Unsere Publikationen 2020

  • Kempf T, Wollert KC. Iron and atherosclerosis: Too much of a good thing can be bad. Eur Heart J. 2020;41:2696-2698. https://pubmed.ncbi.nlm.nih.gov/31324916/.

  • Ricke-Hoch M, Hoes MF, Pfeffer TJ, Schlothauer S, Nonhoff J, Haidari S, Bomer N, Scherr M, Stapel B, Stelling E, Kiyan Y, Falk C, Haghikia A, Binah O, Arany Z, Thum T, Bauersachs J, van der Meer P, Hilfiker-Kleiner D. In peripartum cardiomyopathy plasminogen activator inhibitor-1 is a potential new biomarker with controversial roles. Cardiovasc Res. 2020;116:1875-1886. https://pubmed.ncbi.nlm.nih.gov/31711127/.

  • Hess A, Thackeray JT, Wollert KC, Bengel FM. Radionuclide image-guided repair of the heart. JACC Cardiovasc Imaging. 2020;13:2415-2429. https://pubmed.ncbi.nlm.nih.gov/31864993/.

  • Stojanovic SD, Fuchs M, Fiedler J, Xiao K, Meinecke A, Just A, Pich A, Thum T, Kunz M. Comprehensive bioinformatics identifies key microRNA players in ATG7-deficient lung fibroblasts. Int J Mol Sci. 2020;21:10.3390/ijms21114126. https://pubmed.ncbi.nlm.nih.gov/32527064/.

  • Viereck J, Buhrke A, Foinquinos A, Chatterjee S, Kleeberger JA, Xiao K, Janssen-Peters H, Batkai S, Ramanujam D, Kraft T, Cebotari S, Gueler F, Beyer AM, Schmitz J, Brasen JH, Schmitto JD, Gyongyosi M, Loser A, Hirt MN, Eschenhagen T, Engelhardt S, Bar C, Thum T. Targeting muscle-enriched long non-coding RNA H19 reverses pathological cardiac hypertrophy. Eur Heart J. 2020;41:3462-3474. https://pubmed.ncbi.nlm.nih.gov/32657324/.

  • Konig T, Hanke JS, Dogan G, Kempf T, Sieweke JT, Schafer A, Bauersachs J, Schmitto JD, Napp LC. Advanced preconditioning: Impella 5.5 support for decompensated heart failure before left ventricular assist device surgery. Cardiovasc Revasc Med. 2020. https://pubmed.ncbi.nlm.nih.gov/32950404
  • Hoes MF, Bomer N, Ricke-Hoch M, de Jong TV, Arevalo Gomez KF, Pietzsch S, Hilfiker-Kleiner D, van der Meer P. Human iPSC-derived cardiomyocytes of peripartum patients with cardiomyopathy reveal aberrant regulation of lipid metabolism. Circulation. 2020;142:2288-2291. https://pubmed.ncbi.nlm.nih.gov/33284656/
  • Meinel K, Koestenberger M, Sallmon H, Hansmann G, Pieles GE. Echocardiography for the assessment of pulmonary hypertension and congenital heart disease in the young. Diagnostics (Basel). 2020;11:10.3390/diagnostics11010049. https://pubmed.ncbi.nlm.nih.gov/33396225/
  • Sieweke JT, Pfeffer TJ, Berliner D, Konig T, Hallbaum M, Napp LC, Tongers J, Kuhn C, Schmitto JD, Hilfiker-Kleiner D, Schafer A, Bauersachs J. Cardiogenic shock complicating peripartum cardiomyopathy: Importance of early left ventricular unloading and bromocriptine therapy. Eur Heart J Acute Cardiovasc Care. 2020;9:173-182. https://pubmed.ncbi.nlm.nih.gov/29792513/
  • Akin M, Garcheva V, Sieweke JT, Flierl U, Daum HC, Bauersachs J, Schafer A. Early use of hemoadsorption in patients after out-of hospital cardiac arrest - a matched pair analysis. PLoS One. 2020;15:e0241709. https://pubmed.ncbi.nlm.nih.gov/33141843/
  • Sieweke JT, Akin M, Stetskamp S, Riehle C, Jonigk D, Flierl U, Pfeffer TJ, Hirsch V, Dutzmann J, Hoeper MM, Kuhn C, Bauersachs J, Schafer A. Mechanical circulatory support in refractory cardiogenic shock due to influenza virus-related myocarditis. Eur Respir J. 2020;56:10.1183/13993003.00925-2020. Print 2020 Sep. https://pubmed.ncbi.nlm.nih.gov/32398305/
