Hennis K, Biel M, Fenske S, Wahl-Schott C. Paradigm shift: new concepts for HCN4 function in cardiac pacemaking. Pflugers Arch. 2022 Jul;474(7):649-663. https://doi.org/10.1007/s00424-022-02698-4

Hennis K, Rötzer RD, Rilling J, Wu Y, Thalhammer SB, Biel M, Wahl-Schott C, Fenske S. In vivo and ex vivo electrophysiological study of the mouse heart to characterize the cardiac conduction system, including atrial and ventricular vulnerability. Nat Protoc. 2022 May;17(5):1189-1222. https://doi.org/10.1038/s41596-021-00678-z

Scotto Rosato A, Krogsaeter EK, Jaślan D, Abrahamian C, Montefusco S, Soldati C, Spix B, Pizzo MT, Grieco G, Böck J, Wyatt A, Wünkhaus D, Passon M, Stieglitz M, Keller M, Hermey G, Markmann S, Gruber-Schoffnegger D, Cotman S, Johannes L, Crusius D, Boehm U, Wahl-Schott C, Biel M, Bracher F, De Leonibus E, Polishchuk E, Medina DL, Paquet D, Grimm C. TPC2 rescues lysosomal storage in mucolipidosis type IV, Niemann-Pick type C1, and Batten disease. EMBO Mol Med. 2022 Sep 7;14(9):e15377. https://doi.org/10.15252/emmm.202115377

Al-Samir S, Itel F, Hegermann J, Gros G, Tsiavaliaris G, Endeward V. O2 permeability of lipid bilayers is low, but increases with membrane cholesterol. Cell Mol Life Sci. 2021 Dec;78(23):7649-7662. https://doi.org/10.1007/s00018-021-03974-9

Al-Samir S, Prill M, Supuran CT, Gros G, Endeward V. CO2 permeability of the rat erythrocyte membrane and its inhibition. J Enzyme Inhib Med Chem. 2021 Dec;36(1):1602-1606. https://doi.org/10.1080/14756366.2021.1952194

Benzoni P, Bertoli G, Giannetti F, Piantoni C, Milanesi R, Pecchiari M, Barbuti A, Baruscotti M, Bucchi A. The funny current: Even funnier than 40 years ago. Uncanonical expression and roles of HCN/f channels all over the body. Prog Biophys Mol Biol. 2021 Nov;166:189-204. https://doi.org/10.1016/j.pbiomolbio.2021.08.007

Drakhlis L, Biswanath S, Farr CM, Lupanow V, Teske J, Ritzenhoff K, Franke A, Manstein F, Bolesani E, Kempf H, Liebscher S, Schenke-Layland K, Hegermann J, Nolte L, Meyer H, de la Roche J, Thiemann S, Wahl-Schott C, Martin U, Zweigerdt R. Publisher Correction: Human heart-forming organoids recapitulate early heart and foregut development. Nat Biotechnol. 2021 Jun;39(6):775. https://doi.org/10.1038/s41587-021-00815-9

Hennis K, Biel M, Wahl-Schott C, Fenske S. Beyond pacemaking: HCN channels in sinoatrial node function. Prog Biophys Mol Biol. 2021 Nov;166:51-60. https://doi.org/10.1016/j.pbiomolbio.2021.03.004

Hennis K, Rötzer RD, Piantoni C, Biel M, Wahl-Schott C, Fenske S. Speeding Up the Heart? Traditional and New Perspectives on HCN4 Function. Front Physiol. 2021 May 27;12:669029. https://doi.org/10.3389/fphys.2021.669029

Labus J, Röhrs KF, Ackmann J, Varbanov H, Müller FE, Jia S, Jahreis K, Vollbrecht AL, Butzlaff M, Schill Y, Guseva D, Böhm K, Kaushik R, Bijata M, Marin P, Chaumont-Dubel S, Zeug A, Dityatev A, Ponimaskin E. Amelioration of Tau pathology and memory deficits by targeting 5-HT7 receptor. Prog Neurobiol. 2021 Feb;197:101900. https://doi.org/10.1016/j.pneurobio.2020.101900

