Veröffentlichungen 2021

Ackermann M, Haake K, Kempf H, Kaschutnig P, Weiss A-C, Nguyen AH, Abeln M, Merkert S, Kühnel MP, Hartmann D, Jonigk D, Thum T, Kispert A, Milsom MD, Lachmann N.

A 3D iPSC-differentiation model identifies interleukin-3 as a regulator of early human hematopoietic specification.

Haematologica. 2021 May 1;106(5):1354-1367. doi: 10.3324/haematol.2019.228064.PMID: 32327499

Ackermann M, Jonigk DD.

Microvascular placental alterations in maternal COVID-19.

Am J Obstet Gynecol. 2021 Jul 3:S0002-9378(21)00782-1. doi: 10.1016/j.ajog.2021.06.098. Online ahead of print.

Ackermann M, Tafforeau P, Wagner WL, Walsh C, Werlein C, Kühnel MP, Länger FP, Disney C, Bodey AJ, Bellier A, Verleden SE, Lee PD, Mentzer SJ, Jonigk DD.

The Bronchial Circulation in COVID-19 Pneumonia.

Am J Respir Crit Care Med. 2021 Nov 4. doi: 10.1164/rccm.202103-0594IM. Online ahead of print. PMID: 34734553

Ackermann M, Werlein C, Länger F, Kühnel MP, Jonigk DD.

[COVID-19: effects on the lungs and heart].

Pathologe. 2021 Mar;42(2):164-171. doi: 10.1007/s00292-021-00918-9. Epub 2021 Feb 9.PMID: 33560456

Agaimy A, Stoehr R, Otto M, Bräsen JH, Pfarr N, Konukiewitz B, Kasajima A, Hartmann A, Klöppel G.

Intra-abdominal EWSR1/FUS-CREM-rearranged malignant epithelioid neoplasms: two cases of an emerging aggressive entity with emphasis on misleading immunophenotype.

Virchows Arch. 2021 Jul 6. doi: 10.1007/s00428-021-03140-3. Online ahead of print.

Banan R, Abbetmeier-Basse M, Hong B, Dumitru CA, Sahm F, Nakamura M, Krauss JK, Hartmann C.

The prognostic significance of clinicopathological features in meningiomas: Microscopic brain invasion can predict patient outcome in otherwise benign meningiomas.

Neuropathol Appl Neurobiol. 2021 Oct;47(6):724-735. doi: 10.1111/nan.12700. Epub 2021 Feb 25.

Banan R, Akbarian A, Samii M, Samii A, Bertalanffy H, Lehmann U, Hartmann C, Brüning R.

Diffuse midline gliomas, H3 K27M-mutant are associated with less peritumoral edema and contrast enhancement in comparison to glioblastomas, H3 K27M-wildtype of midline structures.

PLoS One. 2021 Aug 4;16(8):e0249647. doi: 10.1371/journal.pone.0249647. eCollection 2021.

Bartels S, Vogtmann J, Schipper E, Büsche G, Schlue J, Lehmann U, Kreipe H.

Combination of myeloproliferative neoplasm driver gene activation with mutations of splice factor or epigenetic modifier genes increases risk of rapid blastic progression.

Eur J Haematol. 2021 Apr;106(4):520-528. doi: 10.1111/ejh.13579. Epub 2021 Feb 1.PMID: 33460496

Behr J, Günther A, Bonella F, Dinkel J, Fink L, Geiser T, Geissler K, Gläser S, Handzhiev S, Jonigk D, Koschel D, Kreuter M, Leuschner G, Markart P, Prasse A, Schönfeld N, Schupp JC, Sitter H, Müller-Quernheim J, Costabel U.

S2K Guideline for Diagnosis of Idiopathic Pulmonary Fibrosis.

Respiration. 2021;100(3):238-271. doi: 10.1159/000512315. Epub 2021 Jan 22.PMID: 33486500

Berezowska S, Boor P, Jonigk D, Tischler V.

[Update on thoracic pathology 2021-report of the working group thoracic pathology of the German Society of Pathology].

Pathologe. 2021 Oct 5:1-4. doi: 10.1007/s00292-021-00991-0. Online ahead of print. PMID: 34609564

Braubach P, Werlein C, Verleden SE, Maerzke I, Gottlieb J, Warnecke G, Dettmer S, Laenger F, Jonigk D.

Pulmonary Fibroelastotic Remodelling Revisited.

Cells. 2021 Jun 1;10(6):1362. doi: 10.3390/cells10061362.

Bormann T, Maus R, Stolper J, Jonigk D, Welte T, Gauldie J, Kolb M, Maus UA.

Role of the COX2-PGE2 axis in S. pneumoniae-induced exacerbation of experimental fibrosis.

Am J Physiol Lung Cell Mol Physiol. 2021 Mar 1;320(3):L377-L392. doi: 10.1152/ajplung.00024.2020. Epub 2020 Dec 9.PMID: 33296268

Bülau JE, Kreipe HH, Jessen E, von Hardenberg S, Auber B, Grohé C, Leo F.

Pulmonary Cylindromas in CYLD Cutaneous Syndrome: A Rare Differential Diagnosis of Pulmonary Adenoid Cystic Carcinoma.

Clin Lung Cancer. 2021 Mar 27:S1525-7304(21)00070-X. doi: 10.1016/j.cllc.2021.03.016. Online ahead of print.PMID: 33896728 No abstract available.

Buitrago-Molina LE, Dywicki J, Noyan F, Trippler M, Pietrek J, Schlue J, Manns MP, Wedemeyer H, Jaeckel E, Hardtke-Wolenski M.

Splenectomy Prior to Experimental Induction of Autoimmune Hepatitis Promotes More Severe Hepatic Inflammation, Production of IL-17 and Apoptosis.

Biomedicines. 2021 Jan 9;9(1):58. doi: 10.3390/biomedicines9010058.PMID: 33435354

Buitrago-Molina LE, Dywicki J, Noyan F, Schepergerdes L, Pietrek J, Lieber M, Schlue J, Manns MP, Wedemeyer H, Jaeckel E, Hardtke-Wolenski M.

Anti-CD20 Therapy Alters the Protein Signature in Experimental Murine AIH, but Not Exclusively towards Regeneration.

Cells. 2021 Jun 11;10(6):1471. doi: 10.3390/cells10061471. PMID: 34208308

Buitrago-Molina LE, Pietrek J, Noyan F, Schlue J, Manns MP, Wedemeyer H, Hardtke-Wolenski M, Jaeckel E.

Treg-specific IL-2 therapy can reestablish intrahepatic immune regulation in autoimmune hepatitis.

J Autoimmun. 2021 Feb;117:102591. doi: 10.1016/j.jaut.2020.102591. Epub 2020 Dec 30.PMID: 33387980

Busche S, John K, Wandrer F, Vondran FWR, Lehmann U, Wedemeyer H, Essmann F, Schulze-Osthoff K, Bantel H.

BH3-only protein expression determines hepatocellular carcinoma response to sorafenib-based treatment.

Cell Death Dis. 2021 Jul 26;12(8):736. doi: 10.1038/s41419-021-04020-z.

Christgen M, Cserni G, Floris G, Marchio C, Djerroudi L, Kreipe H, Derksen PWB, Vincent-Salomon A.

Lobular Breast Cancer: Histomorphology and Different Concepts of a Special Spectrum of Tumors.

Cancers (Basel). 2021 Jul 22;13(15):3695. doi: 10.3390/cancers13153695.

Derben FC, Engel B, Zachou K, Hartl J, Hartleben B, Bantel H, Schramm C, Dalekos GN, Manns MP, Jaeckel E, Taubert R.

CK-18 cell death markers improve the prediction of histological remission in autoimmune hepatitis during biochemical remission.

Liver Int. 2021 Jan;41(1):123-127. doi: 10.1111/liv.14699.PMID: 33043565

Derlin T, Jaeger B, Jonigk D, Apel RM, Freise J, Shin HO, Weiberg D, Warnecke G, Ross TL, Wester HJ, Seeliger B, Welte T, Bengel FM, Prasse A.

Clinical Molecular Imaging of Pulmonary CXCR4 Expression to Predict Outcome of Pirfenidone Treatment in Idiopathic Pulmonary Fibrosis.

Chest. 2021 Mar;159(3):1094-1106. doi: 10.1016/j.chest.2020.08.2043. Epub 2020 Aug 19.PMID: 32822674

Ditsch N, Kolberg-Liedtke C, Friedrich M, Jackisch C, Albert US, Banys-Paluchowski M, Bauerfeind I, Blohmer JU, Budach W, Dall P, Fallenberg EM, Fasching PA, Fehm T, Gerber B, Gluz O, Harbeck N, Heil J, Huober J, Kreipe HH, Krug D, Kühn T, Kümmel S, Loibl S, Lüftner D, Lux MP, Maass N, Mundhenke C, Nitz U, Park-Simon TW, Reimer T, Rhiem K, Rody A, Schmidt M, Schneeweiss A, Schütz F, Sinn HP, Solbach C, Solomayer EF, Stickeler E, Thomssen C, Untch M, Witzel I, Wöckel A, Müller V, Janni W, Thill M.

AGO Recommendations for the Diagnosis and Treatment of Patients with Early Breast Cancer: Update 2021.

Breast Care (Basel). 2021 Jun;16(3):214-227. doi: 10.1159/000516419. Epub 2021 Jun 1.