  • Sansonetti M, Waleczek FJG, Jung M, Thum T, Perbellini F. Resident cardiac macrophages: Crucial modulators of cardiac (patho)physiology. Basic Res Cardiol. 2020;115:77-020-00836-6. https://pubmed.ncbi.nlm.nih.gov/33284387/
  • Stelling E, Ricke-Hoch M, Erschow S, Hoffmann S, Bergmann AK, Heimerl M, Pietzsch S, Battmer K, Haase A, Stapel B, Scherr M, Balligand JL, Binah O, Hilfiker-Kleiner D. Increased prostaglandin-D2 in male STAT3-deficient hearts shifts cardiac progenitor cells from endothelial to white adipocyte differentiation. PLoS Biol. 2020;18:e3000739. https://pubmed.ncbi.nlm.nih.gov/33370269/
  • Bascunana P, Hess A, Borchert T, Wang Y, Wollert KC, Bengel FM, Thackeray JT. (11)C-methionine PET identifies astroglia involvement in heart-brain inflammation networking after acute myocardial infarction. J Nucl Med. 2020;61:977-980. https://pubmed.ncbi.nlm.nih.gov/31806766/
  • Klinke A, Schubert T, Muller M, Legchenko E, Zelt JGE, Shimauchi T, Napp LC, Rothman AMK, Bonnet S, Stewart DJ, Hansmann G, Rudolph V. Emerging therapies for right ventricular dysfunction and failure. Cardiovasc Diagn Ther. 2020;10:1735-1767. https://pubmed.ncbi.nlm.nih.gov/33224787
  • Inampudi C, Tedford RJ, Hemnes AR, Hansmann G, Bogaard HJ, Koestenberger M, Lang IM, Brittain EL. Treatment of right ventricular dysfunction and heart failure in pulmonary arterial hypertension. Cardiovasc Diagn Ther. 2020;10:1659-1674. https://pubmed.ncbi.nlm.nih.gov/33224779
  • Bernardo RJ, Haddad F, Couture EJ, Hansmann G, de Jesus Perez VA, Denault AY, de Man FS, Amsallem M. Mechanics of right ventricular dysfunction in pulmonary arterial hypertension and heart failure with preserved ejection fraction. Cardiovasc Diagn Ther. 2020;10:1580-1603. https://pubmed.ncbi.nlm.nih.gov/33224775
  • Santens B, Van De Bruaene A, De Meester P, D'Alto M, Reddy S, Bernstein D, Koestenberger M, Hansmann G, Budts W. Diagnosis and treatment of right ventricular dysfunction in congenital heart disease. Cardiovasc Diagn Ther. 2020;10:1625-1645. https://pubmed.ncbi.nlm.nih.gov/33224777
  • Andersen A, van der Feen DE, Andersen S, Schultz JG, Hansmann G, Bogaard HJ. Animal models of right heart failure. Cardiovasc Diagn Ther. 2020;10:1561-1579. https://pubmed.ncbi.nlm.nih.gov/33224774
  • Hansmann G, Rich S, Maron BA. Cardiac catheterization in pulmonary hypertension: Doing it right, with a catheter on the left. Cardiovasc Diagn Ther. 2020;10:1718-1724. https://pubmed.ncbi.nlm.nih.gov/33224785
  • Koestenberger M, Hansmann G. Getting to the bottom of right heart failure. Cardiovasc Diagn Ther. 2020;10:1517-1521. https://pubmed.ncbi.nlm.nih.gov/33224771
  • Koestenberger M, Hansmann G. Left ventricular geometry and near-simultaneous invasive hemodynamics in pediatric pulmonary hypertension. Circ Cardiovasc Imaging. 2020;13:e010787. https://pubmed.ncbi.nlm.nih.gov/32408826
  • Hamrick SEG, Sallmon H, Rose AT, Porras D, Shelton EL, Reese J, Hansmann G. Patent ductus arteriosus of the preterm infant. Pediatrics. 2020;146:10.1542/peds.2020-1209. https://pubmed.ncbi.nlm.nih.gov/33093140