Li Y, Schön C, Chen CC, Yang Z, Liegl R, Murenu E, Schworm B, Klugbauer N, Grimm C, Wahl-Schott C, Michalakis S, Biel M. TPC2 promotes choroidal angiogenesis and inflammation in a mouse model of neovascular age-related macular degeneration. Life Sci Alliance. 2021 Jun 28;4(8):e202101047. https://doi.org/10.26508/lsa.202101047

Müller FE, Schade SK, Cherkas V, Stopper L, Breithausen B, Minge D, Varbanov H, Wahl-Schott C, Antoniuk S, Domingos C, Compan V, Kirchhoff F, Henneberger C, Ponimaskin E, Zeug A. Serotonin receptor 4 regulates hippocampal astrocyte morphology and function. Glia. 2021 Apr;69(4):872-889. doi: 10.1002/glia.23933. https://doi.org/10.1002/glia.23933

Piantoni C, Carnevali L, Molla D, Barbuti A, DiFrancesco D, Bucchi A, Baruscotti M. Age-Related Changes in Cardiac Autonomic Modulation and Heart Rate Variability in Mice. Front Neurosci. 2021 May 17;15:617698. https://doi.org/10.3389/fnins.2021.617698

Protopopova AD, Pumroy RA, de la Roche J, Haug FM, Sousa BB, Gallo PN, Bernardes GJL, Leffler A, Moiseenkova-Bell VY. 2021. „TRPV2 Modulation by Small Molecules and Lipids”, Biophys.J., 2021, 120(3, Suppl. 1), 112a-. https://doi.org/10.1016/j.bpj.2020.11.899

Fenske S, Hennis K, Rötzer RD, Brox VF, Becirovic E, Scharr A, Gruner C, Ziegler T, Mehlfeld V, Brennan J, Efimov IR, Pauža AG, Moser M, Wotjak CT, Kupatt C, Gönner R, Zhang R, Zhang H, Zong X, Biel M, Wahl-Schott C. 2020. “cAMP-dependent regulation of HCN4 controls the tonic entrainment process in sinoatrial node pacemaker cells”. Nat Commun., 2020, Nov 3;11(1):5555. https://doi.org/10.1038/s41467-020-19304-9

Chen CC, Krogsaeter E, Butz ES, Li Y, Puertollano R, Wahl-Schott C, Biel M, Grimm C. 2020. “ TRPML2 is an osmo/mechanosensitive cation channel in endolysosomal organelles.” Sci Adv., 2020, Nov 11;6(46):eabb5064. https://doi.org/10.1126/sciadv.abb5064

Weber N, Holler T, Meißner J, Montag J, Fischer M, de la Roche J, Thiemann S, Peschel N, Kathrin Mayer A, Schwanke K., Piep B, Martin U, Zweigerdt R, Kraft T. 2020. „Hypertrophic Cardiomyopathy: Prolonged Twitch, Calcium Transients and Action Potentials in Human Stem Cell-Derived Cardiomyocytes with β-Myosin Mutation R723G“. Biophys.J., 2020, 118(3, Suppl.1), 257a-. https://doi.org/10.1016/j.bpj.2019.11.1496

Böhm S, Splith V, Riedmayr LM, Rötzer RD, Gasparoni G, Nordström KJV, Wagner JE, Hinrichsmeyer KS, Walter J, Wahl-Schott C, Fenske S, Biel M, Michalakis S, Becirovic E. 2020. „A gene therapy for inherited blindness using dCas9-VPR-mediated transcriptional activation”. Sci Adv. 2020 Aug 19;6(34):eaba5614. https://doi.org/10.1126/sciadv.aba5614

Arlt E, Fraticelli M, Tsvilovskyy V, Nadolni W, Breit A, O'Neill TJ, Resenberger S, Wennemuth G, Wahl-Schott C, Biel M, Grimm C, Freichel M, Gudermann T, Klugbauer N, Boekhoff I, Zierler S. 2020. „TPC1 deficiency or blockade augments systemic anaphylaxis and mast cell activity”. Proc Natl Acad Sci U S A. 2020 Jul 28;117(30):18068-18078. https://doi.org/10.1073/pnas.1920122117

