Publikationen

Ahmadzada B, Felgendreff P, Minshew AM, Amiot BP, Nyberg SL. Producing Human Livers From Human Stem Cells Via Blastocyst Complementation. Curr Opin Biomed Eng. 2024 Sep;31:100537. doi: 10.1016/j.cobme.2024.100537. Epub 2024 May 16. PMID: 38854436; PMCID: PMC11160964.

 

Holzner ML, Mazzaferro V, Busset MDD, Aldrighetti L, Ratti F, Hasegawa K, Arita J, Sapisochin G, Abreu P, Schoning W, Schmelzle M, Nevermann N, Pratschke J, Florman S, Halazun K, Schwartz ME, Tabrizian P. Is Repeat Resection for Recurrent Intrahepatic Cholangiocarcinoma Warranted? Outcomes of an International Analysis. Ann Surg Oncol. 2024 Jul;31(7):4397-4404. doi: 10.1245/s10434-024-14975-w. Epub 2024 Feb 9. PMID: 38334851.

 

Muth V, Stobl F, Michelotto J, Gilles L, Kirwan JA, Eisenberger A, Marchand J, Roschke NN, Moosburner S, Pratschke J, Sauer IM, Raschzok N, Gassner JM. Quality Assessment by Bile Composition in Normothermic Machine Perfusion of Rat Livers. Tissue Eng Part A. 2024 Jul 3. doi: 10.1089/ten.TEA.2024.0048. Epub ahead of print. PMID: 38832856.

 

Sijberden JP, Hoogteijling TJ, Aghayan D, Ratti F, Tan EK, Morrison-Jones V, Lanari J, Haentjens L, Wei K, Tzedakis S, Martinie J, Osei Bordom D, Zimmitti G, Crespo K, Magistri P, Russolillo N, Conci S, Görgec B, Benedetti Cacciaguerra A, D'Souza D, Zozaya G, Caula C, Geller D, Robles Campos R, Croner R, Rehman S, Jovine E, Efanov M, Alseidi A, Memeo R, Dagher I, Giuliante F, Sparrelid E, Ahmad J, Gallagher T, Schmelzle M, Swijnenburg RJ, Fretland ÅA, Cipriani F, Koh YX, White S, Lopez Ben S, Rotellar F, Serrano PE, Vivarelli M, Ruzzenente A, Ferrero A, Di Benedetto F, Besselink MG, Sucandy I, Sutcliffe RP, Vrochides D, Fuks D, Liu R, D'Hondt M, Cillo U, Primrose JN, Goh BKP, Aldrighetti LA, Edwin B, Abu Hilal M; International consortium on Minimally Invasive Liver Surgery (I-MILS). Robotic Versus Laparoscopic Liver Resection in Various Settings: An International Multicenter Propensity Score Matched Study of 10.075 Patients. Ann Surg. 2024 Jul 1;280(1):108-117. doi: 10.1097/SLA.0000000000006267. Epub 2024 Mar 14. PMID: 38482665; PMCID: PMC11161239.

 

Felgendreff P, Hosseiniasl SM, Minshew A, Amiot BP, Wilken S, Ahmadzada B, Huebert RC, Sakrikar NJ, Engles NG, Halsten P, Mariakis K, Barry J, Riesgraf S, Fecteau C, Ross JJ, Nyberg SL. First Application of a Mixed Porcine-Human Repopulated Bioengineered Liver in a Preclinical Model of Post-Resection Liver Failure. Biomedicines. 2024 Jun 7;12(6):1272. doi: 10.3390/biomedicines12061272. PMID: 38927479; PMCID: PMC11201206.

 

Saleh M, Pascual F, Ghallab M, Wu AGR, Chin KM, Ratti F, Giglio MC, Garatti M, Nghia PP, Kato Y, Lim C, Herman P, Coelho FF, Schmelzle M, Pratschke J, Aghayan DL, Liu Q, Marino MV, Belli A, Chiow AKH, Sucandy I, Ivanecz A, Di Benedetto F, Choi SH, Lee JH, Park JO, Prieto M, Guzman Y, Fondevila C, Efanov M, Rotellar F, Choi GH, Robles-Campos R, Kadam P, Sutcliffe RP, Troisi RI, Tang CN, Chong CC, D'Hondt M, Dalla Valle B, Ruzzenente A, Kingham TP, Scatton O, Liu R, Mejia A, Mishima K, Wakabayashi G, Lopez-Ben S, Wang X, Ferrero A, Ettorre GM, Vivarelli M, Mazzaferro V, Giuliante F, Yong CC, Yin M, Monden K, Geller D, Chen KH, Sugioka A, Edwin B, Cheung TT, Long TCD, Abu Hilal M, Aldrighetti L, Soubrane O, Fuks D, Han HS, Cherqui D, Goh BKP; International Robotic and Laparoscopic Liver Resection Study Group Investigators. Factors Associated with and Impact of Open Conversion in Laparoscopic and Robotic Minor Liver Resections: An International Multicenter Study of 10,541 Patients. Ann Surg Oncol. 2024 Jun 15. doi: 10.1245/s10434-024-15498-0. Epub ahead of print. PMID: 38879668.

 

Weigle CA, Beetz O, Wiemann BA, Tessmer P, Störzer S, Cammann S, Vondran FWR, Oldhafer F, Schmelzle M, Richter N. Resection of intrahepatic cholangiocarcinoma in octogenarians: a single-center analysis. Discov Oncol. 2024 Jun 12;15(1):224. doi: 10.1007/s12672-024-01065-2. PMID: 38865024; PMCID: PMC11169410.

 

Ashraf MI*, Mengwasser J*, Reutzel-Selke A, Polenz D, Führer K, Lippert S, Tang P, Michaelis E, Catar R, Pratschke J, Witzel C, Sauer IM, Tullius SG, Kern B. Depletion of donor dendritic cells ameliorates immunogenicity of both skin and hind limb transplants. Front Immunol. 2024 May 10;15:1395945. doi: 10.3389/fimmu.2024.1395945. PMID: 38799435; PMCID: PMC11116604.

 

Santol J, Ammann M, Reese T, Kern AE, Laferl V, Oldhafer F, Dong Y, Rumpf B, Vali M, Wiemann B, Ortmayr G, Brunner SE, Probst J, Aiad M, Jankoschek AS, Gramberger M, Tschoegl MM, Salem M, Surci N, Thonhauser R, Mazari V, Hoblaj T, Thalhammer S, Schmelzle M, Oldhafer KJ, Gruenberger T, Starlinger P. Comparison of the LiMAx test vs. the APRI+ALBI score for clinical utility in preoperative risk assessment in patients undergoing liver surgery - A European multicenter study. Eur J Surg Oncol. 2024 Apr;50(4):108048. doi: 10.1016/j.ejso.2024.108048. Epub 2024 Feb 21. PMID: 38471374.

 

Knitter S, Raschzok N, Hillebrandt KH, Benzing C, Moosburner S, Nevermann N, Haber P, Gül-Klein S, Fehrenbach U, Lurje G, Schöning W, Fangmann J, Glanemann M, Kalff JC, Mehrabi A, Michalski C, Reißfelder C, Schmeding M, Schnitzbauer AA, Stavrou GA, Werner J, Pratschke J, Krenzien F; members of StuDoQ|Liver of Deutsche Gesellschaft für Allgemein-und Viszeralchirurgie/StuDoQ. Short-term postoperative outcomes of lymphadenectomy for cholangiocarcinoma, hepatocellular carcinoma and colorectal liver metastases in the modern era of liver surgery: Insights from the StuDoQ|Liver registry. Eur J Surg Oncol. 2024 Apr;50(4):108010. doi: 10.1016/j.ejso.2024.108010. Epub 2024 Feb 8. PMID: 38394988.

 

Zwirner S, Abu Rmilah AA, Klotz S, Pfaffenroth B, Kloevekorn P, Moschopoulou AA, Schuette S, Haag M, Selig R, Li K, Zhou W, Nelson E, Poso A, Chen H, Amiot B, Jia Y, Minshew A, Michalak G, Cui W, Rist E, Longerich T, Jung B, Felgendreff P, Trompak O, Premsrirut PK, Gries K, Muerdter TE, Heinkele G, Wuestefeld T, Shapiro D, Weissbach M, Koenigsrainer A, Sipos B, Ab E, Zacarias MO, Theisgen S, Gruenheit N, Biskup S, Schwab M, Albrecht W, Laufer S, Nyberg S, Zender L. First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure. Cell. 2024 Mar 28;187(7):1666-1684.e26. doi: 10.1016/j.cell.2024.02.023. Epub 2024 Mar 14. PMID: 38490194; PMCID: PMC11011246.

 

Felgendreff P, Hosseiniasl SM, Felgendreff L, Amiot BP, Minshew A, Ahmadzada B, Qu Z, Wilken S, Arribas Gomez I, Nyberg SL, Cook CN. Comprehensive analysis of brain injury parameters in a preclinical porcine model of acute liver failure. Front Med (Lausanne). 2024 Mar 28;11:1363979. doi: 10.3389/fmed.2024.1363979. PMID: 38606159; PMCID: PMC11007081.

 

Felgendreff P, Lawrence JM, Hosseiniasl SM, Jacobs JF, Amiot BP, Felgendreff L, Minshew A, Sultan A, Ahmadzada B, Rahe MC, Nyberg SL. Clinical characterization of a hypersensitivity mixed bacterial and fungal dermatitis in a translational model of porcine NASH. Front Cell Infect Microbiol. 2024 Jan 24;13:1277045. doi: 10.3389/fcimb.2023.1277045. PMID: 38327680; PMCID: PMC10847572.

 

Schmalkuche K, Rother T, Besli S, Schwinzer R, Blasczyk R, Petersen B, Figueiredo C. Human PD-L1 overexpression decreases xenogeneic human T-cell immune responses towards porcine kidneys. Front Immunol. 2024 Jan 30;15:1279050. doi: 10.3389/fimmu.2024.1279050. PMID: 38352884; PMCID: PMC10861674.

 

Ten Winkel M, Salama H, Timrott K, Kleine M, Kleine-Doepke D, Raehder-Johnson S, Meisel H, Rahberi NN, Abdelhadi S, Rückert F, Reissfelder C, Honselmann KC, Braun R, Faerber B, Lapshyn H, Keck T, Uhl W, Belyaev O, Wellner UF, Bolm L. Patient-reported outcomes at three months after pancreatic surgery for benign and malignant diseases - A prospective observational study. Pancreatology. 2024 Mar;24(2):314-322. doi: 10.1016/j.pan.2024.01.007. Epub 2024 Jan 18. PMID: 38310036.

 

Lei Y, Wolf-van Buerck L, Honarpisheh M, Zhang Y, Schwinzer R, Petersen B, Seissler J. Neonatal islets from human PD-L1 transgenic pigs reduce immune cell activation and cellular rejection in humanized nonobese diabetic-scid IL2rγnull mice. Am J Transplant. 2024 Jan;24(1):20-29. doi: 10.1016/j.ajt.2023.08.026. Epub 2023 Aug 31. PMID: 37659605.

