Publikationen
Dissertationen, Master- und Bachelorarbeiten
Link zu den Dissertationen, Master- und Bachelorarbeiten des Instituts
Originalpublikationen und Reviews (2019-2024)
2024
Airainer M, Seifert R. Lithium, the gold standard drug for bipolar disorder: analysis of current clinical studies. Naunyn Schmiedebergs Arch Pharmacol. 2024. doi: 10.1007/s00210-024-03210-8. Epub ahead of print.
Arning A, Seifert R. Insufficient correctness of package inserts for psychotropic drugs in Germany. Naunyn Schmiedebergs Arch Pharmacol. 2024 Sep 20. doi: 10.1007/s00210-024-03430-y. Epub ahead of print.
Barlage L, Seifert R. Insufficient compliance of the German Therapeutic Products Advertising Act in product catalogues of online pharmacies. Naunyn Schmiedebergs Arch Pharmacol. 2024 Aug 29. doi: 10.1007/s00210-024-03370-7. Epub ahead of print. PMID: 39207596.
Basol ME, Seifert R. Bibliometric analysis of Naunyn-Schmiedeberg's Archives of Pharmacology (1947-1974). Naunyn Schmiedebergs Arch Pharmacol. 2024. doi: 10.1007/s00210-024-03078-8. Epub ahead of print.
Basol ME, Seifert R. The Cold War in pharmacology: a bibliometric analysis of Berlin's contributions to Naunyn‑Schmiedeberg's Archives of Pharmacology (1947-1974). Naunyn Schmiedebergs Arch Pharmacol. 2024 May 17. doi: 10.1007/s00210-024-03115-6. Epub ahead of print.
Bindel LJ, Seifert R. Costs are a major driver of antibacterial drug prescriptions in Germany: market analysis from 1985 to 2022. Naunyn Schmiedebergs Arch Pharmacol. 2024 Jun 6. doi: 10.1007/s00210-024-03171-y. Epub ahead of print.
Bindel LJ, Seifert R. DDD-costs have a strong influence on antibacterial drug prescription in Germany: a differentiated correlation analysis from 1985 to 2022. Naunyn Schmiedebergs Arch Pharmacol. 2024 Jul 23. doi: 10.1007/s00210-024-03288-0. Epub ahead of print.
Bindel LJ, Seifert R. Daily defined dose-costs have a stronger influence on antibacterial drug prescriptions in Germany than bacterial resistance: economic factors are more important than scientific evidence. Naunyn Schmiedebergs Arch Pharmacol. 2024 doi: 10.1007/s00210-024-03435-7. Epub ahead of print.
Böger LS, Seifert R. Pharmacological articles in the German magazine DIE ZEIT (THE TIME)-content, adequacy, and comprehensibility. Naunyn Schmiedebergs Arch Pharmacol. 2024 Mar 25. doi: 10.1007/s00210-024-03053-3. Epub ahead of print
Bünemann S, Seifert R. Bibliometric comparison of Nobel Prize laureates in physiology or medicine and chemistry. Naunyn Schmiedebergs Arch Pharmacol. 2024 Apr 23. doi: 10.1007/s00210-024-03081-z. Epub ahead of print.
Fox LC, Seifert R. Arbitrariness of bibliometric parameters: a case study on leading scientists in the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT). Naunyn Schmiedebergs Arch Pharmacol. 2024 Jun 12. doi: 10.1007/s00210-024-03195-4. Epub ahead of print.
Freibüchler A, Seifert R. Analysis of clinical studies on clozapine from 2012-2022. Naunyn Schmiedebergs Arch Pharmacol. 2024. doi: 10.1007/s00210-024-03209-1. Epub ahead of print.
Gerke L, Seifert R. Lead and arsenic intoxications by traditional and alternative medicine: men are more sensitive than women. Naunyn Schmiedebergs Arch Pharmacol. 2024 doi: 10.1007/s00210-024-03317-y. Epub ahead of print.
Keuper L, Seifert R. Drug advertising in the German free-of-charge health magazine Apotheken Umschau (Pharmacy review): a critical analysis. Naunyn Schmiedebergs Arch Pharmacol. 2024; 397: 2145-2157. doi: 10.1007/s00210-023-02744-7.
Khosravi MA, Seifert R. Clinical trials on curcumin in relation to its bioavailability and effect on malignant diseases: critical analysis. Naunyn Schmiedebergs Arch Pharmacol. 2024; 397: 3477-3491. doi: 10.1007/s00210-023-02825-7.
Kuschel K, Seifert R. Advertisements for prescription-free drugs and dietary supplements in the Deutsche Apotheker Zeitung (German Pharmacist Journal). Naunyn Schmiedebergs Arch Pharmacol. 2024. doi: 10.1007/s00210-024-03401-3. Epub ahead of print.
Leemhuis H, Seifert R. Prescriptions of homeopathic remedies at the expense of the German statutory health insurance from 1985 to 2021: scientific, legal and pharmacoeconomic analysis. Naunyn Schmiedebergs Arch Pharmacol. 2024; 397: 6135-6152,doi: 10.1007/s00210-024-03005-x.
Ludwig L, Seifert R. How does pharmacological and toxicological knowledge evolve? A case study on hydrogen cyanide in German pharmacology and toxicology textbooks from 1878 to 2020. Naunyn Schmiedebergs Arch Pharmacol. 2024 Jun 20. doi: 10.1007/s00210-024-03227-z. Epub ahead of print.
Misera N, Seifert R. Presentation of the obsolete drug reserpine in three German-language pharmacology textbooks. Naunyn Schmiedebergs Arch Pharmacol. 2024; 397:4381-4401, doi: 10.1007/s00210-023-02877-9.
Möller IH, Seifert R. Presentation of pharmacological content in crime novels between 1890 and 2023. Naunyn Schmiedebergs Arch Pharmacol. 2024 Apr 21. doi: 10.1007/s00210-024-03103-w. Epub ahead of print.