Gerndt S, Chen CC, Chao YK, Yuan Y, Burgstaller S, Scotto Rosato A, Krogsaeter E, Urban N, Jacob K, Nguyen ONP, Miller MT, Keller M, Vollmar AM, Gudermann T, Zierler S, Schredelseker J, Schaefer M, Biel M, Malli R, Wahl-Schott C, Bracher F, Patel S, Grimm C. „Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function”. Elife. 2020 Mar 16;9:e54712. https://doi.org/10.7554/elife.54712

Grieschat M, Guzman RE, Langschwager K, Fahlke C, Alekov AK. 2020. „Metabolic energy sensing by mammalian CLC anion/proton exchangers”. EMBO Rep. 2020 Jun 4;21(6):e47872. https://doi.org/10.15252/embr.201947872

Gorinski N, Wojciechowski D, Guseva D, Abdel Galil D, Mueller FE, Wirth A, Thiemann S, Zeug A, Schmidt S, Zareba-Kozioł M, Wlodarczyk J, Skryabin BV, Glage S, Fischer M, Al-Samir S, Kerkenberg N, Hohoff C, Zhang W, Endeward V, Ponimaskin E. 2020. „DHHC7-mediated palmitoylation of the accessory protein barttin critically regulates the functions of ClC-K chloride channels“. J Biol Chem. 2020 May 1;295(18):5970-5983. https://doi.org/10.1074/jbc.ra119.011049

Weber, N., Kowalski, K., Holler, T., Radocaj, A., Fischer, M., Thiemann, S., de la Roche, J., Schwanke, K., Piep, B., Peschel, N., Krumm, U., Lingk, A., Wendland, M., Greten, S., Schmitto, J. D., Ismail, I., Warnecke, G., Zywietz, U., Chichkov, B., Meissner, J., Haverich, A., Martin, U., Brenner, B., Zweigerdt, R., and Kraft, T. 2020. „Advanced Single-Cell Mapping Reveals that in hESC Cardiomyocytes Contraction Kinetics and Action Potential Are Independent of Myosin Isoform”. Stem Cell Reports 14, 788-802. https://doi.org/10.1016/j.stemcr.2020.03.015

Foinquinos, A., Batkai, S., Genschel, C., Viereck, J., Rump, S., Gyongyosi, M., Traxler, D., Riesenhuber, M., Spannbauer, A., Lukovic, D., Weber, N., Zlabinger, K., Hasimbegovic, E., Winkler, J., Fiedler, J., Dangwal, S., Fischer, M., de la Roche, J., Wojciechowski, D., Kraft, T., Garamvolgyi, R., Neitzel, S., Chatterjee, S., Yin, X., Bar, C., Mayr, M., Xiao, K., and Thum, T. 2020. „Preclinical development of a miR-132 inhibitor for heart failure treatment”. Nat Commun 11, 633. https://doi.org/10.1038/s41467-020-14349-2

Hammelmann V, Stieglitz MS, Hülle H, Le Meur K, Kass J, Brümmer M, Gruner C, Rötzer RD, Fenske S, Hartmann J, Zott B, Lüthi A, Spahn S, Moser M, Isbrandt D, Ludwig A, Konnerth A, Wahl-Schott C, Biel M. 2019. „Abolishing cAMP sensitivity in HCN2 pacemaker channels induces generalized seizures”. JCI Insight. 2019 May 2;4(9):e126418. https://doi.org/10.1172/jci.insight.126418

Krogsaeter EK, Biel M, Wahl-Schott C, Grimm C. 2019. „The protein interaction networks of mucolipins and two-pore channels”. Biochim Biophys Acta Mol Cell Res. 2019 Jul;1866(7):1111-1123. https://doi.org/10.1016/j.bbamcr.2018.10.020