Schmoeckel DM, Längin M, Reichart B, Abicht JM, Bender M, Michel S, Kamla CE, Denner J, Tönjes RR, Schwinzer R, Marckmann G, Wolf E, Brenner P, Hagl C. Current status of cardiac xenotransplantation. Thorac Cardiovasc Surg. 2023 Dec 28. doi: 10.1055/a-2235-8854

 

Nevermann N, Bode J, Vischer M, Krenzien F, Lurje G, Pelzer U, Fehrenbach U, Auer TA, Schmelzle M, Pratschke J, Schöning W. Perioperative outcome and long-term survival for intrahepatic cholangiocarcinoma after portal vein embolization and subsequent resection: A propensity-matched study. Eur J Surg Oncol. 2023 Dec;49(12):107100. doi: 10.1016/j.ejso.2023.107100. Epub 2023 Oct 5. PMID: 37918318.

 

Frericks N, Brown RJP, Reinecke BM, Herrmann M, Brüggemann Y, Todt D, Miskey C, Vondran FWR, Steinmann E, Pietschmann T, Sheldon J. Hepatitis C virus cell culture adaptive mutations enhance cell culture propagation by multiple mechanisms but boost antiviral responses in primary human hepatocytes. bioRxiv [Preprint]. 2023 Nov 22:2023.11.22.568224. doi: 10.1101/2023.11.22.568224. PMID: 38045248; PMCID: PMC10690267.

 

von Scheidt W, Reichart B, Meiser B, von Scheidt M, Sen P, Schwarz F, Harmel E, Bengel FM, Dick A, Ueberfuhr P, Reichenspurner H, Jaeckel E, Schwinzer R, Hagl C. Unique 40-year survival after heart transplantation with normal graft function and spontaneous operational tolerance. Clin Res Cardiol. 2023 Nov 20. doi: 10.1007/s00392-023-02341-x. Epub ahead of print. PMID: 37982861.

 

Carriquí-Madroñal B, Sheldon J, Duven M, Stegmann C, Cirksena K, Wyler E, Zapatero-Belinchón FJ, Vondran FWR, Gerold G. The matrix metalloproteinase ADAM10 supports hepatitis C virus entry and cell-to-cell spread via its sheddase activity. PLoS Pathog. 2023 Nov 15;19(11):e1011759. doi: 10.1371/journal.ppat.1011759. PMID: 37967063; PMCID: PMC10650992.

 

Iske J, Schroeter A, Knoedler S, Nazari-Shafti TZ, Wert L, Roesel MJ, Hennig F, Niehaus A, Kuehn C, Ius F, Falk V, Schmelzle M, Ruhparwar A, Haverich A, Knosalla C, Tullius SG, Vondran FWR, Wiegmann B. Pushing the boundaries of innovation: the potential of ex vivo organ perfusion from an interdisciplinary point of view. Front Cardiovasc Med. 2023 Oct 12;10:1272945. doi: 10.3389/fcvm.2023.1272945. PMID: 37900569; PMCID: PMC10602690.

 

Dondorf F, Graf M, Deeb AA, Rohland O, Felgendreff P, Ardelt M, Settmacher U, Rauchfuss F. Pathogen detection in patients with perihilar cholangiocarcinoma: Implications for targeted perioperative antibiotic therapy. Hepatobiliary Pancreat Dis Int. 2023 Oct;22(5):512-518. doi: 10.1016/j.hbpd.2022.01.005. Epub 2022 Jan 31. PMID: 35153139.

 

Iske J, Roesel MJ, Martin F, Schroeter A, Matsunaga T, Maenosono R, Tripathi U, Xiao Y, Nian Y, Caldarone BJ, Vondran FWR, Sage PT, Azuma H, Abdi R, Elkhal A, Pirtskhalava T, Tchkonia T, Kirkland JL, Zhou H, Tullius SG. Transplanting old organs promotes senescence in young recipients. Am J Transplant. 2023 Oct 31:S1600-6135(23)00803-1. doi: 10.1016/j.ajt.2023.10.013. Epub ahead of print. PMID: 37913871.

 

Auer TA, Halskov S, Fehrenbach U, Nevermann NF, Pelzer U, Mohr R, Hamm B, Schöning W, Horst D, Ihlow J, Geisel D. Gd-EOB MRI for HCC subtype differentiation in a western population according to the 5th edition of the World Health Organization classification. Eur Radiol. 2023 Oct;33(10):6902-6915. doi: 10.1007/s00330-023-09669-y. Epub 2023 Apr 28. PMID: 37115216; PMCID: PMC10511376.

 

Pokoyski C, Baars W, Windheim M, Reubold TF, Zischke J, Brinkmann A, Kay-Fedorov PC, Schwinzer R. Expression of viral CD45 ligand E3/49K on porcine cells reduces human anti-pig immune responses. Sci Rep. 2023 Oct 11;13(1):17218. doi: 10.1038/s41598-023-44316-y. PMID: 37821577; PMCID: PMC10567836.

 

Nevermann N, Bode J, Vischer M, Krenzien F, Lurje G, Pelzer U, Fehrenbach U, Auer TA, Schmelzle M, Pratschke J, Schöning W. Perioperative outcome and long-term survival for intrahepatic cholangiocarcinoma after portal vein embolization and subsequent resection: A propensity-matched study. Eur J Surg Oncol. 2023 Oct 5;49(12):107100. doi: 10.1016/j.ejso.2023.107100. Epub ahead of print. PMID: 37918318.

 

Kern B, Ashraf MI, Reutzel-Selke A, Mengwasser J, Polenz D, Michaelis E, Pratschke J, Tullius SG, Witzel C, Sauer IM. Moderate LMWH Anticoagulation Improves Success Rate of Hind Limb Allotransplantation in Mice. Plast Reconstr Surg Glob Open. 2023 Sep 15;11(9):e5249. doi: 10.1097/GOX.0000000000005249. PMID: 38152709; PMCID: PMC10752453.

 

Åberg F, Sallinen V, Tuominen S, Adam R, Karam V, Mirza D, Heneghan MA, Line PD, Bennet W, Ericzon BG, Grat M, Lodge P, Rasmussen A, Schmelzle M, Thorburn D, Fondevila C, Helanterä I, Nordin A; European Liver and Intestine Transplant Association (ELITA). Cyclosporine vs. tacrolimus after liver transplantation for primary sclerosing cholangitis - a propensity score-matched intention-to-treat analysis. J Hepatol. 2023 Sep 16:S0168-8278(23)05100-0. doi: 10.1016/j.jhep.2023.08.031. Epub ahead of print. PMID: 37722533.

 

Kulik U, Moesta C, Spanel R, Borlak J. Dysfunctional Cori and Krebs cycle and inhibition of lactate transporters constitute a mechanism of primary nonfunction of fatty liver allografts. Transl Res. 2023 Sep 17:S1931-5244(23)00146-9. doi: 10.1016/j.trsl.2023.09.006. Epub ahead of print. PMID: 37722450.

 

Nevermann N, Bode J, Vischer M, Feldbrügge L, Knitter S, Krenzien F, Pelzer U, Fehrenbach U, Auer TA, Lurje G, Schmelzle M, Pratschke J, Schöning W. A surgical strategy for intrahepatic cholangiocarcinoma - the hilar first concept. Langenbecks Arch Surg. 2023 Aug 7;408(1):296. doi: 10.1007/s00423-023-03023-y. PMID: 37544932; PMCID: PMC10404569.

 

Schmalkuche K, Schwinzer R, Wenzel N, Valdivia E, Petersen B, Blasczyk R, Figueiredo C. Downregulation of Swine Leukocyte Antigen Expression Decreases the Strength of Xenogeneic Immune Responses towards Renal Proximal Tubular Epithelial Cells. Int J Mol Sci. 2023 Aug 12;24(16):12711. doi: 10.3390/ijms241612711.PMID: 37628892. Free PMC article

 

Bentler M, Hardet R, Ertelt M, Rudolf D, Kaniowska D, Schneider A, Vondran FWR, Schoeder CT, Delphin M, Lucifora J, Ott M, Hacker UT, Adriouch S, Büning H. Modifying immune responses to adeno-associated virus vectors by capsid engineering. Mol Ther Methods Clin Dev. 2023 Aug 22;30:576-592. doi: 10.1016/j.omtm.2023.08.015. PMID: 37693943; PMCID: PMC10485635.

 

Nevermann N, Feldbrügge L, Knitter S, Krenzien F, Raschzok N, Lurje G, Schöning W, Pratschke J, Schmelzle M. Simplifying minimally invasive right hepatectomy. Surg Endosc. 2023 Jul;37(7):5430-5437. doi: 10.1007/s00464-023-09996-7. Epub 2023 Apr 7. PMID: 37029324; PMCID: PMC10322967.

 

Kinast V, Andreica I, Ahrenstorf G, Gömer A, Elsner C, Schlienkamp S, Schrader JA, Klöhn M, Ulrich RG, Broering R, Vondran FWR, Todt D, Behrendt P, Dittmer U, Hamprecht A, Witte T, Baraliakos X, Steinmann E. Janus kinase-inhibition modulates hepatitis E virus infection. Antiviral Res. 2023 Sep;217:105690. doi: 10.1016/j.antiviral.2023.105690. Epub 2023 Jul 28. PMID: 37517633.

 

Lange F, Garn J, Anagho HA, Vondran FWR, von Hahn T, Pietschmann T, Carpentier A. Hepatitis D virus infection, innate immune response and antiviral treatments in stem cell-derived hepatocytes. Liver Int. 2023 Jun 27. doi: 10.1111/liv.15655. Epub ahead of print. PMID: 37366005.

 

Dasci S, Schrem H, Oldhafer F, Beetz O, Kleine-Döpke D, Vondran F, Beneke J, Sarisin A, Ramackers W. Learning surgical knot tying and suturing technique - effects of different forms of training in a controlled randomized trial with dental students. GMS J Med Educ. 2023 Jun 15;40(4):Doc48. doi: 10.3205/zma001630. PMID: 37560044; PMCID: PMC10407582.

 

Schrader JA, Burkard TL, Brüggemann Y, Gömer A, Meister TL, Fu RM, Mehnert AK, Dao Thi VL, Behrendt P, Durantel D, Broering R, Vondran FWR, Todt D, Kinast V, Steinmann E. EGF receptor modulates HEV entry in human hepatocytes. Hepatology. 2023 Jun 1;77(6):2104-2117. doi: 10.1097/HEP.0000000000000308. Epub 2023 Feb 7. PMID: 36745934; PMCID: PMC10187617.

 

Hosseiniasl SM, Felgendreff P, Tharwat M, Amiot B, AbuRmilah A, Minshew AM, Bornschlegl AM, Jalan-Sakrikar N, Smart M, Dietz AB, Huebert RC, Nyberg SL. Biodegradable biliary stents coated with mesenchymal stromal cells in a porcine choledochojejunostomy model. Cytotherapy. 2023 May;25(5):483-489. doi: 10.1016/j.jcyt.2023.01.014. Epub 2023 Feb 25. PMID: 36842850; PMCID: PMC10399303.

 

Knitter S, Feldbrügge L, Nevermann N, Globke B, Galindo SAO, Winklmann T, Krenzien F, Haber PK, Malinka T, Lurje G, Schöning W, Pratschke J, Schmelzle M. Robotic versus laparoscopic versus open major hepatectomy - an analysis of costs and postoperative outcomes in a single-center setting. Langenbecks Arch Surg. 2023 May 29;408(1):214. doi: 10.1007/s00423-023-02953-x. PMID: 37247050; PMCID: PMC10226911.

