• Bratanov D, Kovalev K, Machtens JP, Astashkin R, Chizhov I, Soloviov D, Volkov D, Polovinkin V, Zabelskii D, Mager T, Gushchin I, Rokitskaya T, Antonenko Y, Alekseev A, Shevchenko V, Yutin N, Rosselli R, Baeken C, Borshchevskiy V, Bourenkov G, Popov A, Balandin T, Büldt G, Manstein DJ, Rodriguez-Valera F, Fahlke C, Bamberg E, Koonin E, Gordeliy V. Unique structure and function of viral rhodopsins. (2019) Nat Commun., 10(1):4939. doi: 10.1038/s41467-019-12718-0.

• Manstein DJ, Meiring JCM, Hardeman EC, Gunning PW. Actin-tropomyosin distribution in non-muscle cells. (2019) J Muscle Res Cell Motil.  doi: 10.1007/s10974-019-09514-0. [Epub ahead of print]

• Wollenberg RD, Taft MH, Giese S, Thiel C, Balázs Z, Giese H, Manstein DJ, Sondergaard TE. Phenamacril is a reversible and noncompetitive inhibitor of Fusarium class I myosin. (2019) J Biol Chem. 294(4):1328-1337. doi: 10.1074/jbc.RA118.005408.

• Maack C, Eschenhagen T, Hamdani N, Heinzel FR, Lyon AR, Manstein DJ, Metzger J, Papp Z, Tocchetti CG, Yilmaz MB, Anker SD, Balligand JL, Bauersachs J, Brutsaert D, Carrier L, Chlopicki S, Cleland JG, de Boer RA, Dietl A, Fischmeister R, Harjola VP, Heymans S, Hilfiker-Kleiner D, Holzmeister J, de Keulenaer G, Limongelli G, Linke WA, Lund LH, Masip J, Metra M, Mueller C, Pieske B, Ponikowski P, Ristić A, Ruschitzka F, Seferović PM, Skouri H, Zimmermann WH, Mebazaa A. Treatments targeting inotropy. (2019) Eur Heart J. 40(44):3626-3644. doi: 10.1093/eurheartj/ehy600.

• Latham SL, Ehmke N, Reinke PYA, Taft MH, Eicke D, Reindl T, Stenzel W, Lyons MJ, Friez MJ, Lee JA, Hecker R, Frühwald MC, Becker K, Neuhann TM, Horn D, Schrock E, Niehaus I, Sarnow K, Grützmann K, Gawehn L, Klink B, Rump A, Chaponnier C, Figueiredo C, Knöfler R, Manstein DJ, Di Donato N. Variants in exons 5 and 6 of ACTB cause syndromic thrombocytopenia. (2018) Nat Commun. 9(1):4250. doi: 10.1038/s41467-018-06713-0.

• Bogutzki A, Naue N, Litz L, Pich A, Curth U. E. coli primase and DNA polymerase III holoenzyme are able to bind concurrently to a primed template during DNA replication. (2019) Sci Rep., 9(1):14460. doi: 10.1038/s41598-019-51031-0.

• Prakash O, Führing J, Post J, Shepherd SM, Eadsforth TC, Gray D, Fedorov R and Routier FH. Identification of Leishmania major UDP-Sugar Pyrophosphorylase Inhibitors Using Biosensor-Based Small Molecule Fragment Library Screening. (2019) Molecules, 24(5): 996. DOI:10.3390/molecules24050996

• Ehlert J, Kronemann J, Zumbrägel N, Preller M. Lipase-Catalyzed Chemoselective Ester Hydrolysis of Biomimetically Coupled Aryls for the Synthesis of Unsymmetric Biphenyl Esters. (2019) Molecules. 24(23). pii: E4272. doi: 10.3390/molecules24234272.

• Chaturvedi A, Goparaju R, Gupta C, Weder J, Klünemann T, Araujo Cruz MM, Kloos A, Goerlich K, Schottmann R, Othman B, Struys EA, Bähre H, Grote-Koska D, Brand K, Ganser A, Preller M, Heuser M. In vivo efficacy of mutant IDH1 inhibitor HMS-101 and structural resolution of distinct binding site. (2019) Leukemia. doi: 10.1038/s41375-019-0582-x. [Epub ahead of print]

• Schadzek P, Stahl Y, Preller M, Ngezahayo A. Analysis of the dominant mutation N188T of human connexin46 (hCx46) using concatenation and molecular dynamics simulation. (2019) FEBS Open Bio. 9(5):840-850. doi: 10.1002/2211-5463.12624.