Dobersch S, Rubio K, Singh I, Günther S, Graumann J, Cordero J, Castillo-Negrete R, Huynh MB, Mehta A, Braubach P, Cabrera-Fuentes H, Bernhagen J, Chao CM, Bellusci S, Günther A, Preissner KT, Kugel S, Dobreva G, Wygrecka M, Braun T, Papy-Garcia D, Barreto G.

Positioning of nucleosomes containing γ-H2AX precedes active DNA demethylation and transcription initiation.

Nat Commun. 2021 Feb 16;12(1):1072. doi: 10.1038/s41467-021-21227-y.PMID: 33594057

Dölle M, Ringe KI, Hartleben B, Braubach P, Thol F, Gebel M, Wedemeyer H, Potthoff A, Zender S.

[A supposed hepatocellular adenoma turns out to be intrahepatic splenosis - a case report].

Z Gastroenterol. 2021 Feb;59(2):149-152. doi: 10.1055/a-1340-0498. Epub 2021 Feb 8.PMID: 33556974

Donnerstag F, Götz F, Dadak M, Raab P, Iglesias EC, Werlein C, Lanfermann H, Jonigk D.

Interventional stroke treatment - Is it also safe for arteries? Looking at thrombectomy wall damage through clot histology.

Interv Neuroradiol. 2021 Jun;27(3):404-410. doi: 10.1177/1591019920976673. Epub 2020 Dec 3.PMID: 33269973

Dubich T, Dittrich A, Bousset K, Geffers R, Büsche G, Köster M, Hauser H, Schulz TF, Wirth D.

3D culture conditions support Kaposi's sarcoma herpesvirus (KSHV) maintenance and viral spread in endothelial cells.

J Mol Med (Berl). 2021 Mar;99(3):425-438. doi: 10.1007/s00109-020-02020-8. Epub 2021 Jan 23.PMID: 33484281

Dywicki J, Buitrago-Molina LE, Noyan F, Davalos-Misslitz AC, Hupa-Breier KL, Lieber M, Hapke M, Schlue J, Falk CS, Raha S, Prinz I, Koenecke C, Manns MP, Wedemeyer H, Hardtke-Wolenski M, Jaeckel E.

The Detrimental Role of Regulatory T Cells in Nonalcoholic Steatohepatitis.

Hepatol Commun. 2021 Aug 25. doi: 10.1002/hep4.1807. Online ahead of print. PMID: 34532981

Eggers H, Wichmann J, Omar M, Länger F, Ivanyi P.

[Oncologic aspects in treatment of pathologic fractures].

Unfallchirurg. 2021 Sep;124(9):731-737. doi: 10.1007/s00113-021-01051-1. Epub 2021 Jul 13. PMID: 34255103

Fink L, Jonigk D.

[The updated S2k guideline for the diagnosis of idiopathic pulmonary fibrosis : Essential aspects for pathology].

Pathologe. 2021 Feb;42(1):40-47. doi: 10.1007/s00292-020-00894-6. Epub 2021 Jan 8.PMID: 33416935

Fleig SV, Konen FF, Schröder C, Schmitz J, Gingele S, Bräsen JH, Lovric S, Schmidt BMW, Haller H, Skripuletz T, von Vietinghoff S.

Long-term B cell depletion associates with regeneration of kidney function.

Immun Inflamm Dis. 2021 Jul 29. doi: 10.1002/iid3.499. Online ahead of print.

Förster A, Brand F, Banan R, Hüneburg R, Weber CAM, Ewert W, Kronenberg J, Previti C, Elyan N, Beyer U, Martens H, Hong B, Bräsen JH, Erbersdobler A, Krauss JK, Stangel M, Samii A, Wolf S, Preller M, Aretz S, Wiese B, Hartmann C, Weber RG.

Rare germline variants in the E-cadherin gene CDH1 are associated with the risk of brain tumors of neuroepithelial and epithelial origin.

Acta Neuropathol. 2021 Jul;142(1):191-210. doi: 10.1007/s00401-021-02307-1. Epub 2021 Apr 30.

Frank C, Wickel J, Brämer D, Matschke J, Ibe R, Gazivoda C, Günther A, Hartmann C, Rehn K, Cadar D, Mayer TE, Pörtner K, Wilking H, Schmidt-Chanasit J, Tappe D.

Emerging Microbes & Infections - Original Article: Human Borna disease virus 1 (BoDV-1) encephalitis cases in the north and east of Germany.

Emerg Microbes Infect. 2021 Nov 16:1-19. doi: 10.1080/22221751.2021.2007737. Online ahead of print. PMID: 34783638

Friedrich M, Kühn T, Janni W, Müller V, Banys-Pachulowski M, Kolberg-Liedtke C, Jackisch C, Krug D, Albert US, Bauerfeind I, Blohmer J, Budach W, Dall P, Fallenberg EM, Fasching PA, Fehm T, Gerber B, Gluz O, Hanf V, Harbeck N, Heil J, Huober J, Kreipe HH, Kümmel S, Loibl S, Lüftner D, Lux MP, Maass N, Möbus V, Mundhenke C, Nitz U, Park-Simon TW, Reimer T, Rhiem K, Rody A, Schmidt M, Schneeweiss A, Schütz F, Sinn HP, Solbach C, Solomayer EF, Stickeler E, Thomssen C, Untch M, Witzel I, Wöckel A, Thill M, Ditsch N.

AGO Recommendations for the Surgical Therapy of the Axilla After Neoadjuvant Chemotherapy: 2021 Update.

Geburtshilfe Frauenheilkd. 2021 Oct;81(10):1112-1120. doi: 10.1055/a-1499-8431. Epub 2021 Oct 6. PMID: 34629490

Friedrich M, Kühn T, Janni W, Müller V, Banys-Paluchowski M, Kolberg-Liedtke C, Jackisch C, Krug D, Albert US, Bauerfeind I, Blohmer J, Budach W, Dall P, Fallenberg EM, Fasching PA, Fehm T, Gerber B, Gluz O, Hanf V, Harbeck N, Heil J, Huober J, Kreipe HH, Kümmel S, Loibl S, Lüftner D, Lux MP, Maass N, Möbus V, Mundhenke C, Nitz U, Park-Simon TW, Reimer T, Rhiem K, Rody A, Schmidt M, Schneeweiss A, Schütz F, Sinn HP, Solbach C, Solomayer EF, Stickeler E, Thomssen C, Untch M, Witzel I, Wöckel A, Thill M, Ditsch N.

Correction: AGO Recommendations for the Surgical Therapy of the Axilla After Neoadjuvant Chemotherapy: 2021 Update.

Geburtshilfe Frauenheilkd. 2021 Oct 22;81(10):e31. doi: 10.1055/a-1674-1114. eCollection 2021 Oct. PMID: 34720743

Gburek-Augustat J, Schoene-Bake JC, Bültmann E, Haack T, Buchert R, Synofzik M, Biskup S, Feuerhake F, Sorge I, Hartmann H.

Pitfalls in Genetic Diagnostics: Why Phenotyping is Essential.

Neuropediatrics. 2021 Aug;52(4):274-283. doi: 10.1055/s-0041-1726306. Epub 2021 Mar 31.

Gothe F, Gehrig J, Rapp CK, Knoflach K, Reu-Hofer S, Länger F, Schramm D, Ley-Zaporozhan J, Ehl S, Schwerk N, Faletti L, Griese M.

Early-onset, fatal interstitial lung disease in STAT3 gain-of-function patients.

Pediatr Pulmonol. 2021 Dec;56(12):3934-3941. doi: 10.1002/ppul.25684. Epub 2021 Sep 28. PMID: 34549903

Graeser M, Feuerhake F, Gluz O, Volk V, Hauptmann M, Jozwiak K, Christgen M, Kuemmel S, Grischke EM, Forstbauer H, Braun M, Warm M, Hackmann J, Uleer C, Aktas B, Schumacher C, Kolberg-Liedtke C, Kates R, Wuerstlein R, Nitz U, Kreipe HH, Harbeck N.

Immune cell composition and functional marker dynamics from multiplexed immunohistochemistry to predict response to neoadjuvant chemotherapy in the WSG-ADAPT-TN trial.

J Immunother Cancer. 2021 May;9(5):e002198. doi: 10.1136/jitc-2020-002198.PMID: 33963012

Graeser M, Harbeck N, Gluz O, Würstlein R, Zu Eulenburg C, Schumacher C, Grischke EM, Forstbauer H, Dimpfl M, Braun M, Christgen M, Kreipe HH, Potenberg J, von Schumann R, Aktas B, Kolberg-Liedtke C, Kümmel S, Nitz U.

The use of breast ultrasound for prediction of pathologic complete response in different subtypes of early breast cancer within the WSG-ADAPT subtrials.

Breast. 2021 Oct;59:58-66. doi: 10.1016/j.breast.2021.06.001. Epub 2021 Jun 14.

Graeser M, Schrading S, Gluz O, Strobel K, Würstlein R, Kümmel S, Schumacher C, Grischke EM, Forstbauer H, Braun M, Christgen M, Adams J, Nitzsche H, Just M, Fischer HH, Aktas B, Potenberg J, von Schumann R, Kolberg-Liedtke C, Harbeck N, Kuhl CK, Nitz U.

Early response by MR imaging and ultrasound as predictor of pathologic complete response to 12-week neoadjuvant therapy for different early breast cancer subtypes: Combined analysis from the WSG ADAPT subtrials.