 

Sneidere M, Schrem HH, Mahlmann JC, Beetz O, Cammann S, Oldhafer F, Kleine M, Klempnauer J, Kaltenborn A, Zwirner U, Kulik U. Proposal of a Multivariable Prediction Model for Graded Morbidity after Liver Resection for Colorectal Metastases. Zentralbl Chir. 2023 Apr;148(2):147-155. English. doi: 10.1055/a-1243-0746. Epub 2020 Oct 22. PMID: 33091938.

 

Marth AA, Auer TA, Walter-Rittel TC, Nevermann N, Krenzien F, Schmelzle M, Müller T, Kolck J, Wieners G, Geisel D, Gebauer B, Hamm B, Schöning W, Fehrenbach U. Gd-EOB-DTPA-MRCP to localize bile leakage after liver trauma and surgery: impact on treatment and outcome. Eur Radiol. 2023 Apr 13. doi: 10.1007/s00330-023-09608-x. Epub ahead of print. PMID: 37052657.

 

Colasanti O, Burm R, Huang HE, Riedl T, Traut J, Gillich N, Li TF, Corneillie L, Faure-Dupuy S, Grünvogel O, Heide D, Lee JY, Tran CS, Merle U, Chironna M, Vondran FFW, Esser-Nobis K, Binder M, Bartenschlager R, Heikenwälder M, Meuleman P, Lohmann V. Comparison of HAV and HCV infections in vivo and in vitro reveals distinct patterns of innate immune evasion and activation. J Hepatol. 2023 Apr 29:S0168-8278(23)00309-4. doi: 10.1016/j.jhep.2023.04.023. Epub ahead of print. PMID: 37121436.

 

Panagiotakis E, Selzer T, Böhm G, Schrem H, Vondran FWR, Qu Z, Ockenga J, Hertenstein B, Winterhalter M, Bektas H. Preoperative hemoglobin levels, extended resections and the body mass index influence survival after pancreaticoduodenectomy. Langenbecks Arch Surg. 2023 Mar 20;408(1):124. doi: 10.1007/s00423-023-02863-y. PMID: 36935457.

 

Bojkova D, Reus P, Panosch L, Bechtel M, Rothenburger T, Kandler JD, Pfeiffer A, Wagner JUG, Shumliakivska M, Dimmeler S, Olmer R, Martin U, Vondran FWR, Toptan T, Rothweiler F, Zehner R, Rabenau HF, Osman KL, Pullan ST, Carroll MW, Stack R, Ciesek S, Wass MN, Michaelis M, Cinatl J Jr. Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platform. iScience. 2023 Feb 17;26(2):105944. doi: 10.1016/j.isci.2023.105944. Epub 2023 Jan 7. PMID: 36644320; PMCID: PMC9822553.

 

Schmelzle M, Krenzien F, Dahlke P, Krombholz A, Nevermann N, Feldbrügge L, Winter A, Schöning W, Benzing C, Pratschke J, Neudecker J. Validation of the Enhanced Recovery after Surgery (ERAS) society recommendations for liver surgery: a prospective, observational study. Hepatobiliary Surg Nutr. 2023 Feb 28;12(1):20-36. doi: 10.21037/hbsn-21-294. Epub 2022 Feb 9. PMID: 36860244; PMCID: PMC9944541.

 

Nevermann N, Feldbrügge L, Krenzien F, Ortiz Galindo S, Knitter S, Haber P, Malinka T, Lurje G, Schöning W, Schmelzle M, Pratschke J. Robotic Liver Surgery: Technical Advantages Over Laparoscopic Technique Based on Parameters of Surgical Complexity and Perioperative Outcomes. J Laparoendosc Adv Surg Tech A. 2023 Jan;33(1):56-62. doi: 10.1089/lap.2022.0129. Epub 2022 Jul 26. PMID: 35877812.

 

von Horn C, Zlatev H, Lüer B, Malkus L, Ting S, Minor T. The impact of oxygen supply and erythrocytes during normothermic kidney perfusion. Sci Rep. 2023 Feb 3;13(1):2021. doi: 10.1038/s41598-023-29031-y. PMID: 36737505; PMCID: PMC9898236.

 

Leiskau C, Junge N, Mutschler FE, Laue T, Ohlendorf J, Richter N, Vondran FWR, Pfister ED, Baumann U. Long-Term Outcome Following Liver Transplantation for Primary Hepatic Tumors-A Single Centre Observational Study over 40 Years. Children (Basel). 2023 Jan 22;10(2):202. doi: 10.3390/children10020202. PMID: 36832331; PMCID: PMC9954409.

 

Verlaat L, Riesner K, Kalupa M, Jung B, Mertlitz S, Schwarz C, Mengwasser J, Fricke C, Penack O. Novel pre-clinical mouse models for chronic Graft-versus-Host Disease. Front Immunol. 2023 Jan 24;13:1079921. doi: 10.3389/fimmu.2022.1079921. PMID: 36761159; PMCID: PMC9902926.

Schiffner C, Christiansen H, Brandes I, Grannas G, Wichmann J, Merten R. Neoadjuvant versus definitive radiochemotherapy of locoregionally advanced oesophageal cancer-who benefits? Strahlenther Onkol. 2022 Dec;198(12):1062-1071. doi: 10.1007/s00066-022-01929-y. Epub 2022 Apr 13. PMID: 35416495; PMCID: PMC9700570.

 

Seika P, Marz S, Geffers C, Adam T, Feldbrügge L, Jara M, Pratschke J, Rau B. The Clinical Importance of Preoperative Rectal Swabs in Patients after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy. Visc Med. 2022 Dec;38(6):376-383. doi: 10.1159/000526001. Epub 2022 Aug 18. PMID: 36589250; PMCID: PMC9801311.

 

Junge N, Artmann A, Richter N, Vondran FWR, Böthig D, Sasse M, Köditz H, Baumann U, Beerbaum P, Kaussen T. Intra-Abdominal Hypertension and Compartment Syndrome after Pediatric Liver Transplantation: Incidence, Risk Factors and Outcome. Children (Basel). 2022 Dec 18;9(12):1993. doi: 10.3390/children9121993. PMID: 36553436; PMCID: PMC9777324.

 

Beetz O, Cammann S, Weigle CA, Sieg L, Eismann H, Johanning K, Falk CS, Krech T, Oldhafer F, Vondran FWR. Interleukin-18 and High-Mobility-Group-Protein B1 are Early and Sensitive Indicators for Cell Damage During Normothermic Machine Perfusion after Prolonged Cold Ischemic Storage of Porcine Liver Grafts. Transpl Int. 2022 Oct 20;35:10712. doi: 10.3389/ti.2022.10712. PMID: 36338535; PMCID: PMC9630326.

 

Hensen B, Hellms S, Werlein C, Jonigk D, Gronski PA, Bruesch I, Rumpel R, Wittauer EM, Vondran FWR, Parker DL, Wacker F, Gutberlet M. Correction of heat-induced susceptibility changes in respiratory-triggered 2D-PRF-based thermometry for monitoring of magnetic resonance-guided hepatic microwave ablation in a human-like in vivo porcine model. Int J Hyperthermia. 2022;39(1):1387-1396. doi: 10.1080/02656736.2022.2138987. PMID: 36336401.

 

Schmelzle M, Benzing C, Fischer L, Herden U, Sterneck M, Settmacher U, Bauschke A, Neumann U, Pelzer U, Müller T, Strassburg C, Lang H, Becker T, Königsrainer A, Nadalin S, Quante M, Paul A, Friess H, Klempnauer J, Richter N, Vondran F, Pascher A, Rösch T, Schöning W, Krenzien F, Öllinger R, Seehofer D, Neuhaus P, Pratschke J. Feasibility and Efficacy of Adjuvant Chemotherapy With Gemcitabine After Liver Transplantation for Perihilar Cholangiocarcinoma - A Multi-Center, Randomized, Controlled Trial (pro-duct001). Front Oncol. 2022 Oct 6;12:910871. doi: 10.3389/fonc.2022.910871. PMID: 36330499; PMCID: PMC9624225.

 

Schnitzler LJ, Oldhafer F, Kulik U, Klempnauer J, Reese T, Oldhafer KJ, Beetz O. Preoperative leukocytosis is an independent risk factor for morbidity and survival after resection of colorectal liver metastases. ANZ J Surg. 2022 Oct;92(10):2551-2559. doi: 10.1111/ans.17845. Epub 2022 Jun 20. PMID: 35723493.

 

Bukova M, Funken D, Pfister ED, Baumann U, Richter N, Vondran FFW, Happel CM, Bertram H. Long-term outcome of primary percutaneous stent angioplasty for pediatric posttransplantation portal vein stenosis. Liver Transpl. 2022 Sep;28(9):1463-1474. doi: 10.1002/lt.26488. Epub 2022 May 20. PMID: 35447015.

 

Hoenow S, Yan K, Noll J, Groneberg M, Casar C, Lory NC, Vogelsang M, Hansen C, Wolf V, Fehling H, Sellau J, Mittrücker HW, Lotter H. The Properties of Proinflammatory Ly6Chi Monocytes Are Differentially Shaped by Parasitic and Bacterial Liver Infections. Cells. 2022 Aug 16;11(16):2539. doi: 10.3390/cells11162539. PMID: 36010615; PMCID: PMC9406626.

 

Canesin G, Feldbrügge L, Wei G, Janovicova L, Janikova M, Csizmadia E, Ariffin J, Hedblom A, Herbert ZT, Robson SC, Celec P, Swanson KD, Nasser I, Popov YV, Wegiel B. Heme oxygenase-1 mitigates liver injury and fibrosis via modulation of LNX1/Notch1 pathway in myeloid cells. iScience. 2022 Aug 20;25(9):104983. doi: 10.1016/j.isci.2022.104983. PMID: 36093061; PMCID: PMC9450142.

 

Qu B, Nebioglu F, Leuthold MM, Ni Y, Mutz P, Beneke J, Erfle H, Vondran FWR, Bartenschlager R, Urban S. Dual role of neddylation in transcription of hepatitis B virus RNAs from cccDNA and production of viral surface antigen. JHEP Rep. 2022 Aug 7;4(10):100551. doi: 10.1016/j.jhepr.2022.100551. PMID: 36124123; PMCID: PMC9482114.

 

Meister TL, Brüggemann Y, Nocke MK, Ulrich RG, Schuhenn J, Sutter K, Gömer A, Bader V, Winklhofer KF, Broering R, Verhoye L, Meuleman P, Vondran FWR, Camuzet C, Cocquerel L, Todt D, Steinmann E. A ribavirin-induced ORF2 single-nucleotide variant produces defective hepatitis E virus particles with immune decoy function. Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2202653119. doi: 10.1073/pnas.2202653119. Epub 2022 Aug 15. PMID: 35969792; PMCID: PMC9407633.

 

Praditya DF, Klöhn M, Brüggemann Y, Brown LE, Porco JA Jr, Zhang W, Kinast V, Kirschning A, Vondran FWR, Todt D, Steinmann E. Identification of structurally re-engineered rocaglates as inhibitors against hepatitis E virus replication. Antiviral Res. 2022 Aug;204:105359. doi: 10.1016/j.antiviral.2022.105359. Epub 2022 Jun 18. PMID: 35728703; PMCID: PMC9731315.