  • Hansmann G, Bezzerides V. Paediatric/congenital cardiology physician scientists-an endangered species. Eur J Clin Invest. 2020;50:e13367. https://pubmed.ncbi.nlm.nih.gov/32735699
  • Koestenberger M, Avian A, Cantinotti M, Meinel K, Hansmann G. A novel echocardiographic approach indicates disease severity in pediatric pulmonary hypertension. Pediatr Int. 2020;62:637-639. https://pubmed.ncbi.nlm.nih.gov/32304149
  • Kaemmerer H, Gorenflo M, Huscher D, Pittrow D, Apitz C, Baumgartner H, Berger F, Bruch L, Brunnemer E, Budts W, Claussen M, Coghlan G, Dahnert I, D'Alto M, Delcroix M, Distler O, Dittrich S, Dumitrescu D, Ewert R, Faehling M, Germund I, Ghofrani HA, Grohe C, Grossekreymborg K, Halank M, Hansmann G, Harzheim D, Nemes A, Havasi K, Held M, Hoeper MM, Hofbeck M, Hohenfrost-Schmidt W, Jureviciene E, Gumbiene L, Kabitz HJ, Klose H, Kohler T, Konstantinides S, Koestenberger M, Kozlik-Feldmann R, Kramer HH, Kropf-Sanchen C, Lammers A, Lange T, Meyn P, Miera O, Milger-Kneidinger K, Neidenbach R, Neurohr C, Opitz C, Perings C, Remppis BA, Riemekasten G, Scelsi L, Scholtz W, Simkova I, Skowasch D, Skride A, Stahler G, Stiller B, Tsangaris I, Vizza CD, Vonk Noordegraaf A, Wilkens H, Wirtz H, Diller GP, Grunig E, Rosenkranz S. Pulmonary hypertension in adults with congenital heart disease: Real-world data from the international COMPERA-CHD registry. J Clin Med. 2020;9:10.3390/jcm9051456. https://pubmed.ncbi.nlm.nih.gov/32414075
  • Kohler D, Granja T, Volz J, Koeppen M, Langer HF, Hansmann G, Legchenko E, Geisler T, Bakchoul T, Eggstein C, Haberle HA, Nieswandt B, Rosenberger P. Red blood cell-derived semaphorin 7A promotes thrombo-inflammation in myocardial ischemia-reperfusion injury through platelet GPIb. Nat Commun. 2020;11:1315-020-14958-x. https://pubmed.ncbi.nlm.nih.gov/32161256
  • Chouvarine P, Geldner J, Giagnorio R, Legchenko E, Bertram H, Hansmann G. Trans-right-ventricle and transpulmonary MicroRNA gradients in human pulmonary arterial hypertension. Pediatr Crit Care Med. 2020;21:340-349. https://pubmed.ncbi.nlm.nih.gov/31876555
  • Schweintzger S, Koestenberger M, Schlagenhauf A, Grangl G, Burmas A, Kurath-Koller S, Pocivalnik M, Sallmon H, Baumgartner D, Hansmann G, Gamillscheg A. Safety and efficacy of the endothelin receptor antagonist macitentan in pediatric pulmonary hypertension. Cardiovasc Diagn Ther. 2020;10:1675-1685. https://pubmed.ncbi.nlm.nih.gov/33224780
  • Sallmon H, Berger F, Weber SC, Fischer HS, Hansmann G, Opgen-Rhein B. Interventional creation of an endogenous reverse potts shunt in an infant with pulmonary hypertension and genetic surfactant disorder-a case report. Cardiovasc Diagn Ther. 2020;10:1696-1700. https://pubmed.ncbi.nlm.nih.gov/33224783
  • Giagnorio R, Hansmann G. Mineralocorticoid receptor blockade improves pulmonary hypertension and right ventricular function in bronchopulmonary dysplasia: A case report. Cardiovasc Diagn Ther. 2020;10:1686-1690. https://pubmed.ncbi.nlm.nih.gov/33224781
  • Akin M, Garcheva V, Sieweke JT, Flierl U, Daum HC, Bauersachs J, Schafer A. Early use of hemoadsorption in patients after out-of hospital cardiac arrest - a matched pair analysis. PLoS One. 2020;15:e0241709. https://pubmed.ncbi.nlm.nih.gov/33141843
