2025

Wafai G, Seifert R. Drug advertisements in daily newspapers: a case study with the Hannoversche Allgemeine Zeitung (Hannover General Newspaper). Naunyn Schmiedebergs Arch Pharmacol. 2025 Mar 21. doi: 10.1007/s00210-025-04015-z. Epub ahead of print.

Halling T, Mambrey V, Steinert JM, Seifert R, Dreher A, Marazia C, Loerbroks A, Hansson N. The Gender Award Gap in German medical societies 2000-2023: the Fritz-Külz-Award as an example. Naunyn Schmiedebergs Arch Pharmacol. 2025 Mar 6. doi: 10.1007/s00210-025-03892-8. Epub ahead of print.

Bargsten FE, Seifert R. Devil's claw (Harpagophytum procumbens): is the buzz in Google justified? Naunyn Schmiedebergs Arch Pharmacol. 2025 Mar 5. doi: 10.1007/s00210-025-03974-7. Epub ahead of print.

Bindel LJ, Seifert R. Long-term forecasting and evaluation of medicine consumption for the ATC class H with a focus on thyroid hormones in OECD countries using ARIMA models. Naunyn Schmiedebergs Arch Pharmacol. 2025 Mar 3. doi: 10.1007/s00210-025-03930-5. Epub ahead of print.

Sedding D, Schmidt TM, Bähre H, Bavendiek U, Casas AI, Chen S, Thao-Vi Dao V, Elbatreek MH, Gutzki F, Hahn A, Kleikers P, Krahn T, Macchiusi C, Martin C, Mucke H, Nogales C, Schmidt BML, Seifert R, Sonnenschein K, Tongers J, Thol J, van der Arend I, van Kuijk SMJ, Wingler K, Wu M, Bauersachs J, McGrath B, Schmidt HHHW. Nutritional L-Citrulline and Tetrahydrobiopterin in Peripheral Artery Disease: A Phase II Randomized Trial (CIPER Study). JACC Adv. 2025 Feb 21;4(3):101590. doi: 10.1016/j.jacadv.2025.101590. Epub ahead of print.

Bindel LJ, Seifert R. Most European countries will miss EU targets on antibacterial use by 2030: historical analysis of European and OECD countries, comparison of community and hospital sectors and forecast to 2040. Naunyn Schmiedebergs Arch Pharmacol. 2025 Feb 17. doi: 10.1007/s00210-025-03887-5. Epub ahead of print.

Bindel LJ, Seifert R. Long-term forecast for antibacterial drug consumption in Germany using ARIMA models. Naunyn Schmiedebergs Arch Pharmacol. 2025 Jan 4. doi: 10.1007/s00210-024-03721-4. Epub ahead of print.

van Diest RA, Seifert R, van der Heyden MAG. An extra pair of eyes: adopting innovative approaches to detect integrity issues in Naunyn-Schmiedeberg's Archives of Pharmacology. Naunyn Schmiedebergs Arch Pharmacol. 2025 Jan 3. doi: 10.1007/s00210-024-03697-1. Epub ahead of print

2024

Airainer M, Seifert R. Lithium, the gold standard drug for bipolar disorder: analysis of current clinical studies. Naunyn Schmiedebergs Arch Pharmacol. 2024. doi: 10.1007/s00210-024-03210-8. Epub ahead of print.

Arning A, Seifert R. Insufficient correctness of package inserts for psychotropic drugs in Germany. Naunyn Schmiedebergs Arch Pharmacol. 2024 Sep 20. doi: 10.1007/s00210-024-03430-y. Epub ahead of print.

Barlage L, Seifert R. Insufficient compliance of the German Therapeutic Products Advertising Act in product catalogues of online pharmacies. Naunyn Schmiedebergs Arch Pharmacol. 2024 Aug 29. doi: 10.1007/s00210-024-03370-7. Epub ahead of print.

Barlage L, Seifert R. Substantial non-compliance of online pharmacy catalogues with guidelines. Naunyn Schmiedebergs Arch Pharmacol. 2024 Nov 12. doi: 10.1007/s00210-024-03571-0. Epub ahead of print.

Basol ME, Seifert R. Bibliometric analysis of Naunyn-Schmiedeberg's Archives of Pharmacology (1947-1974). Naunyn Schmiedebergs Arch Pharmacol. 2024. doi: 10.1007/s00210-024-03078-8. Epub ahead of print. 

Basol ME, Seifert R. The Cold War in pharmacology: a bibliometric analysis of Berlin's contributions to Naunyn‑Schmiedeberg's Archives of Pharmacology (1947-1974). Naunyn Schmiedebergs Arch Pharmacol. 2024 May 17. doi: 10.1007/s00210-024-03115-6. Epub ahead of print.