 

Seika P, Biebl M, Raakow J, Berndt N, Feldbrügge L, Maurer MM, Dobrindt E, Thuss-Patience P, Pratschke J, Denecke C. The Association between Neoadjuvant Radio-Chemotherapy and Prolonged Healing of Anastomotic Leakage after Esophageal Resection Treated with EndoVAC Therapy. J Clin Med. 2022 Aug 16;11(16):4773. doi: 10.3390/jcm11164773. PMID: 36013012; PMCID: PMC9410280.

 

Beetz O, Oldhafer F, Weigle CA, Cammann S, DeTemple D, Sieg L, Eismann H, Palmaers T, Vondran FWR. Porcine Liver Transplantation Without Veno-venous Bypass As an Extended Criteria Donor Model. J Vis Exp. 2022 Aug 17;(186). doi: 10.3791/64152. PMID: 36063020.

 

Schmelzle M, Feldbrügge L, Ortiz Galindo SA, Moosburner S, Kästner A, Krenzien F, Benzing C, Biebl M, Öllinger R, Malinka T, Schöning W, Pratschke J. Robotic vs. laparoscopic liver surgery: a single-center analysis of 600 consecutive patients in 6 years. Surg Endosc. 2022 Aug;36(8):5854-5862. doi: 10.1007/s00464-021-08770-x. Epub 2022 May 31. PMID: 35641702; PMCID: PMC9283354.

 

Hillebrandt KH, Moosburner S, Winter A, Nevermann N, Raschzok N, Malinka T, Sauer IM, Schmelzle M, Pratschke J, Chopra S. The influence of the COVID-19 pandemic on surgical therapy and care: a cross-sectional study. BMC Surg. 2022 Jul 5;22(1):259. doi: 10.1186/s12893-022-01708-7. PMID: 35791027; PMCID: PMC9253238.

 

Benzing C, Haiden LM, Krenzien F, Mieg A, Wolfsberger A, Atik CF, Nevermann N, Fehrenbach U, Schöning W, Schmelzle M, Pratschke J. Textbook outcome after major hepatectomy for perihilar cholangiocarcinoma - definitions and influencing factors. Langenbecks Arch Surg. 2022 Jun;407(4):1561-1573. doi: 10.1007/s00423-022-02467-y. Epub 2022 Mar 4. PMID: 35246771; PMCID: PMC9283152.

 

Nevermann N, Schöning W, Malinka T, Fehrenbach U, Müller T, Pratschke J, Schmelzle M. Gallengangsverletzung im Rahmen der laparoskopischen Cholezystektomie : Klassifikation, Erkennung und Reparation [Bile duct injuries during laparoscopic cholecystectomy : Classification, recognition and repair]. Chirurgie (Heidelb). 2022 Jun;93(6):554-565. German. doi: 10.1007/s00104-022-01592-0. Epub 2022 Feb 16. PMID: 35171304.

 

Assfalg V, Miller G, Stocker F, van Meel M, Groenevelt T, Tieken I, Ankerst D, Renders L, Novotny A, Hartmann D, Jell A, Rahmel A, Wahba R, Mühlfeld A, Bouts A, Ysebaert D, Globke B, Jacobs-Tulleneers-Thevissen D, Piros L, Stippel D, Heller K, Eisenberger U, van Laecke S, Weimer R, Rosenkranz AR, Berger S, Fischer L, Kliem V, Vondran F, Sester U, Schneeberger S, Harth A, Kuypers D, Függer R, Arnol M, Christiaans M, Weinmann-Menke J, Krüger B, Hilbrands L, Banas B, Hakenberg O, Minnee R, Schwenger V, Heyne N, van Zuilen A, Reindl-Schwaighofer R, Lopau K, Hüser N, Heemann U. Kidney Transplantation After Rescue Allocation-the Eurotransplant Experience: A Retrospective Multicenter Outcome Analysis. Transplantation. 2022 Jun 1;106(6):1215-1226. doi: 10.1097/TP.0000000000003964. Epub 2022 Oct 4. PMID: 34608103.

 

Oldhafer F, Cammann S, Beetz O, Pfister E, Junge N, Laue T, Richter N, Lurje G, Klempnauer J, Baumann U, Vondran FWR. Hypothermic Oxygenated Perfusion for Transplantation of a Pediatric Extended Right Lobe: Report of the First Case. Transplantation. 2022 Jun 1;106(6):e322-e323. doi: 10.1097/TP.0000000000004062. Epub 2022 May 23. PMID: 35616916.

 

Feldbrügge L, Ortiz Galindo SA, Frisch O, Benzing C, Krenzien F, Riddermann A, Kästner A, Nevermann NF, Malinka T, Schöning W, Pratschke J, Schmelzle M. Safety and feasibility of robotic liver resection after previous abdominal surgeries. Surg Endosc. 2022 May;36(5):2842-2849. doi: 10.1007/s00464-021-08572-1. Epub 2021 Jun 2. PMID: 34076760.

 

Mederacke I, Filliol A, Affo S, Nair A, Hernandez C, Sun Q, Hamberger F, Brundu F, Chen Y, Ravichandra A, Huebener P, Anke H, Shi H, Martínez García de la Torre RA, Smith JR, Henderson NC, Vondran FWR, Rothlin CV, Baehre H, Tabas I, Sancho-Bru P, Schwabe RF. The purinergic P2Y14 receptor links hepatocyte death to hepatic stellate cell activation and fibrogenesis in the liver. Sci Transl Med. 2022 Apr 6;14(639):eabe5795. doi: 10.1126/scitranslmed.abe5795. Epub 2022 Apr 6. PMID: 35385339; PMCID: PMC9436006.

 

Rau B, Feldbrügge L, Gronau F, Alberto Vilchez ME, Thuss-Patience P, Bonnot PE, Glehen O. Indication of Hyperthermic Intraperitoneal Chemotherapy in Gastric Cancer (Gastripec, Gastrichip). Visc Med. 2022 Apr;38(2):81-89. doi: 10.1159/000522604. Epub 2022 Feb 23. PMID: 35614895; PMCID: PMC9082209.

 

Kettler B, Jaeckel E, Taubert R, Wedemeyer HH, Klempnauer J, Richter N, Neubert L, Vondran FWR. Liver Transplantation After Organ Donation Due to Hydrogen Sulfide Intoxication: Report of the First Case. Transplantation. 2022 Apr 1;106(4):e247-e248. doi: 10.1097/TP.0000000000004018. PMID: 35333851.

 

Reinecke B, Frericks N, Lauber C, Dinkelborg K, Matthaei A, Vondran FWR, Behrendt P, Haid S, Brown RJP, Pietschmann T. The Human Liver-Expressed Lectin CD302 Restricts Hepatitis C Virus Infection. J Virol. 2022 Apr 13;96(7):e0199521. doi: 10.1128/jvi.01995-21. Epub 2022 Mar 17. PMID: 35297672; PMCID: PMC9006913.

 

Cammann S, Karabulut S, DeTemple DE, Oldhafer F, Kulik U, Schroeter A, Vondran FWR, Klempnauer J, Kleine M, Timrott K, Beetz O. Antibiotic-Resistant Bacteria Colonizing the Bile Duct Are Associated with Increased Morbidity and Mortality after Resection of Extrahepatic Cholangiocarcinoma. Surg Infect (Larchmt). 2022 Apr;23(3):270-279. doi: 10.1089/sur.2021.117. Epub 2022 Feb 16. PMID: 35172114.

 

Rodieck W, Hallensleben M, Robert J, Beetz O, Grannas G, Cammann S, Oldhafer F, Klempnauer J, Vondran FWR, Kulik U. Impact of perioperative blood transfusions on postoperative renal function and survival after resection of colorectal liver metastases. World J Surg Oncol. 2022 Mar 30;20(1):100. doi: 10.1186/s12957-022-02559-5. PMID: 35354485; PMCID: PMC8966349.

 

Krause N, Mengwasser J, Phithak E, Beato F, Appis M, Milford EL, Pratschke J, Sauer I, Kuehl A, Vogel A, Goodyear M, Hammerich L, Tacke F, Haas JF, Müller T, Utku N. Immune Regulatory 1 Cells: A Novel and Potent Subset of Human T Regulatory Cells. Front Immunol. 2022 Feb 8;12:790775. doi: 10.3389/fimmu.2021.790775. PMID: 35222353; PMCID: PMC8867398.

 

Saunders EA, Engel B, Höfer A, Hartleben B, Vondran FWR, Richter N, Potthoff A, Zender S, Wedemeyer H, Jaeckel E, Taubert R. Outcome and safety of a surveillance biopsy guided personalized immunosuppression program after liver transplantation. Am J Transplant. 2022 Feb;22(2):519-531. doi: 10.1111/ajt.16817. Epub 2021 Sep 13. PMID: 34455702.

 

Ortiz Galindo SA, Haber PK, Benzing C, Krenzien F, Riddermann A, Frisch O, Schöning W, Schmelzle M, Pratschke J, Feldbrügge L. Safety of intermittent Pringle maneuver during minimally invasive liver resection in patients with hepatocellular carcinoma with and without cirrhosis. Langenbecks Arch Surg. 2022 Feb;407(1):235-244. doi: 10.1007/s00423-021-02361-z. Epub 2021 Nov 17. PMID: 34787706; PMCID: PMC8847278.

 

Junge N, Di Giorgio A, Girard M, Demir Z, Kaminska D, Janowska M, Urbonas V, Varnas D, Maggiore G, Alterio T, Leiskau C, Vondran FWR, Richter N, D'Antiga L, Mikolajczyk R, Pfister ED, Baumann U. Cold Ischemia Time and Graft Fibrosis Are Associated with Autoantibodies after Pediatric Liver Transplantation: A Retrospective Cohort Study of the European Reference Network TransplantChild. Children (Basel). 2022 Feb 17;9(2):275. doi: 10.3390/children9020275. PMID: 35204995; PMCID: PMC8870233.

 

Vogel A, Sterneck M, Vondran F, Waidmann O, Klein I, Lindig U, Nadalin S, Settmacher U, Tacke F, Schlitt HJ, Wege H. Der Einsatz der immunonkologischen Therapie beim hepatozellulären Karzinom im Kontext der Lebertransplantation Eine interdisziplinäre Risiko-Nutzen-Abwägung [The use of immuno-oncologic therapy in hepatocellular carcinoma in the context of liver transplantation. An interdisciplinary benefit/risk assessment]. Z Gastroenterol. 2022 Feb;60(2):184-191. German. doi: 10.1055/a-1649-8643. Epub 2021 Oct 20. PMID: 34670296.

 

Honerkamp I, Sandmann L, Richter N, Manns MP, Voigtländer T, Vondran FWR, von Hahn T. Surgical Procedures in Patients Awaiting Liver Transplantation: Complications and Impact on the Liver Function. J Clin Exp Hepatol. 2022 Jan-Feb;12(1):68-79. doi: 10.1016/j.jceh.2021.03.011. Epub 2021 Apr 2. PMID: 35068787; PMCID: PMC8766540.

 

Krenzien F, Nevermann N, Krombholz A, Benzing C, Haber P, Fehrenbach U, Lurje G, Pelzer U, Pratschke J, Schmelzle M, Schöning W. Treatment of Intrahepatic Cholangiocarcinoma-A Multidisciplinary Approach. Cancers (Basel). 2022 Jan 12;14(2):362. doi: 10.3390/cancers14020362. PMID: 35053523; PMCID: PMC8773654.