Int J Cancer. 2021 Feb 3;148(10):2614-27. doi: 10.1002/ijc.33495. Online ahead of print.PMID: 33533487

Greimelmaier K, Hager T, Moskalenko V, Mueller-Huelsbeck S, Feist H, Schmid KW, Seidel A, Jonigk D, Wohlschlaeger J.

Pulmonary echinococcosis: A rare pseudotumour of the lung.

Rare Tumors. 2021 Apr 11;13:20363613211009769. doi: 10.1177/20363613211009769. eCollection 2021.PMID: 33953895

Grosse GM, Werlein C, Blume N, Abu-Fares O, Götz F, Gabriel MM, Ernst J, Leotescu A, Worthmann H, Kühnel MP, Jonigk DD, Falk CS, Weissenborn K, Schuppner R.

Circulating Cytokines and Growth Factors in Acute Cerebral Large Vessel Occlusion-Association with Success of Endovascular Treatment.

Thromb Haemost. 2021 Jul 5. doi: 10.1055/a-1544-5431. Online ahead of print.

Grote I, Bartels S, Kandt L, Bollmann L, Christgen H, Gronewold M, Raap M, Lehmann U, Gluz O, Nitz U, Kuemmel S, Zu Eulenburg C, Braun M, Aktas B, Grischke EM, Schumacher C, Luedtke-Heckenkamp K, Kates R, Wuerstlein R, Graeser M, Harbeck N, Christgen M, Kreipe H.

TP53 mutations are associated with primary endocrine resistance in luminal early breast cancer.

Cancer Med. 2021 Dec;10(23):8581-8594. doi: 10.1002/cam4.4376. Epub 2021 Nov 14. PMID: 34779146

Hacker KS, Jansson K, Pichler J, Salman J, Avsar M, Siemeni T, Knöfel AK, Höffler K, Gottlieb J, Frühauf J, Werner M, Poyanmehr R, Jonigk D, Balzer MS, Hewicker-Trautwein M, Haverich A, Sommer W, Warnecke G.

Delayed non-myeloablative irradiation to induce long-term allograft acceptance in a large animal lung transplantation model.

Transpl Immunol. 2021 Apr;65:101350. doi: 10.1016/j.trim.2020.101350. Epub 2020 Oct 27.PMID: 33127498

Harbeck N, Rastogi P, Martin M, Tolaney SM, Shao ZM, Fasching PA, Huang CS, Jaliffe GG, Tryakin A, Goetz MP, Rugo HS, Senkus E, Testa L, Andersson M, Tamura K, Del Mastro L, Steger GG, Kreipe H, Hegg R, Sohn J, Guarneri V, Cortés J, Hamilton E, André V, Wei R, Barriga S, Sherwood S, Forrester T, Munoz M, Shahir A, San Antonio B, Nabinger SC, Toi M, Johnston SRD, O'Shaughnessy J; monarchE Committee Members.

Adjuvant abemaciclib combined with endocrine therapy for high-risk early breast cancer: updated efficacy and Ki-67 analysis from the monarchE study.

Ann Oncol. 2021 Dec;32(12):1571-1581. doi: 10.1016/j.annonc.2021.09.015. Epub 2021 Oct 14. PMID: 34656740

Harbeck N, von Schumann R, Kates RE, Braun M, Kuemmel S, Schumacher C, Potenberg J, Malter W, Augustin D, Aktas B, Forstbauer H, Tio J, Grischke EM, Biehl C, Liedtke C, De Haas SL, Deurloo R, Wuerstlein R, Kreipe HH, Gluz O.

Immune Markers and Tumor-Related Processes Predict Neoadjuvant Therapy Response in the WSG-ADAPT HER2-Positive/Hormone Receptor-Positive Trial in Early Breast Cancer.

Cancers (Basel). 2021 Sep 29;13(19):4884. doi: 10.3390/cancers13194884. PMID: 34638369

Hagner M, Albrecht M, Guerra M, Braubach P, Halle O, Zhou-Suckow Z, Butz S, Jonigk D, Hansen G, Schultz C, Dittrich AM, Mall MA.

IL-17A from innate and adaptive lymphocytes contributes to inflammation and damage in cystic fibrosis lung disease.

Eur Respir J. 2021 Jun 4;57(6):1900716. doi: 10.1183/13993003.00716-2019. Print 2021 Jun.PMID: 33303549

Hecht A, Meyer JA, Jann JC, Sockel K, Giagounidis A, Götze KS, Letsch A, Haase D, Schlenk RF, Haferlach T, Schafhausen P, Bug G, Lübbert M, Thol F, Büsche G, Schuler E, Nowak V, Obländer J, Fey S, Müller N, Metzgeroth G, Hofmann WK, Germing U, Nolte F, Reinwald M, Nowak D.

Genome-wide DNA methylation analysis pre- and post-lenalidomide treatment in patients with myelodysplastic syndrome with isolated deletion (5q).

Ann Hematol. 2021 Jun;100(6):1463-1471. doi: 10.1007/s00277-021-04492-1. Epub 2021 Apr 27.PMID: 33903952 Clinical Trial.

Hempel T, Elez K, Krüger N, Raich L, Shrimp JH, Danov O, Jonigk D, Braun A, Shen M, Hall MD, Pöhlmann S, Hoffmann M, Noé F.

Synergistic inhibition of SARS-CoV-2 cell entry by otamixaban and covalent protease inhibitors: pre-clinical assessment of pharmacological and molecular properties.

Chem Sci. 2021 Aug 26;12(38):12600-12609. doi: 10.1039/d1sc01494c. eCollection 2021 Oct 6. PMID: 34703545

Hermsen M, Volk V, Bräsen JH, Geijs DJ, Gwinner W, Kers J, Linmans J, Schaadt NS, Schmitz J, Steenbergen EJ, Swiderska-Chadaj Z, Smeets B, Hilbrands LB, Feuerhake F, van der Laak JAWM.

Quantitative assessment of inflammatory infiltrates in kidney transplant biopsies using multiplex tyramide signal amplification and deep learning.

Lab Invest. 2021 Aug;101(8):970-982. doi: 10.1038/s41374-021-00601-w. Epub 2021 May 18.

Hofman P, Ilié M, Chamorey E, Brest P, Schiappa R, Nakache V, Antoine M, Barberis M, Begueret H, Bibeau F, Bonnetaud C, Boström P, Brousset P, Bubendorf L, Carvalho L, Cathomas G, Cazes A, Chalabreysse L, Chenard MP, Copin MC, Côté JF, Damotte D, de Leval L, Delongova P, Thomas de Montpreville V, de Muret A, Dema A, Dietmaier W, Evert M, Fabre A, Forest F, Foulet A, Garcia S, Garcia-Martos M, Gibault L, Gorkiewicz G, Jonigk D, Gosney J, Hofman A, Kern I, Kerr K, Kossai M, Kriegsmann M, Lassalle S, Long-Mira E, Lupo A, Mamilos A, Matěj R, Meilleroux J, Ortiz-Villalón C, Panico L, Panizo A, Papotti M, Pauwels P, Pelosi G, Penault-Llorca F, Pop O, Poté N, Cajal SRY, Sabourin JC, Salmon I, Sajin M, Savic-Prince S, Schildhaus HU, Schirmacher P, Serre I, Shaw E, Sizaret D, Stenzinger A, Stojsic J, Thunnissen E, Timens W, Troncone G, Werlein C, Wolff H, Berthet JP, Benzaquen J, Marquette CH, Hofman V, Calabrese F.

Clinical and molecular practice of European thoracic pathology laboratories during the COVID-19 pandemic. The past and the near future.

ESMO Open. 2021 Feb;6(1):100024. doi: 10.1016/j.esmoop.2020.100024. Epub 2020 Dec 2. PMID: 33399086

Hoffmann M, Hofmann-Winkler H, Smith JC, Krüger N, Arora P, Sørensen LK, Søgaard OS, Hasselstrøm JB, Winkler M, Hempel T, Raich L, Olsson S, Danov O, Jonigk D, Yamazoe T, Yamatsuta K, Mizuno H, Ludwig S, Noé F, Kjolby M, Braun A, Sheltzer JM, Pöhlmann S.

Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity.

EBioMedicine. 2021 Mar;65:103255. doi: 10.1016/j.ebiom.2021.103255. Epub 2021 Mar 4.PMID: 33676899

Hong B, Lalk M, Wiese B, Merten R, Heissler HE, Raab P, Hartmann C, Krauss JK.

Primary and secondary gliosarcoma: differences in treatment and outcome.

Br J Neurosurg. 2021 Feb 4:1-8. doi: 10.1080/02688697.2021.1872773. Online ahead of print.PMID: 33538191

Hupa-Breier KL, Dywicki J, Hartleben B, Wellhöner F, Heidrich B, Taubert R, Mederacke YE, Lieber M, Iordanidis K, Manns MP, Wedemeyer H, Hardtke-Wolenski M, Jaeckel E.

Dulaglutide Alone and in Combination with Empagliflozin Attenuate Inflammatory Pathways and Microbiome Dysbiosis in a Non-Diabetic Mouse Model of NASH.

Biomedicines. 2021 Mar 30;9(4):353. doi: 10.3390/biomedicines9040353.PMID: 33808404

Huusmann S, Lafos M, Meyenburg I, Muschter R, Teichmann HO, Herrmann T.