Obst CS, Seifert R. Updated analysis of the prescription and evaluation of protein kinase inhibitors for oncology in Germany. Naunyn Schmiedebergs Arch Pharmacol. 2024 Aug 23. doi: 10.1007/s00210-024-03377-0. Epub ahead of print. PMID: 39177786.
Rathmann AM, Seifert R. Vitamin A-containing dietary supplements from German and US online pharmacies: market and risk assessment. Naunyn Schmiedebergs Arch Pharmacol. 2024 Mar 28. doi: 10.1007/s00210-024-03050-6. Epub ahead of print.
Seifert R, Schirmer B, Seifert J. How pharmacology can aid in the diagnosis of mental disorders. Naunyn Schmiedebergs Arch Pharmacol. 2024 Sep 4. doi: 10.1007/s00210-024-03413-z. Epub ahead of print. PMID: 39230588.
Specht T, Seifert R. Repurposing of H1-receptor antagonists (levo)cetirizine, (des)loratadine, and fexofenadine as a case study for systematic analysis of trials on clinicaltrials.gov using semi-automated processes with custom-coded software. Naunyn Schmiedebergs Arch Pharmacol. 2024; 397: 2995-3018. doi: 10.1007/s00210-023-02796-9.
Trabert M, Seifert R. Critical analysis of ginkgo preparations: comparison of approved drugs and dietary supplements marketed in Germany. Naunyn Schmiedebergs Arch Pharmacol. 2024; 397:451-461.; doi: 10.1007/s00210-023-02602-6.
Wittau J, Celik S, Kacprowski T, Deserno TM, Seifert R. Fake paper identification in the pool of withdrawn and rejected manuscripts submitted to Naunyn-Schmiedeberg's Archives of Pharmacology. Naunyn Schmiedebergs Arch Pharmacol. 2024; 397: 2171-2181 doi: 10.1007/s00210-023-02741-w.
Wittau J, Seifert R. Metadata analysis of retracted fake papers in Naunyn-Schmiedeberg's Archives of Pharmacology. Naunyn Schmiedebergs Arch Pharmacol. 2024; 397:3995-4011. doi: 10.1007/s00210-023-02850-6. Epub ahead of print.
Wittau J, Seifert R. How to fight fake papers: a review on important information sources and steps towards solution of the problem. Naunyn Schmiedebergs Arch Pharmacol. 2024 Jul 6. doi: 10.1007/s00210-024-03272-8. Epub ahead of print.
Zöllner H, Seifert R. How do German pharmacologists publish in the non-peer-reviewed science magazine Biospektrum? Naunyn Schmiedebergs Arch Pharmacol. 2024; 397:1889-1900. doi: 10.1007/s00210-023-02740-x.
2023
Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA, Annett S, Boison D, Burns KE, Dessauer C, Gertsch J, Helsby NA, Izzo AA, Ostrom R, Papapetropoulos A, Pyne NJ, Pyne S, Robson T, Seifert R, Stasch JP, Szabo C, van der Stelt M, van der Vliet A, Watts V, Wong SS. The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 2023 Oct;180 Suppl 2:S289-S373. doi: 10.1111/bph.16181.
Arning A, Seifert R. Computer-Assisted Analysis of the Intelligibility of Package Inserts. Dtsch Arztebl Int. 2023; 120: 601-602. doi: 10.3238/arztebl.m2023.0153.
Borchert M, Seifert R. Systematic analysis of the pharmacological content of the Tatort (scene of crime) TV series from 2019 to 2021. Naunyn Schmiedebergs Arch Pharmacol. 2023; 96:1957-1975, doi: 10.1007/s00210-023-02427-3.
Covaleda-Cortés G, Mechaly A, Brissac T, Baehre H, Devaux L, England P, Raynal B, Hoos S, Gominet M, Firon A, Trieu-Cuot P, Kaminski PA. The c-di-AMP-binding protein CbpB modulates the level of ppGpp alarmone in Streptococcus agalactiae. FEBS J. 2023; 290: 2968-2992, doi: 10.1111/febs.16724.
Dats LB, von Haugwitz F, Seifert R. Bibliometric development of Naunyn-Schmiedeberg's Archives of Pharmacology. Naunyn Schmiedebergs Arch Pharmacol 2023; 396: 43-61, doi: 10.1007/s00210-022-02307-2.
Dats LB, von Haugwitz F, Seifert R. Correction to: Bibliometric development of Naunyn-Schmiedeberg's Archives of Pharmacology. Naunyn Schmiedebergs Arch Pharmacol 2023; 396: 171, doi: 10.1007/s00210-022-02335-y.
Hattori Y, Seifert R. Reflections on the 150th anniversary of Naunyn-Schmiedeberg's Archives of Pharmacology: past, challenges, and future. Naunyn Schmiedebergs Arch Pharmacol. 2023; 396:1-3. doi: 10.1007/s00210-022-02321-4.
Obst CS, Seifert R. Critical analysis of the prescription and evaluation of protein kinase inhibitors for oncology in Germany. Naunyn Schmiedebergs Arch Pharmacol. 2023; 96:2529-2543; doi: 10.1007/s00210-023-02475-9.
Philippu A, Seifert R. History of pharmacology: 1 - The Department of Pharmacology of the University of Tartu (Dorpat): genealogy and biographies. Naunyn Schmiedebergs Arch Pharmacol 2023; 396: 5-17, doi: 10.1007/s00210-022-02328-x.
Philippu A, Seifert R. History of pharmacology: 2 - The Institute of Pharmacology of the University of Strasbourg: genealogy and biographies. Naunyn Schmiedebergs Arch Pharmacol 2023; 396:19-33; doi: 10.1007/s00210-022-02336-x.
Schrammel JC, König M, Frommer M, Andersen KS, Kirsten M, Seifert R, Neumann D, Schirmer B. Histamine H1- and H4-receptor expression in human colon-derived cell lines. Naunyn Schmiedebergs Arch Pharmacol 2023; 396:3683-3693. doi: 10.1007/s00210-023-02565-8.
