Expression of HLA-A, -B, -C, -DR, -DP, -DQ, and of HLA-D-Associated Invariant Chain (Ii) in Non-Neoplastic Mammary Epithelium Fibroadenoma, Adenoma, and Carcinoma of the Breast.” American Journal of Pathology 135(1):73–83.

Koch A (1988): Medizinische Statistik in Briefen, Teil 12: Eine Einführung in BASIC und SAS. mta (3), S. 1074-1078.

Weber E, Berger J, Koch A (1988): Struktur und Organisation eines Mainframe-Statistikprogrammpaketes auf dem IBM/PC-AT. In: Faulbaum, H. und Uehlinger, H.M. (Hrsg.): Fortschritte der Statistik-Software 1. Gustav Fischer, Stuttgart, S. 163-170.

Koch A (1988): Einheiten mit negativer Norm in quadratischen Zahlkörpern und die Lösung der Pell'schen Minusgleichung. Diplomarbeit, Fakultät für Mathematik an der Universität Heidelberg.

Weber E, Berger J, Edler L, Abel U, Heiselbetz C, Koch A (1986): PC Software für Planung und Auswertung von Experimenten und Studien in der Krebsforschung. In: Ehlers CT, Beland H (Ed.): Perspektiven der Informationsverarbeitung in der Medizin. Kritische Synopse der Nutzung der Informatik in der Medizin. Proceedings der 31. Jahrestagung der GMDS, Göttingen, September 1986. Springer, Berlin, S. 502.

Heiselbetz C, Koch A (1985): EINGABE - eine APL-Funktion für Programmierer zur Rationalisierung der Erstellung von Dialogprogrammen. APL-Journal (5), Mai 1986, S. 54-62.

Heiselbetz C, Koch A (1985): EINGABE - eine APL-Funktion für Programmierer zur Rationalisierung der Erstellung von Dialogprogrammen. Technical Report 1985/5 der Abteilung Biostatistik, Deutsches Krebsforschungszentrum, Heidelberg.

 

• Abstracts

Koch A, Abel U (2000): Methodische Anforderungen an Studien in der Naturheilkunde (Abstr.). Geburtshilfe und Frauenheilkunde (60, Supplement 1), S. S200.

Abel U, Koch A (1997): Randomisation in klinischen Studien: Empirisch begründet oder nur ein Dogma? (Abstr.) Medizinische Klinik (92, suppl. II), p. 21.

Ziegler S, Koch A (1997): Meta-Analysis: The validity of combining results of clinical trials with different duration of follow-up. German Biometric Conference, March 1997, Munich. Biometric Bulletin (14/3), p. 11.

Koch A (1994): Do we need teachware at all? (abstr.) Proceedings of the Fourth International Conference on Teaching Statistics, Marrakech, p. 430.

Koch A (1992): A simulation study with interval censored data (abstr.). Biometric Bulletin (10), p. 14.

• Arbeitsschwerpunkte

- Planung, Durchführung und Auswertung von klinischen Studien

- Biometrische Beratung von Studenten und wissenschaftlichen Mitarbeitern

- Entwicklung von Lehrkonzepten und Durchführung von Lehrveranstaltungen im Fachgebiet Biometrie/Medizinstatistik

- Betreuung von Bachelor- und Masterarbeiten

 

• Forschungsschwerpunkte

- Validierung von Biomarkerstudien

- Meta-Analysen

- Methodik für seltene Erkrankungen

 

• Lebenslauf

- Mitwirkung in Fachgesellschaften -

seit Oktober 2024

stellvertretende Fachbereichsleiterin des Fachausschuss Biometrie der GMDS (Deutsche Gesellschaft für Informatik, Biometrie und Epidemiologie e.V.) https://www.gmds.de/aktivitaeten/medizinische-biometrie/#c775

seit November 2020

Leiterin der Arbeitsgruppe Therapeutische Forschung der GMDS (Deutsche Gesellschaft für Informatik, Biometrie und Epidemiologie e.V.) https://www.gmds.de/de/aktivitaeten/medizinische-biometrie/arbeitsgruppenseiten/therapeutische-forschung/

2010 - 2015

Stellvertretende Sprecherin der Arbeitsgruppe Populationsgenetik und Genomanalyse der IBS-DR (Deutsche Region der Internationalen Biometrischen Gesellschaft) http://www.biometrische-gesellschaft.de/arbeitsgruppen/populationsgenetik-und-genomanalyse.html

 

- Berufliche Tätigkeit -

seit 01/2011

Stellvertretende Institutsleiterin am Institut für Biometrie, Medizinischen Hochschule Hannover

03/2009 - 12/2010

Wissenschaftliche Mitarbeiterin am Institut für Biometrie, Medizinische Hochschule Hannover

12/2004 - 02/2009

Wissenschaftliche Mitarbeiterin in der Medizinischen Klinik II und dem Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck

 

- Hochschulausbildung -

12-2004 - 10/2010

Promotionsstudium der Humanbiologie an der Universität zu Lübeck, Abschluss: Dr. rer. hum. biol., Thema der Promotionsschrift: "Genetisch-epidemiologische Methoden zur Analyse komplexer kardiovaskulärer Phänotypen"

10/2000 - 10/2004

Studium mit Fachrichtung Statistik an der Hochschule Magdeburg-Stendal, Abschluss zur Dipl.-Stat. (FH) Diplomarbeit: "Statistische Analyse zur Prognose von Krebsmortalitäten - Ein Vergleich von Joinpointregressionen und Bayesianischen Alters-Perioden-Kohortenmodellen"

 

• Bücher

Framke T., Großhennig A. (2021) Biostatistik trifft auf OMICS. In: Herrmann C., Berger U., Weiß C., Burkholder I., Rauch G., Kruppa J. (eds) Zeig mir Health Data Science! (1. Aufl. 2021 Edition, S. 65-81). Springer Spektrum, Berlin, Heidelberg.

Großhennig, A (2011): Genetisch-epidemiologische Methoden zur Analyse kardiovaskulärer Phänotypen, Südwestdeutscher Verlag für Hochschulschriften, Saarbrücken, ISBN: 978-3-8381-2480-3

Hemmelmann C, Ahnert P, Foraita R, Großhennig A, Scherag A, Biebler KE (Ed) (2011): Biometrische Aspekte der Genomanalyse IV – Next Generation Sequencing Data Analysis, Shaker Verlag, Aachen, ISBN: 978-3-8440-0155-6

• Publikationen

Suling, Anna, and Anika Großhennig. 2024. “Recognizing Statistical Problems in Reports of Clinical Trials: A Readers’ Aid.” Deutsches Ärzteblatt International. doi: 10.3238/arztebl.m2024.0113.

Müller-Vahl, Kirsten R., Anna Pisarenko, Rieke Ringlstetter, Camelia-Lucia Cimpianu, Carolin Fremer, Elif Weidinger, Eva Beate Jenz, Richard Musil, Alexander Brunnauer, and Anika Großhennig. 2024. “The Effect of Nabiximols on Driving Ability in Adults with Chronic Tic Disorders: Results of a Substudy Analysis of the Double-Blind, Randomized, Placebo-Controlled CANNA-TICS Trial.” Cannabis and Cannabinoid Research 9(5):1349–59. doi: 10.1089/can.2023.0114.

Jochmann, Svenja L., Esther M. W. Sievering, Johanna Ernst, Rieke Ringlstetter, Anika Grosshennig, Karin Weissenborn, and Gerrit M. Grosse. 2023. “Sex-Specific Risk Factors of Nonstenotic Carotid Plaque in Embolic Stroke of Unknown Source: A Case-Control Study.” Stroke 55(2):296–300. doi: 10.1161/STROKEAHA.123.044833.

Sievering, Esther Mw, Anika Grosshennig, Martina Kottas, Johanna Ernst, Rieke Ringlstetter, Armin Koch, Karin Weissenborn, and Gerrit M. Grosse. 2023. “Diagnostic Value of Carotid Intima-Media Thickness and Clinical Risk Scores in Determining Etiology of Ischemic Stroke.” European Stroke Journal 8(3):738–46. doi: 10.1177/23969873231182492.

Bavendiek, Udo, Anika Großhennig, Johannes Schwab, Dominik Berliner, Xiaofei Liu, Lars Maier, Thomas Gaspar, Andreas Rieth, Sebastian Philipp, Rainer Hambrecht, Ralf Westenfeld, Thomas Münzel, Sebastian Winkler, Martin Hülsmann, Dirk Westermann, Marja Zdravkovic, Ralf Lichtinghagen, Heiko von der Leyen, Silke Zimmermann, Christian Veltmann, Michael Böhm, Stefan Störk, Armin Koch, and Johann Bauersachs. 2023. “Simple and Safe Digitoxin Dosing in Heart Failure Based on Data from the DIGIT-HF Trial.” Clinical Research in Cardiology 112(8):1096–1107. doi: 10.1007/s00392-023-02199-z.

Großhennig, Anika, Nele Henrike Thomas, Werner Brannath, and Armin Koch. 2023. “How to Avoid Concerns with the Interpretation of Two Primary Endpoints If Significant Superiority in One Is Sufficient for Formal Proof of Efficacy.” Pharmaceutical Statistics 22(5):836–45. doi: 10.1002/pst.2314.

Kratz, Christian P., Dmitrii Smirnov, Robert Autry, Natalie Jäger, Sebastian M. Waszak, Anika Großhennig, Riccardo Berutti, Mareike Wendorff, Pierre Hainaut, Stefan M. Pfister, Holger Prokisch, Tim Ripperger, and David Malkin. 2023. “Reply to Li and Colleagues.” JNCI: Journal of the National Cancer Institute 115(6):760–61. doi: 10.1093/jnci/djad057.

Müller-Vahl, Kirsten R., Anna Pisarenko, Natalia Szejko, Martina Haas, Carolin Fremer, Ewgeni Jakubovski, Richard Musil, Alexander Münchau, Irene Neuner, Daniel Huys, Ludger Tebartz van Elst, Christoph Schröder, Rieke Ringlstetter, Armin Koch, Eva Beate Jenz, and Anika Großhennig. 2023. “CANNA-TICS: Efficacy and Safety of Oral Treatment with Nabiximols in Adults with Chronic Tic Disorders – Results of a Prospective, Multicenter, Randomized, Double-Blind, Placebo Controlled, Phase IIIb Superiority Study.” Psychiatry Research 323. doi: 10.1016/j.psychres.2023.115135

Stahl, Klaus, Friederike Klein, Torsten Voigtländer, Anika Großhennig, Thorsten Book, Tobias Müller, Alexander Wree, Armin Kuellmer, Jochen Weigt, Alexander Dechene, Edris Wedi, Arne Kandulski, Christian M. Lange, Dennis Holzwart, Dorothee von Witzendorff, Kristina I. Ringe, Heiner Wedemeyer, and Benjamin Heidrich. 2023. “BISCIT: Biliary Interventions in Critically Ill Patients with Secondary Sclerosing Cholangitis-a Study Protocol for a Multicenter, Randomized, Controlled Parallel Group Trial.” Trials 24(1):247. doi: 10.1186/s13063-023-07260-w.

Großhennig, Anika, Sören Wiesner, Juliane Hellfritsch, Ulrich Thome, Matthias Knüpfer, Corinna Peter, Martin Metzelder, Christoph Binder, Ulrike Wanz, Christina Flucher, Björn O. Brands, Andreas Mollweide, Barbara Ludwikowski, Anna Koluch, Simon Scherer, Christian Gille, Till Martin Theilen, Ulrich Rochwalsky, Christian Karpinski, Annekatrin Schulze, Tobias Schuster, Florian Weber, Guido Seitz, Jens Gesche, Matthias Nissen, Maximilian Jäger, Armin Koch, Benno Ure, Omid Madadi-Sanjani, and Martin Lacher. 2023. “MUC-FIRE: Study Protocol for a Randomized Multicenter Open-Label Controlled Trial to Show That MUCous FIstula REfeeding Reduces the Time from Enterostomy Closure to Full Enteral Feeds.” Contemporary Clinical Trials Communications 32:101096. doi: 10.1016/j.conctc.2023.101096.

Kratz, Christian P., Dmitrii Smirnov, Robert Autry, Natalie Jäger, Sebastian M. Waszak, Anika Großhennig, Riccardo Berutti, Mareike Wendorff, Pierre Hainaut, Stefan M. Pfister, Holger Prokisch, Tim Ripperger, and David Malkin. 2022. “Reply to Evans and Woodward.” JNCI: Journal of the National Cancer Institute. doi: 10.1093/jnci/djac224

Müller-Vahl, Kirsten R., Ewgeni Jakubovski, Carolin Fremer, Martina Lenz-Ziegenbein, Anika Großhennig, Carolin Klages, Armin Koch, Martina Haas, and Anna Pisarenko. 2022. “Implications for Blinding in Clinical Trials with THC-Containing Cannabinoids Based on the CANNA-TICS Trial.” Frontiers in Neuroscience 16. doi: 10.3389/fnins.2022.793703.

Kratz, Christian P., Dmitrii Smirnov, Robert Autry, Natalie Jäger, Sebastian M. Waszak, Anika Großhennig, Riccardo Berutti, Mareike Wendorff, Pierre Hainaut, Stefan M. Pfister, Holger Prokisch, Tim Ripperger, and David Malkin. 2022. “ Heterozygous BRCA1/2 and Mismatch Repair Gene Pathogenic Variants in Children and Adolescents with Cancer .” JNCI: Journal of the National Cancer Institute. doi: 10.1093/jnci/djac151.

Gornyk, Daniela, Martina Scharlach, Brigitte Buhr-Riehm, Carolina Judith Klett-Tammen, Sveja Eberhard, Jona Theodor Stahmeyer, Anika Großhennig, Andrea Smith, Sarah Meinicke, Wilfried Bautsch, Gérard Krause, and Stefanie Castell. 2021. “Effectiveness of Trainings of General Practitioners on Antibiotic Stewardship: Methods of a Pragmatic Quasi-Experimental Study in a Controlled Before-After Design in South-East-Lower Saxony, Germany (WASA).” Frontiers in Pharmacology 12(April):1–9. doi: 10.3389/fphar.2021.533248.

Ahlenstiel-Grunow, Thurid, Xiaofei Liu, Raphael Schild, Jun Oh, Christina Taylan, Lutz T. Weber, Hagen Staude, Murielle Verboom, Christoph Schröder, Ruxandra Sabau, Anika Großhennig, and Lars Pape. 2021. “Steering Transplant Immunosuppression by Measuring Virus-Specific T Cell Levels: The Randomized, Controlled IVIST Trial.” Journal of the American Society of Nephrology 32(2):502–16. doi: 10.1681/ASN.2020050645.

Großhennig, Anika, and Armin Koch. 2020. “COVID-19 Hits a Trial: Arguments against Hastily Deviating from the Plan.” Contemporary Clinical Trials 98. doi: 10.1016/j.cct.2020.106155.

Mederacke, Young Seon, Martha M. Kirstein, Anika Großhennig, Silke Marhenke, Frauke Metzler, Michael P. Manns, Arndt Vogel, and Ingmar Mederacke. 2020. “The PNPLA3 Rs738409 GG Genotype Is Associated with Poorer Prognosis in 239 Patients with Autoimmune Hepatitis.” Alimentary Pharmacology and Therapeutics 51(11):1160–68. doi: 10.1111/apt.15722.

Heusser, Karsten, Jens Tank, Olaf Holz, Marcus May, Julia Brinkmann, Stefan Engeli, André Diedrich, Theodor Framke, Armin Koch, Anika Großhennig, A. H. Jan Danser, Fred C. G. J. Sweep, Christoph Schindler, Katharina Schwarz, Norbert Krug, Jens Jordan, and Jens M. Hohlfeld. 2019. “Ultrafine Particles and Ozone Perturb Norepinephrine Clearance Rather than Centrally Generated Sympathetic Activity in Humans.” Scientific Reports 9(1). doi: 10.1038/s41598-019-40343-w.

