Ausgewählte Publikationen
2023
p38 MAPK /MK2 signaling stimulates host cells autophagy pathways to restrict Salmonella infection
Suwandi A, Menon MB, Kotlyarov A, Grassl GA & Gaestel M
Front. Immunol Volume 14 doi: 10.3389/fimmu.2023.1245443
5-Iodotubercidin sensitizes cells to RIPK1-dependent necroptosis by interfering with NFκB signaling
Chauhan C, Kraemer A, Knapp S, Windheim M, Kotlyarov A, Menon MB & Gaestel M
Cell Death Discov 9: 262
On the Therapeutic Potential of ERK4 in Triple-Negative Breast Cancer
Boudghene-Stambouli F, Soulez M, Ronkina N, Dörrie A, Kotlyarov A, Seternes O-M, Gaestel M & Meloche S
Cancers 15: 25
PRMT5-mediated regulatory arginine methylation of RIPK3
Chauhan C, Martinez-Val A, Niedenthal R, Olsen JV, Kotlyarov A, Bekker-Jensen S, Gaestel M & Menon MB
Cell Death Discov 9: 14
2022
MAPK-Activated Protein Kinases: Servant or Partner?
Ronkina N, Gaestel M.
Annu Rev Biochem. 2022 Feb 18. doi: 10.1146/annurev-biochem-081720-114505.
Menon MB, Yakovleva T, Ronkina N, Suwandi A, Odak I, Dhamija S, Sandrock I, Hansmann F, Baumgärtner W, Förster R, Kotlyarov A, Gaestel M.
Front Cell Dev Biol. 2022 Jan 6;9:795798. doi: 10.3389/fcell.2021.795798.
2021
Gaestel M, Nebreda AR, Yaffe MB.
N Engl J Med. 2021 Apr 22;384(16):e59. doi: 10.1056/NEJMc2036236. PMID: 33882214
MK2 degradation as a sensor of signal intensity that controls stress-induced cell fate.
Gutierrez-Prat N, Cubillos-Rojas M, Cánovas B, Kuzmanic A, Gupta J, Igea A, Llonch E, Gaestel M, Nebreda AR.
Proc Natl Acad Sci U S A. 2021 Jul 20;118(29):e2024562118.
2020
Shrestha A, Bruckmueller H, Kildalsen H, Kaur G, Gaestel M, Wetting HL, Mikkola I, Seternes OM.
Sci Rep. 2020 Jul 9;10(1):11388.
2019
The Role of TTP Phosphorylation in the Regulation of Inflammatory Cytokine Production by MK2/3
Ronkina N, Shushakova N, Tiedje C, Yakovleva T, Tollenaere MAX, Scott A, Batth TS, Olsen JV, Helmke A, Bekker-Jensen SH, Clark AR, Kotlyarov A, Gaestel M.
J Immunol. 2019 Oct 15;203(8):2291-2300. doi: 10.4049/jimmunol.1801221.
Germline deletion reveals a non-essential role of the atypical MAPK6/ERK3
Natalia Ronkina, Karin Schuster-Gossler, Florian Hansmann, Heike Kunze-Schumacher, Inga Sandrock, Tatiana Yakovleva, Juri Lafera, Wolfgang Baumgärtner, Andreas Krueger, Immo Prinz, Achim Gossler, Alexey Kotlyarov, Matthias Gaestel
bioRxiv 467597; doi: doi.org/10.1101/467597
Now published in Molecular and Cellular Biology doi: 10.1128/mcb.00516-18
Alternative translation initiation generates a functionally distinct isoform of the stress-activated kinase MK2
Philipp Trulley, Goda Snieckute, Dorte Bekker-Jensen, Manoj B. Menon, Robert Freund, Alexey Kotlyarov, Jesper V. Olsen, Manuel D. Diaz-Munoz, Martin Turner, Simon Bekker-Jensen, Matthias Gaestel, Christopher Tiedje
bioRxiv 429696; doi: doi.org/10.1101/429696
Now published in Cell Reports doi: 10.1016/j.celrep.2019.05.024
2018
MK2-TNF-Signaling Comes Full Circle
Menon MB, Gaestel M.
Trends Biochem Sci. 43, 158-167.
2017
p38 MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signaling in inflammation and infection
Menon MB*, Gropengießer J*, Fischer J, Novikova L, Deuretzbacher A, Lafera J, Schimmeck H, Czymmeck N, Ronkina N, Kotlyarov A, Aepfelbacher M, Gaestel M* & Ruckdeschel K* (2017)(* equal contribution)
Nat Cell Biol. 19:1248-59.