Seifert R, Bugert JJ. cCMP and cUMP phosphodiesterases in viral infections. Trends Biochem Sci 2023; 48: 835-838. doi: 10.1016/j.tibs.2023.05.013.
2022
Bense S, Witte J, Preuße M, Koska M, Pezoldt L, Dröge A, Hartmann O, Müsken M, Schulze J, Fiebig T, Bähre H, Felgner S, Pich A, Häussler S. Pseudomonas aeruginosa post-translational responses to elevated c-di-GMP levels. Mol Microbiol 2022; 117:1213-1226. doi: 10.1111/mmi.14902.
Chen F, Elgaher WAM, Winterhoff M, Büssow K, Waqas FH, Graner E, Pires-Afonso Y, Casares Perez L, de la Vega L, Sahini N, Czichon L, Zobl W, Zillinger T, Shehata M, Pleschka S, Bähre H, Falk C, Michelucci A, Schuchardt S, Blankenfeldt W, Hirsch AKH, Pessler F. Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism. Nat Metab 2022; 4: 534-546. doi: 10.1038/s42255-022-00577-x.
Cohen H, Adani B, Cohen E, Piscon B, Azriel S, Desai P, Bähre H, McClelland M, Rahav G, Gal-Mor O. The ancestral stringent response potentiator, DksA has been adapted throughout Salmonella evolution to orchestrate the expression of metabolic, motility, and virulence pathways. Gut Microbes 2022; 14:1997294. doi: 10.1080/19490976.2021.1997294.
Ding J, Schuergers N, Baehre H, Wilde A. Enzymatic properties of CARF-domain proteins in Synechocystis sp. PCC 6803. Front Microbiol. 2022 Nov 7;13:1046388. doi: 10.3389/fmicb.2022.1046388.
Ellerbeck R, Seifert R. Poisoning cases in the German crime series Tatort (crime scene) from 1974 to 2022. Naunyn Schmiedebergs Arch Pharmacol. 2022; 395:1419-1440. doi: 10.1007/s00210-022-02281-9.
Gruenwald M, Chen F, Bähre H, Pessler F. Itaconate Isomers in Bread. Antioxidants (Basel) 2022; 11: 1382. doi: 10.3390/antiox11071382.
Kaya-Zeeb S, Engelmayer L, Straßburger M, Bayer J, Bähre H, Seifert R, Scherf-Clavel O, Thamm M. Octopamine drives honeybee thermogenesis. Elife 2022; 11:e74334. doi: 10.7554/eLife.74334.
Kircher B, Woltemate S, Gutzki F, Schlüter D, Geffers R, Bähre H, Vital M. Predicting butyrate- and propionate-forming bacteria of gut microbiota from sequencing data. Gut Microbes 2022; 14: 2149019. doi: 10.1080/19490976.2022.2149019.
Koska M, Kordes A, Erdmann J, Willger SD, Thöming JG, Bähre H, Häussler S. Distinct Long- and Short-Term Adaptive Mechanisms in Pseudomonas aeruginosa. Microbiol Spectr 2022; 10: e0304322; doi: 10.1128/spectrum.03043-22.
Li F, Cao L, Bähre H, Kim SK, Schroeder K, Jonas K, Koonce K, Mekonnen SA, Mohanty S, Bai F, Brauner A, Lee VT, Rohde M, Römling U. Patatin-like phospholipase CapV in Escherichia coli - morphological and physiological effects of one amino acid substitution. NPJ Biofilms Microbiomes 2022; 8: 39. doi: 10.1038/s41522-022-00294-z.
Mederacke I, Filliol A, Affo S, Nair A, Hernandez C, Sun Q, Hamberger F, Brundu F, Chen Y, Ravichandra A, Huebener P, Anke H, Shi H, Martínez García de la Torre RA, Smith JR, Henderson NC, Vondran FWR, Rothlin CV, Baehre H, Tabas I, Sancho-Bru P, Schwabe RF. The purinergic P2Y14 receptor links hepatocyte death to hepatic stellate cell activation and fibrogenesis in the liver. Sci Transl Med 2022; 14: eabe5795. doi: 10.1126/scitranslmed.abe5795.
Moradali MF, Ghods S, Bähre H, Lamont RJ, Scott DA, Seifert R. Atypical cyclic di-AMP signaling is essential for Porphyromonas gingivalis growth and regulation of cell envelope homeostasis and virulence. NPJ Biofilms Microbiomes. 2022; 8: 53. doi: 10.1038/s41522-022-00316-w.
Nakane D, Enomoto G, Bähre H, Hirose Y, Wilde A, Nishizaka T. Thermosynechococcus switches the direction of phototaxis by a c-di-GMP-dependent process with high spatial resolution. Elife 2022; 11: e73405. doi: 10.7554/eLife.73405.
Naasner L, Froese N, Hofmann W, Galuppo P, Werlein C, Shymotiuk I, Szaroszyk M, Erschow S, Amanakis G, Bähre H, Kühnel MP, Jonigk DD, Geffers R, Seifert R, Ricke-Hoch M, Wende AR, Blaner WS, Abel ED, Bauersachs J, Riehle C. Vitamin A preserves cardiac energetic gene expression in a murine model of diet-induced obesity. Am J Physiol Heart Circ Physiol 2022; 323: H1352-H1364. doi: 10.1152/ajpheart.00514.2022.
Oberkampf M, Hamiot A, Altamirano-Silva P, Bellés-Sancho P, Tremblay YDN, DiBenedetto N, Seifert R, Soutourina O, Bry L, Dupuy B, Peltier J. c-di-AMP signaling is required for bile salt resistance, osmotolerance, and long-term host colonization by Clostridioides difficile. Sci Signal 2022;15: eabn8171. doi: 10.1126/scisignal.abn8171.
Rick T, Kreiling V, Höing A, Fiedler S, Glatter T, Steinchen W, Hochberg G, Bähre H, Seifert R, Bange G, Knauer SK, Graumann PL, Thormann KM. GGDEF domain as spatial on-switch for a phosphodiesterase by interaction with landmark protein HubP. NPJ Biofilms Microbiomes. 2022; 8: 35. doi: 10.1038/s41522-022-00297-w.