Tissue effects of a newly developed diode pumped pulsed Thulium:YAG laser compared to continuous wave Thulium:YAG and pulsed Holmium:YAG laser.

World J Urol. 2021 Sep;39(9):3503-3508. doi: 10.1007/s00345-021-03634-4. Epub 2021 Mar 16.

Hümmert MW, Stadler M, Hambach L, Gingele S, Bredt M, Wattjes MP, Göhring G, Venturini L, Möhn N, Stangel M, Trebst C, Ganser A, Wegner F, Skripuletz T.

Severe allo-immune antibody-associated peripheral and central nervous system diseases after allogeneic hematopoietic stem cell transplantation.

Sci Rep. 2021 Apr 19;11(1):8527. doi: 10.1038/s41598-021-87989-z.PMID: 33875720

Jayaprakash S, Le LTM, Sander B, Golas MM.

Expression of the Neural REST/NRSF-SIN3 Transcriptional Corepressor Complex as a Target for Small-Molecule Inhibitors.

Mol Biotechnol. 2021 Jan;63(1):53-62. doi: 10.1007/s12033-020-00283-7. Epub 2020 Nov 1.PMID: 33130996

Jonigk D, Märkl B, Helms J.

COVID-19: what the clinician should know about post-mortem findings.

Intensive Care Med. 2021 Jan;47(1):86-89. doi: 10.1007/s00134-020-06302-0. Epub 2020 Nov 3.PMID: 33141245

Junge N, Goldschmidt I, Wiegandt J, Leiskau C, Mutschler F, Laue T, Ohlendorf J, Stalke A, Hartleben B, Stindt J, Keitel V, Baumann U, Pfister ED.

Dubin-Johnson Syndrome as Differential Diagnosis for Neonatal Cholestasis.

J Pediatr Gastroenterol Nutr. 2021 May 1;72(5):e105-e111. doi: 10.1097/MPG.0000000000003061.PMID: 33534365

Jurmeister P, Vollbrecht C, Jöhrens K, Aust D, Behnke A, Stenzinger A, Penzel R, Endris V, Schirmacher P, Fisseler-Eckhoff A, Neumann J, Kirchner T, Büttner R, Merkelbach-Bruse S, Kreipe H, Jonigk D, Jochum W, Rodriguez R, Dietel M, Horst D, Hummel M, von Laffert M.

Status quo of ALK testing in lung cancer: results of an EQA scheme based on in-situ hybridization, immunohistochemistry, and RNA/DNA sequencing.

Virchows Arch. 2021 Aug;479(2):247-255. doi: 10.1007/s00428-021-03106-5. Epub 2021 Jun 25.

Kamp JC, Suhling H, Ramthor M, Hinrichs JB, Soudah B, Adel J, Welte T, Ringshausen FC.

[Eosinophilic Granulomatosis with Polyangiitis with Pulmonary and Cardiac Involvement].

Pneumologie. 2021 Jan;75(1):33-38. doi: 10.1055/a-1209-4292. Epub 2020 Jul 24.PMID: 32707588

Kant TA, Newe M, Winter L, Hoffmann M, Kämmerer S, Klapproth E, Künzel K, Kühnel MP, Neubert L, El-Armouche A, Künzel SR.

Genetic Deletion of Polo-Like Kinase 2 Induces a Pro-Fibrotic Pulmonary Phenotype.

Cells. 2021 Mar 11;10(3):617. doi: 10.3390/cells10030617.PMID: 33799608

Kasajima A, Konukiewitz B, Schlitter AM, Weichert W, Bräsen JH, Agaimy A, Klöppel G.

Mesenchymal/non-epithelial mimickers of neuroendocrine neoplasms with a focus on fusion gene-associated and SWI/SNF-deficient tumors.

Virchows Arch. 2021 Aug 5. doi: 10.1007/s00428-021-03156-9. Online ahead of print.

Katzendorn O, Peters I, Dubrowinskaja N, Tezval H, Tabrizi PF, von Klot CA, Hennenlotter J, Lafos M, Kuczyk MA, Serth J.

DNA methylation of tumor associated calcium signal transducer 2 (TACSTD2) loci shows association with clinically aggressive renal cell cancers.

BMC Cancer. 2021 Apr 21;21(1):444. doi: 10.1186/s12885-021-08172-1.PMID: 33882870

Kaufeld JK, Reinhardt M, Schröder C, Bräsen JH, Wiech T, Brylka P, Khaled A, Bergmann C, Haller H, Gäckler A, Schmidt BMW.

Atypical HUS triggered by infection with SARS-CoV2.

Kidney Int Rep. 2021 Oct;6(10):2709-2712. doi: 10.1016/j.ekir.2021.07.004. Epub 2021 Jul 8.

Koelsche C, Schrimpf D, Stichel D, Sill M, Sahm F, Reuss DE, Blattner M, Worst B, Heilig CE, Beck K, Horak P, Kreutzfeldt S, Paff E, Stark S, Johann P, Selt F, Ecker J, Sturm D, Pajtler KW, Reinhardt A, Wefers AK, Sievers P, Ebrahimi A, Suwala A, Fernández-Klett F, Casalini B, Korshunov A, Hovestadt V, Kommoss FKF, Kriegsmann M, Schick M, Bewerunge-Hudler M, Milde T, Witt O, Kulozik AE, Kool M, Romero-Pérez L, Grünewald TGP, Kirchner T, Wick W, Platten M, Unterberg A, Uhl M, Abdollahi A, Debus J, Lehner B, Thomas C, Hasselblatt M, Paulus W, Hartmann C, Staszewski O, Prinz M, Hench J, Frank S, Versleijen-Jonkers YMH, Weidema ME, Mentzel T, Griewank K, de Álava E, Martín JD, Gastearena MAI, Chang KT, Low SYY, Cuevas-Bourdier A, Mittelbronn M, Mynarek M, Rutkowski S, Schüller U, Mautner VF, Schittenhelm J, Serrano J, Snuderl M, Büttner R, Klingebiel T, Buslei R, Gessler M, Wesseling P, Dinjens WNM, Brandner S, Jaunmuktane Z, Lyskjær I, Schirmacher P, Stenzinger A, Brors B, Glimm H, Heining C, Tirado OM, Sáinz-Jaspeado M, Mora J, Alonso J, Del Muro XG, Moran S, Esteller M, Benhamida JK, Ladanyi M, Wardelmann E, Antonescu C, Flanagan A, Dirksen U, Hohenberger P, Baumhoer D, Hartmann W, Vokuhl C, Flucke U, Petersen I, Mechtersheimer G, Capper D, Jones DTW, Fröhling S, Pfister SM, von Deimling A.

Sarcoma classification by DNA methylation profiling.

Nat Commun. 2021 Jan 21;12(1):498. doi: 10.1038/s41467-020-20603-4.PMID: 33479225

Kordes U, Mautner VF, Oyen F, Hagel C, Hartmann C, Heuser M, Frühwald M, Hasselblatt M, Oehl-Huber K, Siebert R, Schneppenheim R, Schüller U.

Evidence for a low-penetrant extended phenotype of rhabdoid tumor predisposition syndrome type 1 from a kindred with gain of SMARCB1 exon 6.

Pediatr Blood Cancer. 2021 Jun 8:e29185. doi: 10.1002/pbc.29185. Online ahead of print.PMID: 34101994

Kirfel J, Kümpers CC, Fähnrich A, Heidel C, Jokic M, Vlasic I, Marwitz S, Goldmann T, Pasternack H, Bohnet S, Jonigk D, Kühnel MP, Offermann A, Busch H, Perner S.

PD-L1 Dependent Immunogenic Landscape in Hot Lung Adenocarcinomas Identified by Transcriptome Analysis.

Cancers (Basel). 2021 Sep 11;13(18):4562. doi: 10.3390/cancers13184562. PMID: 34572789

Kreipe HH.

[Axel Georgii : 02 August 1927-07 February 2021].

Pathologe. 2021 Oct 20. doi: 10.1007/s00292-021-01017-5. Online ahead of print. PMID: 34671838

Kreipe HH, Sinn P.

[Relevant mutations in predictive breast cancer pathology].

Pathologe. 2021 Jul;42(4):399-404. doi: 10.1007/s00292-021-00929-6. Epub 2021 Apr 6.

Kreipe H, Weichert W.

[Predictive pathology for targeted tumor therapy].

Pathologe. 2021 Jul;42(4):355-356. doi: 10.1007/s00292-021-00951-8. Epub 2021 Jul 1. PMID: 34196776

Kemps PG, Picarsic J, Durham BH, Hélias-Rodzewicz Z, Hiemcke-Jiwa LS, van den Bos C, van de Wetering MD, van Noesel CJM, van Laar JA, Verdijk RM, Flucke UE, Hogendoorn PCW, Woei-A-Jin FJSH, Sciot R, Beilken A, Feuerhake F, Ebinger M, Möhle R, Fend F, Bornemann A, Wiegering V, Ernestus K, Méry T, Gryniewicz-Kwiatkowska O, Dembowska-Baginska B, Evseev DA, Potapenko V, Baykov VV, Gaspari S, Rossi S, Gessi M, Tamburrini G, Héritier S, Donadieu J, Bonneau-Lagacherie J, Lamaison C, Farnault L, Fraitag S, Jullie ML, Haroche J, Collin M, Allotey J, Madni M, Turner K, Picton S, Barbaro PM, Poulin A, Tam IS, El Demellawy D, Empringham B, Whitlock JA, Raghunathan A, Swanson AA, Suchi M, Brandt JM, Yaseen NR, Weinstein JL, Eldem I, Sisk BA, Sridhar V, Atkinson MM, Massoth LR, Hornick JL, Alexandrescu S, Yeo KK, Petrova-Drus K, Peeke SZ, Munoz-Arcos L, Leino DG, Grier DD, Lorsbach R, Roy S, Kumar AR, Garg S, Tiwari N, Schafernak KT, Henry MM, van Halteren AGS, Abla O, Diamond EL, Emile JF.