  • Szepes M, Melchert A, Dahlmann J, Hegermann J, Werlein C, Jonigk D, Haverich A, Martin U, Olmer R, Gruh I. Dual function of iPSC-derived pericyte-like cells in vascularization and fibrosis-related cardiac tissue remodeling in vitro. Int J Mol Sci. 2020;21:10.3390/ijms21238947. https://pubmed.ncbi.nlm.nih.gov/33255686
  • Donnerstag F, Gotz F, Dadak M, Raab P, Iglesias EC, Werlein C, Lanfermann H, Jonigk D. Interventional stroke treatment - is it also safe for arteries? looking at thrombectomy wall damage through clot histology. Interv Neuroradiol. 2020:1591019920976673. https://pubmed.ncbi.nlm.nih.gov/33269973
  • Abbas N, Perbellini F, Thum T. Non-coding RNAs: Emerging players in cardiomyocyte proliferation and cardiac regeneration. Basic Res Cardiol. 2020;115:52-020-0816-0. https://pubmed.ncbi.nlm.nih.gov/32748089
  • Olsson KM, Fuge J, Brod T, Kamp JC, Schmitto J, Kempf T, Bauersachs J, Hoeper MM. Oral iron supplementation with ferric maltol in patients with pulmonary hypertension. Eur Respir J. 2020. https://pubmed.ncbi.nlm.nih.gov/32444411
  • Gross S, Jahn C, Cushman S, Bar C, Thum T. SARS-CoV-2 receptor ACE2-dependent implications on the cardiovascular system: From basic science to clinical implications. J Mol Cell Cardiol. 2020;144:47-53. https://pubmed.ncbi.nlm.nih.gov/32360703
  • Derlin T, Jaeger B, Jonigk D, Apel R, Freise J, Shin HO, Weiberg D, Warnecke G, Ross TL, Wester HJ, Seeliger B, Welte T, Bengel FM, Prasse A. Clinical molecular imaging of pulmonary CXCR4 expression to predict outcome of pirfenidone treatment in IPF. Chest. 2020. https://pubmed.ncbi.nlm.nih.gov/32822674
  • Hess A, Derlin T, Koenig T, Diekmann J, Wittneben A, Wang Y, Wester HJ, Ross TL, Wollert KC, Bauersachs J, Bengel FM, Thackeray JT. Molecular imaging-guided repair after acute myocardial infarction by targeting the chemokine receptor CXCR4. Eur Heart J. 2020. https://pubmed.ncbi.nlm.nih.gov/32901270
  • Pfeffer TJ, Herrmann J, Berliner D, Konig T, Winter L, Ricke-Hoch M, Ponimaskin E, Schuchardt S, Thum T, Hilfiker-Kleiner D, Bauersachs J, Kahl KG. Assessment of major mental disorders in a german peripartum cardiomyopathy cohort. ESC Heart Fail. 2020. https://pubmed.ncbi.nlm.nih.gov/32909398
  • Napp LC, Sanchez Martinez C, Akin M, Garcheva V, Kuhn C, Bauersachs J, Schafer A. Use of extracorporeal membrane oxygenation for eCPR in the emergency room in patients with refractory out-of-hospital cardiac arrest. PLoS One. 2020;15:e0239777. https://pubmed.ncbi.nlm.nih.gov/32986781
  • Watson SA, Dendorfer A, Thum T, Perbellini F. A practical guide for investigating cardiac physiology using living myocardial slices. Basic Res Cardiol. 2020;115:61-020-00822-y. https://pubmed.ncbi.nlm.nih.gov/32914360
  • Viereck J, Buhrke A, Foinquinos A, Chatterjee S, Kleeberger JA, Xiao K, Janssen-Peters H, Batkai S, Ramanujam D, Kraft T, Cebotari S, Gueler F, Beyer AM, Schmitz J, Brasen JH, Schmitto JD, Gyongyosi M, Loser A, Hirt MN, Eschenhagen T, Engelhardt S, Bar C, Thum T. Targeting muscle-enriched long non-coding RNA H19 reverses pathological cardiac hypertrophy. Eur Heart J. 2020. https://pubmed.ncbi.nlm.nih.gov/32657324
  • Ackermann M, Verleden SE, Kuehnel M, Haverich A, Welte T, Laenger F, Vanstapel A, Werlein C, Stark H, Tzankov A, Li WW, Li VW, Mentzer SJ, Jonigk D. Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in covid-19. N Engl J Med. 2020;383:120-128. https://pubmed.ncbi.nlm.nih.gov/32437596
