Werdegang

• Seit 2017: Projektleiterin im Institut für Molekular- und Zellphysiologie der Medizinischen Hochschule Hannover (MHH)
• 2012-2016: Postdoktorandin am Institut für Molekular- und Zellphysiologie, Medizinische Hochschule Hannover, Deutschland.
• 2008 - 2011: Postdoktorandin in Medical Research Council - Laboratory of Molecular Biology (MRC-LMB), Cambridge, United Kingdom.
• 2003 - 2006: Doktorandin am Institut für Molekular- und Zellphysiologie, Medizinische Hochschule Hannover.
• 2001 - 2002: Junior Research Fellow am National Center for Cell Sciences (NCCS), Pune, Indien
• Master of Science (M.Sc.) an der Universität Pune, Maharashtra, Indien.

Aktuelle Forschungsschwerpunkte

• Einzelmoleküluntersuchungen an Motorproteinmolekülen, Mutationen der hypertrophen Kardiomyopathie (HCM) im kardialen β-Myosin.

• Nanobiohybridmotoren

• Muskelatrophie

Expertisen

• Einzelmoleküluntersuchungen mittels TIRF-Mikroskopie, optischen Fallen, Zero-Mode-Lichtwellenleitern.

• Lehre Physiologiekurse (studentisches Praktikum) für Studenten der Humanmedizin und Zahnmedizin und Praktika für Masterstudenten der Biomedizin.

Wissenschaftliche Artikel in Fachzeitschriften

• SENP7 deSUMOylase-governed transcriptional program coordinates sarcomere assembly and is targeted in muscle atrophy,
  Mamta Amrute-Nayak, Luis Vincens Gand, Bushra Khan, Tim Holler, Ekaterini Kefalakes, Maike Kosanke, Theresia Kraft, and Arnab Nayak, 2022, Cell Reports 41, 111702, https://doi.org/10.1016/j.celrep.2022.111702

• Myosin essential light chain 1sa decelerates actin and thin filament gliding on β-myosin molecules, Jennifer Osten, Maral Mohebbi, Petra Uta, Faramarz Matinmehr, Tianbang Wang, Theresia Kraft, Mamta Amrute-Nayak and Tim Scholz, J Gen Physiol . 2022 Oct 3;154(10):e202213149. doi: 10.1085/jgp.202213149. Epub 2022 Sep 2,  PubMed
   
• Cardiac ventricular myosin and slow skeletal myosin exhibit dissimilar chemomechanical properties despite bearing the same myosin heavy chain isoform, Tianbang Wang, Emrulla Spahiu, Jennifer Osten, Florentine Behrens, Fabius Grünhagen, Tim Scholz, Theresia Kraft, Arnab Nayak, Mamta Amrute-Nayak, J Biol Chem . 2022 May 24;102070.  doi: 10.1016/j.jbc.2022.102070. [Online ahead of print] PubMed
   
• MARK4 controls ischaemic heart failure through microtubule detyrosination. Yu X, Chen X, Amrute-Nayak M, Allgeyer E, Zhao A, Chenoweth H, Clement M, Harrison J, Doreth C, Sirinakis G, Krieg T, Zhou H, Huang H, Tokuraku K, Johnston DS, Mallat Z, Li X. Nature. 2021 May 26. doi: 10.1038/s41586-021-03573-5. Online ahead of print. PubMed
   
• Chemotherapy triggers cachexia by deregulating synergetic function of histone-modifying enzymes, Mamta Amrute-Nayak, Gloria Pegoli, Tim Holler, Alfredo Jesus Lopez-Davila, Chiara Lanzuolo, Arnab Nayak, J Cachexia Sarcopenia Muscle, . 2020 Dec 10., doi: 10.1002/jcsm.12645. Online ahead of print, PubMed
   
• Acto-Myosin Cross-Bridge Stiffness Depends on the Nucleotide State of Myosin II. Wang T, Brenner B, Nayak A, and Amrute-Nayak M. Nano Letters, 2020 Sep 15. doi: 10.1021/acs.nanolett.0c02960. [Online ahead of print] PubMed
   
• Single-molecule analysis reveals that regulatory light chains fine-tune skeletal myosin-II function, Nayak A, Wang T, Franz P, Steffen W, Chizhov I, Tsiavaliaris G, Amrute-Nayak M, J Biol Chem. 2020 Apr 9. pii: jbc.RA120.012774. doi: 10.1074/jbc.RA120.012774, PMID: 32273340, Artikel, PubMed
   
• Regulation of SETD7 Methyltransferase by SENP3 Is Crucial for Sarcomere Organization and Cachexia. Nayak A, Lopez-Davila AJ, Kefalakes E, Holler T, Kraft T, Amrute-Nayak M. Cell Rep. 2019 May 28; 27(9):2725-2736.e4. doi: 10.1016/j.celrep.2019.04.107., PMID: 31141694; PubMed
• Transformation of the Nonprocessive Fast Skeletal Myosin II into a Processive Motor. Amrute-Nayak M, Nayak A, Steffen W, Tsiavaliaris G, Scholz T, Brenner B. Small. 2019 Feb;15(7):e1804313. doi: 10.1002/smll.201804313. Epub 2019 Jan 18., PMID: 30657637; PubMed

• MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism. Li X, Thome S, Ma X, Amrute-Nayak M, Finigan A, Kitt L, Masters L, James JR, Shi Y, Meng G, Mallat Z. Nat Commun. 2017 Jun 28;8:15986. doi: 10.1038/ncomms15986., PMID: 28656979; PubMed

• ATP turnover by individual myosin molecules hints at two conformers of the myosin active site. Amrute-Nayak M, Lambeck KA, Radocaj A, Huhnt HE, Scholz T, Hahn N, Tsiavaliaris G, Walter WJ, Brenner B. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2536-41. doi: 10.1073/pnas.1316390111. Epub 2014 Feb 3., PMID: 24550279; PubMed

• Single-molecule assays reveal that RNA localization signals regulate dynein-dynactin copy number on individual transcript cargoes. Amrute-Nayak M, Bullock SL. Nat Cell Biol. 2012 Feb 26; 14(4):416-23. doi: 10.1038/ncb2446., PMID: 22366687; PubMed

• Targeted optimization of a protein nanomachine for operation in biohybrid devices. Amrute-Nayak M, Diensthuber RP, Steffen W, Kathmann D, Hartmann FK, Fedorov R, Urbanke C, Manstein DJ, Brenner B, Tsiavaliaris G. Angew Chem Int Ed Engl. 2010;49(2):312-6. doi: 10.1002/anie.200905200., PMID: 19921669; PubMed

• Inorganic phosphate binds to the empty nucleotide binding pocket of conventional myosin II. Amrute-Nayak M, Antognozzi M, Scholz T, Kojima H, Brenner B. J Biol Chem. 2008 Feb 15;283(7):3773-81. Epub 2007 Dec 12., PMID:18079122; PubMed

Drittmittelfonds

• Deutsche Forschungsgemeinschaft (DFG)

• Fritz Thyssen Stiftung

Förderung von der Medizinischen Hochschule Hannover (MHH)

• Hochschulinternen Leistungsförderung (HilF), Early career research grant.

Kooperationspartner

• Prof. Georgios Tsiavaliaris (Biophysical chemistry, Hannover Medical School)

• Dr. Xuan Li (Cambridge, UK)

• Dr. Toshio Yanagida (Riken, Japan)

• Dr. Mitsuhiro Iwaki, (Riken, Japan)