ALK+ histiocytosis: a new clinicopathologic spectrum highlighting neurologic involvement and responses to ALK inhibition.

Blood. 2021 Nov 2:blood.2021013338. doi: 10.1182/blood.2021013338. Online ahead of print. PMID: 34727172

Kreuter M, Ladner UM, Costabel U, Jonigk D, Heussel CP.

The Diagnosis and Treatment of Pulmonary Fibrosis.

Dtsch Arztebl Int. 2021 Mar 5;118(Forthcoming):arztebl.m2021.0018. doi: 10.3238/arztebl.m2021.0018. Online ahead of print.PMID: 33531115

Kunzke T, Prade VM, Buck A, Sun N, Feuchtinger A, Matzka M, Fernandez IE, Wuyts W, Ackermann M, Jonigk D, Aichler M, Schmid RA, Eickelberg O, Berezowska S, Walch A.

Patterns of Carbon-Bound Exogenous Compounds in Patients with Lung Cancer and Association with Disease Pathophysiology.

Cancer Res. 2021 Dec 1;81(23):5862-5875. doi: 10.1158/0008-5472.CAN-21-1175. Epub 2021 Oct 19. PMID: 34666994

Länger F, Werlein C, Soudah B, Schwerk N, Jonigk D.

[Interstitial lung disease in infancy and early childhood].

Pathologe. 2021 Feb;42(1):25-34. doi: 10.1007/s00292-020-00884-8. Epub 2020 Dec 23.PMID: 33355705

Lehmann U, Jung A.

[Next generation sequencing in histopathology : Applications and methodological challenges].

Pathologe. 2021 Jul;42(4):363-368. doi: 10.1007/s00292-021-00953-6. Epub 2021 Jun 25.

Lehmann U, Stark H, Bartels S, Schlue J, Büsche G, Kreipe H.

Genome-wide DNA methylation profiling is able to identify prefibrotic PMF cases at risk for progression to myelofibrosis.

Clin Epigenetics. 2021 Feb 4;13(1):28. doi: 10.1186/s13148-021-01010-y.PMID: 33541399

Lehmann U, Stenzinger A.

[The molecular pathology breviary: read depth and coverage in NGS analysis].

Pathologe. 2021 Oct 13. doi: 10.1007/s00292-021-01009-5. Online ahead of print. PMID: 34643752

Lehmann U, Stenzinger A.

[The molecular pathological breviary: allele frequencies in NGS analysis].

Pathologe. 2021 Oct 13. doi: 10.1007/s00292-021-01003-x. Online ahead of print. PMID: 34643753

Leimkühler NB, Gleitz HFE, Ronghui L, Snoeren IAM, Fuchs SNR, Nagai JS, Banjanin B, Lam KH, Vogl T, Kuppe C, Stalmann USA, Büsche G, Kreipe H, Gütgemann I, Krebs P, Banz Y, Boor P, Tai EW, Brümmendorf TH, Koschmieder S, Crysandt M, Bindels E, Kramann R, Costa IG, Schneider RK.

Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis.

Cell Stem Cell. 2021 Apr 1;28(4):637-652.e8. doi: 10.1016/j.stem.2020.11.004. Epub 2020 Dec 9.PMID: 33301706

Mahlmann JC, Wirth TC, Hartleben B, Schrem H, Mahlmann JF, Kaltenborn A, Klempnauer J, Kulik U.

Chemotherapy and Hepatic Steatosis: Impact on Postoperative Morbidity and Survival after Liver Resection for Colorectal Liver Metastases.

Visc Med. 2021 Jun;37(3):198-205. doi: 10.1159/000510661. Epub 2020 Oct 9. PMID: 34250077

Malik MNH, Waqas SFH, Zeitvogel J, Cheng J, Geffers R, Gouda ZA, Elsaman AM, Radwan AR, Schefzyk M, Braubach P, Auber B, Olmer R, Müsken M, Roesner LM, Gerold G, Schuchardt S, Merkert S, Martin U, Meissner F, Werfel T, Pessler F.

Congenital deficiency reveals critical role of ISG15 in skin homeostasis.

J Clin Invest. 2021 Nov 30:e141573. doi: 10.1172/JCI141573. Online ahead of print. PMID: 34847081

Mazdak M, Ringlstetter R, Tabrizi PF, Akkoyun M, Wolters M, Schmitz J, Bräsen JH, Peters I, Kuczyk MA, Tezval H.

Comparison of PD-L1 Scores in Primary Kidney Tumors Versus Accompanying Venous Tumor Thrombi: Retrospective, Comparative, Monocentric Study in Treatment-Naive Patients.

Adv Ther. 2021 Jun;38(6):3373-3388. doi: 10.1007/s12325-021-01737-3. Epub 2021 May 21.PMID: 34021481

Mederacke YS, Nienen M, Jarek M, Geffers R, Hupa-Breier K, Babel N, Reinke P, Mederacke I, Vondran FWR, Jonigk D, Wedemeyer H, Jaeckel E.

T cell receptor repertoires within liver allografts are different to those in the peripheral blood.

J Hepatol. 2021 May;74(5):1167-1175. doi: 10.1016/j.jhep.2020.12.014. Epub 2020 Dec 18.PMID: 33347951

Merveille O, Lampert T, Schmitz J, Forestier G, Feuerhake F, Wemmert C.

An automatic framework for fusing information from differently stained consecutive digital whole slide images: A case study in renal histology.

Comput Methods Programs Biomed. 2021 Sep;208:106157. doi: 10.1016/j.cmpb.2021.106157. Epub 2021 May 11.

Mücke U, Hofmann A, Langreen S, Odensass M, Partheil A.

Infant Acute Myeloid Leukemia Presenting as Acute Appendicitis: A Case Report.

Klin Padiatr. 2021 Oct 22. doi: 10.1055/a-1647-2687. Online ahead of print. PMID: 34687026

Nielsen TO, Leung SCY, Rimm DL, Dodson A, Acs B, Badve S, Denkert C, Ellis MJ, Fineberg S, Flowers M, Kreipe HH, Laenkholm AV, Pan H, Penault-Llorca FM, Polley MY, Salgado R, Smith IE, Sugie T, Bartlett JMS, McShane LM, Dowsett M, Hayes DF.

Assessment of Ki67 in Breast Cancer: Updated Recommendations From the International Ki67 in Breast Cancer Working Group.

J Natl Cancer Inst. 2021 Jul 1;113(7):808-819. doi: 10.1093/jnci/djaa201.

Noske A, Ammann JU, Wagner DC, Denkert C, Lebeau A, Sinn P, Kreipe HH, Sommer U, Baretton G, Steiger K, Kiechle M, Hieke-Schulz S, Flores M, Roth W, Weichert W.

A multicentre analytical comparison study of inter-reader and inter-assay agreement of four programmed death-ligand 1 immunohistochemistry assays for scoring in triple-negative breast cancer.

Histopathology. 2021 Mar;78(4):567-577. doi: 10.1111/his.14254. Epub 2020 Nov 27.PMID: 32936950

Obernolte H, Niehof M, Braubach P, Fieguth HG, Jonigk D, Pfennig O, Tschernig T, Warnecke G, Braun A, Sewald K.

Cigarette smoke alters inflammatory genes and the extracellular matrix - investigations on viable sections of peripheral human lungs.

Cell Tissue Res. 2021 Nov 25. doi: 10.1007/s00441-021-03553-1. Online ahead of print. PMID: 34820703

Offermann A, Kang D, Watermann C, Weingart A, Hupe MC, Saraji A, Stegmann-Frehse J, Kruper R, Schüle R, Pantel K, Taubert H, Duensing S, Culig Z, Aigner A, Klapper W, Jonigk D, Philipp Kühnel M, Merseburger AS, Kirfel J, Sailer V, Perner S.

Manuscript Title: Analysis of tripartite motif (TRIM) family gene expression in prostate cancer bone metastases.

Carcinogenesis. 2021 Sep 6:bgab083. doi: 10.1093/carcin/bgab083. Online ahead of print.

Oldhafer F, Wittauer EM, Beetz O, Weigle CA, Sieg L, Eismann H, Braubach P, Bock M, Jonigk D, Johanning K, Vondran FWR.

Supportive Hepatocyte Transplantation after Partial Hepatectomy Enhances Liver Regeneration in a Preclinical Pig Model.

Eur Surg Res. 2021;62(4):238-247. doi: 10.1159/000516690. Epub 2021 May 27.

Pasternack H, Kuempers C, Deng M, Watermann I, Olchers T, Kuehnel M, Jonigk D, Kugler C, Stellmacher F, Goldmann T, Kirfel J, Ammerpohl O, Perner S, Reck M.

Identification of molecular signatures associated with early relapse after complete resection of lung adenocarcinomas.