• Tossidou I, Teng B, Worthmann K, Müller-Deile J, Jobst-Schwan T, Kardinal C, Schroder P, Bolanos-Palmieri P, Haller H, Willerding J, Drost DM, de Jonge L, Reubold T, Eschenburg S, Johnson RI, Schiffer M. Tyrosine Phosphorylation of CD2AP Affects Stability of the Slit Diaphragm Complex. (2019) J Am Soc Nephrol. 30(7):1220-1237. doi: 10.1681/ASN.2018080860.

• Eschenburg S, Reubold TF. Modulation of dynamin function by small molecules. (2018) Biol Chem. 399(12):1421-1432. doi: 10.1515/hsz-2018-0257.

• Meiring JCM, Bryce NS, Wang Y, Taft MH, Manstein DJ, Liu Lau S, Stear J, Hardeman EC, Gunning PW. Co-polymers of Actin and Tropomyosin Account for a Major Fraction of the Human Actin Cytoskeleton. (2018) Curr Biol. 28(14):2331-2337.e5. doi: 10.1016/j.cub.2018.05.053.

• Engelhard C, Chizhov I, Siebert F, Engelhard M. Microbial Halorhodopsins: Light-Driven Chloride Pumps.(2018) Chem Rev. 118(21):10629-10645. doi: 10.1021/acs.chemrev.7b00715.

• Cramer JT, Führing JI, Baruch P, Brütting C, Knölker H-J, Gerardy-Schahn R, and Fedorov R. Decoding Allosteric Networks in Biocatalysts: Rational Approach to Therapies and Biotechnologies. (2018) ACS Catalysis. 8:2683-2692. DOI: 10.1021/acscatal.7b03714

• Chinthalapudi, K., Heissler, S.M., Preller, M., Sellers, J.R., and Manstein, D.J. (2017) Mechanistic Insights into the Active Site and Allosteric Communication Pathways in Human Nonmuscle Myosin-2C. Elife 6, DOI: 10.7554/eLife.32742

• Hirschmann F, Krause F, Baruch P, Chizhov I, Mueller JW, Manstein DJ, Papenbrock J,  Fedorov R. (2017) Structural and biochemical studies of sulphotransferase 18 from Arabidopsis thaliana explain its substrate specificity and reaction mechanism. Sci. Rep. 7(1):4160.

• Meents, A., Wiedorn, M. O., Srajer, V., Henning, R., Sarrou, I., Bergtholdt, J., Barthelmess, M., Reinke, P. Y. A., Dierksmeyer, D., Tolstikova, A., Schaible, S., Messerschmidt, M., Ogata, C. M., Kissick, D. J., Taft, M. H., Manstein, D. J., Lieske, J., Oberthuer, D., Fischetti, R. F. and Chapman, H. N. (2017) Pink-beam serial crystallography. Nat Commun. 8, 1281, DOI: 10.1038/s41467-017-01417-3

• Lohöfener J, Steinke N, Kay-Fedorov P, Baruch P, Nikulin A, Tishchenko S, Manstein DJ, and Fedorov R. The activation mechanism of 2’-5’-oligoadenylate synthetase gives new insights into OAS/cGAS triggers of innate immunity. (2015) Structure. 23(5):851-862. DOI: 10.1016/j.str.2015.03.012.

• Reubold, T.F., Faelber, K., Plattner, N., Posor, Y., Ketel, K., Curth, U., Schlegel, J., Anand, R., Manstein, D.J., Noe, F., Haucke, V., Daumke, O., and Eschenburg, S. (2015) Crystal structure of the dynamin tetramer. Nature 525, 404, rdcu.be/mD09, doi: 10.1038/nature14880

• Führing JI, Cramer JT, Schneider J, Baruch P, Gerardy-Schahn R, and Fedorov R. (2015) A Quaternary Mechanism Enables the Complex Biological Functions of Octameric Human UDP-glucose Pyrophosphorylase, a Key Enzyme in Cell Metabolism. Sci. Rep. 5, 9618; DOI:10.1038/srep09618.

• Rai A, Fedorov R, & Manstein DJ. (2014) Expression, purification and crystallization of a dye-decolourizing peroxidase from Dictyostelium discoideum. Acta Cryst. F70:252-255.

• Mikhaylina AO, Kostareva OS, Sarskikh AV, Fedorov RV, Piendl W, Garber MB, Tishchenko SV (2014) Investigation of the Regulatory Function of Archaeal Ribosomal Protein L4. Biochemistry (Moscow). 79(1):69-76.

