Publikationen 2021

  • Grosse GM, Werlein C, Blume N, Abu-Fares O, Goetz F, Gabriel MM, Ernst J, Leotescu A, Worthmann H, Kuhnel MP, Jonigk D, Falk C, Weissenborn K, Schuppner R. Circulating cytokines and growth factors in acute cerebral large vessel occlusion - association with success of endovascular treatment. Thromb Haemost. 2021. https://pubmed.ncbi.nlm.nih.gov/34225367/.

  • Wu X, Reboll MR, Korf-Klingebiel M, Wollert KC. Angiogenesis after acute myocardial infarction. Cardiovasc Res. 2021;117:1257-1273. https://pubmed.ncbi.nlm.nih.gov/33063086/.

  • Diekmann F, Legchenko E, Chouvarine P, Lichtinghagen R, Bertram H, Happel CM, Hansmann G. Circulating interleukin-7 in human pulmonary arterial hypertension. Front Cardiovasc Med. 2021;8:794549. https://pubmed.ncbi.nlm.nih.gov/34957265/.

  • Feyen E, Ricke-Hoch M, Van Fraeyenhove J, Vermeulen Z, Scherr M, Dugaucquier L, Viereck J, Bruyns T, Thum T, Segers VFM, Hilfiker-Kleiner D, De Keulenaer GW. ERBB4 and multiple MicroRNAs that target ERBB4 participate in pregnancy-related cardiomyopathy. Circ Heart Fail. 2021;14:e006898. https://pubmed.ncbi.nlm.nih.gov/34247489/.

  • Reichardt M, Moller Jensen P, Andersen Dahl V, Bjorholm Dahl A, Ackermann M, Shah H, Langer F, Werlein C, Kuehnel MP, Jonigk D, Salditt T. 3D virtual histopathology of cardiac tissue from covid-19 patients based on phase-contrast X-ray tomography. Elife. 2021;10:10.7554/eLife.71359. https://pubmed.ncbi.nlm.nih.gov/34930527/

  • Hansmann G, Sallmon H, Roehr CC, Kourembanas S, Austin ED, Koestenberger M, European Pediatric Pulmonary Vascular Disease Network (EPPVDN). Pulmonary hypertension in bronchopulmonary dysplasia. Pediatr Res. 2021;89:446-455. https://pubmed.ncbi.nlm.nih.gov/32521539/.

  • Leifheit-Nestler M, Wagner MA, Richter B, Piepert C, Eitner F, Bockmann I, Vogt I, Grund A, Hille SS, Foinquinos A, Zimmer K, Thum T, Muller OJ, Haffner D. Cardiac fibroblast growth factor 23 excess does not induce left ventricular hypertrophy in healthy mice. Front Cell Dev Biol. 2021;9:745892. https://pubmed.ncbi.nlm.nih.gov/34778257/.

  • Diekmann J, Koenig T, Zwadlo C, Neuser J, Thackeray JT, Schafer A, Ross TL, Bauersachs J, Bengel FM. Molecular imaging identifies fibroblast activation beyond the infarct region after acute myocardial infarction. J Am Coll Cardiol. 2021;77:1835-1837. https://pubmed.ncbi.nlm.nih.gov/33832609/.

  • Werner RA, Koenig T, Diekmann J, Haghikia A, Derlin T, Thackeray JT, Napp LC, Wester HJ, Ross TL, Schaefer A, Bauersachs J, Bengel FM. CXCR4-targeted imaging of post-infarct myocardial tissue inflammation: Prognostic value after reperfused myocardial infarction. JACC Cardiovasc Imaging. 2021. https://pubmed.ncbi.nlm.nih.gov/34656473/.

  • Pietzsch S, Wohlan K, Thackeray JT, Heimerl M, Schuchardt S, Scherr M, Ricke-Hoch M, Hilfiker-Kleiner D. Anthracycline-free tumor elimination in mice leads to functional and molecular cardiac recovery from cancer-induced alterations in contrast to long-lasting doxorubicin treatment effects. Basic Res Cardiol. 2021;116:61-021-00902-7. https://pubmed.ncbi.nlm.nih.gov/34669013/.

