Leiden University Medical Centre

Principal Investigator: Prof. Christine Mummery / Valeria Orlova

Researchers: Milena Bellin, Leon Tertoolen

Postdocs: Luca Sala

PhD students: Oleh Halaidych, Xu Cao, Berend van Meer, Elisa Giacomelli

Areas of expertise

- Functional analysis of hPSC derived cardiomyocytes and vascular cells

- Cardiovascualr disease modelling

- Organs on chip technology

Main tasks

- Generation and characterisation of cardiac endothelial cells

- Generation of vascularised cardiac microtissues

Work Package 6

- hiPSC differentiation into cardiac ECs and PCs in suspension culture

- EC production from reporter lines for lineage tracing

- Scale up EC and PC production in stirred bioreactors at GMP standards

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