About us:

Join the Cellular Neurophysiology team at Hannover Medical School, a dynamic group equipped with state-of-the-art laboratory facilities. We invite you to become an integral part of our team and contribute to an exciting and highly relevant research project. Our experienced team offers comprehensive support to ensure you successfully complete your project and hold years of expertise in the variety of involved methods, which include

• Culturing of Primary Cells
• Cutting-edge Microscopy Techniques
• Advanced Multi-color Ca2+-Imaging
• Computational data analysis

Your role:

As a Master thesis candidate, you will learn how to grow astrocyte cultures and equip them with genetically encoded Ca2+ indicators in the cytosol and the ER. Utilizing adeno-associated viruses (AAVs), you will target the ER structure to manipulate its shape and mimic a diseased state. Employing Spinning-disc microscopy, you will record astrocyte Ca2+ activity and use sophisticated computational analysis to assess the impact of ER shape on astrocyte Ca2+ dynamics.

Your profile:

• You hold a bachelor’s degree in a relevant field, e.g., biology, life science, biomedicine, biophysics, computational biology…
• Highly motivated to fully commit to the project
• Exhibit a strong interest in applying quantitative imaging techniques to address biological questions
• Possess a keen affinity for computational methods
• You are open to working with biological materials
• Thrive in a collaborative, team-oriented, and international research environment

Our group language is English, so proficiency in German is not mandatory. However, this presents a unique opportunity for you to acquire or improve your German language skills.

Application requirement:

• Cover letter detailing your background and motivation
• A concise CV (1 page)
• Copy of your Bachelor's degree certificate
• Copy of your high school certificate

Feel free to submit your application at any time via email to

Mueller.franziska@mh-hannover.de or zeug.andre@mh-hannover.de.

Join us at the forefront of cutting-edge neurophysiology research and be part of an exciting academic journey!