  • Usman A, Haase A, Merkert S, Gohring G, Hansmann G, Gall H, Schermuly R, Martin U, Olmer R. Generation of pulmonary arterial hypertension patient-specific induced pluripotent stem cell lines from three unrelated patients with a heterozygous missense mutation in exon 12, a heterozygous in-frame deletion in exon 3 and a missense mutation in exon 11 of the BMPR2 gene. Stem Cell Res. 2021;55:102488. https://pubmed.ncbi.nlm.nih.gov/34388490/.

  • Kokeny G, Calvier L, Hansmann G. PPARgamma and TGFbeta-major regulators of metabolism, inflammation, and fibrosis in the lungs and kidneys. Int J Mol Sci. 2021;22:10.3390/ijms221910431. https://pubmed.ncbi.nlm.nih.gov/34638771/.

  • Chouvarine P, Hansmann G. Construction of transcriptional regulatory networks using total RNA-seq data. STAR Protoc. 2021;2:100769. https://pubmed.ncbi.nlm.nih.gov/34485938/.

  • Wang Y, Polten F, Jackle F, Korf-Klingebiel M, Kempf T, Bauersachs J, Freitag-Wolf S, Lichtinghagen R, Pich A, Wollert KC. A mouse model of cardiogenic shock. Cardiovasc Res. 2021;117:2414-2415. https://pubmed.ncbi.nlm.nih.gov/34499105/.

  • Werner RA, Hess A, Koenig T, Diekmann J, Derlin T, Melk A, Thackeray JT, Bauersachs J, Bengel FM. Molecular imaging of inflammation crosstalk along the cardio-renal axis following acute myocardial infarction. Theranostics. 2021;11:7984-7994. https://pubmed.ncbi.nlm.nih.gov/34335975/.

  • Diekmann F, Chouvarine P, Sallmon H, Meyer-Kobbe L, Kieslich M, Plouffe BD, Murthy SK, Lichtinghagen R, Legchenko E, Hansmann G. Soluble receptor for advanced glycation end products (sRAGE) is a sensitive biomarker in human pulmonary arterial hypertension. Int J Mol Sci. 2021;22:10.3390/ijms22168591. https://pubmed.ncbi.nlm.nih.gov/34445297/.

  • Ricke-Hoch M, Stelling E, Lasswitz L, Gunesch AP, Kasten M, Zapatero-Belinchon FJ, Brogden G, Gerold G, Pietschmann T, Montiel V, Balligand JL, Facciotti F, Hirsch E, Gausepohl T, Elbahesh H, Rimmelzwaan GF, Hofer A, Kuhnel MP, Jonigk D, Eigendorf J, Tegtbur U, Mink L, Scherr M, Illig T, Schambach A, Pfeffer TJ, Hilfiker A, Haverich A, Hilfiker-Kleiner D. Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease. PLoS One. 2021;16:e0255335. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336874/.

  • Ackermann M, Jonigk DD. Microvascular placental alterations in a maternal COVID-19 infection. Am J Obstet Gynecol. 2021. https://pubmed.ncbi.nlm.nih.gov/34228972/.

  • Azibani F, Pfeffer TJ, Ricke-Hoch M, Dowling W, Pietzsch S, Briton O, Baard J, Abou Moulig V, Konig T, Berliner D, Libhaber E, Schlothauer S, Anthony J, Lichtinghagen R, Bauersachs J, Sliwa K, Hilfiker-Kleiner D. Outcome in german and south african peripartum cardiomyopathy cohorts associates with medical therapy and fibrosis markers. ESC Heart Fail. 2020;7:512-522. https://pubmed.ncbi.nlm.nih.gov/32064780/.

  • Garg A, Seeliger B, Derda AA, Xiao K, Gietz A, Scherf K, Sonnenschein K, Pink I, Hoeper MM, Welte T, Bauersachs J, David S, Bar C, Thum T. Circulating cardiovascular microRNAs in critically ill COVID-19 patients. Eur J Heart Fail. 2021;23:468-475. https://pubmed.ncbi.nlm.nih.gov/33421274/.