• Münnich, S., Pathan-Chhatbar, S., and Manstein, D.J. (2014) Crystal structure of the rigor-like human non-muscle myosin-2 motor domain. FEBS Lett, doi: 10.1016/j.febslet.2014.1011.1007

• Martin R, Risacher C, Barthel A, Jäger A, Schmidt AW, Richter S, Böhl M, Preller M, Chinthalapudi K, Manstein DJ, Gutzeit HO, Knölker H-J. (2014) Silver(I)-Catalyzed Route to Pyrroles: Synthesis of Halogenated Pseudilins as Allosteric Inhibitors for Myosin ATPase and X-ray Crystal Structures of the Protein–Inhibitor Complexes. Eur J Org Chem, doi: 10.1002/ejoc.201402177

• Münnich, S., Taft, M. H., Manstein, D.J. (2014) Crystal Structure of Human Myosin 1c - The Motor in GLUT4 Exocytosis: Implications for Ca2+-Regulation and 14-3-3 binding. J Mol Biol, doi: 10.1016/j.jmb.2014.03.004

• Rai, A., Fedorov, R. and Manstein, D. J. (2014) Expression, purification and crystallization of a dye-decolourizing peroxidase from Dictyostelium discoideum Acta Crystallogr Sect F Struct Biol Cryst Commun., doi: 10.1107/S2053230X14000545

• Radke, M. B., Taft, M. H., Stapel, B., Hilfiker-Kleiner, D., Preller, M., and Manstein, D. J. (2014) Small molecule-mediated Refolding and Activation of Myosin Motor Function eLife, doi: 10.7554/eLife.01603

• Führing J, Cramer JT, Routier FH, Lamerz A-C, Baruch P, Gerardy-Schahn R and Fedorov R. Catalytic mechanism and allosteric regulation of UDP-glucose pyrophosphorylase from Leishmania major. (2013) ACS Catalysis. 3:2976-2985.

• Führing J, Damerow S, Fedorov R, Schneider J, Münster-Kühnel AK, Gerardy-Schahn R. Octamerization is essential for enzymatic function of human UDP-glucose pyrophosphorylase. (2013) Glycobiology. 23(4):426-37.

• Preller, M., and Manstein, D.J. (2013) Myosin structure, allostery, and mechano-chemistry. Structure, doi: 10.1016/j.str.2013.09.015

• Münnich, S., and Manstein, D.J. (2013) Expression, purification, crystallization and preliminary X-ray crystallographic analysis of human myosin 1c in complex with calmodulin. Acta Crystallogr Sect F Struct Biol Cryst Commun., doi: 10.1107/S1744309113020988

• Müller, M., Mazur, A.J., Behrmann, E., Diensthuber, R.P., Radke, M.B., Qu, Z., Littwitz, C., Raunser, S., Schoenenberger, C.A., Manstein, D.J., Mannherz, H.G. (2012)
  Functional characterization of the human alpha-cardiac actin mutations Y166C and M305L involved in hypertrophic cardiomyopathy.
  Cell Mol Life Sci 69, 3457-79.
   
• Heissler, S.M., Selvadurai, J., Bond, L.M., Fedorov, R., Kendrick-Jones, J., Buss, F. and Manstein, D.J. (2012)
  Kinetic properties and small-molecule inhibition of human myosin-6.
  FEBS Lett. 2012 Sep 21;586(19):3208-14. doi: 10.1016/j.febslet.2012.07.014. Epub 2012 Jul 31.
   
• Heissler SM, Manstein DJ (2012)
  Functional characterization of the human myosin-7a motor domain.
  Cell Mol Life Sci. 69(2):299-311. doi: 10.1007/s00018-011-0749-8. Epub 2011 Jun 18.
   
• Behrmann E, Müller M, Penczek PA, Mannherz HG, Manstein DJ, Raunser S (2012)
  Structure of the Rigor Actin-Tropomyosin-Myosin Complex.
  Cell 150, 327-338
   
• Rai A, Nöthe H, Tzvetkov N, Korenbaum E, Manstein DJ (2011)
  Dictyostelium dynamin B modulates cytoskeletal structures and membranous organelles.
  Cell Mol Life Sci. 68(16):2751-67. doi: 10.1007/s00018-010-0590-5. Epub 2010 Nov 18
   
• Preller M, Chinthalapudi K, Martin R, Knölker H-J, Manstein DJ (2011)
  Inhibition of Myosin ATPase Activity by Halogenated Pseudilins: A Structure-Activity Study.
  J Med Chem. 54(11):3675-85. Epub 2011 May 13.
   
• Preller M, Bauer S, Adamek N, Fujita-Becker S, Fedorov R, Geeves MA, Manstein DJ (2011)
  Structural basis for the allosteric interference of myosin function by reactive thiol region mutations G680A and G680V.
  J Biol Chem. 2011 Oct 7;286(40):35051-60. Epub 2011 Aug 13.
   
• Polonais V, Javier Foth B, Chinthalapudi K, Marq JB, Manstein DJ, Soldati-Favre D, Frenal K (2011)
  Unusual anchor of a motor complex (MyoD-MLC2) to the plasma membrane of Toxoplasma gondii.
  Traffic. 2011 Mar;12(3):287-300. doi: 10.1111/j.1600-0854.2010.01148.x. Epub 2011 Jan 7.