 

Kurreck A, Gronau F, Alberto Vilchez ME, Abels W, Enghard P, Brandl A, Francis R, Föhre B, Lojewski C, Pratschke J, Thuss-Patience P, Modest D, Rau B, Feldbrügge L. Sodium Thiosulfate Reduces Acute Kidney Injury in Patients Undergoing Cytoreductive Surgery Plus Hyperthermic Intraperitoneal Chemotherapy with Cisplatin: A Single-Center Observational Study. Ann Surg Oncol. 2022 Jan;29(1):152-162. doi: 10.1245/s10434-021-10508-x. Epub 2021 Aug 4. PMID: 34350529; PMCID: PMC8677645.

 

Baron Y, Sens J, Lange L, Nassauer L, Klatt D, Hoffmann D, Kleppa MJ, Barbosa PV, Keisker M, Steinberg V, Suerth JD, Vondran FWR, Meyer J, Morgan M, Schambach A, Galla M. Improved alpharetrovirus-based Gag.MS2 particles for efficient and transient delivery of CRISPR-Cas9 into target cells. Mol Ther Nucleic Acids. 2022 Jan 1;27:810-823. doi: 10.1016/j.omtn.2021.12.033. PMID: 35141043; PMCID: PMC8801357.

Yang T, Poenisch M, Khanal R, Hu Q, Dai Z, Li R, Song G, Yuan Q, Yao Q, Shen X, Taubert R, Engel B, Jaeckel E, Vogel A, Falk CS, Schambach A, Gerovska D, Araúzo-Bravo MJ, Vondran FWR, Cantz T, Horscroft N, Balakrishnan A, Chevessier F, Ott M, Sharma AD. Therapeutic HNF4A mRNA attenuates liver fibrosis in a preclinical model. J Hepatol. 2021 Dec;75(6):1420-1433. doi: 10.1016/j.jhep.2021.08.011. Epub 2021 Aug 25. Erratum in: J Hepatol. 2022 Jul;77(1):270. PMID: 34453962.

 

Engelmann C, Herber A, Franke A, Bruns T, Reuken P, Schiefke I, Zipprich A, Zeuzem S, Goeser T, Canbay A, Berg C, Trebicka J, Uschner FE, Chang J, Mueller T, Aehling N, Schmelzle M, Splith K, Lammert F, Lange CM, Sarrazin C, Trautwein C, Manns M, Häussinger D, Pfeiffenberger J, Galle PR, Schmiedeknecht A, Berg T. Granulocyte-colony stimulating factor (G-CSF) to treat acute-on-chronic liver failure: A multicenter randomized trial (GRAFT study). J Hepatol. 2021 Dec;75(6):1346-1354.doi: 10.1016/j.jhep.2021.07.033. Epub 2021 Aug 5. PMID: 34364917.

 

Czigany Z, Pratschke J, Froněk J, Guba M, Schöning W, Raptis DA, Andrassy J, Kramer M, Strnad P, Tolba RH, Liu W, Keller T, Miller H, Pavicevic S, Uluk D, Kocik M, Lurje I, Trautwein C, Mehrabi A, Popescu I, Vondran FWR, Ju C, Tacke F, Neumann UP, Lurje G. Hypothermic Oxygenated Machine Perfusion Reduces Early Allograft Injury and Improves Post-transplant Outcomes in Extended Criteria Donation Liver Transplantation From Donation After Brain Death: Results From a Multicenter Randomized Controlled Trial (HOPE ECD-DBD). Ann Surg. 2021 Nov 1;274(5):705-712. doi: 10.1097/SLA.0000000000005110. PMID: 34334635.

 

Nicolay W, Moeller R, Kahl S, Vondran FWR, Pietschmann T, Kunz S, Gerold G. Characterization of RNA Sensing Pathways in Hepatoma Cell Lines and Primary Human Hepatocytes. Cells. 2021 Nov 4;10(11):3019. doi: 10.3390/cells10113019. PMID: 34831243; PMCID: PMC8616302.

 

Waldron LS, Cerisuelo MC, Lo D, Sayed BA, Vilca-Melendez H, Magliocca J, Lurz E, Baumann U, Vondran FWR, Richter N, von Schweinitz D, Guba M, Muensterer OJ, Berger M. Diaphragmatic Hernia following Pediatric Liver Transplantation: An Underappreciated Complication Prone to Recur. Eur J Pediatr Surg. 2021 Oct;31(5):396-406. doi: 10.1055/s-0040-1716882. Epub 2020 Nov 13. PMID: 33186999.

 

Aburahma K, Salman J, Engel B, Vondran FWR, Greer M, Boethig D, Siemeni T, Avsar M, Schwerk N, Müller C, Taubert R, Hoeper MM, Welte T, Wedemeyer HH, Richter N, Warnecke G, Tudorache I, Haverich A, Kuehn C, Grannas G, Ius F. Liver-first strategy for a combined lung and liver transplant in patients with cystic fibrosis. Eur J Cardiothorac Surg. 2021 Oct 22;60(4):822-830. doi: 10.1093/ejcts/ezab164. PMID: 33956976.

 

Reichart B, Längin M, Denner J, Schwinzer R, Cowan PJ, Wolf E. Pathways to Clinical Cardiac Xenotransplantation. Transplantation. 2021 Sep 1;105(9):1930-1943. doi: 10.1097/TP.0000000000003588. PMID: 33350675.

 

Hillebrandt K, Nevermann N, Globke B, Moosburner S, Schmelzle M, Pratschke J. Auswirkung der COVID-19-Pandemie auf die hepatopankreatobiliäre Chirurgie und die Organtransplantation [Impact of the COVID-19 pandemic on hepato-pancreato-biliary surgery and organ transplantation]. Chirurg. 2021 Oct;92(10):918-923. German. doi: 10.1007/s00104-021-01463-0. Epub 2021 Jul 23. PMID: 34297148; PMCID: PMC8299733.

 

Beetz O, Timrott A, Weigle CA, Schroeter A, Cammann S, Klempnauer J, Vondran FWR, Oldhafer F. Proposal of a New Definition of "Very Early" Intrahepatic Cholangiocarcinoma-A Retrospective Single-Center Analysis. J Clin Med. 2021 Sep 9;10(18):4073. doi: 10.3390/jcm10184073. PMID: 34575181; PMCID: PMC8468271.

 

Flemming G, Baumann U, Richter N, Vondran F, Tümmler B, Dittrich AM, Müller C, Vogel M, Pfister ED. Survival Benefits Following Liver Transplantation: A Matched-pair Analysis in Pediatric Patients With Cystic Fibrosis. J Pediatr Gastroenterol Nutr. 2021 Sep 1;73(3):385-390. doi: 10.1097/MPG.0000000000003194. PMID: 34091543.

 

Visseren T, Erler NS, Polak WG, Adam R, Karam V, Vondran FWR, Ericzon BG, Thorburn D, IJzermans JNM, Paul A, van der Heide F, Taimr P, Nemec P, Pirenne J, Romagnoli R, Metselaar HJ, Darwish Murad S; European Liver and Intestine Transplantation Association (ELITA). Recurrence of primary sclerosing cholangitis after liver transplantation - analysing the European Liver Transplant Registry and beyond. Transpl Int. 2021 Aug;34(8):1455-1467. doi: 10.1111/tri.13925. Epub 2021 Jun 28. PMID: 34028110; PMCID: PMC8456806.

 

Blossey RD, Kleine-Döpke D, Ringe KI, Pöhnert D, Ringe B, Klempnauer J, Beetz O. Recurrent Hurthle cell thyroid carcinoma does not preclude long-term survival: a case report and review of the literature. J Med Case Rep. 2021 Aug 11;15(1):399. doi: 10.1186/s13256-021-02987-z. PMID: 34376229; PMCID: PMC8356425.

 

Cordes S, Mokhtari Z, Bartosova M, Mertlitz S, Riesner K, Shi Y, Mengwasser J, Kalupa M, McGeary A, Schleifenbaum J, Schrezenmeier J, Bullinger L, Diaz-Ricart M, Palomo M, Carrreras E, Beutel G, Schmitt CP, Beilhack A, Penack O. Endothelial damage and dysfunction in acute graft-versus-host disease. Haematologica. 2021 Aug 1;106(8):2147-2160. doi: 10.3324/haematol.2020.253716. PMID: 32675225; PMCID: PMC8327719.

 

Nevermann N, Wiering L, Wu H, Moroder P, Brandl A, Globke B, Krenzien F, Raschzok N, Schöning W, Lurje G, Öllinger R, Schmelzle M, Pratschke J, Ritschl PV. Transplantation programs facing lack of empirical evidence on SARS-CoV-2 vaccination: A society recommendation consensus update. Transpl Infect Dis. 2021 Aug;23(4):e13696. doi: 10.1111/tid.13696. Epub 2021 Jul 28. PMID: 34288294; PMCID: PMC8420432.

 

Benzing C, Krenzien F, Mieg A, Wolfsberger A, Andreou A, Nevermann N, Pelzer U, Fehrenbach U, Haiden LM, Öllinger R, Schöning W, Schmelzle M, Pratschke J. A tailored approach in lymph node-positive perihilar cholangiocarcinoma. Langenbecks Arch Surg. 2021 Aug;406(5):1499-1509. doi: 10.1007/s00423-021-02154-4. Epub 2021 Jun 1. Erratum in: Langenbecks Arch Surg. 2022 Dec;407(8):3903-3905. PMID: 34075473; PMCID: PMC8370897.

 

Leiskau C, Junge N, Pfister ED, Goldschmidt I, Mutschler F, Laue T, Ohlendorf J, Nasser H, Beneke J, Richter N, Vondran F, Baumann U. Recipient-Specific Risk Factors Impairing Patient and Graft Outcome after Pediatric Liver Transplantation-Analysis of 858 Transplantations in 38 Years. Children (Basel). 2021 Jul 27;8(8):641. doi: 10.3390/children8080641. PMID: 34438532; PMCID: PMC8393592.

 

Albrecht T, Hildenbrand T, Beneke J, Offergeld C, Ramackers W. Qualitätssicherungssystem zur Bewertung eines HNO-Facharztrepetitoriums [Quality management in a postgraduate refresher course in otolaryngology]. HNO. 2021 Jul;69(7):568-574. German. doi: 10.1007/s00106-021-01065-6. Epub 2021 Jun 9. PMID: 34106281; PMCID: PMC8233240.

 

Busche S, John K, Wandrer F, Vondran FWR, Lehmann U, Wedemeyer H, Essmann F, Schulze-Osthoff K, Bantel H. BH3-only protein expression determines hepatocellular carcinoma response to sorafenib-based treatment. Cell Death Dis. 2021 Jul 26;12(8):736. doi: 10.1038/s41419-021-04020-z. PMID: 34312366; PMCID: PMC8313681.

 

Beetz O, Thies J, Weigle CA, Ius F, Winkler M, Bara C, Richter N, Klempnauer J, Warnecke G, Haverich A, Avsar M, Grannas G. Simultaneous heart-kidney transplantation results in respectable long-term outcome but a high rate of early kidney graft loss in high-risk recipients - a European single center analysis. BMC Nephrol. 2021 Jul 9;22(1):258. doi: 10.1186/s12882-021-02430-x. PMID: 34243724; PMCID: PMC8268408.