  • Hinkel R, Batkai S, Bahr A, Bozoglu T, Straub S, Borchert T, Viereck J, Howe A, Hornaschewitz N, Oberberger L, Jurisch V, Kozlik-Feldmann R, Freudenthal F, Ziegler T, Weber C, Sperandio M, Engelhardt S, Laugwitz KL, Moretti A, Klymiuk N, Thum T, Kupatt C. AntimiR-132 attenuates myocardial hypertrophy in an animal model of percutaneous aortic constriction. J Am Coll Cardiol. 2021;77:2923-2935. https://pubmed.ncbi.nlm.nih.gov/34112319/.

  • Stojanovic SD, Fuchs M, Liang C, Schmidt K, Xiao K, Just A, Pfanne A, Pich A, Warnecke G, Braubach P, Petzold C, Jonigk D, Distler JHW, Fiedler J, Thum T, Kunz M. Reconstruction of the miR-506-quaking axis in idiopathic pulmonary fibrosis using integrative multi-source bioinformatics. Sci Rep. 2021;11:12456-021-89531-7. https://pubmed.ncbi.nlm.nih.gov/34127686/.

  • Couch LS, Fiedler J, Chick G, Clayton R, Dries E, Wienecke LM, Fu L, Fourre J, Pandey P, Derda AA, Wang BX, Jabbour R, Shanmuganathan M, Wright P, Lyon AR, Terracciano CM, Thum T, Harding SE. Circulating microRNAs predispose to takotsubo syndrome following high-dose adrenaline exposure. Cardiovasc Res. 2021. https://pubmed.ncbi.nlm.nih.gov/34155498/.

  • Kempf T. Iron supplementation in acute heart failure: energize your life. Eur Heart J. 2021. https://pubmed.ncbi.nlm.nih.gov/34131705/

  • Pfeffer TJ, List M, Muller JH, Scherr M, Bauersachs J, Hilfiker-Kleiner D, Ricke-Hoch M. Perhexiline treatment improves toxic effects of beta-adrenergic receptor stimulation in experimental peripartum cardiomyopathy. ESC Heart Fail. 2021. https://pubmed.ncbi.nlm.nih.gov/34002539/.

  • Hamdani N, Costantino S, Mugge A, Lebeche D, Tschope C, Thum T, Paneni F. Leveraging clinical epigenetics in heart failure with preserved ejection fraction: A call for individualized therapies. Eur Heart J. 2021;42:1940-1958. https://pubmed.ncbi.nlm.nih.gov/33948637/.

  • Glasenapp A, Derlin K, Gutberlet M, Hess A, Ross TL, Wester HJ, Bengel FM, Thackeray JT. Molecular imaging of inflammation and fibrosis in pressure overload heart failure. Circ Res. 2021. https://pubmed.ncbi.nlm.nih.gov/34074134/.

  • Stahl K, Schenk H, Kuhn C, Wiesner O, Hoeper MM, David S. Extracorporeal membrane oxygenation in non-intubated immunocompromised patients. Crit Care. 2021;25:164-021-03584-8. https://pubmed.ncbi.nlm.nih.gov/33931122/.

  • Hansmann G, Christou H, Koestenberger M, Sallmon H. Off-label use of PAH-targeted medications approved for adults and their financial coverage by health insurances are vital for children with pulmonary hypertension. Eur J Clin Invest. 2021:e13571. https://pubmed.ncbi.nlm.nih.gov/33834481/.

  • Diekmann J, Koenig T, Zwadlo C, Dn T, Neuser J, Thackeray JT, Schafer A, Ross TL, Bauersachs J, Bengel FM. Molecular imaging identifies fibroblast activation beyond the infarct region after acute myocardial infarction. J Am Coll Cardiol. 2021;77:1835-1837. https://pubmed.ncbi.nlm.nih.gov/33832609/.

  • Pitoulis FG, Nunez-Toldra R, Xiao K, Kit-Anan W, Mitzka S, Jabbour RJ, Harding SE, Perbellini F, Thum T, de Tombe PP, Terracciano CM. Remodelling of adult cardiac tissue subjected to physiological and pathological mechanical load in vitro. Cardiovasc Res. 2021. https://pubmed.ncbi.nlm.nih.gov/33723566/.