• Naue N, Fedorov R, Pich A, Manstein DJ, Curth U (2011)
  Site-directed mutagenesis of the chi subunit of DNA polymerase III and single-stranded DNA-binding protein of E. coli reveals key residues for their interaction.
  Nucleic Acids Res. 2011 Mar;39(4):1398-407. Epub 2010 Oct 23.

• Heissler SM, Manstein DJ (2011)
  Comparative kinetic and functional characterization of the motor domains of human nonmuscle myosin-2C isoforms.
  J Biol Chem. 2011 Jun 17;286(24):21191-202. Epub 2011 Apr 8.

• Diensthuber RP, Muller M, Heissler SM, Taft MH, Chizhov I, Manstein DJ (2011)
  Phalloidin perturbs the interaction of human non-muscle myosin isoforms 2A and 2C1 with F-actin.
  FEBS Lett. 2011 Mar 9;585(5):767-71. Epub 2011 Feb 3.

• Chinthalapudi K, Taft MH, Martin R, Heissler SM, Preller M, Hartmann FK, Brandstaetter H, Kendrick-Jones J, Tsiavaliaris G, Gutzeit HO, Fedorov R, Buss F, Knölker H-J, Coluccio LM, Manstein DJ (2011)
  Mechanism and specificity of pentachloropseudilin-mediated inhibition of myosin motor activity.
  J Biol Chem. 2011 Aug 26;286(34):29700-8. Epub 2011 Jun 16.

• Al-Omari M, Korenbaum E, Ballmaier M, Lehmann U, Jonigk D, Manstein DJ, Welte T, Mahadeva R, Janciauskiene S (2011)
  The acute phase protein, alpha1-antitrypsin, inhibits neutrophil calpain I and induces random migration.
  Mol Med. 2011 Sep-Oct;17(9-10):865-74. doi: 10.2119/molmed.2011.00089. Epub 2011 Apr 11.

• Montessuit S, Somasekharan SP, Terrones O, Lucken-Ardjomande S, Herzig S, Schwarzenbacher R, Manstein DJ, Bossy-Wetzel E, Basanez G, Meda P, Martinou JC (2010)
  Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization.
  Cell. 2010 Sep 17;142(6):889-901.

• Amrute-Nayak, M., Diensthuber, R.P., Steffen, W., Kathmann, D., Hartmann, F.K., Fedorov, R., Urbanke, C., Manstein, D.J., Brenner, B. and Tsiavaliaris, G. (2010)
  Targeted optimization of a protein nanomachine for operation in biohybrid devices.
  Angew Chem Int Ed Engl. 49:312-6.

Martin, R., Jäger, A., Böhl, M., Richter, S., Fedorov, R., Manstein, D.J., Gutzeit, H.O. and Knölker, H.J. (2009)
Total synthesis of pentabromo- and pentachloropseudilin, and synthetic analogues--allosteric inhibitors of myosin ATPase.
Angew Chem Int Ed Engl. 48:8042-6.

Knoth, T., Warburg, K. ,Katzka, C. ,Rai, A. ,Wolf, A. Brockmeyer, A. Janning, P. Reubold, T.F., Eschenburg, S., Manstein, D.J. Hubel, K. Kaiser, M. and Waldmann, H. (2009)
The Ras Pathway Modulator Melophlin A Targets Dynamins.
Angew Chem Int Ed Engl. 48:7240-7245.

Fedorov, R., Böhl, M., Tsiavaliaris, G., Hartmann, F. K., Taft, M. H., Baruch, P., Brenner, B., Martin, R., Knölker, H.-J., Gutzeit, H. O., and Manstein, D. J. (2009).
Allosteric inhibition of myosin motor activity by pentabromopseudilin.
Nat. Struct. Mol. Biol., doi:10.1038/nsmb.1542 (pdf, 1 MB) E-Print (pdf, 2,5 MB)

Tsiavaliaris, G., Fujita-Becker, S., Dürrwang, U., Diensthuber, R. P., Geeves, M. A., and Manstein, D. J. (2008).
Mechanism, Regulation, and Functional Properties of Dictyostelium Myosin-1B.
J Biol Chem 283, 4520-4527. (Abstract) (pdf, 350 kB)

Taft, M. H., Hartmann, F. K., Rump, A., Keller, H., Chizhov, I., Manstein, D. J., and Tsiavaliaris, G. (2008).
Dictyostelium Myosin-5b is a conditional processive motor.
J Biol. Chem 283, 26902-26910. (Abstract) (pdf, 390 kB)