 

Zapatero-Belinchón FJ, Ötjengerdes R, Sheldon J, Schulte B, Carriquí-Madroñal B, Brogden G, Arroyo-Fernández LM, Vondran FWR, Maasoumy B, von Hahn T, Gerold G. Interdependent Impact of Lipoprotein Receptors and Lipid-Lowering Drugs on HCV Infectivity. Cells. 2021 Jun 29;10(7):1626. doi: 10.3390/cells10071626. PMID: 34209751; PMCID: PMC8303410.

 

Mahlmann JC, Wirth TC, Hartleben B, Schrem H, Mahlmann JF, Kaltenborn A, Klempnauer J, Kulik U. Chemotherapy and Hepatic Steatosis: Impact on Postoperative Morbidity and Survival after Liver Resection for Colorectal Liver Metastases. Visc Med. 2021 Jun;37(3):198-205. doi: 10.1159/000510661. Epub 2020 Oct 9. PMID: 34250077; PMCID: PMC8237789.

 

Feldbrügge L, Langenscheidt A, Krenzien F, Schulz M, Krezdorn N, Kamali K, Hinz A, Bartels M, Fikatas P, Schmelzle M, Pratschke J, Benzing C. Health-Related Quality of Life and Mental Health after Surgical Treatment of Hepatocellular Carcinoma in the Era of Minimal-Invasive Surgery: Resection versus Transplantation. Healthcare (Basel). 2021 Jun 9;9(6):694. doi: 10.3390/healthcare9060694. PMID: 34207501; PMCID: PMC8228687.

 

Gronau F, Jara M, Feldbrügge L, Wolf V, Oeff A, Rau B. Zytoreduktive Chirurgie und hypertherme intraperitoneale Chemotherapie beim Magenkarzinom [Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in gastric cancer]. Chirurg. 2021 Jun;92(6):522-527. German. doi: 10.1007/s00104-021-01371-3. Epub 2021 Feb 23. PMID: 33620502.

 

Leiskau C, Samuel S, Pfister ED, Junge N, Beneke J, Stupak J, Richter N, Vondran F, Schrem H, Baumann U. Low-dose steroids do make a difference: Independent risk factors for impaired linear growth after pediatric liver transplantation. Pediatr Transplant. 2021 Jun;25(4):e13989. doi: 10.1111/petr.13989. Epub 2021 Mar 10. PMID: 33689189.

 

Aregay A, Engel B, Port K, Vondran FWR, Bremer B, Niehaus C, Khera T, Richter N, Jaeckel E, Cornberg M, Taubert R, Wedemeyer H. Distinct Immune Imprints of Post-Liver Transplantation Hepatitis C Persist Despite Viral Clearance. Liver Transpl. 2021 Jun;27(6):887-899. doi: 10.1002/lt.26031. PMID: 33641215.

 

Oldhafer F, Wittauer EM, Beetz O, Weigle CA, Sieg L, Eismann H, Braubach P, Bock M, Jonigk D, Johanning K, Vondran FWR. Supportive Hepatocyte Transplantation after Partial Hepatectomy Enhances Liver Regeneration in a Preclinical Pig Model. Eur Surg Res. 2021;62(4):238-247. doi: 10.1159/000516690. Epub 2021 May 27. PMID: 34044396.

 

Mederacke YS, Nienen M, Jarek M, Geffers R, Hupa-Breier K, Babel N, Reinke P, Mederacke I, Vondran FWR, Jonigk D, Wedemeyer H, Jaeckel E. T cell receptor repertoires within liver allografts are different to those in the peripheral blood. J Hepatol. 2021 May;74(5):1167-1175. doi: 10.1016/j.jhep.2020.12.014. Epub 2020 Dec 18. PMID: 33347951.

 

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Sandhu B, Perez-Matos MC, Tran S, Singhal G, Syed I, Feldbrügge L, Mitsuhashi S, Pelletier J, Huang J, Yalcin Y, Csizmadia E, Tiwari-Heckler S, Enjyoji K, Sévigny J, Maratos-Flier E, Robson SC, Jiang ZG. Global deletion of NTPDase3 protects against diet-induced obesity by increasing basal energy metabolism. Metabolism. 2021 May;118:154731. doi: 10.1016/j.metabol.2021.154731. Epub 2021 Feb 23. PMID: 33631144; PMCID: PMC8052311.

 

Ostroumov D, Duong S, Wingerath J, Woller N, Manns MP, Timrott K, Kleine M, Ramackers W, Roessler S, Nahnsen S, Czemmel S, Dittrich-Breiholz O, Eggert T, Kühnel F, Wirth TC. Transcriptome Profiling Identifies TIGIT as a Marker of T-Cell Exhaustion in Liver Cancer. Hepatology. 2021 Apr;73(4):1399-1418. doi: 10.1002/hep.31466. Erratum in: Hepatology. 2022 May 13;: PMID: 32716559.

 

Fráguas-Eggenschwiler M, Eggenschwiler R, Söllner JH, Cortnumme L, Vondran FWR, Cantz T, Ott M, Niemann H. Direct conversion of porcine primary fibroblasts into hepatocyte-like cells. Sci Rep. 2021 Apr 29;11(1):9334. doi: 10.1038/s41598-021-88727-1. PMID: 33927320; PMCID: PMC8085017.

 

Tegtmeyer B, Vieyres G, Todt D, Lauber C, Ginkel C, Engelmann M, Herrmann M, Pfaller CK, Vondran FWR, Broering R, Vafadarnejad E, Saliba AE, Puff C, Baumgärtner W, Miskey C, Ivics Z, Steinmann E, Pietschmann T, Brown RJP. Initial HCV infection of adult hepatocytes triggers a temporally structured transcriptional program containing diverse pro- and anti-viral elements. J Virol. 2021 Apr 26;95(10):e00245-21. doi: 10.1128/JVI.00245-21. Epub 2021 Mar 3. PMID: 33658347; PMCID: PMC8139656.

 

Feldbrügge L, Gronau F, Brandl A, Auer TA, Oeff A, Thuss-Patience P, Pratschke J, Rau B. Systemic Chemotherapy Including Ramucirumab in Combination With Pressurized Intra-Peritoneal Aerosol Chemotherapy Is a Safe Treatment Option for Peritoneal Metastasis of Gastric Cancer. Front Oncol. 2021 Apr 12;10:610572. doi: 10.3389/fonc.2020.610572. PMID: 33912438; PMCID: PMC8074678.

 

Haber PK, Maier C, Kästner A, Feldbrügge L, Ortiz Galindo SA, Geisel D, Fehrenbach U, Biebl M, Krenzien F, Benzing C, Schöning W, Pratschke J, Schmelzle M. Predicting the Risk of Postoperative Complications in Patients Undergoing Minimally Invasive Resection of Primary Liver Tumors. J Clin Med. 2021 Feb 10;10(4):685. doi: 10.3390/jcm10040685. PMID: 33578875; PMCID: PMC7916554.

 

Memaran N, Küpper C, Borchert-Mörlins B, von Wick A, Bauer E, Jäckel E, Maasoumy B, Vondran FWR, Sugianto RI, von der Born J, Schmidt BMW, Melk A. Prospective assessment of subclinical cardiovascular damage and associated factors in liver transplant recipients. Transpl Int. 2021 Jan;34(1):127-138. doi: 10.1111/tri.13773. Epub 2020 Nov 10. PMID: 33070384.

 

Kamali C, Kamali K, Brunnbauer P, Splith K, Pratschke J, Schmelzle M, Krenzien F. Extended liver resection in mice: state of the art and pitfalls-a systematic review. Eur J Med Res. 2021 Jan 9;26(1):6. doi: 10.1186/s40001-020-00478-3. PMID: 33422147; PMCID: PMC7797144.

Knitter S, Andreou A, Kradolfer D, Beierle AS, Pesthy S, Eichelberg AC, Kästner A, Feldbrügge L, Krenzien F, Schulz M, Banz V, Lachenmayer A, Biebl M, Schöning W, Candinas D, Pratschke J, Beldi G, Schmelzle M. Minimal-Invasive Versus Open Hepatectomy for Colorectal Liver Metastases: Bicentric Analysis of Postoperative Outcomes and Long-Term Survival Using Propensity Score Matching Analysis. J Clin Med. 2020 Dec 13;9(12):4027. doi: 10.3390/jcm9124027. PMID: 33322087; PMCID: PMC7764401.

 

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Beetz O, Weigle CA, Cammann S, Vondran FWR, Timrott K, Kulik U, Bektas H, Klempnauer J, Kleine M, Oldhafer F. Preoperative leukocytosis and the resection severity index are independent risk factors for survival in patients with intrahepatic cholangiocarcinoma. Langenbecks Arch Surg. 2020 Nov;405(7):977-988. doi: 10.1007/s00423-020-01962-4. Epub 2020 Aug 19. PMID: 32815017; PMCID: PMC7541380.

 

Wandrer F, Frangež Ž, Liebig S, John K, Vondran F, Wedemeyer H, Veltmann C, Pfeffer TJ, Shibolet O, Schulze-Osthoff K, Simon HU, Bantel H. Autophagy alleviates amiodarone-induced hepatotoxicity. Arch Toxicol. 2020 Oct;94(10):3527-3539. doi: 10.1007/s00204-020-02837-9. Epub 2020 Jul 10. PMID: 32651653; PMCID: PMC7502042.

 

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Yang D, Dai Z, Yang T, Balakrishnan A, Yuan Q, Vondran FWR, Manns MP, Ott M, Cantz T, Sharma AD. MicroRNA-125b-5p Regulates Hepatocyte Proliferation During the Termination Phase of Liver Regeneration. Hepatol Commun. 2020 Sep 15;4(12):1851-1863. doi: 10.1002/hep4.1597. PMID: 33305155; PMCID: PMC7706294.

 

Stocklassa T, Borchert-Mörlins B, Memaran N, Einecke G, Schmitt R, Richter N, Vondran FW, Bauer E, Markefke S, Melk A, Schmidt BMW. Sex Differences in Subclinical Cardiovascular Organ Damage After Renal Transplantation: A Single-Center Cohort Study. J Womens Health (Larchmt). 2021 Sep;30(9):1352-1361. doi: 10.1089/jwh.2020.8594. Epub 2020 Nov 18. PMID: 33211603.

 

DeTemple DE, Cammann S, Bahlmann J, Buettner M, Heisterkamp A, Vondran FWR, Kalies SK. Longitudinal imaging and femtosecond laser manipulation of the liver: How to generate and trace single-cell-resolved micro-damage in vivo. PLoS One. 2020 Oct 15;15(10):e0240405. doi: 10.1371/journal.pone.0240405. PMID: 33057345; PMCID: PMC7561146.

 

Carpentier A, Sheldon J, Vondran FWR, Brown RJ, Pietschmann T. Efficient acute and chronic infection of stem cell-derived hepatocytes by hepatitis C virus. Gut. 2020 Sep;69(9):1659-1666. doi: 10.1136/gutjnl-2019-319354. Epub 2020 Feb 29. PMID: 32114504; PMCID: PMC7456736.