Bräsen, Jan Hinrich, Young Seon Mederacke, Jessica Schmitz, Kateryna Diahovets, Abedalrazag Khalifa, Björn Hartleben, Fermín Person, Thorsten Wiech, Eric Steenbergen, Anika Großhennig, Michael P. Manns, Roland Schmitt, and Ingmar Mederacke. 2019. “Cholemic Nephropathy Causes Acute Kidney Injury and Is Accompanied by Loss of Aquaporin 2 in Collecting Ducts.” Hepatology 69(5):2107–19. doi: 10.1002/hep.30499.

Lingner, Heidrun, Lena Blase, Anika Großhennig, and Guido Schmiemann. 2018. “Manual Therapy Applied by General Practitioners for Nonspecific Low Back Pain: Results of the ManRück Pilot-Study.” Chiropractic and Manual Therapies 26(1). doi: 10.1186/s12998-018-0202-2.

Lingner, Heidrun, Heike Buhr-Schinner, Stefan Hummel, Jochen Van Der Meyden, Anika Grosshennig, Daniel Nowik, and Konrad Schultz. 2018. “Short-Term Effects of a Multimodal 3-Week Inpatient Pulmonary Rehabilitation Programme for Patients with Sarcoidosis: The ProKaSaRe Study.” Respiration 95(5):343–53. doi: 10.1159/000486964.

Spineli, Loukia M., Eva Jenz, Anika Großhennig, and Armin Koch. 2017. “Critical Appraisal of Arguments for the Delayed-Start Design Proposed as Alternative to the Parallel-Group Randomized Clinical Trial Design in the Field of Rare Disease.” Orphanet Journal of Rare Diseases 12(1). doi: 10.1186/s13023-017-0692-3.

Abbas, M., S. Steffens, M. Bellut, H. Eggers, A. Großhennig, J. U. Becker, G. Wegener, A. J. Schrader, V. Grünwald, and P. Ivanyi. 2016. “Intratumoral Expression of Programmed Death Ligand 1 (PD-L1) in Patients with Clear Cell Renal Cell Carcinoma (CcRCC).” Medical Oncology 33(7):80. doi: 10.1007/s12032-016-0794-0.

Abbas, Mahmoud, Sandra Steffens, Maria Bellut, Jan U. Becker, Anika Großhennig, Hendrik Eggers, Gerd Wegener, Markus A. Kuczyk, Hans H. Kreipe, Viktor Grünwald, Andres J. Schrader, and Philipp Ivanyi. 2016. “Do Programmed Death 1 (PD-1) and Its Ligand (PD-L1) Play a Role in Patients with Non-Clear Cell Renal Cell Carcinoma?” Medical Oncology 33(6):59. doi: 10.1007/s12032-016-0770-8.

Heusser, Karsten, Jens Tank, Julia Brinkmann, Christoph Schroeder, Marcus May, Anika Großhennig, Daniela Wenzel, André Diedrich, Fred C. G. J. Sweep, Heidrun Mehling, Friedrich C. Luft, and Jens Jordan. 2016. “Preserved Autonomic Cardiovascular Regulation with Cardiac Pacemaker Inhibition: A Crossover Trial Using High-Fidelity Cardiovascular Phenotyping.” Journal of the American Heart Association 5(1). doi: 10.1161/JAHA.115.002674.

Volk, V., A. Schneider, L. M. Spineli, A. Grosshennig, and R. Stripecke. 2016. “The Gender Gap: Discrepant Human T-Cell Reconstitution after Cord Blood Stem Cell Transplantation in Humanized Female and Male Mice.” Bone Marrow Transplantation 51(4):596–97.

Deterding, Katja, Norbert Grüner, Peter Buggisch, Peter R. Galle, Ulrich Spengler, Holger Hinrichsen, Thomas Berg, Andrej Potthoff, Anika Großhennig, Armin Koch, Helmut Diepolder, Stefan Lüth, Sandra Feyerabend, Maria C. Jung, Magdalena Rogalska-Taranta, Verena Schlaphoff, Markus Cornberg, Michael P. Manns, Heiner Wedemeyer, and Johannes Wiegand. 2016. “Symptoms of Anxiety and Depression Are Frequent in Patients with Acute Hepatitis C and Are Not Associated with Disease Severity.” European Journal of Gastroenterology and Hepatology 28(2):187–92. doi: 10.1097/MEG.0000000000000517.

Schmiemann, Guido, Lena Blase, Christoph Seeber, Stefanie Joos, Jost Steinhäuser, Stefanie Ernst, Anika Großhennig, Eva Hummers-Pradier, and Heidrun Lingner. 2015. “Manual Therapy by General Medical Practitioners for Nonspecific Low Back Pain in Primary Care: The Manrück Study Protocol of a Clinical Trial.” Journal of Chiropractic Medicine 14(1):39–45. doi: 10.1016/j.jcm.2015.02.003.

Schubert, Stephanie, Cordula Haas, Christine Bartsch, Mandana Mirshekarnejad, Sarah Kohrs, Irene Roettinger, Anika Grosshennig, Manfred Stuhrmann, Caroline Scholz, and Jörg Schmidtke. 2015. “Variants in TSPYL1 Are Not Associated with Sudden Infant Death Syndrome in a Cohort of Deceased Infants from Switzerland.” Molecular and Cellular Probes 29(1):31–34. doi: 10.1016/j.mcp.2014.10.006.

Lingner, Heidrun, Anika Großhennig, Kathrin Flunkert, Heike Buhr-Schinner, Rolf Heitmann, Ulrich Tönnesmann, Jochen van der Meyden, and Konrad Schultz. 2015. “ProKaSaRe Study Protocol: A Prospective Multicenter Study of Pulmonary Rehabilitation of Patients With Sarcoidosis.” JMIR Research Protocols 4(4):e134. doi: 10.2196/resprot.4948.

Hong, Bujung, Frank Biertz, Peter Raab, Dirk Scheinichen, Philipp Ertl, Anika Grosshennig, Makoto Nakamura, Elvis J. Hermann, Josef M. Lang, Heinrich Lanfermann, and Joachim K. Krauss. 2015. “Normobaric Hyperoxia for Treatment of Pneumocephalus after Posterior Fossa Surgery in the Semisitting Position: A Prospective Randomized Controlled Trial.” PLoS ONE 10(5). doi: 10.1371/journal.pone.0125710.

Hueper, Katja, Faikah Gueler, Jan Hinrich Bräsen, Marcel Gutberlet, Mi Sun Jang, Frank Lehner, Nicolas Richter, Nils Hanke, Matti Peperhove, Petros Martirosian, Susanne Tewes, Van Dai Vo Chieu, Anika Großhennig, Hermann Haller, Frank Wacker, Wilfried Gwinner, and Dagmar Hartung. 2015. “Functional MRI Detects Perfusion Impairment in Renal Allografts with Delayed Graft Function.” American Journal of Physiology - Renal Physiology 308(12):F1444–51. doi: 10.1152/ajprenal.00064.2015.

Gonnermann, Andrea, Theodor Framke, Anika Großhennig, and Armin Koch. 2015. “No Solution yet for Combining Two Independent Studies in the Presence of Heterogeneity.” Statistics in Medicine 34(16):2476–80. doi: 10.1002/sim.6473.

Schober, Tilmann, Theodor Framke, Anika Großhennig, Christoph Klein, Hans Kreipe, and Britta Maecker-Kolhoff. 2015. “CD30 in Pediatric Post-Transplant Lymphoproliferative Disease after Solid Organ Transplant: Characterization of a New Therapeutic Target.” Leukemia and Lymphoma 56(3):832–33.

Behrens, Katharina, Melina A. Del Pozo, Anika Großhennig, Marcel Sieberer, and Iris T. Graef-Calliess. 2015. “How Much Orientation towards the Host Culture Is Healthy? Acculturation Style as Risk Enhancement for Depressive Symptoms in Immigrants.” International Journal of Social Psychiatry 61(5):498–505. doi: 10.1177/0020764014560356.

Schroeder, C., K. Heusser, A. A. Zoerner, A. Großhennig, D. Wenzel, M. May, F. C. G. J. Sweep, H. Mehling, F. C. Luft, J. Tank, and J. Jordan. 2014. “Pacemaker Current Inhibition in Experimental Human Cardiac Sympathetic Activation: A Double-Blind, Randomized, Crossover Study.” Clinical Pharmacology and Therapeutics 95(6):601–7. doi: 10.1038/clpt.2014.25.

Kreuzer, Martin, Jenny Prüfe, Dirk Bethe, Charlotte Vogel, Anika Großhennig, Armin Koch, Martina Oldhafer, Marie-Luise Dierks, Urs-Vito Albrecht, Silvia Müther, Reinhard Brunkhorst, and Lars Pape. 2014. “The TRANSNephro-Study Examining a New Transition Model for Post-Kidney Transplant Adolescents and an Analysis of the Present Health Care: Study Protocol for a Randomized Controlled Trial.” Trials 15(1):505. doi: 10.1186/1745-6215-15-505.

Ahlenstiel-Grunow, Thurid, Armin Koch, Anika Großhennig, Cornelia Frömke, Martina Sester, Urban Sester, Christoph Schröder, and Lars Pape. 2014. “A Multicenter, Randomized, Open-Labeled Study to Steer Immunosuppressive and Antiviral Therapy by Measurement of Virus (CMV, ADV, HSV)-Specific T Cells in Addition to Determination of Trough Levels of Immunosuppressants in Pediatric Kidney Allograft Recip.” Trials 15(1). doi: 10.1186/1745-6215-15-324.

Calle Serrano, B., A. Großhennig, M. Homs, B. Heidrich, A. Erhardt, K. Deterding, J. Jaroszewicz, B. Bremer, A. Koch, M. Cornberg, M. P. Manns, M. Buti, and H. Wedemeyer. 2014. “Development and Evaluation of a Baseline-Event-Anticipation Score for Hepatitis Delta.” Journal of Viral Hepatitis 21(11):e154–63. doi: 10.1111/jvh.12251.

Gillmann, Hans Jörg, Antje Meinders, Anika Großhennig, Jan Larmann, Christoph Bünte, Simone Calmer, Bianca Sahlmann, Saad Rustum, Thomas Aper, Ralf Lichtinghagen, Armin Koch, Omke E. Teebken, and Gregor Theilmeier. 2014. “Perioperative Levels and Changes of High-Sensitivity Troponin T Are Associated with Cardiovascular Events in Vascular Surgery Patients.” Critical Care Medicine 42(6):1498–1506. doi: 10.1097/CCM.0000000000000249.

Großhennig, A., N. Benda, and A. Koch. 2013. “Die Bedeutung von Biomarkern Für Eine Personalisierte Medizin.” Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 56(11):1480–88. doi: 10.1007/s00103-013-1828-9.

Deterding, Katja, Norbert Grüner, Peter Buggisch, Johannes Wiegand, Peter R. Galle, Ulrich Spengler, Holger Hinrichsen, Thomas Berg, Andrej Potthoff, Nisar Malek, Anika Großhennig, Armin Koch, Helmut Diepolder, Stefan Lüth, Sandra Feyerabend, Maria Christina Jung, Magdalena Rogalska-Taranta, Verena Schlaphoff, Markus Cornberg, Michael P. Manns, and Heiner Wedemeyer. 2013. “Delayed versus Immediate Treatment for Patients with Acute Hepatitis C: A Randomised Controlled Non-Inferiority Trial.” The Lancet Infectious Diseases 13(6):497–506. doi: 10.1016/S1473-3099(13)70059-8.

Schober, Tilmann, Theodor Framke, Hans Kreipe, Thomas F. Schulz, Anika Grohennig, Kais Hussein, Ulrich Baumann, Lars Pape, Stephan Schubert, Anne Margret Wingen, Thomas Jack, Armin Koch, Christoph Klein, and Britta Maecker-Kolhoff. 2013. “Characteristics of Early and Late PTLD Development in Pediatric Solid Organ Transplant Recipients.” Transplantation 95(1):240–46. doi: 10.1097/TP.0b013e318277e344.

Schiffer, Lena, Mario Schiffer, Saskia Merkel, Anke Schwarz, Michael Mengel, Christopher Jürgens, Christoph Schroeder, Alexander A. Zoerner, Kerstin Püllmann, Verena Bröcker, Jan U. Becker, Maximilian E. Dämmrich, Jana Träder, Anika Großhennig, Frank Biertz, Hermann Haller, Armin Koch, and Wilfried Gwinner. 2012. “Rationale and Design of the RIACT-Study: A Multi-Center Placebo Controlled Double Blind Study to Test the Efficacy of RItuximab in Acute Cellular Tubulointerstitial Rejection with B-Cell Infiltrates in Renal Transplant Patients: Study Protocol for a Rando.” Trials 13. doi: 10.1186/1745-6215-13-199.

Ziegler, Andreas, Armin Koch, Katja Krockenberger, and Anika Großhennig. 2012. “Personalized Medicine Using DNA Biomarkers: A Review.” Human Genetics 131(10):1627–38.

Mederacke, I., C. Yurdaydin, A. Großhennig, A. Erhardt, Y. Cakaloglu, K. Yalcin, S. Gurel, S. Zeuzem, K. Zachou, C. Chatzikyrkou, H. Bozkaya, G. N. Dalekos, M. P. Manns, and H. Wedemeyer. 2012. “Renal Function during Treatment with Adefovir plus Peginterferon Alfa-2a vs Either Drug Alone in Hepatitis B/D Co-Infection.” Journal of Viral Hepatitis 19(6):387–95. doi: 10.1111/j.1365-2893.2011.01560.x.

Atschekzei, Faranaz, Jörg Hennenlotter, Stefanie Jänisch, Anika Großhennig, Wolfgang Tränkenschuh, Sandra Waalkes, Inga Peters, Thilo Dörk, Axel S. Merseburger, Arnulf Stenzl, Markus A. Kuczyk, and Jürgen Serth. 2012. “SFRP1 CpG Island Methylation Locus Is Associated with Renal Cell Cancer Susceptibility and Disease Recurrence.” Epigenetics 7(5):447–57. doi: 10.4161/epi.19614.

Eggers, H., S. Steffens, A. Grosshennig, J. U. Becker, J. Hennenlotter, A. Stenzl, A. S. Merseburger, M. A. Kuczyk, and J. Serth. 2012. “Prognostic and Diagnostic Relevance of Hypermethylated in Cancer 1 (HIC1) CpG Island Methylation in Renal Cell Carcinoma.” International Journal of Oncology 40(5):1650–58. doi: 10.3892/ijo.2012.1367.

Peters, Inga, Hendrik Eggers, Faranaz Atschekzei, Jörg Hennenlotter, Sandra Waalkes, Wolfgang Tränkenschuh, Anika Großhennig, Axel S. Merseburger, Arnulf Stenzl, Markus A. Kuczyk, and Jürgen Serth. 2012. “GATA5 CpG Island Methylation in Renal Cell Cancer: A Potential Biomarker for Metastasis and Disease Progression.” BJU International 110. doi: 10.1111/j.1464-410X.2011.10862.x.

Javaher, Poupak, Manfred Stuhrmann, Christina Wilke, Eileen Frenzel, Georgi Manukjan, Anika Grosshenig, Frank Dechend, Eva Schwaab, Jörg Schmidtke, and Stephanie Schubert. 2012. “Should TSPYL1 Mutation Screening Be Included in Routine Diagnostics of Male Idiopathic Infertility?” Fertility and Sterility 97(2):402–6. doi: 10.1016/j.fertnstert.2011.11.002.

Großhennig A, Framke T, Koch A (2011): Now: Prediction intervals - was I2 really an advantage? (epup ): Rapid response on Riley, RD et al. (2011): Interpretation of random effects meta-analyses., BMJ.: 342:d549

Kulik, U., T. Framke, A. Grohennig, A. Ceylan, H. Bektas, J. Klempnauer, and F. Lehner. 2011. “Liver Resection of Colorectal Liver Metastases in Elderly Patients.” World Journal of Surgery 35(9):2063–72. doi: 10.1007/s00268-011-1180-x.