Riehle C, Sieweke JT, Bakshi S, Ha CM, Junker Udesen NL, Møller-Helgestad OK, Froese N, Berg Ravn H, Bähre H, Geffers R, Seifert R, Møller JE, Wende AR, Bauersachs J, Schäfer A. miRNA-200b-A Potential Biomarker Identified in a Porcine Model of Cardiogenic Shock and Mechanical Unloading. Front Cardiovasc Med 2022; 9:881067. doi: 10.3389/fcvm.2022.881067.
Schirmer B, Giehl K, Kubatzky KF. Report of the 24th Meeting on Signal Transduction 2021. Int J Mol Sci 2022; 23: 2015. doi: 10.3390/ijms23042015.
Seifert R, Alexander S. Perspective article: A proposal for rational drug class terminology. Br J Pharmacol. 2022; 179(17):4311-4314. doi: 10.1111/bph.15916.
Seifert R, Schirmer B. cCMP and cUMP come into the spotlight, finally. Trends Biochem Sci 2022; 47: 461-463. doi: 10.1016/j.tibs.2021.12.008.
Sohail A, Iqbal AA, Sahini N, Chen F, Tantawy M, Waqas SFH, Winterhoff M, Ebensen T, Schultz K, Geffers R, Schughart K, Preusse M, Shehata M, Bähre H, Pils MC, Guzman CA, Mostafa A, Pleschka S, Falk C, Michelucci A, Pessler F. Correction: Itaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection. PLoS Pathog 2022; 18:e1011002. doi: 10.1371/journal.ppat.1011002. Erratum for: PLoS Pathog. 2022; 18: e1010219.
Sohail A, Iqbal AA, Sahini N, Chen F, Tantawy M, Waqas F, Winterhoff M, Ebensen T, Schultz K, Geffers R, Schughart K, Preusse M, Shehata M, Bähre H, Pils MC, Guzman CA, Mostafa A, Pleschka S, Falk C, Michelucci A, Pessler F. Itaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection. PLoS Pathog 2022; 18: e1010219. doi: 10.1371/journal.ppat.1010219.
Tantawy E, Schwermann N, Ostermeier T, Garbe A, Bähre H, Vital M, Winstel V. Staphylococcus aureus Multiplexes Death-Effector Deoxyribonucleosides to Neutralize Phagocytes. Front Immunol. 2022; 13:847171.
doi: 10.3389/fimmu.2022.847171.
Zehetbauer R, von Haugwitz F, Seifert R. Gender-specific analysis of the authors and the editorial board of Naunyn-Schmiedeberg's Archives of Pharmacology from 2000 to 2020. Naunyn Schmiedebergs Arch Pharmacol 2022; 395: 39-50. doi: 10.1007/s00210-021-02166-3
2021
Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Davies JA, Boison D, Burns KE, Dessauer C, Gertsch J, Helsby NA, Izzo AA, Koesling D, Ostrom R, Pyne NJ, Pyne S, Russwurm M, Seifert R, Stasch JP, van der Stelt M, van der Vliet A, Watts V, Wong SS. THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol 2021; 178 Suppl 1:S313-S411. doi: 10.1111/bph.15542.
Andersen JB, Hultqvist LD, Jansen CU, Jakobsen TH, Nilsson M, Rybtke M, Uhd J, Fritz BG, Seifert R, Berthelsen J, Nielsen TE, Qvortrup K, Givskov M, Tolker-Nielsen T. Identification of small molecules that interfere with c-di-GMP signaling and induce dispersal of Pseudomonas aeruginosa biofilms. NPJ Biofilms Microbiomes 2021; 7:59. doi: 10.1038/s41522-021-00225-4.
Braun F, Recalde A, Bähre H, Seifert R, Albers SV. Putative Nucleotide-Based Second Messengers in the Archaeal Model Organisms Haloferax volcanii and Sulfolobus acidocaldarius. Front Microbiol 2021; 12:779012. doi: 10.3389/fmicb.2021.779012.
Bünsow D, Tantawy E, Ostermeier T, Bähre H, Garbe A, Larsen J, Winstel V. Methicillin-resistant Staphylococcus pseudintermedius synthesizes deoxyadenosine to cause persistent infection. Virulence 2021; 12: 989-1002. doi: 10.1080/21505594.2021.1903691.
Cohen H, Adani B, Cohen E, Piscon B, Azriel S, Desai P, Bähre H, McClelland M, Rahav G, Gal-Mor O. The ancestral stringent response potentiator, DksA has been adapted throughout Salmonella evolution to orchestrate the expression of metabolic, motility, and virulence pathways. Gut Microbes. 2022; 14: 1997294. doi: 10.1080/19490976.2021.1997294.
Dorado-Morales P, Martínez I, Rivero-Buceta V, Díaz E, Bähre H, Lasa I, Solano C. Elevated c-di-GMP levels promote biofilm formation and biodesulfurization capacity of Rhodococcus erythropolis. Microb Biotechnol 2021; 14: 923-937. doi: 10.1111/1751-7915.13689.
Durán V, Grabski E, Hozsa C, Becker J, Yasar H, Monteiro JT, Costa B, Koller N, Lueder Y, Wiegmann B, Brandes G, Kaever V, Lehr CM, Lepenies B, Tampé R, Förster R, Bošnjak B, Furch M, Graalmann T, Kalinke U. Fucosylated lipid nanocarriers loaded with antibiotics efficiently inhibit mycobacterial propagation in human myeloid cells. J Control Release 2021; 334: 201-212. doi: 10.1016/j.jconrel.2021.04.012.
Fortuna A, Bähre H, Visca P, Rampioni G, Leoni L. The two Pseudomonas aeruginosa DksA stringent response proteins are largely interchangeable at the whole transcriptome level and in the control of virulence-related traits. Environ Microbiol 2021; 3: 5487-5504. doi: 10.1111/1462-2920.15693
Harloff M, Prüschenk S, Seifert R, Schlossmann J. Activation of soluble guanylyl cyclase signalling with cinaciguat improves impaired kidney function in diabetic mice. Br J Pharmacol 2022; 179: 2460-2475.. doi: 10.1111/bph.15425.