Stolboushkina, E., Nikonov, S., Nikulin, A., Blasi, U., Manstein, D. J., Fedorov, R., Garber, M., and Nikonov, O. (2008).
Crystal structure of the intact archaeal translation initiation factor 2 demonstrates very high conformational flexibility in the alpha- and beta-subunits.
J Mol. Biol. 382, 680-691. (Abstract) (pdf, 3.2 MB)

Nikonov, O., Stolboushkina, E., Nikulin, A., Hasenohrl, D., Blasi, U., Manstein, D. J., Fedorov, R., Garber, M., and Nikonov, S. (2007).
New insights into the interactions of the translation initiation factor 2 from archaea with guanine nucleotides and initiator tRNA.
J Mol Biol 373, 328-336. (Abstract) (pdf, 2.5 MB)

Hachikubo, Y., Ito, K., Schiefelbein, J., Manstein, D. J., and Yamamoto, K. (2007).
Enzymatic activity and motility of recombinant Arabidopsis myosin XI. MYA1
Plant Cell Physiol 48, 886-891. (Abstract) (pdf, 174 kB)

Fujita-Becker, S.,Tsiavaliaris, G., Ohkura, R., Shimada, T., Manstein, D.J., and Sutoh, K. (2006).
Functional characterization of the N-terminal region of myosin-2.
J Biol Chem 281, 36102-36109. (Abstract)(pdf)

Fedorov, R., Witte, G., Urbanke, C., Manstein, D.J., and Curth, U. (2006).
3D structure of Thermus aquaticus single-stranded DNA-binding protein gives insight into the functioning of SSB proteins.
Nucleic Acids Res 34, 6708-6717. (Abstract) (pdf 5.7 MB)

Ulrike Dürrwang, Setsuko Fujita-Becker, Muriel Erent, F. Jon Kull, Georgios Tsiavaliaris, Michael A. Geeves, and Dietmar J. Manstein (2006)
Dictyostelium myosin-IE is a fast molecular motor involved in phagocytosis
J. Cell Science 119, 550-558 (Abstract) (pdf)

Reubold, T. F., Eschenburg, S., Becker, A., Leonard, M., Schmid, S. L., Vallee, R. B., Kull, F. J. and Manstein, D. J. (2005)
Crystal structure of the GTPase domain of rat dynamin 1
Proc. Natl. Acad. Sci. U.S.A. 102, 13093-13098 (pdf)

Fujita-Becker, S., Dürrwang, U., Erent, M., Clark, R. J., Geeves, M. A. and Manstein, D. J. (2005)
Changes in Mg2+ ion concentration and heavy chain phosphorylation regulate the motor activity of a class I myosin
J. Biol. Chem. 280, 6064-6071 (pdf)

Van Dijk, J., Lafont, C., Knetsch, M. L., Derancourt, J., Manstein, D. J., Long, E. C. and Chaussepied, P. (2004)
Conformational changes in actin-myosin isoforms probed by Ni(II).Gly-Gly-His reactivity
J. Muscle Res. Cell Motil. 25, 527-537

Tsiavaliaris, G., Fujita-Becker, S. & Manstein, D.J. (2004)
Molecular engineering of a backwards moving myosin motor
Nature 427, 558-561 (Abstract)(pdf)

Schlosser, A., Klockow, B., Manstein, D.J., & Lehmann, W.D. (2003)
Analysis of post-translational modification and characterization of the domain structure of dynamin A from Dictyostelium discoideum.
J. Mass. Spectrom. 38 (3) 277-282 (Abstract)(pdf)

Reubold, T.F., Eschenburg, S., Becker, A., Kull, F.J. & Manstein, D.J. (2003)
A structural model for actin-induced nucleotide release in myosin
Nature Struct. Biol., 10, 826-830. (Abstract)(pdf)

Krylyshkina, O., Anderson, K.I., Kaverina, I., Upmann, I., Manstein, D.J., Small, J.V. & Toomre, D.K.
Nanometer targeting of microtubules to focal adhesions
J. Cell Biol., 161, 853-859. (Abstract)(pdf)

Ito K., Kashiyama T., Shimada K, Yamaguchi A., Awata J, Hachikubo Y., Manstein D.J., Yamamoto K. (2003)
Recombinant motor domain constructs of Chara corallina myosin display fast motility and high ATPase activity
Biochem. Biophys. Res. Commun. 312, 958-64. (Abstract) (pdf)

Ballweber, E., Kiessling, P., Manstein, D.J., & Mannherz, H.G. (2003)
Interaction of Myosin subfragment 1 with forms of monomeric actin
Biochemistry 42 (10) 3060-3069 (Abstract)