 

Kinast V, Plociennikowska A, Anggakusuma, Bracht T, Todt D, Brown RJP, Boldanova T, Zhang Y, Brüggemann Y, Friesland M, Engelmann M, Vieyres G, Broering R, Vondran FWR, Heim MH, Sitek B, Bartenschlager R, Pietschmann T, Steinmann E. C19orf66 is an interferon-induced inhibitor of HCV replication that restricts formation of the viral replication organelle. J Hepatol. 2020 Sep;73(3):549-558. doi: 10.1016/j.jhep.2020.03.047. Epub 2020 Apr 12. PMID: 32294532.

 

Stahl K, Busch M, Fuge J, Schneider A, Manns MP, Seeliger B, Schmidt JJ, Wiesner O, Schmidt BMW, Taubert R, Vondran FWR, Hoeper MM, David S. Therapeutic plasma exchange in acute on chronic liver failure. J Clin Apher. 2020 Aug;35(4):316-327. doi: 10.1002/jca.21799. Epub 2020 Jun 24. PMID: 32583446.

 

Nevermann NF, Hillebrandt KH, Knitter S, Ritschl PV, Krenzien F, Benzing C, Bahra M, Biebl M, Sauer IM, Öllinger R, Schöning W, Schmelzle M, Pratschke J; COVID-19 Surgical Oncology Collaboration Group. COVID-19 pandemic: implications on the surgical treatment of gastrointestinal and hepatopancreatobiliary tumours in Europe. Br J Surg. 2020 Aug;107(9):e301-e302. doi: 10.1002/bjs.11751. Epub 2020 Jun 10. PMID: 32521041; PMCID: PMC7300698.

 

Beetz O, Sarisin A, Kaltenborn A, Klempnauer J, Winkler M, Grannas G. Multivisceral resection for adenocarcinoma of the pancreatic body and tail-a retrospective single-center analysis. World J Surg Oncol. 2020 Aug 20;18(1):218. doi: 10.1186/s12957-020-01973-x. PMID: 32819373; PMCID: PMC7441692.

 

Beetz O, Bajunaid A, Meißler L, Vondran FWR, Kleine M, Cammann S, Hanke JS, Schmitto JD, Haverich A, Klempnauer J, Ringe KI, Oldhafer F, Timrott K. Abdominal Surgery in Patients with Ventricular Assist Devices: a Single-Center Report. ASAIO J. 2020 Aug;66(8):890-898. doi: 10.1097/MAT.0000000000001085. PMID: 32740349.

 

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Feldbrügge L, Splith K, Kämmerer I, Richter S, Riddermann A, Ortiz Galindo SA, Krenzien F, Müller T, Csizmadia E, Pratschke J, Robson SC, Schmelzle M. Ecto-Nucleotide Triphosphate Diphosphohydrolase-2 (NTPDase2) Deletion Increases Acetaminophen-Induced Hepatotoxicity. Int J Mol Sci. 2020 Aug 20;21(17):5998. doi: 10.3390/ijms21175998. PMID: 32825435; PMCID: PMC7504458.

 

Feldbrügge L, Wabitsch S, Benzing C, Krenzien F, Kästner A, Haber PK, Atanasov G, Andreou A, Öllinger R, Pratschke J, Schmelzle M. Safety and feasibility of laparoscopic liver resection in patients with a history of abdominal surgeries. HPB (Oxford). 2020 Aug;22(8):1191-1196. doi: 10.1016/j.hpb.2019.11.006. Epub 2019 Dec 9. PMID: 31831317.

 

Oldhafer F, Wittauer EM, Beetz O, Vondran FWR. Long-term Functional Maintenance of Exteriorized Portal Venous Catheters in a Porcine Animal Model. J Surg Res. 2020 Jul;251:187-194. doi: 10.1016/j.jss.2020.02.003. Epub 2020 Mar 9. PMID: 32163793.

 

Ritschl PV, Nevermann N, Wiering L, Wu HH, Moroder P, Brandl A, Hillebrandt K, Tacke F, Friedersdorff F, Schlomm T, Schöning W, Öllinger R, Schmelzle M, Pratschke J. Solid organ transplantation programs facing lack of empiric evidence in the COVID-19 pandemic: A By-proxy Society Recommendation Consensus approach. Am J Transplant. 2020 Jul;20(7):1826-1836. doi: 10.1111/ajt.15933. Epub 2020 May 10. PMID: 32323460; PMCID: PMC7264649.

 

Sellau J, Groneberg M, Fehling H, Thye T, Hoenow S, Marggraff C, Weskamm M, Hansen C, Stanelle-Bertram S, Kuehl S, Noll J, Wolf V, Metwally NG, Hagen SH, Dorn C, Wernecke J, Ittrich H, Tannich E, Jacobs T, Bruchhaus I, Altfeld M, Lotter H. Androgens predispose males to monocyte-mediated immunopathology by inducing the expression of leukocyte recruitment factor CXCL1. Nat Commun. 2020 Jul 10;11(1):3459. doi: 10.1038/s41467-020-17260-y. PMID: 32651360; PMCID: PMC7351718.

 

Vieyres G, Reichert I, Carpentier A, Vondran FWR, Pietschmann T. The ATGL lipase cooperates with ABHD5 to mobilize lipids for hepatitis C virus assembly. PLoS Pathog. 2020 Jun 15;16(6):e1008554. doi: 10.1371/journal.ppat.1008554. PMID: 32542055; PMCID: PMC7316345.

 

Bahlmann J, Madrahimov N, Daniel F, Theidel D, DeTemple DE, Buettner M, Bleich A, Haverich A, Heisterkamp A, Kalies S. Establishment of a guided, in vivo, multi-channel, abdominal, tissue imaging approach. Sci Rep. 2020 Jun 8;10(1):9224. doi: 10.1038/s41598-020-65950-w. PMID: 32513950; PMCID: PMC7280182.

 

Lauterbach-Rivière L, Bergez M, Mönch S, Qu B, Riess M, Vondran FWR, Liese J, Hornung V, Urban S, König R. Hepatitis B Virus DNA is a Substrate for the cGAS/STING Pathway but is not Sensed in Infected Hepatocytes. Viruses. 2020 May 29;12(6):592. doi: 10.3390/v12060592. PMID: 32485908; PMCID: PMC7354540.

 

Krenzien F, Katou S, Papa A, Sinn B, Benzing C, Feldbrügge L, Kamali C, Brunnbauer P, Splith K, Lorenz RR, Ritschl P, Wiering L, Öllinger R, Schöning W, Pratschke J, Schmelzle M. Increased Cell-Free DNA Plasma Concentration Following Liver Transplantation Is Linked to Portal Hepatitis and Inferior Survival. J Clin Med. 2020 May 20;9(5):1543. doi: 10.3390/jcm9051543. PMID: 32443763; PMCID: PMC7291032.

 

Carvalho Oliveira M, Valdivia E, Verboom M, Yuzefovych Y, Sake HJ, Pogozhykh O, Niemann H, Schwinzer R, Petersen B, Seissler J, Blasczyk R, Figueiredo C. Generating low immunogenic pig pancreatic islet cell clusters for xenotransplantation. J Cell Mol Med. 2020 May;24(9):5070-5081. doi: 10.1111/jcmm.15136. Epub 2020 Mar 25. PMID: 32212307; PMCID: PMC7205796.

 

Timrott K, Beetz O, Oldhafer F, Klempnauer J, Vondran FWR, Jäger MD. The importance of MHC class II in allogeneic bone marrow transplantation and chimerism-based solid organ tolerance in a rat model. PLoS One. 2020 May 22;15(5):e0233497. doi: 10.1371/journal.pone.0233497. PMID: 32442182; PMCID: PMC7244129.

 

Weigle CA, Lieke T, Vondran FWR, Timrott K, Klempnauer J, Beetz O. An Immunological Model for Heterotopic Heart and Cardiac Muscle Cell Transplantation in Rats. J Vis Exp. 2020 May 8;(159). doi: 10.3791/60956. PMID: 32449721.

 

Wiesener A, Knaup KX, Büttner-Herold M, Dieterle A, Stoeckert J, Riedl B, Morath C, Wald A, Vondran F, Braun F, Schödel J, Schueler M, Schiffer M, Amann K, Reis A, Kraus C, Wiesener MS. Molecular diagnosis of kidney transplant failure based on urine. Am J Transplant. 2020 May;20(5):1410-1416. doi: 10.1111/ajt.15738. Epub 2020 Jan 20. PMID: 31814324.

 

Hein R, Sake HJ, Pokoyski C, Hundrieser J, Brinkmann A, Baars W, Nowak-Imialek M, Lucas-Hahn A, Figueiredo C, Schuberth HJ, Niemann H, Petersen B, Schwinzer R. Triple (GGTA1, CMAH, B2M) modified pigs expressing an SLA class Ilow phenotype-Effects on immune status and susceptibility to human immune responses. Am J Transplant. 2020 Apr;20(4):988-998. doi: 10.1111/ajt.15710. Epub 2019 Dec 28. PMID: 31733031.

 

Ramackers W, Rataj D, Werwitzke S, Bergmann S, Winkler M, Wünsch A, Bähr A, Wolf E, Klymiuk N, Ayares D, Tiede A. Expression of human thrombomodulin on porcine endothelial cells can reduce platelet aggregation but did not reduce activation of complement or endothelium - an experimental study. Transpl Int. 2020 Apr;33(4):437-449. doi: 10.1111/tri.13573. Epub 2020 Feb 9. PMID: 31926034.

 

Bojkova D, Westhaus S, Costa R, Timmer L, Funkenberg N, Korencak M, Streeck H, Vondran F, Broering R, Heinrichs S, Lang KS, Ciesek S. Sofosbuvir Activates EGFR-Dependent Pathways in Hepatoma Cells with Implications for Liver-Related Pathological Processes. Cells. 2020 Apr 17;9(4):1003. doi: 10.3390/cells9041003. PMID: 32316635; PMCID: PMC7225999.

 

Beetz O, Weigle CA, Nogly R, Klempnauer J, Pape L, Richter N, Vondran FWR. Surgical complications in pediatric kidney transplantation-Incidence, risk factors, and effects on graft survival: A retrospective single-center study. Pediatr Transplant. 2021 Mar;25(2):e13871. doi: 10.1111/petr.13871. Epub 2020 Oct 14. PMID: 33053269.

 

Hruby J, Spunda R, Mericka P, Mlcek M, Pecha O, Splith K, Schmelzle M, Krenzien F, Lindner J, Spacek M, Matia I. Influence of the new standardized clinical cryopreservation/slow thawing protocol on immunogenicity of arterial allografts in rats. PLoS One. 2020 Mar 10;15(3):e0230234. doi: 10.1371/journal.pone.0230234. PMID: 32155226; PMCID: PMC7064217.

 

Beetz O, Söffker R, Cammann S, Oldhafer F, Vondran FWR, Imkamp F, Klempnauer J, Kleine M. Extended hepatic metastasectomy for renal cell carcinoma-new aspects in times of targeted therapy: a single-center experience over three decades. Langenbecks Arch Surg. 2020 Feb;405(1):97-106. doi: 10.1007/s00423-019-01852-4. Epub 2020 Jan 14. PMID: 31938833; PMCID: PMC7036059.