Agustian, Putri A., Mario Schiffer, Wilfried Gwinner, Irini Schäfer, Katharina Theophile, Friedrich Modde, Clemens L. Bockmeyer, Jana Traeder, Ulrich Lehmann, Anika Großhennig, Hans H. Kreipe, Verena Bröcker, and Jan Ulrich Becker. 2011. “Diminished Met Signaling in Podocytes Contributes to the Development of Podocytopenia in Transplant Glomerulopathy.” American Journal of Pathology 178(5):2007–19. doi: 10.1016/j.ajpath.2011.01.042.

Tank, Jens, Heike Biller, Karsten Heusser, Olaf Holz, André Diedrich, Theodor Framke, Armin Koch, Anika Grosshennig, Wolfgang Koch, Norbert Krug, Jens Jordan, and Jens M. Hohlfeld. 2011. “Effect of Acute Ozone Induced Airway Inflammation on Human Sympathetic Nerve Traffic: A Randomized, Placebo Controlled, Crossover Study.” PLoS ONE 6(4). doi: 10.1371/journal.pone.0018737.

Damm, Frederik, Michael Heuser, Michael Morgan, Katharina Wagner, Kerstin Görlich, Anika Großhennig, Iyas Hamwi, Felicitas Thol, Ewa Surdziel, Walter Fiedler, Michael Lübbert, Lothar Kanz, Christoph Reuter, Gerhard Heil, Ruud Delwel, Bob Löwenberg, Peter J. M. Valk, Jürgen Krauter, and Arnold Ganser. 2011. “Integrative Prognostic Risk Score in Acute Myeloid Leukemia with Normal Karyotype.” Blood 117(17):4561–68. doi: 10.1182/blood-2010-08-303479.

Reichelt, Angela, Christian Zeckey, Frank Hildebrand, Anika Grosshennig, Hoen Oh Shin, Michael Galanski, and Mark Keberle. 2012. “Imaging of the Brain in Polytraumatized Patients Comparing 64-Row Spiral CT with Incremental (Sequential) CT.” European Journal of Radiology 81(4):789–93. doi: 10.1016/j.ejrad.2011.01.090.

Erdmann, Jeanette, Christina Willenborg, Janja Nahrstaedt, Michael Preuss, Inke R. König, Jens Baumert, Patrick Linsel-Nitschke, Christian Gieger, Stephanie Tennstedt, Petra Belcredi, Zouhair Aherrahrou, Norman Klopp, Christina Loley, Klaus Stark, Christian Hengstenberg, Petra Bruse, Jennifer Freyer, Arnika K. Wagner, Anja Medack, Wolfgang Lieb, Anika Großhennig, Hendrik B. Sager, Adrian Reinhardt, Arne Schäfer, Stefan Schreiber, Nour Eddine El Mokhtari, Dorette Raaz-Schrauder, Thomas Illig, Christoph D. Garlichs, Arif B. Ekici, André Reis, Jrgen Schrezenmeir, Diana Rubin, Andreas Ziegler, H. E. Wichmann, Angela Doering, Christa Meisinger, Thomas Meitinger, Annette Peters, and Heribert Schunkert. 2011. “Genome-Wide Association Study Identifies a New Locus for Coronary Artery Disease on Chromosome 10p11.23.” European Heart Journal 32(2):158–68. doi: 10.1093/eurheartj/ehq405.

Assimes, Themistocles L., Hilma Hlm, Sekar Kathiresan, Muredach P. Reilly, Gudmar Thorleifsson, Benjamin F. Voight, Jeanette Erdmann, Christina Willenborg, Dhananjay Vaidya, Changchun Xie, Chris C. Patterson, Thomas M. Morgan, Mary Susan Burnett, Mingyao Li, Mark A. Hlatky, Joshua W. Knowles, John R. Thompson, Devin Absher, Carlos Iribarren, Alan Go, Stephen P. Fortmann, Stephen Sidney, Neil Risch, Hua Tang, Richard M. Myers, Klaus Berger, Monika Stoll, Svati H. Shah, Gudmundur Thorgeirsson, Karl Andersen, Aki S. Havulinna, J. Enrique Herrera, Nauder Faraday, Yoonhee Kim, Brian G. Kral, Rasika A. Mathias, Ingo Ruczinski, Bhoom Suktitipat, Alexander F. Wilson, Lisa R. Yanek, Lewis C. Becker, Patrick Linsel-Nitschke, Wolfgang Lieb, Inke R. Knig, Christian Hengstenberg, Marcus Fischer, Klaus Stark, Wibke Reinhard, Janina Winogradow, Martina Grassl, Anika Grosshennig, Michael Preuss, Stefan Schreiber, H. Erich Wichmann, Christa Meisinger, Jean Yee, Yechiel Friedlander, Ron Do, James B. Meigs, Gordon Williams, David M. Nathan, Calum A. MacRae, Liming Qu, Robert L. Wilensky, William H. Matthai, Atif N. Qasim, Hakon Hakonarson, Augusto D. Pichard, Kenneth M. Kent, Lowell Satler, Joseph M. Lindsay, Ron Waksman, Christopher W. Knouff, Dawn M. Waterworth, Max C. Walker, Vincent E. Mooser, Jaume Marrugat, Gavin Lucas, Isaac Subirana, Joan Sala, Rafael Ramos, Nicola Martinelli, Oliviero Olivieri, Elisabetta Trabetti, Giovanni Malerba, Pier Franco Pignatti, Candace Guiducci, Daniel Mirel, Melissa Parkin, Joel N. Hirschhorn, Rosanna Asselta, Stefano Duga, Kiran Musunuru, Mark J. Daly, Shaun Purcell, Sandra Eifert, Peter S. Braund, Benjamin J. Wright, Anthony J. Balmforth, Stephen G. Ball, Willem H. Ouwehand, Panos Deloukas, Michael Scholz, Francois Cambien, Andreas Huge, Thomas Scheffold, Veikko Salomaa, Domenico Girelli, Christopher B. Granger, Leena Peltonen, Pascal P. McKeown, David Altshuler, Olle Melander, Joseph M. Devaney, Stephen E. Epstein, Daniel J. Rader, Roberto Elosua, James C. Engert, Sonia S. Anand, Alistair S. Hall, Andreas Ziegler, Christopher J. O’Donnell, John A. Spertus, David Siscovick, Stephen M. Schwartz, Diane Becker, Unnur Thorsteinsdottir, Kari Stefansson, Heribert Schunkert, Nilesh J. Samani, and Thomas Quertermous. 2010. “Lack of Association between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies.” Journal of the American College of Cardiology 56(19):1552–63. doi: 10.1016/j.jacc.2010.06.022.

Teupser, Daniel, Ronny Baber, Uta Ceglarek, Markus Scholz, Thomas Illig, Christian Gieger, Lesca M. Holdt, Alexander Leichtle, Karin H. Greiser, Dominik Huster, Patrick Linsel-Nitschke, Arne Schäfer, Peter S. Braund, Laurence Tiret, Klaus Stark, Dorette Raaz-Schrauder, Georg M. Fiedler, Wolfgang Wilfert, Frank Beutner, Stephan Gielen, Anika Großhennig, Inke R. König, Peter Lichtner, Iris M. Heid, Alexander Kluttig, Nour E. El Mokhtari, Diana Rubin, Arif B. Ekici, André Reis, Christoph D. Garlichs, Alistair S. Hall, Gert Matthes, Christian Wittekind, Christian Hengstenberg, Francois Cambien, Stefan Schreiber, Karl Werdan, Thomas Meitinger, Markus Loeffler, Nilesh J. Samani, Jeanette Erdmann, H. Erich Wichmann, Heribert Schunkert, and Joachim Thiery. 2010. “Genetic Regulation of Serum Phytosterol Levels and Risk of Coronary Artery Disease.” Circulation: Cardiovascular Genetics 3(4):331–39. doi: 10.1161/CIRCGENETICS.109.907873.

Ivanyi, Philipp, Thomas Winkler, Anika Großhennig, Christoph Reuter, Axel S. Merseburger, Arnold Ganser, and Viktor Grünwald. 2010. “Treatment with Tyrosine Kinase Inhibitors in Patients with Metastatic Renal Cell Carcinoma Is Associated with Drug-Induced Hyperparathyroidism: A Single Center Experience in 59 Patients.” World Journal of Urology 28(3):311–17. doi: 10.1007/s00345-010-0558-y.

Damm, Frederik*, Michael Heuser*, Michael Morgan, Haiyang Yun, Anika Großhennig, Gudrun Göhring, Brigitte Schlegelberger, Konstanze Döhner, Oliver Ottmann, Michael Lübbert, Wolfgang Heit, Lothar Kanz, Günter Schlimok, Aruna Raghavachar, Walter Fiedler, Hartmut Kirchner, Hartmut Döhner, Gerhard Heil, Arnold Ganser, and Jürgen Krauter. 2010. “Single Nucleotide Polymorphism in the Mutational Hotspot of WT1 Predicts a Favorable Outcome in Patients with Cytogenetically Normal Acute Myeloid Leukemia.” Journal of Clinical Oncology 28(4):578–85. doi: 10.1200/JCO.2009.23.0342.

Vasan, Ramachandran S., Nicole L. Glazer, Janine F. Felix, Wolfgang Lieb, Philipp S. Wild, Stephan B. Felix, Norbert Watzinger, Martin G. Larson, Nicholas L. Smith, Abbas Dehghan, Anika Großhennig, Arne Schillert, Alexander Teumer, Reinhold Schmidt, Sekar Kathiresan, Thomas Lumley, Yurii S. Aulchenko, Inke R. König, Tanja Zeller, Georg Homuth, Maksim Struchalin, Jayashri Aragam, Joshua C. Bis, Fernando Rivadeneira, Jeanette Erdmann, Renate B. Schnabel, Marcus Dörr, Robert Zweiker, Lars Lind, Richard J. Rodeheffer, Karin Halina Greiser, Daniel Levy, Talin Haritunians, Jaap W. Deckers, Jan Stritzke, Karl J. Lackner, Uwe Völker, Erik Ingelsson, Iftikhar Kullo, Johannes Haerting, Christopher J. O’Donnell, Susan R. Heckbert, Bruno H. Stricker, Andreas Ziegler, Thorsten Reffelmann, Margaret M. Redfield, Karl Werdan, Gary F. Mitchell, Kenneth Rice, Donna K. Arnett, Albert Hofman, John S. Gottdiener, Andre G. Uitterlinden, Thomas Meitinger, Maria Blettner, Nele Friedrich, Thomas J. Wang, Bruce M. Psaty, Cornelia M. van Duijn, H. Erich Wichmann, Thomas F. Munzel, Heyo K. Kroemer, Emelia J. Benjamin, Jerome I. Rotter, Jacqueline C. Witteman, Heribert Schunkert, Helena Schmidt, Henry Völzke, and Stefan Blankenberg. 2009. “Genetic Variants Associated With Cardiac Structure and Function.” JAMA. doi: 10.1001/jama.2009.978-a.

Erdmann, Jeanette, Anika Großhennig, Peter S. Braund, Inke R. König, Christian Hengstenberg, Alistair S. Hall, Patrick Linsel-Nitschke, Sekar Kathiresan, Ben Wright, David Alexandre Trégouët, Francois Cambien, Petra Bruse, Zouhair Aherrahrou, Arnika K. Wagner, Klaus Stark, Stephen M. Schwartz, Veikko Salomaa, Roberto Elosua, Olle Melander, Benjamin F. Voight, Christopher J. O’Donnell, Leena Peltonen, David S. Siscovick, David Altshuler, Piera Angelica Merlini, Flora Peyvandi, Luisa Bernardinelli, Diego Ardissino, Arne Schillert, Stefan Blankenberg, Tanja Zeller, Philipp Wild, Daniel F. Schwarz, Laurence Tiret, Claire Perret, Stefan Schreiber, Nour Eddine El Mokhtari, Arne Schäfer, Winfried März, Wilfried Renner, Peter Bugert, Harald Klüter, Jürgen Schrezenmeir, Diana Rubin, Stephen G. Ball, Anthony J. Balmforth, H. Erich Wichmann, Thomas Meitinger, Marcus Fischer, Christa Meisinger, Jens Baumert, Annette Peters, Willem H. Ouwehand, Panos Deloukas, John R. Thompson, Andreas Ziegler, Nilesh J. Samani, and Heribert Schunkert. 2009. “New Susceptibility Locus for Coronary Artery Disease on Chromosome 3q22.3.” Nature Genetics 41(3):280–82. doi: 10.1038/ng.307.

Trégouët, David Alexandre, Inke R. König, Jeanette Erdmann, Alexandru Munteanu, Peter S. Braund, Alistair S. Hall, Anika Großhennig, Patrick Linsel-Nitschke, Claire Perret, Maylis DeSuremain, Thomas Meitinger, Ben J. Wright, Michael Preuss, Anthony J. Balmforth, Stephen G. Ball, Christa Meisinger, Cécile Germain, Alun Evans, Dominique Arveiler, Gérald Luc, Jean Bernard Ruidavets, Caroline Morrison, Pim Van Der Harst, Stefan Schreiber, Katharina Neureuther, Arne Schäfer, Peter Bugert, Nour E. El Mokhtari, Jürgen Schrezenmeir, Klaus Stark, Diana Rubin, H. Erich Wichmann, Christian Hengstenberg, Willem Ouwehand, Andreas Ziegler, Laurence Tiret, John R. Thompson, Francois Cambien, Heribert Schunkert, and Nilesh J. Samani. 2009. “Genome-Wide Haplotype Association Study Identifies the SLC22A3-LPAL2-LPA Gene Cluster as a Risk Locus for Coronary Artery Disease.” Nature Genetics 41(3):283–85. doi: 10.1038/ng.314.

Kathiresan, Sekar, Benjamin F. Voight, Shaun Purcell, Kiran Musunuru, Diego Ardissino, Pier M. Mannucci, Sonia Anand, James C. Engert, Nilesh J. Samani, Heribert Schunkert, Jeanette Erdmann, Muredach P. Reilly, Daniel J. Rader, Thomas Morgan, John A. Spertus, Monika Stoll, Domenico Girelli, Pascal P. McKeown, Chris C. Patterson, David S. Siscovick, Christopher J. O’Donnell, Roberto Elosua, Leena Peltonen, Veikko Salomaa, Stephen M. Schwartz, Olle Melander, David Altshuler, Pier Angelica Merlini, Carlo Berzuini, Luisa Bernardinelli, Flora Peyvandi, Marco Tubaro, Patrizia Celli, Maurizio Ferrario, Raffaela Fetiveau, Nicola Marziliano, Giorgio Casari, Michele Galli, Flavio Ribichini, Marco Rossi, Francesco Bernardi, Pietro Zonzin, Alberto Piazza, Jean Yee, Yechiel Friedlander, Jaume Marrugat, Gavin Lucas, Isaac Subirana, Joan Sala, Rafael Ramos, James B. Meigs, Gordon Williams, David M. Nathan, Calum A. MacRae, Aki S. Havulinna, Goran Berglund, Joel N. Hirschhorn, Rosanna Asselta, Stefano Duga, Marta Spreafico, Mark J. Daly, James Nemesh, Joshua M. Korn, Steven A. McCarroll, Aarti Surti, Candace Guiducci, Lauren Gianniny, Daniel Mirel, Melissa Parkin, Noel Burtt, Stacey B. Gabriel, John R. Thompson, Peter S. Braund, Benjamin J. Wright, Anthony J. Balmforth, Stephen G. Ball, Alistair S. Hall, Patrick Linsel-Nitschke, Wolfgang Lieb, Andreas Ziegler, Inke R. König, Christian Hengstenberg, Marcus Fischer, Klaus Stark, Anika Grosshennig, Michael Preuss, H. Erich Wichmann, Stefan Schreiber, Willem Ouwehand, Panos Deloukas, Michael Scholz, Francois Cambien, Cardiogenics, Mingyao Li, Zhen Chen, Robert Wilensky, William Matthai, Atif Qasim, Hakon H. Hakonarson, Joe Devaney, Mary Susan Burnett, Augusto D. Pichard, Kenneth M. Kent, Lowell Satler, Joseph M. Lindsay, Ron Waksman, Stephen E. Epstein, Thomas Scheffold, Klaus Berger, Andreas Huge, Nicola Martinelli, Oliviero Olivieri, Roberto Corrocher, Hilma Hólm, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Kari Stefansson, Ron Do, Changchun Xie, and David Siscovick. 2009. “Genome-Wide Association of Early-Onset Myocardial Infarction with Single Nucleotide Polymorphisms and Copy Number Variants.” Nature Genetics 41(3):334–41. doi: 10.1038/ng.327.