Tsiavaliaris, G., Fujita-Becker, S., Batra, R., Levitsky, D.I., Kull, F.J., Geeves, M.A. & Manstein, D.J. (2002)
Mutations in the relay loop region result in dominant-negative inhibition of myosin II function in Dictyostelium
EMBO Reports, 3, 1099-1105 (Abstract) (pdf)

Linke, W.A., Kulke, M., Li, H., Fujita-Becker S., Neagoe C., Manstein, D.J., Gautel, M., Fernandez, J.M. (2002)
PEVK Domain of Titin: An Entropic Spring with Actin-Binding Properties
J. Struct. Biol. 137, 194-205. (Abstract)

Kollmar, M. Dürrwang, U., Kliche, W., Manstein, D.J., & Kull, F.J. (2002)
Crystal structure of the motor domain of a class-I myosin
EMBO J. 21, 2517-25 (Abstract)

Knetsch, M.L.W., Tsiavaliaris, G., Zimmermann, S., Rühl, S., &. Manstein, D.J. (2002)
Expression vectors for studying cytoskeletal proteins in Dictyostelium discoideum
J. Mus. Res. Cell Motil. 23, 605-611 (Abstract)

Klockow, B., Tichelaar, W., Madden, D., Niemann, H.H., Akiba, T., Hirose, K., & Manstein, D.J. (2002)
The dynamin a ring complex: molecular organization and nucleotide-dependent conformational changes
EMBO J. 21, 240-250. (Abstract) (pdf, 500 kB)

Herm-Gotz, A., Weiss, S., Fujita-Becker, S., Ruff, C., Meyhöfer, E., Soldati, T., Manstein, D.J., Geeves, M.A., & Soldati, D. (2002)
Toxoplasma gondii class XIV myosin is a fast, single-headed, plus-end directed motor
EMBO J. 21, 2149-2158. (Abstract) (pdf, 400 kB)

Ruff, C., Furch, M., Brenner, B., Manstein, D.J. & Meyhöfer, E. (2001)
Single-molecule tracking of myosins with genetically engineered amplifier domains
Nature Struct. Biol., 8, 226-229. (Abstract) (pdf, 590 kB)

Niemann, H.H., Knetsch, M.L.W. Scherer, A., Manstein, D.J., & Kull, F.J. (2001)
Crystal structure of a dynamin GTPase domain
EMBO J., 21, 5813-5821. (Abstract) (pdf, 400 kB)

Kulke, M., Fujita-Becker, S., Rostkova, E., Neagoe, C., Labeit, D., Manstein, D.J., Gautel, M., & Linke, W.A. (2001)
Interaction between PEVK-titin and actin filaments: origin of a viscous force component in cardiac myofibrils
Circ. Res., 89, 874-881. (Abstract)

Knetsch, M.L.W., Schäfers, N., Horstmann, H. & Manstein, D. J. (2001)
A Bcr/Abr-related protein controls the organization of a tubolocisternal organelle, F-Actin dynamics, and cytokinesis in Dictyostelium
EMBO J., 20, 1620-1629. (Abstract) (pdf, 350 kB)

Kliche, W., Fujita-Becker, S., Kollmar, M., Manstein, D.J. & Kull, F.J. (2001)
Structure of a genetically engineered molecular motor
EMBO J., 20, 40-46. (Abstract)

Ponomarev, M.A., Furch, M., Levitsky, D.I. & Manstein, D.J. (2000)
Charge changes in loop 2 affect the thermal unfolding of the myosin motor domain bound to F-actin
Biochemistry, 39, 4527-4532. (Abstract) (pdf)

Furch, M., Remmel, B., Geeves, M.A. & Manstein, D.J. (2000)
Stabilization of the actomyosin complex by negative charges on myosin
Biochemistry 39, 11602-11608. (Abstract) (pdf)

Wienke, D.C., Knetsch, M.L.W., Neuhaus, E.M., Reedy, M.C. & Manstein, D.J. (1999)
Disruption of a dynamin homologue affects en­docytosis, organelle morphology and cytokinesis in Dictyostelium discoideum
Mol. Biol. Cell 10, 225-243. (Abstract) (pdf, 966 kB)

Van Dijk, J., Furch, M., Lafont, C., Manstein, D.J., & Chaussepied, P. (1999)
Functional characterization of the secondary actin binding site of myosin II
Biochemistry, 38, 15078-15085. (Abstract) (pdf, 160 kB)

Van Dijk, J., Furch, M., Derancourt, J., Batra, R., Knetsch, M.L.W., Manstein, D.J., & Chaussepied, P.(1999)
Differences in the interaction of actin with the motor domains of non-muscle and muscle myosin II
Europ. J. Biochem. 260, 672-683. (Abstract) (pdf, 844 kB)