  • Sliwa K, van der Meer P, Petrie MC, Frogoudaki A, Johnson MR, Hilfiker-Kleiner D, Hamdan R, Jackson AM, Ibrahim B, Mbakwem A, Tschope C, Regitz-Zagrosek V, Omerovic E, Roos-Hesselink J, Gatzoulis M, Tutarel O, Price S, Heymans S, Coats AJS, Muller C, Chioncel O, Thum T, de Boer RA, Jankowska E, Ponikowski P, Lyon AR, Rosano G, Seferovic PM, Bauersachs J. Risk stratification and management of women with cardiomyopathy/heart failure planning pregnancy or presenting during/after pregnancy: A position statement from the heart failure association of the european society of cardiology study group on peripartum cardiomyopathy. Eur J Heart Fail. 2021;23:527-540. https://pubmed.ncbi.nlm.nih.gov/33609068/.

  • Kesting AC, Hansmann G, Sallmon H. Toward a standardized multidisciplinary team approach in preterm infants at-risk for pulmonary hypertension. J Perinatol. 2021;41:801-802. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049864/.

  • Sallmon H, Timme N, Atasay B, Erdeve O, Hansmann G, Singh Y, Weber SC, Shelton EL. Current controversy on platelets and patent ductus arteriosus closure in preterm infants. Front Pediatr. 2021;9:612242. https://pubmed.ncbi.nlm.nih.gov/33718298/.

  • Chouvarine P, Photiadis J, Cesnjevar R, Scheewe J, Bauer UMM, Pickardt T, Kramer HH, Dittrich S, Berger F, Hansmann G. RNA expression profiles and regulatory networks in human right ventricular hypertrophy due to high pressure load. iScience. 2021;24:102232. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994198/.

  • Drakhlis L, Biswanath S, Farr CM, Lupanow V, Teske J, Ritzenhoff K, Franke A, Manstein F, Bolesani E, Kempf H, Liebscher S, Schenke-Layland K, Hegermann J, Nolte L, Meyer H, de la Roche J, Thiemann S, Wahl-Schott C, Martin U, Zweigerdt R. Human heart-forming organoids recapitulate early heart and foregut development. Nat Biotechnol. 2021. https://pubmed.ncbi.nlm.nih.gov/33558697/

  • Bueno H, Moura B, Lancellotti P, Bauersachs J. The year in cardiovascular medicine 2020: Heart failure and cardiomyopathies. Eur Heart J. 2021. https://pubmed.ncbi.nlm.nih.gov/33388764/

  • Seeliger B, Dobler M, Friedrich R, Stahl K, Kuhn C, Bauersachs J, Steinhagen F, Ehrentraut SF, Schewe JC, Putensen C, Welte T, Hoeper MM, Tiede A, David S, Bode C. Comparison of anticoagulation strategies for veno-venous ECMO support in acute respiratory failure. Crit Care. 2021;24:701-020-03348-w. https://pubmed.ncbi.nlm.nih.gov/33397427/
  • Akin M, Garcheva V, Sieweke JT, Adel J, Flierl U , Bauersachs J, Schäfer A. Neuromarkers and neurological outcome in out-of-hospital cardiac arrest patients treated with therapeutic hypothermia-experience from the HAnnover COoling REgistry (HACORE). PLoS One. 2021;16(1):e0245210. https://pubmed.ncbi.nlm.nih.gov/33411836/
  • Ciccarelli M, Dawson D, Falcao-Pires I, Giacca M, Hamdani N, Heymans S, Hooghiemstra A, Leeuwis A, Hermkens D, Tocchetti CG, van der Velden J, Zacchigna S, Thum T. Reciprocal organ interactions during heart failure-a position paper from the ESC working group on myocardial function. Cardiovasc Res. 2021. https://pubmed.ncbi.nlm.nih.gov/33483724/
  • Wirth A, Wolf B, Huang CK, Glage S, Hofer SJ, Bankstahl M, Bar C, Thum T, Kahl KG, Sigrist SJ, Madeo F, Bankstahl JP, Ponimaskin E. Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length. Geroscience. 2021. https://pubmed.ncbi.nlm.nih.gov/33517527/
  • Yerabolu D, Weiss A, Kojonazarov B, Boehm M, Schlueter BC, Ruppert C, Gunther A, Jonigk D, Grimminger F, Ghofrani HA, Seeger W, Weissmann N, Schermuly RT. Targeting jak-stat signaling in experimental pulmonary hypertension. Am J Respir Cell Mol Biol. 2021;64:100-114. https://pubmed.ncbi.nlm.nih.gov/33052714/