Samani, N. J., P. Deloukas, J. Erdmann, C. Hengstenberg, K. Kuulasmaa, R. McGinnis, H. Schunkert, N. Soranzo, J. Thompson, L. Tiret, A. Ziegler, P. Amouyel, D. Arveiler, S. M. Boekholdt, P. Braund, P. Bruse, S. J. Bumpstead, P. Bugert, F. Cambien, J. Danesh, A. Doering, P. Ducimetière, R. M. Dunn, N. E. El Mokhtari, A. Evans, P. Ewels, J. Ferrières, M. Fischer, P. Frossard, S. Garner, C. Gieger, M. J. Gohri, A. H. Goodall, A. Grosshennig, A. Hall, R. Hardwick, A. Haukijärvi, T. Illig, J. Karvanen, J. Kastelein, F. Kee, K. T. Khaw, H. Klüter, I. R. König, P. Laiho, G. Luc, W. März, W. McLaren, C. Meisinger, C. Morrison, X. Ou, W. H. Ouwehand, M. Preuss, C. Proust, R. Ravindrarajah, W. Renner, K. Rice, J. B. Ruidavets, D. Saleheen, V. Salomaa, M. S. Sandhu, A. S. Schäfer, M. Scholz, S. Schreiber, K. Silander, R. Singh, K. Stark, B. Stegmayr, J. Stephens, M. D. Trip, E. van der Schoot, J. Virtamo, N. J. Wareham, H. E. Wichmann, P. G. Wiklund, B. Wright, and J. J. Zwaginga. 2009. “Large Scale Association Analysis of Novel Genetic Loci for Coronary Artery Disease.” Arteriosclerosis, Thrombosis, and Vascular Biology 29(5):774–80. doi: 10.1161/ATVBAHA.108.181388.

Linsel-Nitschke, Patrick*, Anika Götz*, Anja Medack, Inke R. König, Petra Bruse, Wolfgang Lieb, Björn Mayer, Klaus Stark, Christian Hengstenberg, Marcus Fischer, Andrea Baessler, Andreas Ziegler, Heribert Schunkert, and Jeanette Erdmann. 2008. “Genetic Variation in the Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP)Is Associated with Myocardial Infarction in the German Population.” Clinical Science 115(10):309–15. doi: 10.1042/CS20070468.

Samani, Nilesh J., Peter S. Braund, Jeanette Erdmann, Anika Götz, MacIej Tomaszewski, Patrick Linsel-Nitschke, Cother Hajat, Massimo Mangino, Christian Hengstenberg, Klaus Stark, Andreas Ziegler, Mark Caulfield, Paul R. Burton, Heribert Schunkert, and Martin D. Tobin. 2008. “The Novel Genetic Variant Predisposing to Coronary Artery Disease in the Region of the PSRC1 and CELSR2 Genes on Chromosome 1 Associates with Serum Cholesterol.” Journal of Molecular Medicine 86(11):1233–41. doi: 10.1007/s00109-008-0387-2.

Lieb, Wolfgang*, Tanja Zeller*, Massimo Mangino*, Anika Götz, Peter Braund, Juergen J. Wenzel, Christian Horn, Carole Proust, Patrick Linsel-Nitschke, Philippe Amouyel, Petra Bruse, Dominique Arveiler, Inke R. König, Jean Ferrières, Andreas Ziegler, Anthony J. Balmforth, Alun Evans, Pierre Ducimetière, Francois Cambien, Christian Hengstenberg, Klaus Stark, Alistair S. Hall, Heribert Schunkert, Stefan Blankenberg, Nilesh J. Samani, Jeanette Erdmann, Laurence Tiret, Laurence W. Tiret contributed equally Lieb, Anika Götz, Christian Horn, Patrick Linsel-Nitschke, Petra Bruse, Heribert Schunkert, Jeanette Erdmann, Wolfgang Lieb, Tanja Zeller, Juergen J. Wenzel, Stefan Blankenberg, Massimo Mangino, Peter Braund, Nilesh J. Samani, Inke R. König, Andreas Ziegler, Carole Proust, Francois Cambien, Laurence Tiret, and Philippe Amouyel. 2008. “Lack of Association of Genetic Variants in the LRP8 Gene with Familial and Sporadic Myocardial Infarction.” Journal of Molecular Medicine 86(10):1163–70. doi: 10.1007/s00109-008-0376-5.

Linsel-Nitschke, Patrick, Anika Götz, Jeanette Erdmann, Ingrid Braenne, Peter Braund, Christian Hengstenberg, Klaus Stark, Marcus Fischer, Stefan Schreiber, Nour Eddine El Mokhtari, Arne Schaefer, Jürgen Schrezenmeier, Diana Rubin, Anke Hinney, Thomas Reinehr, Christian Roth, Jan Ortleep, Peter Hanrath, Alistair S. Hall, Massimo Mangino, Wolfgang Lieb, Claudia Lamina, Iris M. Heid, Angela Doering, Christian Gieger, Annette Peters, Thomas Meitinger, H. Erich Wichmann, Inke R. König, Andreas Ziegler, Florian Kronenberg, Nilesh J. Samani, and Heribert Schunkert. 2008. “Lifelong Reduction of LDL-Cholesterol Related to a Common Varriant in the LDL-Receptor Gene Decreases the Risk of Coronary Artery Disease - A Mendelian Randomisation Study.” PLoS ONE 3(8). doi: 10.1371/journal.pone.0002986.

Schunkert, Heribert, Anika Götz, Peter Braund, Ralph McGinnis, David Alexandre Tregouet, Massimo Mangino, Patrick Linsel-Nitschke, Francois Cambien, Christian Hengstenberg, Klaus Stark, Stefan Blankenberg, Laurence Tiret, Pierre Ducimetiere, Andrew Keniry, Mohammed J. R. Ghori, Stefan Schreiber, Nour Eddine El Mokhtari, Alistair S. Hall, Richard J. Dixon, Alison H. Goodall, Henrike Liptau, Helen Pollard, Daniel F. Schwarz, Ludwig A. Hothorn, H. Erich Wichmann, Inke R. König, Marcus Fischer, Christa Meisinger, Willem Ouwehand, Panos Deloukas, John R. Thompson, Jeanette Erdmann, Andreas Ziegler, and Nilesh J. Samani. 2008. “Repeated Replication and a Prospective Meta-Analysis of the Association between Chromosome 9p21.3 and Coronary Artery Disease.” Circulation 117(13):1675–84. doi: 10.1161/CIRCULATIONAHA.107.730614.

Lieb, Wolfgang, Björn Mayer, Inke R. König, Iris Borwitzky, Anika Götz, Silke Kain, Christian Hengstenberg, Patrick Linsel-Nitschke, Marcus Fischer, Angela Döring, H. Erich Wichmann, Thomas Meitinger, Reinhold Kreutz, Andreas Ziegler, Heribert Schunkert, and Jeanette Erdmann. 2008. “Lack of Association between the MEF2A Gene and Myocardial Infarction.” Circulation 117(2):185–91. doi: 10.1161/CIRCULATIONAHA.107.728485.

Mayer, Björn, Wolfgang Lieb, Peter W. Radke, Anika Götz, Marcus Fischer, Andrea Bässler, Lars C. Doehring, Zouhair Aherrahrou, Henrike Liptau, Jeanette Erdmann, Stephan Holmer, Hans Werner Hense, Christian Hengstenberg, and Heribert Schunkert. 2007. “Association between Arterial Pressure and Coronary Artery Calcification.” Journal of Hypertension 25(8):1731–38. doi: 10.1097/HJH.0b013e328165cbb6.

Aherrahrou, Zouhair, Lars C. Doehring, Piotr M. Kaczmarek, Henrike Liptau, Eva Maria Ehlers, Andrea Pomarino, Sandra Wrobel, Anika Götz, Bjoern Mayer, Jeanette Erdmann, and Heribert Schunkert. 2007. “Ultrafine Mapping of Dyscalc1 to an 80-Kb Chromosomal Segment on Chromosome 7 in Mice Susceptible for Dystrophic Calcification.” Physiological Genomics 28(2):203–12. doi: 10.1152/physiolgenomics.00133.2006.

Mayer, Björn*, Wolfgang Lieb*, Anika Götz, Inke R. König, Lena F. Kauschen, Patrick Linsel-Nitschke, Andrea Pomarino, Stephan Holmer, Christian Hengstenberg, Angela Doering, Hannelore Loewel, Hans Werner Hense, Andreas Ziegler, Jeanette Erdmann, and Heribert Schunkert. 2006. “Association of a Functional Polymorphism in the CYP4A11 Gene with Systolic Blood Pressure in Survivors of Myocardial Infarction.” Journal of Hypertension 24(10):1965–70. doi: 10.1097/01.hjh.0000244944.34546.8e.

Lieb, Wolfgang*, Jochen Graf*, Anika Götz, Inke R. König, Björn Mayer, Marcus Fischer, Jan Stritzke, Christian Hengstenberg, Stephan R. Holmer, Angela Döring, Hannelore Löwel, Heribert Schunkert, and Jeanette Erdmann. 2006. “Association of Angiotensin-Converting Enzyme 2 (ACE2) Gene Polymorphisms with Parameters of Left Ventricular Hypertrophy in Men: Results of the MONICA Augsburg Echocardiographic Substudy.” Journal of Molecular Medicine 84(1):88–96. doi: 10.1007/s00109-005-0718-5.

Mayer, Bjoern, Wolfgang Lieb, Anika Götz, Inke R. König, Zouhair Aherrahrou, Annett Thiemig, Stephan Holmer, Christian Hengstenberg, Angela Doering, Hannelore Loewel, Hans Werner Hense, Heribert Schunkert, and Jeanette Erdmann. 2005. “Association of the T8590C Polymorphism of CYP4A11 with Hypertension in the MONICA Augsburg Echocardiographic Substudy.” Hypertension 46(4):766–71. doi: 10.1161/01.HYP.0000182658.04299.15.


*authors contributed equally

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seit 10/2016

Medizinische Dokumentarin am Institut für Biometrie, Medizinische Hochschule Hannover

08/2004 - 09/2016

Angestellte der Arbeitsgruppe "Perinatale Neuroepidemiologie", Medizinische Hochschule Hannover

02/2002 - 07/2004

Angestellte des Regionalen Rechenzentrums für Niedersachsen an der Universität Hannover (RRZN) mit der Aufgabe "Anwenderunterstützung auf dem Gebiet Statistik"

09/2001 - 11/2001

Praktikum am Institut für Biometrie, Epidemiologie und Informationsverarbeitung (IBEI), Tierärztliche Hochschule Hannover

02/2000 - 07/2000

Praktikum im Zentrum für Qualität und Management im Gesundheitswesen (Einrichtung der Ärztekammer Niedersachen)

 

- Studium -

09/1998 - 08/2002

Fachhochschule Hannover, Biowissenschaftliche Dokumentation, Abschluss: Diplom

Diplomarbeit zum Thema "Statistische Modellbildung zur Entwicklung von Bilanzrechnungen in der Eiproduktion"

 

• Arbeitsschwerpunkte:

- Entwicklung von Algorithmen zur Analyse von EKG-Signalen

- Qualitätskontrolle von EKG-Daten

- Systemnahe Programmierung

- IT-Beauftragter

- Sicherheits-Beauftragter

 

• Lebenslauf

seit 06/2002

Technischer Angestellter am Institut für Biometrie der Medizinischen Hochschule Hannover

09/1989 – 05/2002

Technischer Angestellter in der Arbeitsgruppe Biometrie der Medizinischen Hochschule Hannover

09/1985 – 08/1989

Studium der Elektrotechnik (Vertiefungsrichtung Informationstechnik) an der Fachhochschule  Hannover (Abschluss: Dipl.-Ing. (FH))

 

• Publikationen

Alter, Peter, Henrik Watz, Kathrin Kahnert, Klaus F. Rabe, Frank Biertz, Ronald Fischer, Philip Jung, Jana Graf, Robert Bals, Claus F. Vogelmeier, and Rudolf A. Jörres. 2019. “Effects of Airway Obstruction and Hyperinflation on Electrocardiographic Axes in COPD.” Respiratory Research 20(1):61. doi: 10.1186/s12931-019-1025-y.

Khawaja A, Litwin J, Auzinger T, O’Rourke W, Devine T, Furlong A, Lehmann C, Fischer R (2011): Analyzing the Delineation Precision of Hannover ECG System (HES): A Validation Study. Computing in Cardiology 2011;38:617-620

Baas, T., F. Gravenhorst, R. Fischer, A. Khawaja, and O. Dössel. 2010. “Comparison of Three T-Wave Delineation Algorithms Based on Wavelet Filterbank, Correlation and PCA.” Computing in Cardiology 37:264–364.

Khawaja, A., R. Petrovic, A. Safer, T. Baas, O. Dössel, and R. Fischer. 2010. “Analyzing Thorough QT Study 1 & 2 in the Telemetric and Holter ECG Warehouse (THEW) Using Hannover ECG System HES ® : A Validation Study.” Computing in Cardiology 37:349–52.

Zywietz, T. K., A. Khawaja, R. Petrovic, R. Fischer, and J. Reinstaedtler. 2009. “Increasing Patient Safety in Drug Trials with Computer Based Analysis-a Study with 13.000 Resting ECGs.” Computers in Cardiology 36:245–48.

Fischer, R., M. F. Sinner, R. Petrovic, E. Tarita, S. Kääb, and T. K. Zywietz. 2008. “Testing the Quality of 12 Lead Holter Analysis Algorithms.” Computers in Cardiology 35:435–56.

Zywietz TK, Fischer R (2007): Intelligent Internet Based, High Quality ECG Analysis for Clinical Trials. MEDICON 2007-IFMBE Proceedings;16;22-25

Chronaki, C. E., F. Chiarugi, and R. Fischer. 2006. “OpenECG: Medical Device Interoperability as a Quality Label for EHealth Services.” Computers in Cardiology 33:465–68.

Fischer, R., F. Chiarugi, and T. K. Zywietz. 2006. “Enhanced Integrated Format and Content Checking for Processing of SCP ECG Records.” Computers in Cardiology 33:413–16.