 

Fischer K, Rieblinger B, Hein R, Sfriso R, Zuber J, Fischer A, Klinger B, Liang W, Flisikowski K, Kurome M, Zakhartchenko V, Kessler B, Wolf E, Rieben R, Schwinzer R, Kind A, Schnieke A. Viable pigs after simultaneous inactivation of porcine MHC class I and three xenoreactive antigen genes GGTA1, CMAH and B4GALNT2. Xenotransplantation. 2020 Jan;27(1):e12560. doi: 10.1111/xen.12560. Epub 2019 Oct 8. PMID: 31591751.

 

Todt D, Friesland M, Moeller N, Praditya D, Kinast V, Brüggemann Y, Knegendorf L, Burkard T, Steinmann J, Burm R, Verhoye L, Wahid A, Meister TL, Engelmann M, Pfankuche VM, Puff C, Vondran FWR, Baumgärtner W, Meuleman P, Behrendt P, Steinmann E. Robust hepatitis E virus infection and transcriptional response in human hepatocytes. Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1731-1741. doi: 10.1073/pnas.1912307117. Epub 2020 Jan 2. PMID: 31896581; PMCID: PMC6983376.

Ko C, Bester R, Zhou X, Xu Z, Blossey C, Sacherl J, Vondran FWR, Gao L, Protzer U. A New Role for Capsid Assembly Modulators To Target Mature Hepatitis B Virus Capsids and Prevent Virus Infection. Antimicrob Agents Chemother. 2019 Dec 20;64(1):e01440-19. doi: 10.1128/AAC.01440-19. PMID: 31658963; PMCID: PMC7187577.

 

Sake HJ, Frenzel A, Lucas-Hahn A, Nowak-Imialek M, Hassel P, Hadeler KG, Hermann D, Becker R, Eylers H, Hein R, Baars W, Brinkmann A, Schwinzer R, Niemann H, Petersen B. Possible detrimental effects of beta-2-microglobulin knockout in pigs. Xenotransplantation. 2019 Nov;26(6):e12525. doi: 10.1111/xen.12525. Epub 2019 May 22. PMID: 31119817.

 

Rothweiler S, Feldbrügge L, Jiang ZG, Csizmadia E, Longhi MS, Vaid K, Enjyoji K, Popov YV, Robson SC. Selective deletion of ENTPD1/CD39 in macrophages exacerbates biliary fibrosis in a mouse model of sclerosing cholangitis. Purinergic Signal. 2019 Sep;15(3):375-385. doi: 10.1007/s11302-019-09664-3. Epub 2019 Jun 26. PMID: 31243614; PMCID: PMC6737175.

 

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Oldhafer F, Ringe KI, Timrott K, Kleine M, Beetz O, Ramackers W, Cammann S, Klempnauer J, Bektas H, Vondran FWR. Response to "Critical appraisal of the modified ante situm liver resection-is the original method the better choice?". Langenbecks Arch Surg. 2019 Aug;404(5):649-651. doi: 10.1007/s00423-019-01795-w. Epub 2019 Jun 29. PMID: 31256253.

 

Beetz O, Kolb J, Buck B, Trautewig B, Timrott K, Vondran FWR, Meder I, Löbbert C, Hundrieser J, Klempnauer J, Bektaş H, Lieke T. Recipient natural killer cells alter the course of rejection of allogeneic heart grafts in rats. PLoS One. 2019 Aug 22;14(8):e0220546. doi: 10.1371/journal.pone.0220546. PMID: 31437165; PMCID: PMC6705777.

 

Oldhafer F, Wittauer EM, Falk CS, DeTemple DE, Beetz O, Timrott K, Kleine M, Vondran FWR. Alloresponses of Mixed Lymphocyte Hepatocyte Culture to Immunosuppressive Drugs as an In-Vitro Model of Hepatocyte Transplantation. Ann Transplant. 2019 Aug 13;24:472-480. doi: 10.12659/AOT.915982. PMID: 31406101; PMCID: PMC6705178.

 

Figueiredo C, Oldhafer F, Wittauer EM, Carvalho-Oliveira M, Akhdar A, Beetz O, Chen-Wacker C, Yuzefovych Y, Falk CS, Blasczyk R, Vondran FWR. Silencing of HLA class I on primary human hepatocytes as a novel strategy for reduction in alloreactivity. J Cell Mol Med. 2019 Aug;23(8):5705-5714. doi: 10.1111/jcmm.14484. Epub 2019 Jun 10. PMID: 31180181; PMCID: PMC6653539.

 

Hundrieser J, Hein R, Pokoyski C, Brinkmann A, Düvel H, Dinkel A, Trautewig B, Siegert JF, Römermann D, Petersen B, Schwinzer R. Role of human and porcine MHC DRB1 alleles in determining the intensity of individual human anti-pig T-cell responses. Xenotransplantation. 2019 Jul;26(4):e12523. doi: 10.1111/xen.12523. Epub 2019 May 9. PMID: 31074044.

 

Wabitsch S, Benzing C, Krenzien F, Splith K, Haber PK, Arnold A, Nösser M, Kamali C, Hermann F, Günther C, Hirsch D, Sauer IM, Pratschke J, Schmelzle M. Human Stem Cells Promote Liver Regeneration After Partial Hepatectomy in BALB/C Nude Mice. J Surg Res. 2019 Jul;239:191-200. doi: 10.1016/j.jss.2019.02.010. Epub 2019 Mar 4. PMID: 30844633.

 

Kinast V, Leber SL, Brown RJP, Vieyres G, Behrendt P, Eßbach C, Strnad P, Vondran FWR, Cornberg M, Wex C, Pietschmann T, Haybaeck J, Todt D, Steinmann E. Identification of Keratin 23 as a Hepatitis C Virus-Induced Host Factor in the Human Liver. Cells. 2019 Jun 18;8(6):610. doi: 10.3390/cells8060610. PMID: 31216713; PMCID: PMC6628310.

 

Stockmann M, Vondran FWR, Fahrner R, Tautenhahn HM, Mittler J, Bektas H, Malinowski M, Jara M, Klein I, Lock JF; Collaborative Fast‐track Liver Study Group. Randomized clinical trial comparing liver resection with and without perioperative assessment of liver function. BJS Open. 2018 Jun 14;2(5):301-309. doi: 10.1002/bjs5.81. PMID: 30263981; PMCID: PMC6156169.

 

Wabitsch S, Kästner A, Haber PK, Feldbrügge L, Winklmann T, Werner S, Pratschke J, Schmelzle M. Laparoscopic versus open hemihepatectomy-a cost analysis after propensity score matching. Langenbecks Arch Surg. 2019 Jun;404(4):469-475. doi: 10.1007/s00423-019-01790-1. Epub 2019 May 7. PMID: 31065781.

 

Ramackers W, Werwitzke S, Klose J, Friedrich L, Johanning K, Bergmann S, Klempnauer J, Winkler M, Tiede A. Investigation of the influence of xenoreactive antibodies on activation of complement and coagulation in an ex vivo perfusion animal study using porcine kidneys. Transpl Int. 2019 May;32(5):546-556. doi: 10.1111/tri.13396. Epub 2019 Jan 22. PMID: 30597634.

 

Schwager Y, Littbarski SA, Nolte A, Kaltenborn A, Emmanouilidis N, Kleine-Döpke D, Klempnauer J, Schrem H. Prediction of Three-Year Mortality After Deceased Donor Kidney Transplantation in Adults with Pre-Transplant Donor and Recipient Variables. Ann Transplant. 2019 May 17;24:273-290. doi: 10.12659/AOT.913217. PMID: 31097680; PMCID: PMC6540619.

 

Wittauer EM, Oldhafer F, Augstein E, Beetz O, Kleine M, Schumacher C, Sieg L, Eismann H, Johanning K, Bleich A, Vondran FWR. Porcine model for the study of liver regeneration enhanced by non-invasive 13C-methacetin breath test (LiMAx test) and permanent portal venous access. PLoS One. 2019 May 31;14(5):e0217488. doi: 10.1371/journal.pone.0217488. PMID: 31150446; PMCID: PMC6544243.

 

Winkelmann M, Butz AL, Clausen JD, Blossey RD, Zeckey C, Weber-Spickschen S, Mommsen P. Admission blood glucose as a predictor of shock and mortality in multiply injured patients. SICOT J. 2019;5:17. doi: 10.1051/sicotj/2019015. Epub 2019 May 28. PMID: 31134892; PMCID: PMC6538364.

 

Strowitzki MJ, Radhakrishnan P, Pavicevic S, Scheer J, Kimmer G, Ritter AS, Tuffs C, Volz C, Vondran F, Harnoss JM, Klose J, Schmidt T, Schneider M. High hepatic expression of PDK4 improves survival upon multimodal treatment of colorectal liver metastases. Br J Cancer. 2019 Apr;120(7):675-688. doi: 10.1038/s41416-019-0406-9. Epub 2019 Feb 27. PMID: 30808993; PMCID: PMC6461828.

 

Krenzien F, Keshi E, Splith K, Griesel S, Kamali K, Sauer IM, Feldbrügge L, Pratschke J, Leder A, Schmelzle M. Diagnostic Biomarkers to Diagnose Acute Allograft Rejection After Liver Transplantation: Systematic Review and Meta-Analysis of Diagnostic Accuracy Studies. Front Immunol. 2019 Apr 11;10:758. doi: 10.3389/fimmu.2019.00758. PMID: 31031758; PMCID: PMC6470197.

 

Tsay HC, Yuan Q, Balakrishnan A, Kaiser M, Möbus S, Kozdrowska E, Farid M, Tegtmeyer PK, Borst K, Vondran FWR, Kalinke U, Kispert A, Manns MP, Ott M, Sharma AD. Hepatocyte-specific suppression of microRNA-221-3p mitigates liver fibrosis. J Hepatol. 2019 Apr;70(4):722-734. doi: 10.1016/j.jhep.2018.12.016. Epub 2018 Dec 22. Erratum in: J Hepatol. 2022 Jul;77(1):269. PMID: 30582979.

 

Schumacher C, Eismann H, Sieg L, Friedrich L, Scheinichen D, Vondran FWR, Johanning K. Use of Rotational Thromboelastometry in Liver Transplantation Is Associated With Reduced Transfusion Requirements. Exp Clin Transplant. 2019 Apr;17(2):222-230. doi: 10.6002/ect.2017.0236. Epub 2018 Oct 5. PMID: 30295585.

 

Wiltberger G, Wu Y, Lange U, Hau HM, Tapper E, Krenzien F, Atanasov G, Benzing C, Feldbrügge L, Csizmadia E, Broschewitz J, Bartels M, Seehofer D, Jonas S, Berg T, Hessel P, Ascherl R, Neumann UP, Pratschke J, Robson SC, Schmelzle M. Protective effects of coffee consumption following liver transplantation for hepatocellular carcinoma in cirrhosis. Aliment Pharmacol Ther. 2019 Mar;49(6):779-788. doi: 10.1111/apt.15089. PMID: 30811647.

 

Mederacke YS, Vondran FW, Kollrich S, Schulde E, Schmitt R, Manns MP, Klempnauer J, Schwinzer R, Noyan F, Jaeckel E. Transient increase of activated regulatory T cells early after kidney transplantation. Sci Rep. 2019 Jan 31;9(1):1021. doi: 10.1038/s41598-018-37218-x. PMID: 30705299; PMCID: PMC6355855