  • Weber N, Kowalski K, Holler T, Radocaj A, Fischer M, Thiemann S, de la Roche J, Schwanke K, Piep B, Peschel N, Krumm U, Lingk A, Wendland M, Greten S, Schmitto JD, Ismail I, Warnecke G, Zywietz U, Chichkov B, Meissner J, Haverich A, Martin U, Brenner B, Zweigerdt R, Kraft T. Advanced single-cell mapping reveals that in hESC cardiomyocytes contraction kinetics and action potential are independent of myosin isoform. Stem Cell Reports. 2020;14:788-802. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220955
  • Azibani F, Pfeffer TJ, Ricke-Hoch M, Dowling W, Pietzsch S, Briton O, Baard J, Abou Moulig V, Konig T, Berliner D, Libhaber E, Schlothauer S, Anthony J, Lichtinghagen R, Bauersachs J, Sliwa K, Hilfiker-Kleiner D. Outcome in german and south african peripartum cardiomyopathy cohorts associates with medical therapy and fibrosis markers. ESC Heart Fail. 2020;7:512-522. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160487
  • Stenner HT, Eigendorf J, Kerling A, Kueck M, Hanke AA, Boyen J, Nelius AK, Melk A, Boethig D, Bara C, Hilfiker A, Berliner D, Bauersachs J, Hilfiker-Kleiner D, Eberhard J, Stiesch M, Schippert C, Haverich A, Tegtbur U, Haufe S. Effects of six month personalized endurance training on work ability in middle-aged sedentary women: A secondary analysis of a randomized controlled trial. J Occup Med Toxicol. 2020;15:8-020-00261-4. eCollection 2020. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201966
  • Neubert L, Borchert P, Stark H, Hoefer A, Vogel-Claussen J, Warnecke G, Eubel H, Kuenzler P, Kreipe HH, Hoeper MM, Kuehnel M, Jonigk D. Molecular profiling of vascular remodeling in chronic pulmonary disease. Am J Pathol. 2020;190:1382-1396. https://pubmed.ncbi.nlm.nih.gov/32275906
  • Ackermann M, Verleden SE, Kuehnel M, Haverich A, Welte T, Laenger F, Vanstapel A, Werlein C, Stark H, Tzankov A, Li WW, Li VW, Mentzer SJ, Jonigk D. Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in covid-19. N Engl J Med. 2020. https://pubmed.ncbi.nlm.nih.gov/32437596
  • Borchert T, Hess A, Lukacevic M, Ross TL, Bengel FM, Thackeray JT. Angiotensin-converting enzyme inhibitor treatment early after myocardial infarction attenuates acute cardiac and neuroinflammation without effect on chronic neuroinflammation. Eur J Nucl Med Mol Imaging. 2020;47:1757-1768. https://pubmed.ncbi.nlm.nih.gov/32125488
  • Chouvarine P, Giera M, Kastenmuller G, Artati A, Adamski J, Bertram H, Hansmann G. Trans-right ventricle and transpulmonary metabolite gradients in human pulmonary arterial hypertension. Heart. 2020. https://pubmed.ncbi.nlm.nih.gov/32079620
  • Foinquinos A, Batkai S, Genschel C, Viereck J, Rump S, Gyongyosi M, Traxler D, Riesenhuber M, Spannbauer A, Lukovic D, Weber N, Zlabinger K, Hasimbegovic E, Winkler J, Fiedler J, Dangwal S, Fischer M, de la Roche J, Wojciechowski D, Kraft T, Garamvolgyi R, Neitzel S, Chatterjee S, Yin X, Bar C, Mayr M, Xiao K, Thum T. Preclinical development of a miR-132 inhibitor for heart failure treatment. Nat Commun. 2020;11:633-020-14349-2. https://pubmed.ncbi.nlm.nih.gov/32005803