Fischer R, Klein G, Widiger B, Hoy L, Zywietz C (2005): Discrimination between Atrial Flutter and Atrial Fibrillation by Computing a Flutter Index. Computers in Cardiology 2005;32:81-84

Zywietz C, Widiger B, Fischer R (2004): Extension of the HES Program for Processing Pediatric ECGs. Computers in Cardiology 2004;31:169-172

Zywietz C, Kraemer M, Fischer R, Widiger B (2004): Integrating the ECG Enterprise - HES-EKG with the Built-in Vital Signs Information Nomenclature.
Computers in Cardiology 2004;31:41-44

Zywietz C, Fischer R (2004): Integrated Content and Format Checking for Processing of SCP ECG Records. Computers in Cardiology 2004;31:37-40

Fischer R, Zywietz C, Widiger B (2004): Conformance Testing Tools for the Interchange Format of SCP Files. MEDICON 2004-IFMBE Proceedings;6;#225

Zywietz C, Fischer R, Widiger B (2004): Application of the SCP Standard for Stress-and Holter ECGs. MEDICON 2004-IFMBE Proceedings;6;#110

Zywietz C, Fischer R, Widiger B (2004): Application of SCP for Stress and Holter Electrocardiography. 2nd OpenECG Workshop 2004; Proceedings; 70-71

Zywietz C, Widiger B, Fischer R (2003): A System for Comprehensive Comparison of Serial ECG Beats and Serial ECG Recordings. Computers in Cardiology 2003;30:689-692

Fischer R, Chiarugi F, Schmid JJ, Norgall T, Zywietz C (2003): Communication and Retrieval of ECG Data: How Many Standards Do We Need? Computers in Cardiology 2003;30:21-24

Zywietz C, Widiger B, Fischer R, Joseph G (2002): A System for Comprehensive ECG Waveform and Trend Analysis Accompanying Polysomnographic Sleep Apnea Detection. Computers in Cardiology 2002;29:577-580

Zywietz C, Alraun W, Fischer R (2001): Quality Assurance in Biosignal Processing - Procedures and Recommendations for Evaluation for Electrocardiological Analysis Systems. Computers in Cardiology 2001;28:201-204

Zywietz C, Fischer R, Joseph G (2001): Communication and Storage of Compressed Resting and Exercise ECGs Using the Revised SCP-ECG Standard. Computers in Cardiology 2001;28:189-192

Zywietz C, Joseph G, Fischer R (2000): A System for Integrated ECG Analysis and Cardiac Emergency Care. Computers in Cardiology 2000;27:793-796

Fischer R, Wiese B, Joseph G, Widiger B, Zywietz C (1999): QT Dispersion Validity in View of Measurement Accuracy. Computers in Cardiology 1999;26:73-76

Joseph G, Zywietz C, Fischer R, Widiger B (1998): Influence of Measurement Parameter Changes and Statistical Parameter Characteristics on the Stability of ECG Classification in HES ECG. Computers in Cardiology 1998;25:61-64

Joseph G, Zywietz C, Fischer R (1992): Standardisierung der Übertragung von Biosignalen in der Europäischen Gemeinschaft - Das SCP-ECG Protokoll
in Michaelis J, Hommel G, Wellek S (eds): Europäische Perspektiven der Medizinischen Informatik, Biometrie und Epidemiologie, MMV Verlag München, 1992, pp 239-242.

Joseph G, Fischer R, Alraun W, Zywietz Chr (1991): Data compression of resting ECG. 1st European Conference on Biomedical Engineering, Nice/France 1991;February.

Zywietz Chr, Joseph G, Fischer R (1990): Compression of diagnostic resting electrocardiograms. Computers in Cardiology 1990;17:391-394

• Arbeitsschwerpunkte/Aufgaben

- biometrische Beratung

- klinische Studien

- Lehre

 

• Lebenslauf

2018

Promotion zum Dr. rer. nat.

seit 05/2009

Wissenschaftlicher Mitarbeiter am Institut für Biometrie, Medizinische Hochschule Hannover

10/2002 - 03/2009

Studium der Statistik an der TU Dortmund, Abschluss als Diplom-Statistiker

02/2006 - 12/2006

Zwei Auslandssemester am Department of Statistics der University of Auckland, Abschluss: Postgraduate Diploma in Science (with merit)

• Publikationen

Rippin, Gerd, Héctor Sanz, Wilhelmina E. Hoogendoorn, Nicolás M. Ballarini, Joan A. Largent, Eleni Demas, Douwe Postmus, Theodor Framke, Lukas M. Aguirre Dávila, Chantal Quinten, and Francesco Pignatti. 2024. “Examining the Effect of Missing Data and Unmeasured Confounding on External Comparator Studies: Case Studies and Simulations.” Drug Safety. doi: 10.1007/s40264-024-01467-9.

Hofner, Benjamin, Elina Asikanius, Wolfgang Jacquet, Theodor Framke, Katrien Oude Rengerink, Lukas Aguirre Dávila, Maria Grünewald, Florian Klinglmüller, Martin Posch, Finbarr P. Leacy, Thomas Lang, Armin Koch, Jörg Zinserling, and Kit Roesextra. 2024. “Vaccine Development during a Pandemic: General Lessons for Clinical Trial Design.” Statistics in Biopharmaceutical Research 16(2):158–70. doi: 10.1080/19466315.2023.2211538.

Billingham, Lucinda, Lynn Brown, Theodor Framke, Alastair Greystoke, Eivind Hovig, Siddhartha Mathur, Philippe Page, Elias Pean, Sahar Barjesteh van Waalwijk van Doorn-Khosrovani, Richardus Vonk, Sacha Wissink, Hilke Zander, and Ruth Plummer. 2024. “Histology Independent Drug Development – Is This the Future for Cancer Drugs?” Cancer Treatment Reviews 123:102674. doi: 10.1016/j.ctrv.2023.102674.

Sridhara, Rajeshwari, Elizabeth Barksdale, Olga Marchenko, Qi Jiang, Yuki Ando, Erick Bloomquist, Michael Coory, Melissa Crouse, Evgeny Degtyarev, Theodor Framke, Boris Freidlin, David E. Gerber, Thomas Gwise, Filip Josephson, Lorenzo Hess, Paul Kluetz, Daniel Li, Sumithra Mandrekar, Martin Posch, Khadija Rantell, Bohdana Ratitch, Andrew Raven, Kit Roes, Kaspar Rufibach, Sinan B. Sarac, Richard Simon, Harpreet Singh, Marc Theoret, Andrew Thomson, Emmanuel Zuber, Yuan Li Shen, and Richard Pazdur. 2023. “Cancer Clinical Trials beyond Pandemic: Report of an American Statistical Association Biopharmaceutical Section Open Forum Discussion.” Statistics in Biopharmaceutical Research 15(2):444–49. doi: 10.1080/19466315.2022.2103181.

Schwarz, Anke, Frank Schäfer, Theodor Framke, Silvia Linnenweber-Held, Nicolas Richter, and Hermann Haller. 2021. “Risk Factors Influencing the Outcomes of Kidney Re-Transplantation.” Annals of Transplantation 26:1–23. doi: 10.12659/AOT.928922.

Heinemann, Nele Carolin, Sabine Tischer-Zimmermann, Torge Christian Wittke, Julian Eigendorf, Arno Kerling, Theodor Framke, Anette Melk, Hans Gert Heuft, Rainer Blasczyk, Britta Maecker-Kolhoff, and Britta Eiz-Vesper. 2020. “High-Intensity Interval Training in Allogeneic Adoptive T-Cell Immunotherapy - A Big HIT?” Journal of Translational Medicine 18(1). https://doi.org/10.1186/s12967-020-02301-3

Konrad, Simon, Theodor Framke, Eugen Kludt, Andreas Büchner, Thomas Lenarz, and Gerrit Paasche. 2020. “Do Impedance Changes Correlate With a Delayed Hearing Loss After Hybrid L24 Implantation?” Ear & Hearing Publish Ah. doi: 10.1097/aud.0000000000000914.

May, Marcus, Theodor Framke, Bernd Junker, Carsten Framme, Amelie Pielen, and Christoph Schindler*. 2019. “How and Why SGLT2 Inhibitors Should Be Explored as Potential Treatment Option in Diabetic Retinopathy: Clinical Concept and Methodology.” Therapeutic Advances in Endocrinology and Metabolism 10. doi: 10.1177/2042018819891886.

Albrecht, Urs Vito, Theodor Framke, and Ute Von Jan. 2019. “Quality Awareness and Its Influence on the Evaluation of APP Meta-Information by Physicians: Validation Study.” Journal of Medical Internet Research 21(11):e16442. doi: 10.2196/16442.

Heusser, Karsten, Jens Tank, Olaf Holz, Marcus May, Julia Brinkmann, Stefan Engeli, André Diedrich, Theodor Framke, Armin Koch, Anika Großhennig, A. H. Jan Danser, Fred C. G. J. Sweep, Christoph Schindler, Katharina Schwarz, Norbert Krug, Jens Jordan, and Jens M. Hohlfeld. 2019. “Ultrafine Particles and Ozone Perturb Norepinephrine Clearance Rather than Centrally Generated Sympathetic Activity in Humans.” Scientific Reports 9(1).  doi: 10.1038/s41598-019-40343-w.

Könneker, Sören, G. F. Broelsch, J. W. Kuhbier, T. Framke, N. Neubert, K. Dastagir, T. Mett, P. M. Vogt, and A. Jokuszies. 2017. “Outcome Analysis of End-to-End and End-to-Side Anastomoses in 131 Patients Undergoing Microsurgical Free Flap Reconstruction of the Lower Extremity.” Journal of Reconstructive Microsurgery Open 02(01):e7–14. DOI: 10.1055/s-0036-1593815.

Keil, Carsten, Lukas Aguirre Dávila, Theodor Framke, Henrike Lenzen, Michael Manns, Tim Lankisch, and Torsten Voigtländer. 2017. “Patients with Primary Sclerosing Cholangitis Require More Sedation during Endoscopic Retrograde Cholangiography.” Endoscopy International Open 05(04):E315–20. doi: 10.1055/s-0043-104858.

Framke T (2017): “Limonade und Schokolade – wie kann man Versuchsplanung versüßen?” In: Vonthein, R., Burkholder, I., Muche, R., Rauch, G. [Hrsg.] Zeig mir mehr Biostatistik! Mehr Ideen und neues Material für einen guten Biometrie-Unterricht, Springer Spektrum, 2017, S. 51-60, DOI: 10.1007/978-3-662-54825-7.

Lueer, K., H. Biller, A. Casper, H. Windt, M. Mueller, P. Badorrek, D. Haefner, T. Framke, A. Koch, H. Ziehr, N. Krug, W. Koch, and J. M. Hohlfeld. 2016. “Safety, Efficacy and Repeatability of a Novel House Dust Mite Allergen Challenge Technique in the Fraunhofer Allergen Challenge Chamber.” Allergy: European Journal of Allergy and Clinical Immunology 71(12):1693–1700. DOI 10.1111/all.12947

Leo, Fabian, Stephan Bartels, Lavinia Mägel, Theodor Framke, Guntram Büsche, Danny Jonigk, Matthias Christgen, Ulrich Lehmann, and Hans Kreipe. 2016. “Prognostic Factors in the Myoepithelial-like Spindle Cell Type of Metaplastic Breast Cancer.” Virchows Archiv 469(2):191–201. DOI 10.1007/s00428-016-1950-9

Höhn, Matthias, Ute Von Jan, Theodor Framke, and Urs Vito Albrecht. 2016. “Classification of Health Related Applications.” Pp. 139–42 in Studies in Health Technology and Informatics. Vol. 226. DOI 10.3233/978-1-61499-664-4-139

Paparoupa, Maria, Loukia Spineli, Theodor Framke, Huy Ho, Frank Schuppert, and Adrian Gillissen. 2016. “Pulmonary Embolism in Pneumonia: Still a Diagnostic Challenge? Results of a Case-Control Study in 100 Patients.” Disease Markers. doi: 10.1155/2016/8682506

Schwarz, Anke, Silvia Linnenweber-Held, Albert Heim, Theodor Framke, Hermann Haller, and Corinna Schmitt. 2016. “Viral Origin, Clinical Course, and Renal Outcomes in Patients with BK Virus Infection after Living-Donor Renal Transplantation.” Transplantation 100(4):844–53. DOI: 10.1097/TP.0000000000001066-

Gonnermann, Andrea, Theodor Framke, Anika Großhennig, and Armin Koch. 2015. “No Solution yet for Combining Two Independent Studies in the Presence of Heterogeneity.” Statistics in Medicine 34(16):2476–80. DOI: 10.1002/sim.6473.

Schober, Tilmann, Theodor Framke, Anika Großhennig, Christoph Klein, Hans Kreipe, and Britta Maecker-Kolhoff. 2015. “CD30 in Pediatric Post-Transplant Lymphoproliferative Disease after Solid Organ Transplant: Characterization of a New Therapeutic Target.” Leukemia and Lymphoma 56(3):832–33. DOI:10.3109/10428194.2014.941837

Framke T (2014): „Erhöhen Youtube-Videos auch Deinen Puls?“ In: Rauch G, Muche R, Vonthein R [Hrsg.]: Zeig mir Biostatistik! Ideen und Material für einen guten Biometrie-Unterricht. Berlin u.a.: Springer Spektrum, 2014, S. 25-34.

Koch, Armin, and Theodor Framke. 2014. “Reliably Basing Conclusions on Subgroups of Randomized Clinical Trials.” Journal of Biopharmaceutical Statistics 24(1):42–57. doi: 10.1080/10543406.2013.856020.

Pferdmenges, D. C., U. Baumann, A. Müller-Heine, T. Framke, and E. D. Pfister. 2013. “Prognostic Marker for Liver Disease Due to Alpha1-Antitrypsin Deficiency.” Klinische Padiatrie 225(5):257–62. doi: 10.1055/s-0033-1347196.

Schober, Tilmann, Theodor Framke, Hans Kreipe, Thomas F. Schulz, Anika Grohennig, Kais Hussein, Ulrich Baumann, Lars Pape, Stephan Schubert, Anne Margret Wingen, Thomas Jack, Armin Koch, Christoph Klein, and Britta Maecker-Kolhoff. 2013. “Characteristics of Early and Late PTLD Development in Pediatric Solid Organ Transplant Recipients.” Transplantation 95(1):240–46. doi: 10.1097/TP.0b013e318277e344.

Schwarz, Anke, Silvia Linnenweber-Held, Albert Heim, Verena Bröcker, Daniela Rieck, Theodor Framke, Lubna Raggub, and Hermann Haller. 2012. “Factors Influencing Viral Clearing and Renal Function during Polyomavirus BK-Associated Nephropathy after Renal Transplantation.” Transplantation 94(4):396–402. doi: 10.1097/TP.0b013e31825a505d.

Vosskuhl, K., A. A. Negm, T. Framke, T. Weismller, M. P. Manns, H. Wedemeyer, R. R. Plentz, J. Wedemeyer, and T. O. Lankisch. 2012. “Measurement of IgG4 in Bile: A New Approach for the Diagnosis of IgG4-Associated Cholangiopathy.” Endoscopy 44(1):48–52. doi: 10.1055/s-0030-1256872.

Kulik, U., T. Framke, A. Grohennig, A. Ceylan, H. Bektas, J. Klempnauer, and F. Lehner. 2011. “Liver Resection of Colorectal Liver Metastases in Elderly Patients.” World Journal of Surgery 35(9):2063–72. doi: 10.1007/s00268-011-1180-x.

Tank, Jens, Heike Biller, Karsten Heusser, Olaf Holz, André Diedrich, Theodor Framke, Armin Koch, Anika Grosshennig, Wolfgang Koch, Norbert Krug, Jens Jordan, and Jens M. Hohlfeld. 2011. “Effect of Acute Ozone Induced Airway Inflammation on Human Sympathetic Nerve Traffic: A Randomized, Placebo Controlled, Crossover Study.” PLoS ONE 6(4). doi: 10.1371/journal.pone.0018737.

 

• Vorträge

09/2023:  "Estimand framework (regulatory perspective)" in Session "Innovative trial designs and estimands", CDDF Workshop September 2023, Amsterdam (NL), https://cddf.org/events/past-events/cddf-meetings-2023/cddf-workshop-september-2023/

11/2022: “A multidisciplinary approach to Complex Clinical Trials” in Session: “Histology independent drug development – is this future for cancer drugs?”, CDDF Workshop November 2022, Hybrid workshop – Amsterdam (NL)

10/2022: “A multidisciplinary approach to Complex Clinical Trials” in Session “HM1: A decade of innovative clinical trials – What have we learned and where are we going?”, TOPRA Annual Symposium 2022 - Human Medicines Symposium, Hybrid workshop – Vienna (AT)

09/2022: “Regulatory view on complex innovative designs – A multi-disciplinary approach to progress Complex Clinical Trials”. 7th EFSPI Workshop on Regulatory Statistics 2022 - Basel, CH

11/ 2021: “Causal inference in drug development – a regulatory perspective”, Conference topic: Application of Causal Inference in Drug Development, European Statistical Forum - LS Academy (virtual)

10/2021: “Studies based on patient registries and contextualization of the results of uncontrolled trials – A methodological perspective”, Biopharmaceutical Regulatory Workshop: Regulatory Initiatives on Rare Diseases (virtual)

06/2021: “Overview of innovative designs seen by European regulators (including examples of RWE use)”, Session 8: Unwrapping RCT Duplicate, DIA Future of Evidence and Smart Health Conference (hybrid)

04/2021: “What is Real World Data and its Role in Oncology?”, FDA-EMA 4 PART VIRTUAL SEMINAR SERIES (virtual)

09/2017: „No solution yet – few studies and heterogeneity“, ASTERIX End Symposium, Zaandam (NL).