Sci Rep. 2021 May 5;11(1):9532. doi: 10.1038/s41598-021-89030-9.PMID: 33953302

Petriv N, Neubert L, Vatashchuk M, Timrott K, Suo H, Hochnadel I, Huber R, Petzold C, Hrushchenko A, Yatsenko AS, Shcherbata HR, Wedemeyer H, Lichtinghagen R, Falfushynska H, Lushchak V, Manns MP, Bantel H, Semchyshyn H, Yevsa T.

Increase of α-dicarbonyls in liver and receptor for advanced glycation end products on immune cells are linked to nonalcoholic fatty liver disease and liver cancer.

Oncoimmunology. 2021 Feb 8;10(1):1874159. doi: 10.1080/2162402X.2021.1874159.PMID: 33628620

Preuß EB, Schubert S, Werlein C, Stark H, Braubach P, Höfer A, Plucinski EKJ, Shah HR, Geffers R, Sewald K, Braun A, Jonigk DD, Kühnel MP.

The challenge of long-term cultivation of human precision-cut lung slices.

Am J Pathol. 2021 Nov 9:S0002-9440(21)00481-8. doi: 10.1016/j.ajpath.2021.10.020. Online ahead of print. PMID: 34767811

Raap M, Gierendt L, Kreipe HH, Christgen M.

Transcription factor AP-2beta in development, differentiation and tumorigenesis.

Int J Cancer. 2021 Sep 15;149(6):1221-1227. doi: 10.1002/ijc.33558. Epub 2021 Mar 26.

Raap M, Gierendt L, Werlein C, Kuehnle E, Kreipe HH, Christgen M.

Co-expression of transcription factor AP-2beta (TFAP2B) and GATA3 in human mammary epithelial cells with intense, apicobasal immunoreactivity for CK8/18.

J Mol Histol. 2021 Dec;52(6):1257-1264. doi: 10.1007/s10735-021-09980-2. Epub 2021 Jun 11.

Radner M, van Luttikhuizen JL, Bartels S, Bublitz J, Grote I, Rieger L, Christgen H, Stark H, Werlein C, Lafos M, Steinemann D, Lehmann U, Christgen M, Kreipe H.

Chromosome 2q gain and epigenetic silencing of GATA3 in microglandular adenosis of the breast.

J Pathol Clin Res. 2021 May;7(3):220-232. doi: 10.1002/cjp2.195. Epub 2020 Dec 31.

Ricke-Hoch M, Stelling E, Lasswitz L, Gunesch AP, Kasten M, Zapatero-Belinchón FJ, Brogden G, Gerold G, Pietschmann T, Montiel V, Balligand JL, Facciotti F, Hirsch E, Gausepohl T, Elbahesh H, Rimmelzwaan GF, Höfer A, Kühnel MP, Jonigk D, Eigendorf J, Tegtbur U, Mink L, Scherr M, Illig T, Schambach A, Pfeffer TJ, Hilfiker A, Haverich A, Hilfiker-Kleiner D.

Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease.

PLoS One. 2021 Aug 4;16(8):e0255335. doi: 10.1371/journal.pone.0255335. eCollection 2021.

Rigamonti A, Feuerhake F, Donadon M, Locati M, Marchesi F.

Histopathological and Immune Prognostic Factors in Colo-Rectal Liver Metastases.

Cancers (Basel). 2021 Mar 3;13(5):1075. doi: 10.3390/cancers13051075.PMID: 33802446

Roy-Chowdhury E, Brauns N, Helmke A, Nordlohne J, Bräsen JH, Schmitz J, Volkmann J, Fleig SV, Kusche-Vihrog K, Haller H, von Vietinghoff S.

Human CD16+ monocytes promote a pro-atherosclerotic endothelial cell phenotype via CX3CR1-CX3CL1 interaction.

Cardiovasc Res. 2021 May 25;117(6):1510-1522. doi: 10.1093/cvr/cvaa234.PMID: 32717023

Stojanović SD, Fuchs M, Liang C, Schmidt K, Xiao K, Just A, Pfanne A, Pich A, Warnecke G, Braubach P, Petzold C, Jonigk D, Distler JHW, Fiedler J, Thum T, Kunz M.

Reconstruction of the miR-506-Quaking axis in Idiopathic Pulmonary Fibrosis using integrative multi-source bioinformatics.

Sci Rep. 2021 Jun 14;11(1):12456. doi: 10.1038/s41598-021-89531-7.

Samii A, Sorokin M, Kar S, Makovskaia L, Garazha A, Hartmann C, Moisseev A, Kim E, Giese A, Buzdin A.

Case of multifocal glioblastoma with four fusion transcripts of ALK, FGFR2, NTRK2, and NTRK3 genes stresses the need for tumor tissue multisampling for transcriptomic analysis.

Cold Spring Harb Mol Case Stud. 2021 Aug 2;7(4):a006100. doi: 10.1101/mcs.a006100. Print 2021 Aug.

Saraji A, Offermann A, Stegmann-Frehse J, Hempel K, Kang D, Krupar R, Watermann C, Jonigk D, Kühnel MP, Kirfel J, Perner S, Sailer V.

Cracking it - successful mRNA extraction for digital gene expression analysis from decalcified, formalin-fixed and paraffin-embedded bone tissue.

PLoS One. 2021 Sep 16;16(9):e0257416. doi: 10.1371/journal.pone.0257416. eCollection 2021. PMID: 34529723

Scharm SC, Vogel-Claussen J, Schaefer-Prokop C, Dettmer S, Knudsen L, Jonigk D, Fuge J, Apel RM, Welte T, Wacker F, Prasse A, Shin HO.

Quantification of dual-energy CT-derived functional parameters as potential imaging markers for progression of idiopathic pulmonary fibrosis.

Eur Radiol. 2021 Sep;31(9):6640-6651. doi: 10.1007/s00330-021-07798-w. Epub 2021 Mar 16.

Saunders EA, Engel B, Höfer A, Hartleben B, Vondran FW, Richter N, Potthoff A, Zender S, Wedemeyer H, Jaeckel E, Taubert R.

Outcome and safety of a surveillance biopsy guided personalized immunosuppression program after liver transplantation.

Am J Transplant. 2021 Aug 28. doi: 10.1111/ajt.16817. Online ahead of print.

Schilpp C, Lochbaum R, Braubach P, Jonigk D, Frick M, Dietl P, Wittekindt OH.

TGF-β1 increases permeability of ciliated airway epithelia via redistribution of claudin 3 from tight junction into cell nuclei.

Pflugers Arch. 2021 Feb;473(2):287-311. doi: 10.1007/s00424-020-02501-2. Epub 2021 Jan 2.PMID: 33386991 Free PMC article.

Schipke J, Kuhlmann S, Hegermann J, Fassbender S, Kühnel M, Jonigk D, Mühlfeld C.

Lipofibroblasts in Structurally Normal, Fibrotic and Emphysematous Human Lungs.

Am J Respir Crit Care Med. 2021 Jul 15;204(2):227-230. doi: 10.1164/rccm.202101-0043LE.

Smadja DM, Mentzer SJ, Fontenay M, Laffan MA, Ackermann M, Helms J, Jonigk D, Chocron R, Pier GB, Gendron N, Pons S, Diehl JL, Margadant C, Guerin C, Huijbers EJM, Philippe A, Chapuis N, Nowak-Sliwinska P, Karagiannidis C, Sanchez O, Kümpers P, Skurnik D, Randi AM, Griffioen AW.

COVID-19 is a systemic vascular hemopathy: insight for mechanistic and clinical aspects.

Angiogenesis. 2021 Jun 28:1-34. doi: 10.1007/s10456-021-09805-6. Online ahead of print.

Schmidbauer M, Rong S, Gutberlet M, Chen R, Bräsen JH, Hartung D, Meier M, Wacker F, Haller H, Gueler F, Greite R, Derlin K.

Diffusion-Weighted Imaging and Mapping of T1 and T2 Relaxation Time for Evaluation of Chronic Renal Allograft Rejection in a Translational Mouse Model.

J Clin Med. 2021 Sep 23;10(19):4318. doi: 10.3390/jcm10194318. PMID: 34640336

Schreiber S, Aden K, Bernardes JP, Conrad C, Tran F, Höper H, Volk V, Mishra N, Blase JI, Nikolaus S, Bethge J, Kühbacher T, Röcken C, Chen M, Cottingham I, Petri N, Rasmussen BB, Lokau J, Lenk L, Garbers C, Feuerhake F, Rose-John S, Waetzig GH, Rosenstiel P.

Therapeutic Interleukin-6 Trans-signaling Inhibition by Olamkicept (sgp130Fc) in Patients With Active Inflammatory Bowel Disease.

Gastroenterology. 2021 Jun;160(7):2354-2366.e11. doi: 10.1053/j.gastro.2021.02.062. Epub 2021 Mar 2.PMID: 33667488

Schweizer L, Thierfelder F, Thomas C, Soschinski P, Kim HY, Jödicke R, Woltering N, Förster A, Teichmann D, Siewert C, Klein K, Schmid S, Nunninger M, Thomale UW, Onken J, Mühleisen H, Schittenhelm J, Tatagiba M, von Deimling A, Reuss DE, Solomon DA, Heppner FL, Koch A, Hartmann C, Staszewski O, Capper D.

Molecular characterisation of sporadic endolymphatic sac tumours and comparison to von Hippel-Lindau disease-related tumours.

