Publications

Full publication list and statistics:

https://scholar.google.com/citations?user=pBB2knYAAAAJ&hl=de

10 most important publications:

1. Perner C, Flayer CH, Zhu X, Aderhold PA, Dewan ZNA, Voisin T, Camire RB, Chow OA, Chiu IM, Sokol CL. Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens. Immunity. November 17, 2020; PMID: 33098765; 10.1016/j.immuni.2020.10.001
    
2. Voisin T, Perner C, Messou MA, Shiers S, Ualiyeva S, Kanaoka Y, Price TJ, Sokol CL, Bankova LG, Austen KF, Chiu IM, Chiu IM. The CysLT2R receptor mediates leukotriene C4-driven acute and chronic itch. Proc Natl Acad Sci U S A. 2021 Mar 30; 118(13). PMID: 33753496.
    
3. Perner C, Sokol CL. Protocol for dissection and culture of murine dorsal root ganglia neurons to study neuropeptide release. STAR Protoc. 2021 Mar 19; 2(1):100333. PMID: 33615276.
    
4. Perner C, Kruger E. Endoplasmic Reticulum Stress and Its Role in Homeostasis and Immunity of Central and Peripheral Neurons. Front Immunol. 2022;13:859703. Epub 2022/05/17. doi: 10.3389/fimmu.2022.859703. PubMed PMID: 35572517
    
5. Perner C, Perner F, Gaur N, Zimmermann S, Witte OW, Heidel FH, Grosskreutz J, Prell T: Plasma VCAM1 levels correlate with disease severity in Parkinson´s disease. J Neuroinflammation. 16(1):94, 05/2019; PMID: 31068198
    
6. Perner C, Perner F, Stubendorff B, Förster M, Witte OW, Heidel FH, Prell T, Grosskreutz J: Dysregulation of chemokine receptor expression and function in leukocytes from ALS patients. J Neuroinflammation. 15(1), 03/2018; PMID: 29592817
    
7. Ebert C, Perner F, Wolleschak D, Schnöder TM, Fischer T and Heidel FH.: Expression and function of ABC-transporter protein ABCB1 correlates with inhibitory capacity of Ruxolitinib in vitro and in vivo. Hematologica. 101(3), 03/2016; PMID: 26589910
    
8.  Perner F, Perner C, Ernst T, Heidel FH. Roles of JAK2 in Aging, Inflammation, Hematopoiesis and Malignant Transformation. Cells. 2019 Aug 08; 8(8). PMID: 31398915.
    
9. DuBreuil DM, Lai X, Zhu K, Chahyadinata G, Perner C, Chiang B, Battenberg A, Sokol C, Wainger B. Phenotypic screen identifies the natural product silymarin as a novel anti-inflammatory analgesic. Mol Pain. 2022 Dec 16:17448069221148351. doi: 10.1177/17448069221148351. PMID: 36526437.
    
10. Perner F, Schnöder TM, Ranjan S, Wolleschak D, Ebert C, Pils MC, Frey S, Polanetzki A, Fahldieck C, Schönborn U, Schraven B, Isermann B, Fischer T and Heidel FH.: Specificity of JAK-kinase inhibition determines impact on human and murine T-cell function. Leukemia. 30(4), 04/2016; PMID: 26242463
    
     

Projects

„Immune cell influence on aging of sensory neurons“ - DFG PE 2864/5-1, project number: 532419713

Chronic low-grade sterile inflammation is a hallmark of aging and has been shown to be associated with functional decline and age-related diseases in different organ systems. However, for the vast majority of age associated diseases, we have little understanding of the functional effect of certain immune cell subsets and their context-specificity. This challenge will be addressed by this proposed research, focusing on pathological aging of the peripheral sensory nervous system and associated symptoms of neuropathy including neuropathic itch and pain. The overarching aim is to determine the impact of immune cells on neuronal function during lifetime and identify mechanism of pathologic neuro-immune – interactions that are drivers of sensory neuron aging. This will advance our understanding of disease-associated transcriptional programs underlying sensory neuron aging and answer questions of sensory neuron function that is shaped by immune cell-environment interactions.

„Define immune cell dependent- and independent age-related alterations in sensory neuron physiology.” – Else Kröner-Fresenius Stiftung; Memorialstipendium to Dr.  Caroline Perner

Peripheral neurons, which are ubiquitously present in all tissues of the body, communicate with their microenvironment via paracrine messengers. We and others could show, that sensory neurons react directly to stimulants like pathogens or allergens and shape immunity and host defence by releasing neuropeptides. Other studies have reported that neurons in turn are influenced and primed by cytokines, a phenomenon well known through increased pain in locally inflamed tissue.

How this bidirectional communication changes during aging is yet not been addressed. Chronic pain and itch conditions are a main source of decreased quality of life in the elderly population. Peripheral neuropathies effecting proprioception are causing gait instability and increase the risk to fall and with this start a vicious cycle of morbidity and mortality. This project will be the first attempt to characterize and define how excitability and neuropeptide release of sensory neurons is affected by aging.