Krishnan SM, Nordlohne J, Dietz L, Vakalopoulos A, Haning P, Hartmann E, Seifert R, Hüser J, Mathar I, Sandner P. Assessing the Use of the sGC Stimulator BAY-747, as a Potential Treatment for Duchenne Muscular Dystrophy. Int J Mol Sci 2021; 22: 8016. doi: 10.3390/ijms22158016.
Krüger L, Herzberg C, Wicke D, Bähre H, Heidemann JL, Dickmanns J, Schmitt K, Ficner R, Stülke J.. A meet-up of two second messengers: the c-di-AMP receptor DarB controls (p)ppGpp synthesis in Bacillus subtilis. Nat Commun. 2021; 12: 1210.
Neumann J, Grobe JM, Weisgut J, Schwelberger HG, Fogel WA, Marušáková M, Wache H, Bähre H, Buchwalow IB, Dhein S, Hofmann B, Kirchhefer U, Gergs U. Histamine can be Formed and Degraded in the Human and Mouse Heart. Front Pharmacol. 2021; 12: 582916. doi: 10.3389/fphar.2021.582916.
Neumann D, Seifert R. Probiotics in Naunyn-Schmiedeberg's Archives of Pharmacology. Naunyn Schmiedebergs Arch Pharmacol 2021; 394:1595-1597. doi: 10.1007/s00210-021-02110-5.
Oeser S, Wallner T, Nils S, Bučinská L, Sivabalasarma S, Bähre H, Albers SV, Wilde A. Minor pilins are involved in motility and natural competence of the cyanobacterium Synechocystis sp. PCC 6803. Mol Microbiol 2021; 116: 743-765. doi: 10.1111/mmi.14768.
Ostrom KF, LaVigne JE, Brust TF, Seifert R, Dessauer CW, Watts VJ, Ostrom RS. Physiological Roles of Mammalian Transmembrane Adenylyl Cyclase Isoforms. Physiol Rev 2022; 102: 815-857.
DOI: 10.1152/physrev.00013.2021. DOI: 10.1152/physrev.00013.2021
Perduns R, Volk J, Plum M, Jochums A, Gutzki F, Kaever V, Geurtsen W. Camphorquinone alters the expression of extracellular proteases in a 3D co-culture model of the oral mucosa. Dent Mater 2021; 37: 236-248. doi: 10.1016/j.dental.2020.11.005.
Ring J, Beyer K, Biedermann T, Bircher A, Fischer M, Fuchs T, Heller A, Hoffmann F, Huttegger I, Jakob T, Klimek L, Kopp MV, Kugler C, Lange L, Pfaar O, Rietschel E, Rueff F, Schnadt S, Seifert R, Stöcker B, Treudler R, Vogelberg C, Werfel T, Worm M, Sitter H, Brockow K. Guideline (S2k) on acute therapy and management of anaphylaxis: 2021 update: S2k-Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the Medical Association of German Allergologists (AeDA), the Society of Pediatric Allergology and Environmental Medicine (GPA), the German Academy of Allergology and Environmental Medicine (DAAU), the German Professional Association of Pediatricians (BVKJ), the Society for Neonatology and Pediatric Intensive Care (GNPI), the German Society of Dermatology (DDG), the Austrian Society for Allergology and Immunology (ÖGAI), the Swiss Society for Allergy and Immunology (SGAI), the German Society of Anaesthesiology and Intensive Care Medicine (DGAI), the German Society of Pharmacology (DGP), the German Respiratory Society (DGP), the patient organization German Allergy and Asthma Association (DAAB), the German Working Group of Anaphylaxis Training and Education (AGATE). Allergo J Int 2021; 30:20-49. doi: 10.1007/s15007-020-4750-0.
Ring J, Beyer K, Biedermann T, Bircher A, Fischer M, Fuchs T, Heller A, Hoffmann F, Huttegger I, Jakob T, Klimek L, Kopp MV, Kugler C, Lange L, Pfaar O, Rietschel E, Rueff F, Schnadt S, Seifert R, Stöcker B, Treudler R, Vogelberg C, Werfel T, Worm M, Sitter H, Brockow K. Guideline (S2k) on acute therapy and management of anaphylaxis: 2021 update: S2k-Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the Medical Association of German Allergologists (AeDA), the Society of Pediatric Allergology and Environmental Medicine (GPA), the German Academy of Allergology and Environmental Medicine (DAAU), the German Professional Association of Pediatricians (BVKJ), the Society for Neonatology and Pediatric Intensive Care (GNPI), the German Society of Dermatology (DDG), the Austrian Society for Allergology and Immunology (ÖGAI), the Swiss Society for Allergy and Immunology (SGAI), the German Society of Anaesthesiology and Intensive Care Medicine (DGAI), the German Society of Pharmacology (DGP), the German Respiratory Society (DGP), the patient organization German Allergy and Asthma Association (DAAB), the German Working Group of Anaphylaxis Training and Education (AGATE). Allergo J Int. 30:1-25 (2021)
Ring J, Beyer K, Biedermann T, Bircher A, Fischer M, Fuchs T, Heller A, Hoffmann F, Huttegger I, Jakob T, Klimek L, Kopp MV, Kugler C, Lange L, Pfaar O, Rietschel E, Rueff F, Schnadt S, Seifert R, Stöcker B, Treudler R, Vogelberg C, Werfel T, Worm M, Sitter H, Brockow K. Messages for patients and relatives from the 2021 update of the guideline on acute therapy and management of anaphylaxis. Allergo J Int 2021 Sep 27:1-6. doi: 10.1007/s40629-021-00185-3.