Halloin, C., Schwanke, K., Lobel, W., Franke, A., Szepes, M., Biswanath, S., Wunderlich, S., Merkert, S., Weber, N., Osten, F., de la Roche, J., Polten, F., Christoph Wollert, K., Kraft, T., Fischer, M., Martin, U., Gruh, I., Kempf, H., and Zweigerdt, R. 2019. „Continuous WNT Control Enables Advanced hPSC Cardiac Processing and Prognostic Surface Marker Identification in Chemically Defined Suspension Culture”. Stem Cell Reports 13, 366-379. https://doi.org/10.1016/j.stemcr.2019.06.004

Fricke, T. C., Echtermeyer, F., Zielke, J., de la Roche, J., Filipovic, M. R., Claverol, S., Herzog, C., Tominaga, M., Pumroy, R. A., Moiseenkova-Bell, V. Y., Zygmunt, P. M., Leffler, A., and Eberhardt, M. J. 2019. “Oxidation of methionine residues activates the high-threshold heat-sensitive ion channel TRPV2”. Proc Natl Acad Sci U S A 2019 Nov 26;116(48):24359-24365 https://doi.org/10.1073/pnas.1904332116

Engels, L., Olmer, R., de la Roche, J., Gohring, G., Ulrich, S., Haller, R., Martin, U., and Merkert, S. 2019.„Generation of a CFTR knock-in reporter cell line (MHHi006-A-1) from a human induced pluripotent stem cell line”. Stem Cell Res 40, 101542 https://doi.org/10.1016/j.scr.2019.101542w

de la Roche, J., Angsutararux, P., Kempf, H., Janan, M., Bolesani, E., Thiemann, S., Wojciechowski, D., Coffee, M., Franke, A., Schwanke, K., Leffler, A., Luanpitpong, S., Issaragrisil, S., Fischer, M., and Zweigerdt, R. 2019.„Comparing human iPSC-cardiomyocytes versus HEK293T cells unveils disease-causing effects of Brugada mutation A735V of NaV1.5 sodium channels”. Sci Rep 9, 11173 https://doi.org/10.1038/s41598-019-47632-4

Stieglitz MS, Fenske S, Hammelmann V, Becirovic E, Schöttle V, Delorme JE, Schöll-Weidinger M, Mader R, Deussing J, Wolfer DP, Seeliger MW, Albrecht U, Wotjak CT, Biel M, Michalakis S, Wahl-Schott C.2018. „Disturbed Processing of Contextual Information in HCN3 Channel Deficient Mice”. Front Mol Neurosci. 2018 Jan 9;10:436. https://doi.org/10.3389/fnmol.2017.00436

Wojciechowski D, Thiemann S, Schaal C, Rahtz A, de la Roche J, Begemann B, Becher T, Fischer M. 2018. „Activation of renal ClC-K chloride channels depends on an intact N terminus of their accessory subunit barttin”. J Biol Chem. 2018 Jun 1;293(22):8626-8637. https://doi.org/10.1074/jbc.ra117.000860

Beer LA, Tatge H, Schneider C, Ruschig M, Hust M, Barton J, Thiemann S, Fühner V, Russo G, Gerhard R. 2018. „The Binary Toxin CDT of Clostridium Difficile as a Tool for Intracellular Delivery of Bacterial Glucosyltransferase Domains”. Toxins (Basel). 2018 Jun 1;10(6):225. https://doi.org/10.3390/toxins10060225

Hanff E, Zinke M, Böhmer A, Niebuhr J, Maassen M, Endeward V, Maassen N, Tsikas D. 2018. „GC-MS determination of nitrous anhydrase activity of bovine and human carbonic anhydrase II and IV”. Anal Biochem. 2018 Jun 1;550:132-136. https://doi.org/10.1016/j.ab.2018.05.001

Arias-Hidalgo M, Al-Samir S, Gros G, Endeward V. 2018. „Cholesterol is the main regulator of the carbon dioxide permeability of biological membranes”. Am J Physiol Cell Physiol. 2018 Aug 1;315(2):C137-C140. https://doi.org/10.1152/ajpcell.00139.2018

Lin HA, Déan-Ben XL, Reiss M, Schöttle V, Wahl-Schott CA, Efimov IR, Razansky D. 2018. „Ultrafast Volumetric Optoacoustic Imaging of Whole Isolated Beating Mouse Heart”. Sci Rep. 2018 Sep 20;8(1):14132. https://doi.org/10.1038/s41598-018-32317-1