Knetsch, M.L.W., Uyeda, T.Q.P., & Manstein, D.J. (1999)
Disturbed communication between actin- and nucleotide binding sites in a myosin II with truncated 50K/20K junction
J. Biol. Chem. 274, 20133-20138. (Abstract) (pdf, 122 kB)

Furch, M., Fujita-Becker, S., Geeves, M.A., Holmes, K.C. & Manstein, D.J. (1999)
Role of the salt-bridge between switch-1 and switch-2 of Dictyostelium myosin
J. Mol. Biol. 290, 797-809. (Abstract) (pdf, 330 kB)

Batra, R. & Manstein, D.J. (1999)
Functional characterisation of Dictyostelium myosin II with conserved tryptophanyl residue 501 mutated to tyrosine
Biol. Chem. 380, 1017-1023. (Abstract)

Batra, R., Geeves, M.A., &. Manstein, D.J. (1999)
Kinetic analysis of myosin motor domains with glycine-to-alanine mutations in the reactive thiol region
Biochemistry 38, 6126-6134 (Abstract) (pdf)

Levitsky, D.I., Ponomarev, M.A., Geeves, M.A., Shnyrov, V.L. & Manstein, D.J. (1998)
Differential scanning calorimetric study of the thermal unfolding of the motor domain fragments of Dictyostelium discoideum myosin II
Europ. J. Biochem. 251, 275-280. (Abstract) (pdf, 11 MB)

Furch, M., Geeves, M.A. & Manstein, D.J. (1998)
Modulation of actin affinity and actomyosin ATPase by charge changes in the myosin motor domain
Biochemistry 37, 6317-6326. (Abstract)

Friedman, A. L., Geeves, M. A., Manstein, D.J. & Spudich, J.A. (1998)
Kinetic Characterization of myosin head fragments with long-lived myosin.ATP states
Biochemistry 37, 9679-9687. (Abstract) (pdf)

Kurzawa, S.E., Manstein, D.J. & Geeves, M.A. (1997)
Dictyostelium discoideum myosin II: characterization of functional motor fragments
Biochemistry 36, 317-323. (Abstract) (pdf, 163 kB)

Anson, M. Geeves, M.A., Kurzawa, S. & Manstein, D.J. (1996)
Myosins with artificial lever arms
EMBO J. 15, 6069-6074. (Abstract) (pdf, 15 MB)

Woodward, S.K.A., Geeves, M.A. & Manstein, D.J. (1995)
Kinetic characterization of the catalytic domain of Dictyostelium discoideum myosin
Biochemistry 34, 16056-16064. (Abstract) (pdf, 15 MB)

Manstein, D.J. & Hunt, D.M. (1995)
Overexpression of myosin motor domains in Dictyostelium discoideum: Screening of transformants and pu­rification of the affinity tagged protein
J. Mus. Res. Cell Motil. 16, 325-332. (Abstract) (pdf, 13 MB)

Manstein, D.J., Schuster, H.-P., Morandini, P. & Hunt, D.M. (1995)
Cloning vectors for the production of proteins in Dictyostelium discoideum
Gene 162, 129-134. (Abstract) (pdf, 436 kB)

Schröder, R.R., Manstein, D.J., Jahn, W., Holden, H.M., Rayment, I., Holmes, K.C. & Spudich, J.A. (1993)
Three-dimensional atomic model of F-actin decorated with Dictyostelium myosin S1
Nature 364, 171-174. (Abstract) (pdf, 4.9 MB)

Ritchie, M.D., Geeves, M.A., Woodward, S.K.A. & Manstein, D.J. (1993)
Kinetic characterization of a cytoplasmic motor domain expressed in Dictyostelium discoideum
Proc. Natl. Acad. Sci. USA 90, 8619-8623. (Abstract) (pdf)

Manstein, D.J., Ruppel, K.M., Kubalek, L. & Spudich, J.A. (1991)
Manipulation and expression of molecular motors in Dictyostelium discoideum
J. Cell Science, 14s, 63-65. (Abstract)

Egelhoff, T.T., Manstein, D.J. & Spudich, J.A. (1990)
Complementation of myosin null mutants in Dictyostelium discoideum by direct functional selection
Develop. Biol. 137, 359-367. (Abstract)

Manstein, D.J., Titus, M.A., De Lozanne, A. & Spudich, J.A. (1989)
Gene replacement in Dictyostelium: generation of myosin null mutants
EMBO J. 8, 923-932. (Abstract)

Manstein, D.J., Ruppel, K.M. & Spudich, J.A. (1989)
Expression and cha­racterization of a functional myosin head fragment in Dictyostelium discoideum
Science 246, 656-658. (Abstract) (pdf, 5.6 MB)

Egelhoff, T.T., Brown, S.S., Manstein, D.J. & Spudich, J.A. (1989)
Hygromycin resistance as a selectable marker in Dictyostelium
Mol. Cell. Biol. 9, 1965-1968. (Abstract) (pdf,15 MB)