Ring J, Beyer K, Bircher A, Biedermann T, Fischer M, Fuchs T, Heller AR, Hoffmann F, Huttegger I, Jakob T, Klimek L, Kopp MV, Kugler C, Lange L, Pfaar O, Rietschel E, Ruëff F, Schnadt S, Seifert R, Stöcker B, Treudler R, Vogelberg C, Werfel T, Worm M, Sitter H, Brockow K. Kurzfassung der Leitlinie "Akuttherapie und Management der Anaphylaxie - Update 2021" für Patienten und Angehörige. Allergo J. 2021; 30: 24-31. doi: 10.1007/s15007-021-4907-5.
Rodriguez-Garcia E, Zabaleta N, Gil-Farina I, Gonzalez-Aparicio M, Echeverz M, Bähre H, Solano C, Lasa I, Gonzalez-Aseguinolaza G, Hommel M. AdrA as a Potential Immunomodulatory Candidate for STING-Mediated Antiviral Therapy That Required Both Type I IFN and TNF-α Production. J Immunol 2021; 206: 376-385. doi: 10.4049/jimmunol.2000953.
Sabel BA, Seifert R. How criminal science publishing gangs damage the genesis of knowledge and technology-a call to action to restore trust. Naunyn Schmiedebergs Arch Pharmacol 2021; 394: 2147-2151. doi: 10.1007/s00210-021-02158-3.
Schirmer B, Neumann D. The Function of the Histamine H4 Receptor in Inflammatory and Inflammation-Associated Diseases of the Gut. Int J Mol Sci 2021; 22: 6116. doi: 10.3390/ijms22116116.
Seifert R. How Naunyn-Schmiedeberg's Archives of Pharmacology deals with fraudulent papers from paper mills.
Naunyn-Schmiedeberg's Arch Pharmacol 2021; 394:431-436. doi: 10.1007/s00210-021-02056-8.
Seifert R, Schirmer B. Why Naunyn-Schmiedeberg's Archives of Pharmacology abandons traditional names of drug classes. Naunyn-Schmiedeberg's Arch Pharmacol 2021; 394:1321-1325. doi: 10.1007/s00210-021-02111-4.
Seifert R, Schirmer B. A case to stop the use of the term 'antibiotics'. Trends Microbiol 29: 963-966. doi: 10.1016/j.tim.2021.03.017.
Seifert R, Schirmer B. Problems associated with the use of the term “antibiotics”. Naunyn-Schmiedeberg's Arch Pharmacol 2021; 394: 2153-2166. doi.org/10.1007/s00210-021-02144-9.
Selim KA, Haffner M, Burkhardt M, Mantovani O, Neumann N, Albrecht R, Seifert R, Krüger L, Stülke J, Hartmann MD, Hagemann M, Forchhammer K. Diurnal metabolic control in cyanobacteria requires perception of second messenger signaling molecule c-di-AMP by the carbon control protein SbtB. Sci Adv. 2021; 7: eabk0568. doi: 10.1126/sciadv.abk0568.
Slavik KM, Morehouse BR, Ragucci AE, Zhou W, Ai X, Chen Y, Li L, Wei Z, Bähre H, König M, Seifert R, Lee ASY, Cai H, Imler JL, Kranzusch PJ. cGAS-like receptors sense RNA and control 3'2'-cGAMP signaling in Drosophila. Nature 2021; 597: 109-113. doi: 10.1038/s41586-021-03743-5.
Winterhoff M, Chen F, Sahini N, Ebensen T, Kuhn M, Kaever V, Bähre H, Pessler F. Establishment, Validation, and Initial Application of a Sensitive LC-MS/MS Assay for Quantification of the Naturally Occurring Isomers Itaconate, Mesaconate, and Citraconate. Metabolites 2021; 11: 270. doi: 10.3390/metabo11050270.
Worm M, Ring J, Klimek L, Jakob T, Lange L, Treudler R, Beyer K, Werfel T, Biedermann T, Bircher A, Fischer M, Fuchs T, Heller AR, Hoffmann F, Huttegger I, Kopp MV, Kugler C, Lommatzsch M, Pfaar O, Rietschel E, Ruëff F, Schnadt S, Seifert R, Stöcker B, Vogelberg C, Sitter H, Gieler U, Brockow K. Management des Anaphylaxie-Risikos bei Covid-19-Impfung. HNO Nachr 2021; 51:18-21. doi: 10.1007/s00060-021-7480-3.
Worm M, Ring J, Klimek L, Jakob T, Lange L, Treudler R, Beyer K, Werfel T, Biedermann T, Bircher A, Fischer M, Fuchs T, Heller AR, Hoffmann F, Huttegger I, Kopp MV, Kugler C, Lommatzsch M, Pfaar O, Rietschel E, Rueff F, Schnadt S, Seifert R, Stöcker B, Vogelberg C, Sitter H, Gieler U, Brockow K. Covid-19 vaccination and risk of anaphylaxis - Recommendations for practical management. MMW Fortschr Med 2021; 163:48-51
Zhu S, Stanslowsky N, Fernández-Trillo J, Mamo TM, Yu P, Kalmbach N, Ritter B, Eggenschwiler R, Ouwendijk WJD, Mzinza D, Tan L, Leffler A, Spohn M, Brown RJP, Kropp KA, Kaever V, Ha TC, Narayanan P, Grundhoff A, Förster R, Schambach A, Verjans GMGM, Schmidt M, Kispert A, Cantz T, Gomis A, Wegner F, Viejo-Borbolla A. Generation of hiPSC-derived low threshold mechanoreceptors containing axonal termini resembling bulbous sensory nerve endings and expressing Piezo1 and Piezo2. Stem Cell Res 2021; 56: 102535. doi: 10.1016/j.scr.2021.102535.
2020
Chaturvedi A, Goparaju R, Gupta C, Weder J, Klünemann T, Araujo Cruz MM, Kloos A, Goerlich K, Schottmann R, Othman B, Struys EA, Bähre H, Grote-Koska D, Brand K, Ganser A, Preller M, Heuser M. In vivo efficacy of mutant IDH1 inhibitor HMS-101 and structural resolution of distinct binding site. Leukemia 2020; 34: 416-426.