03/2016: „Title: Wie führen Lehrbücher der Statistik den p-Wert ein?“, DAGStat, Göttingen.

03/2015: „Heterogeneity in multi-regional clinical trials and subgroup analyses“, Biometrisches Kolloquium, Dortmund.

11/2015: „Critical appraisal of p-values and experiences from consulting“ (with L. Spineli), Lehre Workshop der IBS-DR, Heidelberg.

07/2014: “Part IV: Stratification and relation to other research areas - Heterogeneity  in  Multi-Regional Clinical Trials”, Symposium on Small Populations, Wien.

03/2014:  „Erhöhen Youtube-Videos auch Deinen Puls? – Erfahrungsbericht einer randomisierten, klinischen Studie“, Biometrisches Kolloquium, Bremen.

03/2013: „Random zero: Meta-analyses with three, two and one studies“, DAGStat, Freiburg.

09/2011:  „Wie viel Heterogenität ist zu viel?“ beim Workshop „Heterogenitätsbewertung in Meta-Analysen“,  GMDS,  Mainz.

03/2011: “Cochran’s Q for the assessment of heterogeneity”, International Symposium on Biopharmaceutical Statistics, Berlin.

 

• Lebenslauf

- Studium -

10/2015 - 02/2018

Studium Public Health an der Medizinischen Hochschule Hannover, Abschluss: Master of Science

09/2007 - 01/2011

Studium Medizinische Dokumentation an der Fachhochschule Hannover, Abschluss: Bachelor of Arts

 

- Berufliche Tätigkeit -

seit 04/2018

Wissenschaftlicher Mitarbeiter am Institut für Biometrie, Medizinische Hochschule Hannover

06/2016 - 02/2018

Studentische Hilfskraft bei Xcenda GmbH, Hannover

07/2014 - 10/2015

Clinical Data Manager beim Institut für klinische Forschung, Berlin

02/2011 - 08/2011

Coordinator Submission & Registration Management bei Abbott Products GmbH, Hannover

06/2010 - 07/2010

Studentische Hilfskraft bei Medizinische Hochschule Hannover

02/2009 - 01/2011

Studentische Hilfskraft bei Solvay Pharmaceuticals GmbH/Abbott Products GmbH, Hannover

• Publikationen

Häckl, Sebastian, Armin Koch, and Florian Lasch. 2023. “Type-I-Error Rate Inflation in Mixed Models for Repeated Measures Caused by Ambiguous or Incomplete Model Specifications.” Pharmaceutical Statistics 22(6):1046–61. doi: 10.1002/pst.2328.

Haufe, Sven, Hedwig Theda Boeck, Sebastian Häckl, Johanna Boyen, Momme Kück, Clara Catharina van Rhee, Johann-Matthias Graf von der Schulenburg, Jan Zeidler, Torben Schmidt, Heiko Johannsen, Dennis Holzwart, Armin Koch, and Uwe Tegtbur. 2022. “Impact of Electrically Assisted Bicycles on Physical Activity and Traffic Accident Risk: A Prospective Observational Study.” BMJ Open Sport & Exercise Medicine 8(4):e001275. doi: 10.1136/bmjsem-2021-001275.

Haas, Martina, Ewgeni Jakubovski, Katja Kunert, Carolin Fremer, Nadine Buddensiek, Sebastian Häckl, Martina Lenz-Ziegenbein, Richard Musil, Veit Roessner, Alexander Münchau, Irene Neuner, Armin Koch, and Kirsten Müller-Vahl. 2022. “ONLINE-TICS: Internet-Delivered Behavioral Treatment for Patients with Chronic Tic Disorders.” Journal of Clinical Medicine 11(1):250. doi: 10.3390/jcm11010250.

Bunk, Daniel, Michael Eisenburger, Sebastian Häckl, Jörg Eberhard, Meike Stiesch, and Jasmin Grischke. 2020. “The Effect of Adjuvant Oral Irrigation on Self‐administered Oral Care in the Management of Peri‐implant Mucositis: A Randomized Controlled Clinical Trial.” Clinical Oral Implants Research 31(10):946–58. doi: 10.1111/clr.13638.

Von Versen-Hoÿnck, Frauke, Sebastian Häckl, Elif Seda Selamet Tierney, Kirk P. Conrad, Valerie L. Baker, and Virginia D. Winn. 2020. “Maternal Vascular Health in Pregnancy and Postpartum after Assisted Reproduction.” Hypertension 549–60. doi: 10.1161/HYPERTENSIONAHA.119.13779..

Jakubovski, Ewgeni, Anna Pisarenko, Carolin Fremer, Martina Haas, Marcus May, Carsten Schumacher, Christoph Schindler, Sebastian Häckl, Lukas Aguirre Davila, Armin Koch, Alexander Brunnauer, Camelia Lucia Cimpianu, Beat Lutz, Laura Bindila, and Kirsten Müller-Vahl. 2020. “The CANNA-TICS Study Protocol: A Randomized Multi-Center Double-Blind Placebo Controlled Trial to Demonstrate the Efficacy and Safety of Nabiximols in the Treatment of Adults With Chronic Tic Disorders.” Frontiers in Psychiatry 11. doi: 10.3389/fpsyt.2020.575826.

Häckl, Sebastian, Armin Koch, and Florian Lasch. 2019. “Empirical Evaluation of the Implementation of the EMA Guideline on Missing Data in Confirmatory Clinical Trials: Specification of Mixed Models for Longitudinal Data in Study Protocols.” Pharmaceutical Statistics 18(6):636–44. doi: 10.1002/pst.1964.

Häckl, Sebastian. 2011. “Regulatory Affairs – Interne Prozesse Auf Den Prüfstand.” Mdi – Forum Der Medizin-Dokumentation Und Medizin-Informatik 13(4):163–66.

Fortwengel G [Hrsg.], Trenker M, Lütkens S, Hertwig K, Haeckl S, Böckler I, Dymek R, Hahn A, Kuhn C, Lindner B, Neumann C, Paul M, Schachteli N (2011): Guide for Investigator Initiated Trials. 10.1159/isbn.978-3-8055-9685-5.

Goldschmidt, Imeke, Eva Doreen Pfister, Malte Becker, Sebastian Häckl, Oliver Johannes Bott, and Ulrich Baumann. 2011. “Acceptance and Adverse Events of the 2009 H1N1 Vaccination in Immunosuppressed Pediatric Liver Transplant Recipients.” Journal of Pediatrics 158(2):329–33. doi: 10.1016/j.jpeds.2010.10.034.

• Vorträge

09/23 – R Ringlstetter, CS Klages, J Hardt, S Häckl, K Müller-Vahl, A Großhennig: „Lessons learned from randomized controlled trials in patients with Tourette syndrome and chronic tic disorders” in session “Study Design”, GMDS 2023 – Heilbronn (GER). doi: 10.3205/23gmds059

09/20- Florian Lasch, Sebastian Häckl, Armin Koch (2020) : Empirical evaluation of the implementation of the EMA guideline on missing data in confirmatory clinical trials: Specification of mixed models for longitudinal data in study protocols, PSI Journal Club, September, 16, 2020.

02/11 - Häckl S (2011): Prozessanalyse und Prozessoptimierung beim Tracking von MRP-Variations unter Berücksichtigung der Verordnung (EG) Nr. 1234/2008. 11.DVMD-Jahrestagung. Hannover. 17.02.2011

• Lebenslauf

- Berufliche Tätigkeit -

seit 05/2020

Wissenschaftlicher Mitarbeiter am Institut für Biometrie, Medizinische Hochschule Hannover

04/2019 - 09/2019

Medical Writer, SKC Beratungsgesellschaft mbH, Hannover

01/2018 - 03/2018

Studentische Hilfskraft im Institut für Biometrie, Medizinische Hochschule Hannover

 

- Studium -

10/2016 - 11/2018

Studium der Biomedizin an der Medizinischen Hochschule Hannover, Abschluss: Master of Science

10/2013 - 09/2016

Studium der Pflanzenbiotechnologie an der Leibniz Universität Hannover, Abschluss: Bachelor of Science

• Publikationen

Stahl, Klaus, Friederike Klein, Torsten Voigtländer, Anika Großhennig, Thorsten Book, Tobias Müller, Alexander Wree, Armin Kuellmer, Jochen Weigt, Alexander Dechene, Edris Wedi, Arne Kandulski, Christian M. Lange, Dennis Holzwart, Dorothee von Witzendorff, Kristina I. Ringe, Heiner Wedemeyer, and Benjamin Heidrich. 2023. “BISCIT: Biliary Interventions in Critically Ill Patients with Secondary Sclerosing Cholangitis-a Study Protocol for a Multicenter, Randomized, Controlled Parallel Group Trial.” Trials 24(1):247. doi: 10.1186/s13063-023-07260-w.

Haufe, Sven, Hedwig Theda Boeck, Sebastian Häckl, Johanna Boyen, Momme Kück, Clara Catharina van Rhee, Johann-Matthias Graf von der Schulenburg, Jan Zeidler, Torben Schmidt, Heiko Johannsen, Dennis Holzwart, Armin Koch, and Uwe Tegtbur. 2022. “Impact of Electrically Assisted Bicycles on Physical Activity and Traffic Accident Risk: A Prospective Observational Study.” BMJ Open Sport & Exercise Medicine 8(4):e001275. doi: 10.1136/bmjsem-2021-001275.

• Vorträge

09/2021: D Holzwart, S Wiesner, A Großhennig, T Framke - „Biostatistics meets Omics“ in Session: Medizinische Biometrie II – Komplexe und hochdimensionale Daten, GMDS 2021, Online conference

• Arbeitsschwerpunkte:

- Datenmanagement

 

• Werdegang:

- Berufliche Tätigkeit-

seit 04/2020

Medizinische Dokumentarin am Institut für Biometrie, Medizinische Hochschule Hannover

06/2009 - 03/2020

Studienkoordinatorin, KRH Klinikum Siloah, Klinik für Hämatologie, Onkologie und Immunologie

01/2008 - 03/2008

Studentische Mitarbeiterin im Zentrum für Qualität und Management im Gesundheitswesen, Einrichtung der Ärztekammer Niedersachsen

08/2007 - 10/2007

Praktikum im Zentrum für Qualität und Management im Gesundheitswesen, Einrichtung der Ärztekammer Niedersachsen

08/2005 - 06/2007

Studentische Mitarbeiterin in der Bibliothek, Medizinische Hochschule Hannover

05/2006 - 07/2006

Praktikum im Tumorzentrum, Medizinische Hochschule Hannover, Klinisches Krebsregister

 

- Studium -

09/2004 - 10/2008

Fachhochschule Hannover, Biowissenschaftliche Dokumentation, Abschluss: Diplom Dokumentarin (FH)

Diplomarbeit zum Thema "Epidemiologie von Mehrlingsfrühgeburten in Niedersachsen 2002 - 2006"

09/1992 - 02/1997

Medizinische Universität Iran, Teheran, Bibliothekwesen im Bereich der Medizin, Abschluss: Diplom med. Bibliothekarin

• Arbeitsschwerpunkte:

- Biometrische Beratung

- Klinische Studien

 

• Lebenslauf

-Berufliche Tätigkeit -

seit 03/2017

Wissenschaftliche Mitarbeiterin am Institut für Biometrie, Medizinische Hochschule Hannover

11/2015 – 01/2017

Wissenschaftliche Hilfskraft am Institut für Biometrie, Medizinische Hochschule Hannover

08/2015 – 09/2015

Praktikum am Institut für Biometrie, Medizinische Hochschule Hannover

07/2014 – 09/2014

Praktikum im Zentrum für Innere Medizin, Klinik Eichstätt

 

- Studium -

10/2014 – 02/2017

Studium Medical Biometry/Biostatistics an der Universität Bremen

Abschluss: Master of Science

10/2013 – 09/2014

Studium Medical Process Management an der Friedrich-Alexander Universität Erlangen-Nürnberg

09/2008 – 07/2013

Studium Health Information Technology and Management an der Anhui Medical University

Abschluss: Bachelor of Medicine

• Publikationen

Liu, Xiaofei, Norbert Benda, Clemens Mittmann, and Armin Koch. 2024. “Combining Recurrent and Terminal Events Into a Composite Endpoint May Be Problematic.” Statistics in Biopharmaceutical Research 1–8. doi: 10.1080/19466315.2024.2395404.

David, Sascha, Christian Bode, Klaus Stahl, Julius Schmidt, Benjamin Seeliger, Thorben Pape, Bernhard Schmidt, Marius M. Hoeper, Heiner Wedemeyer, Tobias Welte, Kai Schmidt-Ott, Pedro David Wendel Garcia, Daniel A. Hofmänner, Rea Andermatt, Reto Schuepbach, Andriyana Bankova, Hans Joerg Gillmann, Thomas Stueber, Carolin Jung, Andre Gerdes, Christian Putensen, Andrea Sauer, Lennart Wild, Felix Lehmann, Markus A. Weigand, Christian Nusshag, Judith Schenz, Sebastian O. Decker, Mascha O. Fiedler, Florian Uhle, Michael Bauer, Julia Leonhardt, Frank Bloos, Silke Rummler, Philipp Enghard, Abakar Magomedov, Daniel Zickler, Julius Kunz, Jochen Dutzmann, Alexander Vogt, Matthias Girndt, Silke Markau, Mathias Kochanek, Jan Hendrik Naendrup, Alexander Zarbock, Melanie Meersch, Thilo von Groote, Mahan Sadjadi, Carola Wempe, Steffen Mitzner, Markus Heim, Stefanie Pilge, Nicolas Bubendorfer, Gerhard Schneider, Tobias Lahmer, Sebastian Rasch, Thorsten Brenner, Marc M. Berger, Jens Brands, Florian Espeter, Julius Freytag, Stefan Kluge, Dominik Jarczak, Axel Nierhaus, Jan T. Kielstein, M. Winkler, Thomas Fühner, Jan Schmieszek, Jan Menne, Martin Sauer, Georg Richter, Ingmar Lautenschläger, David Radke, Ansgar Reising, Alexander Keil, Joern Bramstedt, Mustafa Fahham, Carsten Willam, Larissa Herbst, Karl Bihlmaier, Christoph Buettner, Peter Schellongowski, Elisabeth Lobmeyr-Längle, Gürgkan Sengölge, Thomas Staudinger, Joerg C. Schefold, Philipp Venetz, Jan Waskowski, Carmen A. Pfortmueller, Michael Joannidis, Gert Mayer, Romuald Bellmann, Armin Koch, and Xiaofei Liu. 2023. “EXCHANGE-2: Investigating the Efficacy of Add-on Plasma Exchange as an Adjunctive Strategy against Septic Shock—a Study Protocol for a Randomized, Prospective, Multicenter, Open-Label, Controlled, Parallel-Group Trial.” Trials 24(1):277. doi: 10.1186/s13063-023-07300-5.