Neuropathol Appl Neurobiol. 2021 Oct;47(6):756-767. doi: 10.1111/nan.12741. Epub 2021 Jun 24.

Sflomos G, Schipper K, Koorman T, Fitzpatrick A, Oesterreich S, Lee AV, Jonkers J, Brunton VG, Christgen M, Isacke C, Derksen PWB, Brisken C.

Atlas of Lobular Breast Cancer Models: Challenges and Strategic Directions.

Cancers (Basel). 2021 Oct 27;13(21):5396. doi: 10.3390/cancers13215396. PMID: 34771558

Sievers P, Sill M, Blume C, Tauziede-Espariat A, Schrimpf D, Stichel D, Reuss DE, Dogan H, Hartmann C, Mawrin C, Hasselblatt M, Stummer W, Schick U, Hench J, Frank S, Ketter R, Schweizer L, Schittenhelm J, Puget S, Brandner S, Jaunmuktane Z, Küsters B, Abdullaev Z, Pekmezci M, Snuderl M, Ratliff M, Herold-Mende C, Unterberg A, Aldape K, Ellison DW, Wesseling P, Reifenberger G, Wick W, Perry A, Varlet P, Pfister SM, Jones DTW, von Deimling A, Sahm F; German Consortium “Aggressive Meningiomas”.

Clear cell meningiomas are defined by a highly distinct DNA methylation profile and mutations in SMARCE1.

Acta Neuropathol. 2021 Feb;141(2):281-290. doi: 10.1007/s00401-020-02247-2. Epub 2020 Dec 14.PMID: 33319313 Free PMC article.

COVID-19 is a systemic vascular hemopathy: insight for mechanistic and clinical aspects.

Angiogenesis. 2021 Nov;24(4):755-788. doi: 10.1007/s10456-021-09805-6. Epub 2021 Jun 28. PMID: 34184164

Soudah B, Raap M, Gottlieb J, Fuehner T, Suhling H, Greer M, Bollmann B-A.

Zytologische Evaluation von Transbronchialer Nadelaspiration (TBNA) aus mediastinalen Lymphknoten mittels endobronchialem Ultra[1]schall (EBUS) Erfahrungen der Medizinischen Hochschule Hannover aus 12 Jahren

Cyto-Info, 91-97, 3/2021

Stahl K, Bräsen JH, Hoeper MM, David S.

Absence of SARS-CoV-2 RNA in COVID-19-associated intestinal endothelialitis.

Intensive Care Med. 2021 Mar;47(3):359-360. doi: 10.1007/s00134-020-06326-6. Epub 2021 Jan 3.PMID: 33388837 Free PMC article. No abstract available.

Stanke F, Janciauskiene S, Tamm S, Wrenger S, Raddatz EL, Jonigk D, Braubach P.

Effect of Alpha-1 Antitrypsin on CFTR Levels in Primary Human Airway Epithelial Cells Grown at the Air-Liquid-Interface.

Molecules. 2021 Apr 30;26(9):2639. doi: 10.3390/molecules26092639.PMID: 33946490 Free PMC article.

Stauch G, Fritz P, Rokai R, Sediqi A, Firooz H, Voelker HU, Weinhara M, Mollin J, Soudah B, Dalquen P, Brinckmann F, Dippon J.

The Importance of Clinical Data for the Diagnosis of Breast Tumours in North Afghanistan.

Int J Breast Cancer. 2021 Jul 30;2021:6625239. doi: 10.1155/2021/6625239. eCollection 2021.

Stenzinger A, van Tilburg CM, Tabatabai G, Länger F, Graf N, Griesinger F, Heukamp LC, Hummel M, Klingebiel T, Hettmer S, Vokuhl C, Merkelbach-Bruse S, Overkamp F, Reichardt P, Scheer M, Weichert W, Westphalen CB, Bokemeyer C, Ivanyi P, Loges S, Schirmacher P, Wörmann B, Bielack S, Seufferlein TTW.

[Diagnosis and therapy of tumors with NTRK gene fusion].

Pathologe. 2021 Feb;42(1):103-115. doi: 10.1007/s00292-020-00864-y.PMID: 33258061

Stojanović SD, Fuchs M, Liang C, Schmidt K, Xiao K, Just A, Pfanne A, Pich A, Warnecke G, Braubach P, Petzold C, Jonigk D, Distler JHW, Fiedler J, Thum T, Kunz M.

Reconstruction of the miR-506-Quaking axis in Idiopathic Pulmonary Fibrosis using integrative multi-source bioinformatics.

Sci Rep. 2021 Jun 14;11(1):12456. doi: 10.1038/s41598-021-89531-7.PMID: 34127686

Strassmann D, Hensen B, Grünwald V, Stange K, Eggers H, Länger F, Omar M, Zardo P, Christiansen H, Reuter CW, Wacker FK, Ganser A, Ivanyi P.

Impact of sarcopenia in advanced and metastatic soft tissue sarcoma.

Int J Clin Oncol. 2021 Nov;26(11):2151-2160. doi: 10.1007/s10147-021-01997-7. Epub 2021 Jul 27. PMID: 34318390

Struck JP, Kramer MW, Katzendorn O, Hupe MC, Ozimek T, Hennig MJP, Wießmeyer JR, von Klot CAJ, Kuczyk MA, Kreipe HH, Merseburger AS, Perner S, Dressler FF.

Bicentric Retrospective Analysis of en Bloc Resection and Muscularis Mucosae Detection Rate in Non-Muscle Invasive Bladder Tumors: A Real-World Scenario.

Adv Ther. 2021 Jan;38(1):258-267. doi: 10.1007/s12325-020-01529-1. Epub 2020 Oct 22.PMID: 33094476

Suwala AK, Stichel D, Schrimpf D, Kloor M, Wefers AK, Reinhardt A, Maas SLN, Kratz CP, Schweizer L, Hasselblatt M, Snuderl M, Abedalthagafi MSJ, Abdullaev Z, Monoranu CM, Bergmann M, Pekrun A, Freyschlag C, Aronica E, Kramm CM, Hinz F, Sievers P, Korshunov A, Kool M, Pfister SM, Sturm D, Jones DTW, Wick W, Unterberg A, Hartmann C, Dodgshun A, Tabori U, Wesseling P, Sahm F, von Deimling A, Reuss DE.

Primary mismatch repair deficient IDH-mutant astrocytoma (PMMRDIA) is a distinct type with a poor prognosis.

Acta Neuropathol. 2021 Jan;141(1):85-100. doi: 10.1007/s00401-020-02243-6. Epub 2020 Nov 20.

Suwala AK, Stichel D, Schrimpf D, Maas SLN, Sill M, Dohmen H, Banan R, Reinhardt A, Sievers P, Hinz F, Blattner-Johnson M, Hartmann C, Schweizer L, Boldt HB, Kristensen BW, Schittenhelm J, Wood MD, Chotard G, Bjergvig R, Das A, Tabori U, Hasselblatt M, Korshunov A, Abdullaev Z, Quezado M, Aldape K, Harter PN, Snuderl M, Hench J, Frank S, Acker T, Brandner S, Winkler F, Wesseling P, Pfister SM, Reuss DE, Wick W, von Deimling A, Jones DTW, Sahm F.

Glioblastomas with primitive neuronal component harbor a distinct methylation and copy-number profile with inactivation of TP53, PTEN, and RB1.

Acta Neuropathol. 2021 Jul;142(1):179-189. doi: 10.1007/s00401-021-02302-6. Epub 2021 Apr 19

Taubert R, Engel B, Diestelhorst J, Hupa-Breier KL, Behrendt P, Baerlecken NT, Sühs KW, Janik MK, Zachou K, Sebode M, Schramm C, Londoño MC, Habes S; UK-AIH Consortium, Oo YH, Lalanne C, Pape S, Schubert M, Hust M, Dübel S, Thevis M, Jonigk D, Beimdiek J, Buettner FFR, Drenth JP, Muratori L, Adams DH, Dyson JK, Renand A, Graupera I, Lohse AW, Dalekos GN, Milkiewicz P, Stangel M, Maasoumy B, Witte T, Wedemeyer H, Manns MP, Jaeckel E.

Quantification of polyreactive immunoglobulin G facilitates the diagnosis of autoimmune hepatitis.

Hepatology. 2021 Sep 2. doi: 10.1002/hep.32134. Online ahead of print.

Thill M, Friedrich M, Kolberg-Liedtke C, Albert US, Banys-Paluchowski M, Bauerfeind I, Blohmer JU, Budach W, Dall P, Fallenberg EM, Fasching PA, Fehm T, Gerber B, Gluz O, Harbeck N, Heil J, Huober J, Jackisch C, Kreipe HH, Krug D, Kühn T, Kümmel S, Loibl S, Lüftner D, Lux MP, Maass N, Mundhenke C, Nitz U, Park-Simon TW, Reimer T, Rhiem K, Rody A, Schmidt M, Schneeweiss A, Schütz F, Sinn HP, Solbach C, Solomayer EF, Stickeler E, Thomssen C, Untch M, Witzel I, Wöckel A, Müller V, Janni W, Ditsch N.

AGO Recommendations for the Diagnosis and Treatment of Patients with Locally Advanced and Metastatic Breast Cancer: Update 2021.

Breast Care (Basel). 2021 Jun;16(3):228-235. doi: 10.1159/000516420. Epub 2021 May 27.