Costamagna D, Duelen R, Penna F, Neumann D, Costelli P, Sampaolesi M. Interleukin-4 administration improves muscle function, adult myogenesis, and lifespan of colon carcinoma-bearing mice. Cachexia Sarcopenia Muscle 2020; 11: 783-801.
de Araujo LS, Pessler K, Sühs KW, Novoselova N, Klawonn F, Kuhn M, Kaever V, Müller-Vahl K, Trebst C, Skripuletz T, Stangel M, Pessler F. Phosphatidylcholine PC ae C44:6 in cerebrospinal fluid is a sensitive biomarker for bacterial meningitis. J Transl Med 2020 18: 9.
Gibhardt J, Heidemann JL, Bremenkamp R, Rosenberg J, Seifert R, Kaever V, Ficner R, Commichau FM. An extracytoplasmic protein and a moonlighting enzyme modulate synthesis of c-di-AMP in Listeria monocytogenes. Environ Microbiol 2020; 22: 2771-2791
Latoscha A, Drexler DJ, Al-Bassam MM, Bandera AM, Kaever V, Findlay KC, Witte G, Tschowri N. c-di-AMP hydrolysis by the phosphodiesterase AtaC promotes differentiation of multicellular bacteria. Proc Natl Acad Sci U S A. 2020; 117:7392-7400.
Liu Y, Lee C, Li F, Trček J, Bähre H, Guo RT, Chen CC, Chernobrovkin A, Zubarev R, Römling U. A Cyclic di-GMP Network Is Present in Gram-Positive Streptococcus and Gram-Negative Proteus Species. ACS Infect Dis 2020; 6: 2672–2687.
Schäfer H, Beckert B, Frese CK, Steinchen W, Nuss AM, Beckstette M, Hantke I, Driller K, Sudzinová P, Krásný L, Kaever V, Dersch P, Bange G, Wilson DN, Turgay K. The alarmones (p)ppGpp are part of the heat shock response of Bacillus subtilis. PLoS Genet 2020; 16: e1008275
Schimmel K, Jung M, Foinquinos A, San José G, Beaumont J, Bock K, Grote-Levi L, Xiao K, Bär C, Pfanne A, Just A, Zimmer K, Ngoy S, López B, Ravassa S, Samolovac S, Janssen-Peters H, Remke J, Scherf K, Dangwal S, Piccoli MT, Kleemiss F, Kreutzer FP, Kenneweg F, Leonardy J, Hobuß L, Santer L, Do QT, Geffers R, Braesen JH, Schmitz J, Brandenberger C, Müller DN, Wilck N, Kaever V, Bähre H, Batkai S, Fiedler J, Alexander KM, Wertheim BM, Fisch S, Liao R, Diez J, González A, Thum T. Natural Compound Library Screening Identifies New Molecules for the Treatment of Cardiac Fibrosis and Diastolic Dysfunction. Circulation 2020; 141: 751-767.
Schirmer B., Neumann B. Cytokines. In: Nijkamp and Parnham's Principles of Immunopharmacology. Parnham, Michael J., Nijkamp, Frans P., Rossi, Adriano (Eds.). Springer International Publishing.
Schirmer B., Giehl, K., Kubatzky, K.F. Report of the 23rd Meeting on Signal Transduction 2019-Trends in Cancer and Infection. Int J Mol Sci 2020, 21: E2728.
Schirmer B, Lindemann L, Bittkau KS, Isaev R, Bösche D, Juchem M, Seifert R, Neumann D. Mouse Colonic Epithelial cells functionally express the histamine H4 receptor. J Pharmacol Exp Ther 2020; 373:167-174.
Schirmer B, Rother T, Bruesch I, Bleich A, Werlein C, Jonigk D, Seifert R, Neumann D. Genetic Deficiency of the Histamine H4-Receptor Reduces Experimental Colorectal Carcinogenesis in Mice. Cancers (Basel) 2020; 12: pii: E912.
Schneider EH, Hofmeister O, Kälble S, Seifert R. Apoptotic and anti-proliferative effect of guanosine and guanosine derivatives in HuT-78 T lymphoma cells. Naunyn Schmiedebergs Arch Pharmacol 2020; 393: 1251-1267
Seifert R, Schirmer B. A Simple Mechanistic Terminology of Psychoactive Drugs: A Proposal. Naunyn Schmiedebergs Arch Pharmacol 2020; 393: 1331-1339
Thibeaux R, Soupé-Gilbert ME, Kainiu M, Girault D, Bierque E, Fernandes J, Bähre H, Douyère A, Eskenazi N, Vinh J, Picardeau M, Goarant C. The Zoonotic Pathogen Leptospira Interrogans Mitigates Environmental Stress Through cyclic-di-GMP-controlled Biofilm Production. NPJ Biofilms Microbiomes 2020; 6: 24.
Thöming JG, Tomasch J, Preusse M, Koska M, Grahl N, Pohl S, Willger SD, Kaever V, Müsken M, Häussler S.
Parallel evolutionary paths to produce more than one Pseudomonas aeruginosa biofilm phenotype.
NPJ Biofilms Microbiomes. 2020; 6: 2.
Wallner T, Pedroza L, Voigt K, Kaever V, Wilde A. The cyanobacterial phytochrome 2 regulates the expression of motility-related genes through the second messenger cyclic di-GMP. Photochem Photobiol Sci 2020; 11:783-801
2019
Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C6, Davies JA; CGTP Collaborators (Beuve A, Boison D, Brouckaert P, Burnett JC, Burns K, Dessauer C, Friebe A, Garthwaite J, Gertsch J, Helsby N, Izzo AA, Koesling D, Kuhn M, Ostrom R, Papapetropoulos A, Potter LR, Pyne NJ, Pyne S, Russwurm M, Schmidt HH, Seifert R, Stasch JP, Szabo C, van der Stelt M, van der Vliet A, Watts V.) THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol 2019; 176: S297-S396.