Bavendiek, Udo, Anika Großhennig, Johannes Schwab, Dominik Berliner, Xiaofei Liu, Lars Maier, Thomas Gaspar, Andreas Rieth, Sebastian Philipp, Rainer Hambrecht, Ralf Westenfeld, Thomas Münzel, Sebastian Winkler, Martin Hülsmann, Dirk Westermann, Marja Zdravkovic, Ralf Lichtinghagen, Heiko von der Leyen, Silke Zimmermann, Christian Veltmann, Michael Böhm, Stefan Störk, Armin Koch, and Johann Bauersachs. 2023. “Simple and Safe Digitoxin Dosing in Heart Failure Based on Data from the DIGIT-HF Trial.” Clinical Research in Cardiology. doi: 10.1007/s00392-023-02199-z.

Hamacher, Rainer, Xiaofei Liu, Markus K. Schuler, Leopold Hentschel, Patrick Schöffski, Hans-Georg Kopp, Sebastian Bauer, Bernd Kasper, Lars Lindner, Jens-Markus Chemnitz, Martina Crysandt, Alexander Stein, Björn Steffen, Stephan Richter, Gerlinde Egerer, Philipp Ivanyi, Annegret Kunitz, and Viktor Grünwald. 2023. “A Post Hoc Analysis of the EPAZ Trial: The Role of Geriatric Variables in Elderly Soft Tissue Sarcoma Patients on Toxicity and Outcome.” European Journal of Cancer 181:145–54. doi: 10.1016/j.ejca.2022.12.012.

Ahlenstiel-Grunow, Thurid, Xiaofei Liu, Raphael Schild, Jun Oh, Christina Taylan, Lutz T. Weber, Hagen Staude, Murielle Verboom, Christoph Schröder, Ruxandra Sabau, Anika Großhennig, and Lars Pape. 2021. “Steering Transplant Immunosuppression by Measuring Virus-Specific T Cell Levels: The Randomized, Controlled IVIST Trial.” Journal of the American Society of Nephrology 32(2):502–16. doi: 10.1681/ASN.2020050645.

Holstein, Katharina, Xiaofei Liu, Andrea Smith, Paul Knöbl, Robert Klamroth, Ulrich Geisen, Hermann Eichler, Wolfgang Miesbach, and Andreas Tiede. 2020. “Bleeding and Response to Hemostatic Therapy in Acquired Hemophilia A: Results from the GTH-AH 01/2010 Study.” Blood 136(3):279–87. doi: 10.1182/blood.2019003639.

Grünwald, Viktor, Annika Karch, Markus Schuler, Patrick Schöffski, Hans Georg Kopp, Sebastian Bauer, Bernd Kasper, Lars H. Lindner, Jens Marcus Chemnitz, Martina Crysandt, Alexander Stein, Björn Steffen, Stephan Richter, Gerlinde Egerer, Philipp Ivanyi, Silke Zimmermann, Xiaofei Liu, and Annegret Kunitz. 2020. “Randomized Comparison of Pazopanib and Doxorubicin as First-Line Treatment in Patients with Metastatic Soft Tissue Sarcoma Age 60 Years or Older: Results of a German Intergroup Study.” Journal of Clinical Oncology 38(30):3555–64. doi: 10.1200/JCO.20.00714.

Byng, Danalyn, Johanna I. Lutter, Margarethe E. Wacker, Rudolf A. Jörres, Xiaofei Liu, Stefan Karrasch, Holger Schulz, Claus Vogelmeier, and Rolf Holle. 2019. “Determinants of Healthcare Utilization and Costs in COPD Patients: First Longitudinal Results from the German COPD Cohort COSYCONET.” International Journal of COPD 14:1423–39. doi: 10.2147/COPD.S201899.

Baier, Claas, Ramin Ipaktchi, Frank Schwab, Andrea Smith, Xiaofei Liu, Ella Ebadi, Anne Limbourg, Tobias R. Mett, Franz-Christoph Bange, and Peter Maria Vogt. 2019. “Universal Decolonization with Octenidine: First Experiences in a Tertiary Burn Intensive Care Unit.” Burns Open 3(1):8–11. https://doi.org/10.1016/j.burnso.2018.10.003

Haeseler, Gertrud, Dirk Schaefers, Natalie Prison, Jörg Ahrens, Xiaofei Liu, and Annika Karch. 2017. “Combatting Pain after Orthopedic/Trauma Surgery- Perioperative Oral Extended-Release Tapentadol vs. Extended-Release Oxycodone/Naloxone.” BMC Anesthesiology 17(1). doi: 10.1186/s12871-017-0383-6

• Kongressbeiträge

09/2023 – Xiaofei Liu, Armin Koch:  „Analysis of recurrent heart failure hospitalisation – why an assessment of mortality should be the gatekeeper?” in session “Medical Biometry I”, GMDS 2023 – Heilbronn (GER). dx.doi.org/10.3205/23gmds055

• Lebenslauf

- Berufliche Tätigkeit -

Seit 08/2022

Wissenschaftliche Mitarbeiterin am Institut für Biometrie, Medizinische Hochschule Hannover

10/2021 – 07/2022

Datenmanagerin am Institut für Biometrie, Medizinische Hochschule Hannover

04/2021 – 02/2022

Praktikum und Verfassen der Masterarbeit am Institut für Biometrie, Medizinische Hochschule Hannover

11/2018 – 09/2021

Studentische Hilfskraft in der Studienzentrale der Klinik für Urologie und Urologische Onkologie, Medizinische Hochschule Hannover

03/2018 – 07/2018

Praktikum in der Studienzentrale KRANIOPHARYNGEOM 2000/2007 der Abteilung Pädiatrische Onkologie und Hämatologie, Klinikum Oldenburg AöR

 

- Studium -

03/2020 - 02/2022

Studium „Medizinisches Informationsmanagement“ an der Hochschule Hannover, Abschluss: Master of Science

09/2016 – 03/2020

Studium „Medizinisches Informationsmanagement“ an der Hochschule Hannover, Abschluss: Bachelor of Arts

• Publikationen

Müller-Vahl, Kirsten R., Anna Pisarenko, Rieke Ringlstetter, Camelia-Lucia Cimpianu, Carolin Fremer, Elif Weidinger, Eva Beate Jenz, Richard Musil, Alexander Brunnauer, and Anika Großhennig. 2024. “The Effect of Nabiximols on Driving Ability in Adults with Chronic Tic Disorders: Results of a Substudy Analysis of the Double-Blind, Randomized, Placebo-Controlled CANNA-TICS Trial.” Cannabis and Cannabinoid Research 9(5):1349–59. doi: 10.1089/can.2023.0114.

Jochmann, Svenja L., Esther M. W. Sievering, Johanna Ernst, Rieke Ringlstetter, Anika Grosshennig, Karin Weissenborn, and Gerrit M. Grosse. 2023. “Sex-Specific Risk Factors of Nonstenotic Carotid Plaque in Embolic Stroke of Unknown Source: A Case-Control Study.” Stroke 55(2):296–300. doi: 10.1161/STROKEAHA.123.044833.

Müller-Vahl, Kirsten R., Anna Pisarenko, Natalia Szejko, Martina Haas, Carolin Fremer, Ewgeni Jakubovski, Richard Musil, Alexander Münchau, Irene Neuner, Daniel Huys, Ludger Tebartz van Elst, Christoph Schröder, Rieke Ringlstetter, Armin Koch, Eva Beate Jenz, and Anika Großhennig. 2023. “CANNA-TICS: Efficacy and Safety of Oral Treatment with Nabiximols in Adults with Chronic Tic Disorders – Results of a Prospective, Multicenter, Randomized, Double-Blind, Placebo Controlled, Phase IIIb Superiority Study.” Psychiatry Research 323. doi: 10.1016/j.psychres.2023.115135

Sievering, Esther Mw, Anika Grosshennig, Martina Kottas, Johanna Ernst, Rieke Ringlstetter, Armin Koch, Karin Weissenborn, and Gerrit M. Grosse. 2023. “Diagnostic Value of Carotid Intima-Media Thickness and Clinical Risk Scores in Determining Etiology of Ischemic Stroke.” European Stroke Journal 8(3):738–46. doi: 10.1177/23969873231182492.

• Kongressbeiträge

09/23 – R Ringlstetter, CS Klages, J Hardt, S Häckl, K Müller-Vahl, A Großhennig: „Lessons learned from randomized controlled trials in patients with Tourette syndrome and chronic tic disorders” in session “Study Design”, GMDS 2023 – Heilbronn (GER). doi: 10.3205/23gmds059

• Lebenslauf

- Berufliche Tätigkeit -

seit 07/2021

Wissenschaftliche Mitarbeiterin am Institut für Biometrie, Medizinische Hochschule Hannover

08/2015 - 09/2019

Studentische Hilfskraft mit Tätigkeiten im Bereich Lehre als Tutorin und Korrektorin, Leibniz Universität Hannover

09/2013 - 08/2014

Freiwilliges Wissenschaftliches Jahr am Institut für Quantenoptik, Leibniz Universität Hannover

- Studium -

04/2018 - 06/2021

Studium der Mathematik, Leibniz Universität Hannover, Abschluss: Master of Science, Masterarbeit: „Bayesian Statistics and Markov Chain Monte Carlo Methods for Epidemiological Models with the Example of COVID-19“

09/2019 - 01/2020

Auslandssemester, University of Bristol

04/2015 - 03/2018

Studium der Mathematik, Leibniz Universität Hannover, Abschluss: Bachelor of Science

10/2014 – 03/2015

Studium des Fächerübergreifenden Bachelors in Mathematik und Physik, Leibniz Universität Hannover

• Publikationen

Alevizakos, Vasilios, Gergo Mitov, Marcus Schiller, Anna Lena Bergmann, Leonie Theis, and Constantin von See. 2023. “Comparison of Temperature Changes in Different Irrigation Methods Used in Guided Piezosurgery: In Vitro Study.” Oral and Maxillofacial Surgery 28(2):653–58. doi: 10.1007/s10006-023-01183-1.

• Werdegang:

- Berufliche Tätigkeit-

Seit 07/2021

Wissenschaftliche Mitarbeiterin am Institut für Biometrie, Medizinische Hochschule Hannover

07/2020 - 06/2021

Verfassen der Masterarbeit und Mitarbeiterin am Institut für Biometrie, Medizinische Hochschule Hannover

08/2019 - 09/2019

Praktikum, EPID, Helmholtz-Zentrum für Infektionsforschung, Braunschweig

03/2018 - 04/2018

Praktikum am Institut für Biometrie, Epidemiologie und Informationsverarbeitung, Tierärztliche Hochschule Hannover

 

- Studium -

10/2018 - 09/2021

Studium "Medical Biometry/Biostatistics" an der Universität Bremen,

Abschluss: Master of Science

01/2020 - 04/2020

Auslandssemester an der University of Guelph-Humber, Toronto

10/2015 - 06/2018

Studium "Biologie" an der Leibniz Universität, Hannover

Abschluss: Bachelor of Science

10/2014 - 10/2015

Studium "Biochemie" an der Leibniz Universität, Hannover

• Kongressbeiträge

09/2023 - NH Thomas, A Koch, A Großhennig:  „Dual primary endpoints – innovative idea or avoidable risk?” (Tandem presentation –  part 2) in session “Medical Statistics & Decision-Making”, GMDS 2023 – Heilbronn (GER). https://dx.doi.org/10.3205/23gmds073

09/2023 - NH Thomas, A Koch, A Großhennig: „Dual primary endpoints – innovative idea or avoidable risk?” (Tandem presentation –  part 1) in session “Clinical Trials 1”, CEN-IBS 2023 – Basel (CH). https://cen2023.github.io/home/data/ConferenceBook%201.1.pdf

08/2022 - NH Thomas, A Koch, A Großhennig: „Conclusive decision-making with two primary endpoints“ in session “Biometrie – Klinische Studien”, GMDS & TMF Annual Conference 2022 – Virtual. https://doi.org/10.3205/22GMDS091

• Publikationen

Großhennig, Anika, Nele Henrike Thomas, Werner Brannath, and Armin Koch. 2023. “How to Avoid Concerns with the Interpretation of Two Primary Endpoints If Significant Superiority in One Is Sufficient for Formal Proof of Efficacy.” Pharmaceutical Statistics 22(5):836–45. doi: 10.1002/pst.2314.

Merten, Roland, Mirko Fischer, Hans Christiansen, Susanne Hellms, Christoph Alexander Joachim von Klot, Nele Henrike Thomas, and Anne Caroline Knöchelmann. 2023. “Using A Further Planning MRI after Neoadjuvant Androgen Deprivation Therapy Significantly Reduces the Radiation Exposure of Organs at Risk in External Beam Radiotherapy of Prostate Cancer.” Journal of Clinical Medicine 12(2):574. doi: 10.3390/jcm12020574

Kirchner, Theresa, Sophia Heinrich, Agnes Bonifacius, Bastian Engel, Louisa Ruhl, Isabell Pink, Nele Thomas, Joerg Martens, Marius M. Hoeper, Rainer Blasczyk, Heiner Wedemeyer, Elmar Jaeckel, Yang Li, Christine S. Falk, Britta Eiz-Vesper, and Richard Taubert. 2022. “Reduced Humoral but Stable Cellular SARS-CoV-2-Specific Immunity in Liver Transplant Recipients in the First Year after COVID-19.” PLOS ONE 17(11):e0276929. doi: 10.1371/journal.pone.0276929.

Binz, Camilla, Alma Osmanovic, Nele H. Thomas, Benjamin Stolte, Maren Freigang, Isabell Cordts, Ramona Griep, Zeljko Uzelac, Claudia D. Wurster, Christoph Kamm, Hannah A. Siegler, Gary Wieselmann, Andreas Hermann, Paul Lingor, Marcus Deschauer, Albert C. Ludolph, Thomas Meyer, René Günther, Tim Hagenacker, Susanne Petri, and Olivia Schreiber-Katz. 2022. “Validity and Reliability of the German Multidimensional Fatigue Inventory in Spinal Muscular Atrophy.” Annals of Clinical and Translational Neurology 9(3):351–62. doi: 10.1002/acn3.51520.

• Arbeitsschwerpunkte:

- Biometrische Beratung

- Klinische Studien

 

• Lebenslauf

- Berufliche Tätigkeiten -

seit 04/2019

Wissenschaftlicher Mitarbeiter am Institut für Biometrie, Medizinische Hochschule Hannover

07/2017 - 09/2018

Wissenschaftliche Hilfskraft am Max-Planck-Institut für demografische Forschung, Rostock; COMPADRE Plant Matrix Database and COMADRE Animal Matrix Database Digitization Team

 

- Studium -

04/2017 - 09/2018

Studium Demographie an der Universität Rostock

Abschluss: Master of Science

10/2016 - 03/2017

Studium Soziologie an der Universität Rostock

10/2013 - 09/2016

Studium Soziologie an der Universität Bremen

Abschluss: Bachelor of Arts

• Publikationen

Madadi-Sanjani, Omid, Joachim F. Kuebler, Julia Brendel, Sara Costanzo, Anna L. Granström, Emrah Aydin, Stavros Loukogeorgakis, Martin Lacher, Soeren Wiesner, Anja Domenghino, Pierre-Alain Clavien, Annika Mutanen, Simon Eaton, and Benno M. Ure. 2024. “Validation of the Clavien-Madadi Classification for Unexpected Events in Pediatric Surgery: A Collaborative ERNICA Project.” Journal of Pediatric Surgery 59(9):1672–79. doi: 10.1016/j.jpedsurg.2024.03.022.

Fortmann, Caroline, Thomas Göen, Soeren Wiesner, Jan Hegermann, Rim Kiblawi, Martha Dohna, Benno M. Ure, Diane Miriam Renz, Claus Petersen, and Joachim F. Kuebler. 2023. “Titanium Nitride Coating of Pectus Bar Increases Metal Contamination after Minimally-Invasive Repair of Pectus Excavatum” edited by A. Farmany. PLOS ONE 18(10):e0292616. doi: 10.1371/journal.pone.0292616.