Manstein, D.J., Massey, V., Ghisla, S. & Pai, E.F., (1988)
Stereochemistry and accessibility of prosthetic groups in flavoproteins
Biochemistry 27, 2300-2305. (Abstract) (pdf, 17 MB)

Manstein, D.J., Pai, E.F., Schopfer, L.M., & Massey, V. (1986)
Absolute stereochemistry of flavins in enzyme catalyzed reactions
Biochemistry 25, 6807-6816. (Abstract)

Manstein, D.J. & Pai, E.F. (1986)
Purification and characterization of FAD synthetase from Brevibacterium ammoniagenes
J. Biol. Chem. 261, 16169-16973. (Abstract) (pdf, 9 MB)

Manstein, D.J., Berriman, J., Leonard, K. & Rosenbusch, J.P. (1986)
Ultrastructure of native lipoprotein from Escherichia coli envelopes
J. Mol. Biol. 189, 701-707. (Abstract) (pdf, 14 MB)

• Preller, M. and Manstein, D.J. (2012)
  4.8 Myosin Motors: Structural Aspects and Functionality.
  In Comprehensive Biophysics. (Editor-in-Chief: Edward, H.E., ed.), pp. 118-150. Elsevier, Amsterdam.

• Heissler, S.M. and Manstein, D.J. (2012).
  Nonmuscle myosin-2: mix and match.
  in Cell Mol Life Sci (Epub ahead of print), DOI: 10.1007/s00018-012-1002-9.

• Martin, R. et al. (2010)
  Biomolecular Chemistry Directed Towards Drug Development.
  in Med Chem Res 19, S23-S26.

Oiwa, K. and Manstein, D.J. (2007)
How linear motor proteins work
in Lecture Notes in Physics, 711, Controlled Nanoscale Motion – Nobel Symposium 131, H. Linke, A. Mansson (eds.) Springer, Berlin, Heidelberg, New York, pp. 41-59. (pdf, 880 kB)

Geeves, M.A., Fedorov, R. and Manstein, D.J. (2005)
Molecular mechanism of actomyosin-based motility.
in Cell Mol Life Sci 62, 1462-77. (pdf)

Manstein, D.J. (2004)
Molecular engineering of myosin.
in Philos Trans R Soc Lond B Biol Sci 359, 1907-12. (Abstract)

Toomre, D. & Manstein, D.J. (2001)
Lighting up the cell surface with evanescent wave microscopy
Trends Cell Biol., 11, 298-303. (Abstract) (pdf, 2.5 MB)

Manstein, D.J. (1993)
Myosin function in the motile behaviour of cells
in Cell Behaviour: Adhesion & Motility, Jones, G., Wigley, C., Warn, R. (eds.), The company of Biologists Limited, Cambridge UK, pp. 375-381. (pdf, 11 MB)

Forke, R., Gruner, K.K., Knott, K.E., Auschill, S., Agarwal, S., Martin, R.,Böhl, M., Richter, S., Tsiavaliaris, G., Fedorov, R., Manstein, D.J., Gutzeit, H.O. and Knölker, H.-J. (2010)
Total Synthesis of Biologically Active Alkaloids Using Transition Metals
Pure Appl. Chem. 82:1975-1991. (pdf 2MB)

Schröder, R.R., Manstein, D., Jahn, W., & Spudich, J.A. (1993)
Energy filtering and correction for the contrast transfer function (CTF) of frozen hydrated objects as illustrated by a reconstruction of Dictyostelium S1 decorated Actin
in Proc. 51st Annual Meeting of the Microscopy Society of America; Bailey, G.W. and Rieder C.L. (eds.), MSA, San Francisco Press, San Francisco, CA, pp. 118-119.

Egelhoff, T.T., Titus, M.A., Manstein, D.J., Ruppel, K.M. & Spudich, J.A. (1991)
Molecular genetic tools for the study of the cytoskeleton in Dictyostelium
Meth. Enzymol. 196, 319-334. (Abstract) (pdf, 14 MB)

Manstein, D.J., Massey, V. & Pai E.F. (1987)
Absolute stereochemistry of flavins
in Flavins & Flavoproteins, Edmondson, D.E., McCormick, D.B.(eds.) Walter de Gruyter & Co., Berlin, New York, pp. 3-12. (Abstract)

Manstein, D.J. & Pai, E.F. (1987)
Purification and characterization of the bifunctional enzyme FAD synthetase from Brevibacterium ammoniagenes
in Flavins & Flavoproteins, Edmondson, D.E., McCormick, D.B.(eds.) Walter de Gruyter & Co., Berlin, New York, pp. 455-458. (Abstract)