  • Glasenapp A, Derlin K, Wang Y, Bankstahl M, Meier M, Wollert KC, Bengel FM, Thackeray JT. Multimodality imaging of inflammation and ventricular remodeling in pressure-overload heart failure. J Nucl Med. 2020;61:590-596. https://pubmed.ncbi.nlm.nih.gov/31653713
  • Hansmann G, Meinel K, Bukova M, Chouvarine P, Wahlander H, Koestenberger M, European Pediatric Pulmonary Vascular Disease Network (EPPVDN). Selexipag for the treatment of children with pulmonary arterial hypertension: First multicenter experience in drug safety and efficacy. J Heart Lung Transplant. 2020. https://pubmed.ncbi.nlm.nih.gov/32362477
  • Hasan B, Hansmann G, Budts W, Heath A, Hoodbhoy Z, Jing ZC, Koestenberger M, Meinel K, Mocumbi AO, Radchenko GD, Sallmon H, Sliwa K, Kumar RK, European Pediatric Pulmonary Vascular Disease Network (EPPVDN), endorsed by AEPC, CSC, PASCAR, PCS, and PCSI. Challenges and special aspects of pulmonary hypertension in middle- to low-income regions: JACC state-of-the-art review. J Am Coll Cardiol. 2020;75:2463-2477. https://pubmed.ncbi.nlm.nih.gov/32408981
  • Stojanovic SD, Fuchs M, Kunz M, Xiao K, Just A, Pich A, Bauersachs J, Fiedler J, Sedding D, Thum T. Inflammatory drivers of cardiovascular disease: Molecular characterization of senescent coronary vascular smooth muscle cells. Front Physiol. 2020;11:520. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261939
  • Werner RA, Bengel FM. Personalized prediction of mode of cardiac death in heart failure using supervised machine learning in the context of cardiac innervation imaging. J Nucl Cardiol. 2020. https://pubmed.ncbi.nlm.nih.gov/32557155
  • Werner RA, Thackeray JT, Bengel FM. Does lipid-lowering medication improve cardiac sympathetic nerve integrity? J Nucl Cardiol. 2020. https://pubmed.ncbi.nlm.nih.gov/32043241
  • Werner RA, Thackeray JT, Diekmann J, Weiberg D, Bauersachs J, Bengel FM. The changing face of nuclear cardiology: Guiding cardiovascular care towards molecular medicine. J Nucl Med. 2020. https://pubmed.ncbi.nlm.nih.gov/32303601
  • Hirsch VG, Tongers J, Bode J, Berliner D, Widder JD, Escher F, Mutsenko V, Chung B, Rostami F, Guba-Quint A, Giannitsis E, Schultheiss HP, Vogt C, Bauersachs J, Wollert KC, Kempf T. Cardiac iron concentration in relation to systemic iron status and disease severity in non-ischaemic heart failure with reduced ejection fraction. Eur J Heart Fail. 2020. https://pubmed.ncbi.nlm.nih.gov/32155309
  • Koestenberger M, Avian A, Chouvarine P, Gamillscheg A, Cvirn G, Schweintzger S, Kurath-Koller S, Cantinotti M, Hohmann D, Hansmann G. Right ventricular end-systolic remodeling index in the assessment of pediatric pulmonary arterial hypertension. the european pediatric pulmonary vascular disease network (EPPVDN). Pediatr Res. 2020. https://www.ncbi.nlm.nih.gov/pubmed/31923914
  • Stojanovic SD, Fiedler J, Bauersachs J, Thum T, Sedding DG. Senescence-induced inflammation: An important player and key therapeutic target in atherosclerosis. Eur Heart J. 2020. https://pubmed.ncbi.nlm.nih.gov/31898722
  • Tongers J, Sieweke JT, Kuhn C, Napp LC, Flierl U, Rontgen P, Schmitto JD, Sedding DG, Haverich A, Bauersachs J, Schafer A. Early escalation of mechanical circulatory support stabilizes and potentially rescues patients in refractory cardiogenic shock. Circ Heart Fail. 2020;13:e005853. https://pubmed.ncbi.nlm.nih.gov/32164431