Wojciechowski D, Kovalchuk E, Yu L, Tan H, Fahlke C, Stölting G, Alekov AK. 2018. „Barttin Regulates the Subcellular Localization and Posttranslational Modification of Human Cl-/H+ Antiporter ClC-5“. Front Physiol. 2018 Oct 23;9:1490. https://doi.org/10.3389/fphys.2018.01490

Plesch E, Chen CC, Butz E, Scotto Rosato A, Krogsaeter EK, Yinan H, Bartel K, Keller M, Robaa D, Teupser D, Holdt LM, Vollmar AM, Sippl W, Puertollano R, Medina D, Biel M, Wahl-Schott C, Bracher F, Grimm C. 2018. „Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells“. Elife. Nov 27;7:e39720. https://doi.org/10.7554/elife.39720

Arias-Hidalgo M, Yuan Q, Carta F, Supuran CT, Gros G, Endeward V. 2018. „CO2 Permeability of Rat Hepatocytes and Relation of CO2 Permeability to CO2 Production”. Cell Physiol Biochem. 2018;46(3):1198-1208. https://doi.org/10.1159/000489070

Ruhe F, Olling A, Abromeit R, Rataj D, Grieschat M, Zeug A, Gerhard R, Alekov A. 2017. „Overexpression of the Endosomal Anion/Proton Exchanger ClC-5 Increases Cell Susceptibility toward Clostridium difficile  Toxins TcdA and TcdB”. Front Cell Infect Microbiol. 2017 Mar 13;7:67. https://doi.org/10.3389/fcimb.2017.00067

Endeward V, Arias-Hidalgo M, Al-Samir S, Gros G. 2017. „CO₂ Permeability of Biological Membranes and Role of CO₂ Channels”. Membranes (Basel). 2017 Oct 24;7(4):61. https://doi.org/10.3390/membranes7040061

Herrmann S, Rajab H, Christ I, Schirdewahn C, Höfler D, Fischer MJM, Bruno A, Fenske S, Gruner C, Kramer F, Wachsmann T, Wahl-Schott C, Stieber J, Biel M, Ludwig A. 2017. „Protein kinase A regulates inflammatory pain sensitization by modulating HCN2 channel activity in nociceptive sensory neurons”. Pain. 2017 Oct;158(10):2012-2024. https://doi.org/10.1097/j.pain.0000000000001005

Jara-Avaca, M., Kempf, H., Ruckert, M., Robles-Diaz, D., Franke, A., de la Roche, J., Fischer, M., Malan, D., Sasse, P., Solodenko, W., Drager, G., Kirschning, A., Martin, U., and Zweigerdt, R. 2017. „EBIO Does Not Induce Cardiomyogenesis in Human Pluripotent Stem Cells but Modulates Cardiac Subtype Enrichment by Lineage-Selective Survival”. Stem Cell Reports 8, 305-317 https://doi.org/10.1016/j.stemcr.2016.12.012

Stoetzer, C., Martell, C., de la Roche, J., and Leffler, A. 2017. „Inhibition of Voltage-Gated Na+ Channels by Bupivacaine Is Enhanced by the Adjuvants Buprenorphine, Ketamine, and Clonidine”. Reg Anesth Pain Med 42, 462-468 https://doi.org/10.1097/aap.0000000000000596

Eberhardt, M. J., Schillers, F., Eberhardt, E. M., Risser, L., de la Roche, J., Herzog, C., Echtermeyer, F., and Leffler, A. 2017. „Reactive metabolites of acetaminophen activate and sensitize the capsaicin receptor TRPV1”. Sci Rep 7, 12775 https://doi.org/10.1038/s41598-017-13054-3

Eberhardt, M., Stueber, T., de la Roche, J., Herzog, C., Leffler, A., Reeh, P. W., and Kistner, K. 2017. „TRPA1 and TRPV1 are required for lidocaine-evoked calcium influx and neuropeptide release but not cytotoxicity in mouse sensory neurons”. PLoS One 12, e0188008 https://doi.org/10.1371/journal.pone.0188008