Braun F, Thomalla L, van der Does C, Quax TEF, Allers T, Kaever V, Albers SV. Cyclic nucleotides in archaea: Cyclic di-AMP in the archaeon Haloferax volcanii and its putative role. Microbiologyopen 2019; e829.
Chen F, Lukat P, Iqbal AA, Saile K, Kaever V, van den Heuvel J, Blankenfeldt W, Büssow K, Pessler F. Crystal structure of cis-aconitate decarboxylase reveals the impact of naturally occurring human mutations on itaconate synthesis. Proc Natl Acad Sci U S A 2019; 116: 20644-20654
Grobe S, Doberenz S, Ferreira K, Krueger J, Brönstrup M, Kaever V, Häußler S. Identification and quantification of (t)RNA modifications in Pseudomonas aeruginosa by liquid chromatography-tandem mass spectrometry. Chembiochem 2019; 20: 1430-1437.
Koppenhöfer S, Wang H, Scharfe M, Kaever V, Wagner-Döbler I, Tomasch J. Integrated Transcriptional Regulatory Network of Quorum Sensing, Replication Control, and SOS Response in Dinoroseobacter shibae. Front Microbiol 2019; 10: 803.
Kordes A, Grahl N, Koska M, Preusse M, Arce-Rodriguez A, Abraham WR, Kaever V, Häussler S. Establishment of an induced memory response in Pseudomonas aeruginosa during infection of a eukaryotic host. ISME J 2019; 13: 2018-2030.
Kuhla B, Kaever V, Tuchscherer A, Kuhla A. Involvement of plasma endocannabinoids and the hypothalamic endocannabinoid system in increasing feed intake after parturition of dairy cows. Neuroendocrinology 2020, 110, 3-4, 246-257
Li F, Cimdins A, Rohde M, Jänsch L, Kaever V, Nimtz M, Römling U. DncV Synthesizes Cyclic GMP-AMP and Regulates Biofilm Formation and Motility in Escherichia coli ECOR31. MBio 2019; 10: pii: e02492-18.
Melzer C, Rehn V, Yang Y, Bähre H, von der Ohe J, Hass R. Taxol-Loaded MSC-Derived Exosomes Provide a Therapeutic Vehicle to Target Metastatic Breast Cancer and Other Carcinoma Cells. Cancers (Basel). 2019; 11: pii: E798.
Nicholls TJ, Spåhr H, Jiang S, Siira SJ, Koolmeister C, Sharma S, Kauppila JHK, Jiang M, Kaever V, Rackham O, Chabes A, Falkenberg M, Filipovska A, Larsson NG, Gustafsson CM. Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria. Mol Cell 2019; 76: 784-796
Perduns R, Volk J, Plum M, Gutzki F, Kaever V, Geurtsen W. Effects of HEMA on Nrf2-related gene expression using a newly developed 3D co-culture model of the oral mucosa. Dent Mater 2019; pii: S0109-5641.
Ratuszny D, Sühs KW, Novoselova N, Kuhn M, Kaever V, Skripuletz T, Pessler F, Stangel M. Identification of Cerebrospinal Fluid Metabolites as Biomarkers for Enterovirus Meningitis. Int J Mol Sci 2019; 20: pii: E337.
Rossmann FM, Rick T, Mrusek D, Sprankel L, Dörrich AK, Leonhard T, Bubendorfer S, Kaever V, Bange G, Thormann KM. The GGDEF domain of the phosphodiesterase PdeB in Shewanella putrefaciens mediates recruitment by the polar landmark protein HubP. J Bacteriol 2019; pii: JB.00534-18.
Sayner SL, Choi CS, Maulucci ME, Ramila, KC, Zhou C, Scruggs AK, Yarbrough T, Blair LAH, King JAC, Seifert R, Kaever V, Bauer NN. Extracellular vesicles: another compartment for the second messenger, cyclic adenosine monophosphate (cAMP). Am J Physiol Lung Cell Mol Physiol 2019; 316: L691-L700.
Schwabe U, Seifert R. Parkinsonmittelhandlung der multiplen Sklerose. In: Arzneiverordnungsreport 2019; Hrsg. Schwabe U, Paffrath, D, Ludwig WD, Klauber J; Springer-Verlag Deutschland.
Scharrenbroich J, Kaever V, Dove S, Seifert R, Schneider EH. Hydrolysis of the non-canonical cyclic nucleotide cUMP by PDE9A: kinetics and binding mode. Naunyn Schmiedebergs Arch Pharmacol 2019; 392: 199-208.
Schirmer B, Giehl K, Kubatzky KF. Report of the Signal Transduction Society Meeting 2018-Signaling: From Past to Future. Int J Mol Sci. 2019; 20: pii: E227.
Schneider EH. Microglial histamine H4R in the pathophysiology of Parkinson's disease-a new actor on the stage? Naunyn Schmiedebergs Arch Pharmacol; 392: 641-645
Seifert R. Basic Knowledge of Pharmacology. Springer International Publishing, 492 Seiten
Seifert R, Günther J, Berlit P. Pharmakologische Behandlung der multiplen Sklerose. In: Arzneiverordnungsreport 2019; Hrsg. Schwabe U, Paffrath, D, Ludwig WD, Klauber J; Springer-Verlag Deutschland.
Sperling L, Mulero Alegría MD, Kaever V, Curtis PD. Analysis of Brevundimonas subvibrioides developmental signaling systems reveals inconsistencies between phenotypes and c-di-GMP levels. J Bacteriol 2019; pii: JB.00447-19
Sühs KW, Novoselova N, Kuhn M, Seegers L, Kaever V, Müller-Vahl K, Trebst C, Skripuletz T, Stangel M, Pessler F. Kynurenine is a cerebrospinal fluid biomarker for bacterial and viral CNS infections. J Infect Dis 2019; 220: 127-138.
Wissig J, Grischin J, Bassler J, Schubert C, Friedrich T, Bähre H, Schultz JE, Unden G. CyaC, a redox-regulated adenylate cyclase of Sinorhizobium meliloti with a quinone responsive diheme-B membrane anchor domain. Mol Microbiol 2019; 112: 16-28.