Thomas C, Federico A, Sill M, Bens S, Oyen F, Nemes K, Johann PD, Hartmann C, Hartmann W, Sumerauer D, Paterno V, Samii A, Kordes U, Siebert R, Frühwald MC, Paulus W, Kool M, Hasselblatt M.

Atypical Teratoid/Rhabdoid Tumor (AT/RT) With Molecular Features of Pleomorphic Xanthoastrocytoma.

Am J Surg Pathol. 2021 Sep 1;45(9):1228-1234. doi: 10.1097/PAS.0000000000001694.

Tumpara S, Korenbaum E, Kühnel M, Jonigk D, Olejnicka B, Davids M, Welte T, Martinez-Delgado B, Janciauskiene S.

A Novel Mouse Monoclonal Antibody C42 against C-Terminal Peptide of Alpha-1-Antitrypsin.

Int J Mol Sci. 2021 Feb 21;22(4):2141. doi: 10.3390/ijms22042141.PMID: 33670003

Tuschen K, Bräsen JH, Schmitz J, Vischedyk M, Weidemann A.

Relapse of class V lupus nephritis after vaccination with COVID-19 mRNA vaccine.

Kidney Int. 2021 Aug 2:S0085-2538(21)00738-9. doi: 10.1016/j.kint.2021.07.019. Online ahead of print.

Uecker M, Lehmann U, Braubach P, Schukfeh N, Madadi-Sanjani O, Ure BM, Petersen C, Kuebler JF.

Choledochal Cysts Resected during Childhood Show No Mutations of KRAS and BRAF as Early Markers of Malignancy in Cholangiocytes.

Eur J Pediatr Surg. 2021 Feb;31(1):20-24. doi: 10.1055/s-0040-1715610. Epub 2020 Aug 20.PMID: 32820496

Verleden SE, Braubach P, Kuehnel M, Dickgreber N, Brouwer E, Tittmann P, Laenger F, Jonigk D.

Molecular approach to the classification of chronic fibrosing lung disease-there and back again.

Virchows Arch. 2021 Jan;478(1):89-99. doi: 10.1007/s00428-020-02964-9. Epub 2020 Nov 9.PMID: 33169196

Verleden SE, Kirby M, Everaerts S, Vanstapel A, McDonough JE, Verbeken EK, Braubach P, Boone MN, Aslam D, Verschakelen J, Ceulemans LJ, Neyrinck AP, Van Raemdonck DE, Vos R, Decramer M, Hackett TL, Hogg JC, Janssens W, Verleden GM, Vanaudenaerde BM.

Small airway loss in the physiologically ageing lung: a cross-sectional study in unused donor lungs.

Lancet Respir Med. 2021 Feb;9(2):167-174. doi: 10.1016/S2213-2600(20)30324-6. Epub 2020 Oct 5.PMID: 33031747

Volk V, Theobald SJ, Danisch S, Khailaie S, Kalbarczyk M, Schneider A, Bialek-Waldmann J, Krönke N, Deng Y, Eiz-Vesper B, Dragon AC, von Kaisenberg C, Lienenklaus S, Bleich A, Keck J, Meyer-Hermann M, Klawonn F, Hammerschmidt W, Delecluse HJ, Münz C, Feuerhake F, Stripecke R.

PD-1 Blockade Aggravates Epstein-Barr Virus+ Post-Transplant Lymphoproliferative Disorder in Humanized Mice Resulting in Central Nervous System Involvement and CD4+ T Cell Dysregulations.

Front Oncol. 2021 Jan 12;10:614876. doi: 10.3389/fonc.2020.614876. eCollection 2020.PMID: 33511078

von Stillfried S, Acker T, Aepfelbacher M, Baretton G, Bülow RD, Bürrig KF, Holtherm HU, Jonigk D, Knüchel R, Majeed RW, Röhrig R, Wienströer J, Boor P.

[Cooperative approach of pathology and neuropathology in the COVID-19 pandemic : German registry for COVID-19 autopsies (DeRegCOVID) and German network for autopsies in pandemics (DEFEAT PANDEMIcs)].

Pathologe. 2021 Mar;42(2):216-223. doi: 10.1007/s00292-020-00891-9. Epub 2021 Feb 16.PMID: 33594614

Walsh C, Tafforeau P, Wagner WL, Jafree DJ, Bellier A, Werlein C, Kühnel MP, Boller E, Walker-Samuel S, Robertus JL, Long DA, Jacob J, Marussi S, Brown E, Holroyd N, Jonigk DD, Ackermann M, Lee PD.

Multiscale three-dimensional imaging of intact human organs down to the cellular scale using hierarchical phase-contrast tomography.

bioRxiv. 2021 Feb 3:2021.02.03.429481. doi: 10.1101/2021.02.03.429481. Preprint. Preprints have not been peer reviewed. PMID: 33564772

Walsh CL, Tafforeau P, Wagner WL, Jafree DJ, Bellier A, Werlein C, Kühnel MP, Boller E, Walker-Samuel S, Robertus JL, Long DA, Jacob J, Marussi S, Brown E, Holroyd N, Jonigk DD, Ackermann M, Lee PD.

Imaging intact human organs with local resolution of cellular structures using hierarchical phase-contrast tomography.

Nat Methods. 2021 Nov 4. doi: 10.1038/s41592-021-01317-x. Online ahead of print. PMID: 34737453

Watermann C, Pasternack H, Idel C, Ribbat-Idel J, Brägelmann J, Kuppler P, Offermann A, Jonigk D, Kühnel MP, Schröck A, Dreyer E, Rosero C, Nathansen J, Dubrovska A, Tharun L, Kirfel J, Wollenberg B, Perner S, Krupar R.

Recurrent HNSCC Harbor an Immunosuppressive Tumor Immune Microenvironment Suggesting Successful Tumor Immune Evasion.

Clin Cancer Res. 2021 Jan 15;27(2):632-644. doi: 10.1158/1078-0432.CCR-20-0197. Epub 2020 Oct 27.PMID: 33109740

Werlein C, Ackermann M, Hoffmann TL, Laenger F, Jonigk D.

[Fibrotic remodeling of the lung following lung and stem-cell transplantation].

Pathologe. 2021 Feb;42(1):17-24. doi: 10.1007/s00292-020-00898-2. Epub 2021 Jan 8.

Weissinger EM, Metzger J, Schleuning M, Schmid C, Messinger D, Beutel G, Wagner-Drouet EM, Schetelig J, Baurmann H, Rank A, Stolzl F, Schäfer-Eckart K, Westphal K, Bethge W, von Harsdorf S, Bunjes DW, Heidenreich D, Klein S, Holler E, Kreipe HH, Jonigk D, Türüchanow I, Raad J, Papkalla A, von der Leyen H, Hambach L, Hamwi I, Ehrlich S, Krauter J, Stadler M, Ganser A.

A multicenter prospective, randomized, placebo-controlled phase II/III trial for preemptive acute graft-versus-host disease therapy.

Leukemia. 2021 Jun;35(6):1763-1772. doi: 10.1038/s41375-020-01059-3. Epub 2020 Oct 20.PMID: 33082512

Welland S, deCastro T, Bathon M, Wirth TC, Reineke-Plaaß T, Saborowski M, Lehmann U, Saborowski A, Vogel A.

Molecular diagnostics and therapies for gastrointestinal tumors: a real-world experience.

J Cancer Res Clin Oncol. 2021 Aug 26. doi: 10.1007/s00432-021-03774-5. Online ahead of print.

Wirsik NM, Ehlers J, Mäder L, Ilina EI, Blank AE, Grote A, Feuerhake F, Baumgarten P, Devraj K, Harter PN, Mittelbronn M, Naumann U.

TGF-β activates pericytes via induction of the epithelial-to-mesenchymal transition protein SLUG in glioblastoma.

Neuropathol Appl Neurobiol. 2021 Oct;47(6):768-780. doi: 10.1111/nan.12714. Epub 2021 May 5.

Wong DWL, Klinkhammer BM, Djudjaj S, Villwock S, Timm MC, Buhl EM, Wucherpfennig S, Cacchi C, Braunschweig T, Knüchel-Clarke R, Jonigk D, Werlein C, Bülow RD, Dahl E, von Stillfried S, Boor P.

Multisystemic Cellular Tropism of SARS-CoV-2 in Autopsies of COVID-19 Patients.

Cells. 2021 Jul 27;10(8):1900. doi: 10.3390/cells10081900.

Wronski S, Beinke S, Obernolte H, Belyaev NN, Saunders KA, Lennon MG, Schaudien D, Braubach P, Jonigk D, Warnecke G, Zardo P, Fieguth HG, Wilkens L, Braun A, Hessel EM, Sewald K; U-BIOPRED Study Group.

Rhinovirus-induced Human Lung Tissue Responses Mimic COPD and Asthma Gene Signatures.

Am J Respir Cell Mol Biol. 2021 Nov;65(5):544-554. doi: 10.1165/rcmb.2020-0337OC.

Yerabolu D, Weiss A, Kojonazarov B, Boehm M, Schlueter BC, Ruppert C, Günther A, Jonigk D, Grimminger F, Ghofrani HA, Seeger W, Weissmann N, Schermuly RT.

Targeting Jak-Stat Signaling in Experimental Pulmonary Hypertension.

Am J Respir Cell Mol Biol. 2021 Jan;64(1):100-114. doi: 10.1165/rcmb.2019-0431OC.PMID: 33052714

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