Großhennig, Anika, Sören Wiesner, Juliane Hellfritsch, Ulrich Thome, Matthias Knüpfer, Corinna Peter, Martin Metzelder, Christoph Binder, Ulrike Wanz, Christina Flucher, Björn O. Brands, Andreas Mollweide, Barbara Ludwikowski, Anna Koluch, Simon Scherer, Christian Gille, Till Martin Theilen, Ulrich Rochwalsky, Christian Karpinski, Annekatrin Schulze, Tobias Schuster, Florian Weber, Guido Seitz, Jens Gesche, Matthias Nissen, Maximilian Jäger, Armin Koch, Benno Ure, Omid Madadi-Sanjani, and Martin Lacher. 2023. “MUC-FIRE: Study Protocol for a Randomized Multicenter Open-Label Controlled Trial to Show That MUCous FIstula REfeeding Reduces the Time from Enterostomy Closure to Full Enteral Feeds.” Contemporary Clinical Trials Communications 32:101096. doi: 10.1016/j.conctc.2023.101096.

Madadi-Sanjani, Omid, Joachim F. Kuebler, Julia Brendel, Soeren Wiesner, Annika Mutanen, Simon Eaton, Anja Domenghino, Pierre-Alain Clavien, and Benno M. Ure. 2023. “Implementation and Validation of a Novel Instrument for the Grading of Unexpected Events in Paediatric Surgery: Clavien–Madadi Classification.” British Journal of Surgery 110(5):576–83. doi: 10.1093/bjs/znad034.

Fortmann, Caroline, Thomas Goeen, Norman Zinne, Soeren Wiesner, Benno M. Ure, Claus Petersen, and Joachim F. Kuebler. 2022. “Nickel Contamination after Minimally-Invasive Repair of Pectus Excavatum Persists after Bar Removal.” PloS One 17(10):e0275567. doi: 10.1371/journal.pone.0275567.

Madadi-Sanjani, Omid, Christoph Zoeller, Joachim F. Kuebler, Alejandro D. Hofmann, Jens Dingemann, Soeren Wiesner, Julia Brendel, and Benno M. Ure. 2021. “Severity Grading of Unexpected Events in Paediatric Surgery: Evaluation of Five Classification Systems and the Comprehensive Complication Index (CCI®).” BJS Open 5(6). doi: 10.1093/bjsopen/zrab138.

Kendall, Bruce E., Masami Fujiwara, Jasmin Diaz-Lopez, Sandra Schneider, Jakob Voigt, and Sören Wiesner. 2019. “Persistent Problems in the Construction of Matrix Population Models.” Ecological Modelling 406:33–43. doi: 10.1016/j.ecolmodel.2019.03.011

• Arbeitsschwerpunkte:

- Biometrische Beratung

- Klinische Studien

- Qualitätsbeauftragte

 

• Lebenslauf

- Berufliche Tätigkeit -

seit 04/2012

Wissenschaftliche Mitarbeiterin am Institut für Biometrie, Medizinische Hochschule Hannover

03/2010 - 03/2012

Biometrikerin am AQUA-Institut für angewandte Qualitätsförderung und Forschung im Gesundheitswesen

03/2008 - 02/2010

Wissenschaftliche Mitarbeiterin in der Begleitforschung des Modellprojektes „Pro Kind“ am Kriminologischen Forschungsinstitut Niedersachsen (KFN)

 

- Studium -

10/2008 - 02/2011

Ergänzungsstudiengang: Bevölkerungsmedizin und Gesundheitswesen (Public Health) an der Medizinischen Hochschule Hannover 

Studienschwerpunkt: Epidemiologie, Abschluss: Master of Public Health

01/2005 - 02/2008

Studium der Sozialwissenschaften  an der Leibniz Universität Hannover

Studienschwerpunkt: Empirische Sozialforschung, Abschluss: Diplom Sozialwissenschaftlerin

09/2004 - 01/2005

Studium an der John Moores University in Liverpool (Fachbereich: European Studies)

10/2002 - 08/2004

Studium der Sozialwissenschaften an der Leibniz Universität Hannover

 

• Publikationen

Günther, Julia, Yvonne Ziert, Kristin Andresen, Ulrich Pecks, and Frauke von Versen-Höynck. 2024. “Variability in COVID-19 Symptom Presentation during Pregnancy and Its Impact on Maternal and Infant Outcomes across the Pandemic.” International Journal of Infectious Diseases 146. doi: 10.1016/j.ijid.2024.107157.

Maier, Hannah Benedictine, Alexandra Neyazi, Gabriel L. Bundies, Fiona Meyer-Bockenkamp, Stefan Bleich, Hansi Pathak, Yvonne Ziert, Barbara Neuhaus, Franz Josef Müller, Iris Pollmann, Thomas Illig, Stefanie Mücke, Meike Müller, Brinja Kira Möller, Steffen Oeltze-Jafra, Tim Kacprowski, Jan Voges, Fabian Müntefering, Josef Scheiber, Andreas Reif, Mareike Aichholzer, Christine Reif-Leonhard, Maren Schmidt-Kassow, Ulrich Hegerl, Hanna Reich, Stefan Unterecker, Heike Weber, Jürgen Deckert, Nicole Bössel-Debbert, Hans J. Grabe, Michael Lucht, and Helge Frieling. 2024. “Validation of the Predictive Value of BDNF -87 Methylation for Antidepressant Treatment Success in Severely Depressed Patients—a Randomized Rater-Blinded Trial.” Trials 25(1). doi: 10.1186/s13063-024-08061-5.

Von Reusner, Marek Jonas, Bettina Märtens, Stephanie Barthel, Axel Weiser, Yvonne Ziert, Diana Steinmann, and Burcu Babadağ-Savaş. 2024. “Interdisciplinary Integrative Oncology Group-Based Program: Evaluation of Long-Term Effects on Resilience and Use of Complementary and Alternative Medicine in Patients With Cancer.” Integrative Cancer Therapies 23. doi: 10.1177/15347354241269931.

Ziert, Yvonne, Michael Abou-Dakn, Clara Backes, Constanze Banz-Jansen, Nina Bock, Michael Bohlmann, Charlotte Engelbrecht, Teresa Mia Gruber, Antonella Iannaccone, Magdalena Jegen, Corinna Keil, Ioannis Kyvernitakis, Katharina Lang, Angela Lihs, Jula Manz, Christine Morfeld, Manuela Richter, Gregor Seliger, Marina Sourouni, Constantin Sylvius von Kaisenberg, Silke Wegener, Ulrich Pecks, and Frauke von Versen-Höynck. 2022. “Maternal and Neonatal Outcomes of Pregnancies with COVID-19 after Medically Assisted Reproduction: Results from the Prospective COVID-19-Related Obstetrical and Neonatal Outcome Study.” American Journal of Obstetrics and Gynecology 227(3):495.e1-495.e11. doi: 10.1016/j.ajog.2022.04.021.

Savaş, Burcu Babadağ, Bettina Märtens, Holger Cramer, Petra Voiss, Julia Longolius, Axel Weiser, Yvonne Ziert, Hans Christiansen, and Diana Steinmann. 2022. “Effects of an Interdisciplinary Integrative Oncology Group-Based Program to Strengthen Resilience and Improve Quality of Life in Cancer Patients: Results of a Prospective Longitudinal Single-Center Study.” Integrative Cancer Therapies 21. doi: 10.1177/15347354221081770.

Dey Hazra, Rony-Orijit, Robert Maximillian Blach, Yvonne Ziert, Alexander Ellwein, Mara Warnhoff, Marek Hanhoff, Helmut Lill, and Gunnar Jensen. 2022. “Are Patient-Reported Outcome Scores a Reasonable Substitute for Clinical Follow-up After Surgically Managed Acromioclavicular Joint Injuries?” Orthopaedic Journal of Sports Medicine 10(5):232596712210940. doi: 10.1177/23259671221094056.

Waschkies, Freya, Luka Kroning, Thilo Schill, Arvind Chandra, Cordula Schippert, Dagmar Töpfer, Yvonne Ziert, and Frauke von Versen-Höynck. 2021. “Pregnancy Outcomes After Frozen-Thawed Embryo Transfer in the Absence of a Corpus Luteum.” Frontiers in Medicine 8(September):1–11. doi: 10.3389/fmed.2021.727753.

Albrecht, Fenja, Heidi Wolters, Yvonne Ziert, Beate Timmermann, Rolf Dieter Kortmann, Christiane Matuschek, Christian Rübe, Carmen Martini, Hans Christiansen, Hans Theodor Eich, Normann Willich, and Diana Steinmann. 2021. “Evaluation of Treatment-Associated Eye Toxicity after Irradiation in Childhood and Adolescence—Results from the Registry of the Evaluation of Side Effects after Radiotherapy in Childhood and Adolescence (RiSK).” Strahlentherapie Und Onkologie 197(8):700–710. doi: 10.1007/s00066-021-01793-2.

Pellicer, Adelina, Ramón Fernández, Vincent Jullien, Clare Gleeson, María Carmen Bravo, Paloma López Ortego, Laura Sánchez, Marta Ybarra, Héctor Rojas-Anaya, Fernando Cabañas, Armin Koch, Andrea Smith, Heike Rabe, Philip Amess, Neil Aiton, David Crook, Ramon Fernandez-Alvarez, Liam Mahoney, Heike Rabe, Rebecca Ramsay, Héctor Rojas-Anaya, Sonia Sobowiec Kouman, Vincent Jullien, Thomas Le Saux, Gerard Pons, Sarah Zohar, Frank Biertz, Marjan Brinkhaus, Armin Koch, Andrea Smith, Yvonne Ziert, Jon Lopez Heredia, Maria Cruz Lopez Herrera, Victoria Mielgo, Wolfgang Göpel, Christoph Härtel, Charalampos Kotidis, Mark Turner, Michael Weindling, Claudia Roll, Maria del Carmen Bravo, Fernando Cabañas, Paloma López-Ortego, Marta Pavía, Adelina Pellicer, Clare Gleeson, Simon Bryson, Melinda Matyas, Gabriela Zaharie, Géza Bokodi, Miklós Szabó, Tibor Ertl, Simone Funke, Ebru Ergenekon, Kivilcim Gücüyener, Ebnem Soysal, and Christiane Dammann. 2020. “Pharmacokinetic Study (Phase I−II) of a New Dobutamine Formulation in Preterm Infants Immediately after Birth.” Pediatric Research. doi: 10.1038/s41390-020-1009-0.

Fischer, Friederike, Rüdiger Klapdor, Susanne Gruessner, Yvonne Ziert, Peter Hillemanns, and Hermann Hertel. 2015. “Radiofrequency Endometrial Ablation for the Treatment of Heavy Menstrual Bleeding among Women at High Surgical Risk.” International Journal of Gynecology and Obstetrics 131(2):123–28. doi: 10.1016/j.ijgo.2015.05.028.

Doose, Michael, Marc Ziegenbein, Olaf Hoos, Dominik Reim, Wojciech Stengert, Niklas Hoffer, Charlotte Vogel, Yvonne Ziert, and Marcel Sieberer. 2015. “Self-Selected Intensity Exercise in the Treatment of Major Depression: A Pragmatic RCT.” International Journal of Psychiatry in Clinical Practice 19(4):267–76. doi: 10.3109/13651501.2015.1082599.

Koch, Armin, and Yvonne Ziert. 2016. “Does It Help That Efficacy Has Been Proven Once We Start Discussing (Added) Benefit?” Biometrical Journal 58(1):89–103. doi: 10.1002/bimj.201400017.

Ziert, Y., V. Kurtz, and T. Jungmann. 2009. “Gesundheits- Und Entwicklungsförderung Durch Hausbesuche Für Erstgebärende Frauen in Schwierigen Lebenslagen – Erste Ergebnisse Aus Der Evaluationsforschung Des Modellprojektes „Pro Kind“.” Das Gesundheitswesen 71(08/09). doi: 10.1055/s-0029-1239301.

Jungmann, Tanja, Yvonne Ziert, Vivien Kurtz, and Tilman Brand. 2009. “Preventing Adverse Developmental Outcomes and Early Onset Conduct Problems through Prenatal and Infancy Home Visitation: The German Pilot Project ‘pro Kind.’” International Journal of Developmental Sciences 3(3):292–98. doi: 10.3233/DEV-2009-3307.

Ziert Y (2008): Präventive Gesundheitsförderung bei der Polizei Niedersachsen. Evaluation einer betrieblichen Gesundheitsförderungsmaßnahme. Saarbrücken: Verlag Dr. Müller.

• Buchbeiträge

Ziert Y, König T (2011): Datenvalidierung, in: AQUA-Institut (Hrsg). Qualitätsreport 2010. Göttingen: AQUA Institut für angewandte Qualitätsförderung und Forschung im Gesundheitswesen, S. 159-162.

Ziert Y (2010): Datenvalidierung, in: AQUA-Institut (Hrsg). Qualitätsreport 2009. Göttingen: AQUA-Institut für angewandte Qualitätsförderung und Forschung im Gesundheitswesen, S. 142-145.

• Vorträge

Ziert Y, Heller G (2011): Überprüfung der Datenqualität in der externen stationären Qualitätssicherung. Vortrag im Rahmen des TMF-Workshops: Messung der Qualität biomedizinischer Daten am 04. April 2011, Berlin.

Ziert Y, Schmitt-Reißer B (2010): Ergebnisse der Datenvalidierung: Mammachirurgie und Operative Gynäkologie. Vortrag im Rahmen der 28. Münchener Konferenz für Qualitätssicherung 2010
Geburtshilfe – Neonatologie – operative Gynäkologie  vom 25.-26. November, München.

Kurtz V, Ziert Y, Jungmann T (2010): Infants' mental development: Does home visiting compensate for negative consequences of not breastfeeding? Preliminary results of the pilot project "Pro Kind". Poster Presentation at the 12th World Congress of the World Association for Infant Mental Health (WAIMH). Leipzig: 03.07.2010.

Ziert Y (2010): Umsetzung der Datenvalidierung. Vortrag im Rahmen der Fachtagung zur Sektorenübergreifenden Qualität im Gesundheitswesen „Qualität kennt keine Grenzen – Neue Orientierung im Gesundheitswesen“ am 16. Juni, Göttingen.

Ziert Y, Schneider R (2009): Prävention von Entwicklungsverzögerungen – erste Befunde der Evaluation zum Modellprojekt Pro Kind. Vortrag im Rahmen des 3. Nationalen Präventionstages vom 27.-28. November, Dresden.

Ziert Y, Adamaszek K (2009): Das Hausbesuchsprogramm Pro Kind und seine Vernetzung. Vortrag im Rahmen des 3. Nationalen Präventionstages vom 27.-28. November, Dresden.

Ziert Y, Jungmann T (2009): Preventing adverse developmental outcomes and early onset conduct problems through prenatal and infancy home visitation: The German pilot project Pro Kind. Vortrag im Rahmen des XIVth „Workshop Aggression“, 6.-08. November, Berlin.

Ziert Y, Kurtz V, Jungmann T (2009): Gesundheits- und Entwicklungsförderung durch Hausbesuche für erstgebärende Frauen in schwierigen Lebenslagen – Erste Ergebnisse aus der Evaluationsforschung des Modellprojektes „Pro Kind“. Poster im Rahmen der Jahrestagung der DGSMP und der DGMS vom 23.-25. September, Hamburg.

Ziert Y, Kurtz V, Jungmann T (2009): Prävention durch Frühe Hilfen: Das Modellprojekt Pro Kind: Erste Ergebnisse aus der Evaluationsforschung. Vortrag im Rahmen der 4. Jahrestagung der Deutschen Gesellschaft für Epidemiologie, 16.-19. September, Münster.

• Auszeichnungen

Posterpreis 2009 der Deutschen Gesellschaft für Sozialmedizin und der Deutschen Gesellschaft für Medizinsoziologie für ein herausragendes Poster in der Session VI „Frauen und geschlechtsspezifische Gesundheitsforschung“ im Rahmen der Jahrestagung der DGSMP und der DGMS vom 23.-25. September 2009 in Hamburg.

 

• Arbeitsschwerpunkte:

- Biostatistics & Statistical Reporting

 

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