Benyó Z, Clementi E, Cremers S, Dávid B, Guzik T, Heusch G, Jarvis M, Orhan K, Seifert R, Tímár J, Ungvari Z, Ferdinandy P. Scientific integrity in the era of predatory journals: Insights from an editors in chief symposium. Br J Pharmacol. 2024 Aug;181(15):2387-2390. doi: 10.1111/bph.16480. Epub 2024 Jun 9.

Bindel LJ, Seifert R. Costs are a major driver of antibacterial drug prescriptions in Germany: market analysis from 1985 to 2022. Naunyn Schmiedebergs Arch Pharmacol. 2024 Jun 6. doi: 10.1007/s00210-024-03171-y. Epub ahead of print. 

Bindel LJ, Seifert R. DDD-costs have a strong influence on antibacterial drug prescription in Germany: a differentiated correlation analysis from 1985 to 2022. Naunyn Schmiedebergs Arch Pharmacol. 2024 Jul 23. doi: 10.1007/s00210-024-03288-0. Epub ahead of print.

Bindel LJ, Seifert R. Daily defined dose-costs have a stronger influence on antibacterial drug prescriptions in Germany than bacterial resistance: economic factors are more important than scientific evidence. Naunyn Schmiedebergs Arch Pharmacol. Sep 20. doi: 10.1007/s00210-024-03435-7. Epub ahead of print.

Bindel LJ, Seifert R. Development of bacterial resistance in Germany from 2008 to 2022 - major culprit pathogens, antibacterial drugs, and prescribing practices. Naunyn Schmiedebergs Arch Pharmacol. 2024 Oct 23. doi: 10.1007/s00210-024-03533-6. Online ahead of print.

Böger LS, Seifert R. Pharmacological articles in the German magazine DIE ZEIT (THE TIME)-content, adequacy, and comprehensibility. Naunyn Schmiedebergs Arch Pharmacol. 2024 Mar 25. doi: 10.1007/s00210-024-03053-3. Epub ahead of print

Bünemann S, Seifert R. Bibliometric comparison of Nobel Prize laureates in physiology or medicine and chemistry. Naunyn Schmiedebergs Arch Pharmacol. 2024 Apr 23. doi: 10.1007/s00210-024-03081-z. Epub ahead of print.

Cervoni M, Sposato D, Ferri G, Bähre H, Leoni L, Rampioni G, Visca P, Recchiuti A, Imperi F. The diadenosine tetraphosphate hydrolase ApaH contributes to Pseudomonas aeruginosa pathogenicity. PLoS Pathog. 2024 Aug 19;20(8):e1012486. doi: 10.1371/journal.ppat.1012486. eCollection 2024 Aug.

Fox LC, Seifert R. Arbitrariness of bibliometric parameters: a case study on leading scientists in the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT). Naunyn Schmiedebergs Arch Pharmacol. 2024 Jun 12. doi: 10.1007/s00210-024-03195-4. Epub ahead of print. 

Freibüchler A, Seifert R. Analysis of clinical studies on clozapine from 2012-2022. Naunyn Schmiedebergs Arch Pharmacol. 2024. doi: 10.1007/s00210-024-03209-1. Epub ahead of print. 

Gerke L, Seifert R. Lead and arsenic intoxications by traditional and alternative medicine: men are more sensitive than women. Naunyn Schmiedebergs Arch Pharmacol. 2024  doi: 10.1007/s00210-024-03317-y. Epub ahead of print. 

Glasenapp A, Bankstahl JP, Bähre H, Glage S, Bankstahl M. Subcutaneous and orally self-administered high-dose carprofen shows favorable pharmacokinetic and tolerability profiles in male and female C57BL/6J mice. Front Vet Sci. 2024 Sep 20;11:1430726. doi: 10.3389/fvets.2024.1430726. eCollection 2024.

Groß C, Seifert R. Critical analysis of Echinacea preparations marketed in Germany. Naunyn Schmiedebergs Arch Pharmacol. 2024 Nov 28. doi: 10.1007/s00210-024-03634-2. Epub ahead of print.

Hein L, Aktories K & Seifert R. Obituary: Klaus Starke (1937–2024). Naunyn-Schmiedeberg's Arch Pharmacol. 2024; 397: 2529–2530. doi.org/10.1007/s00210-024-03040-8.

Keuper L, Seifert R. Drug advertising in the German free-of-charge health magazine Apotheken Umschau (Pharmacy review): a critical analysis. Naunyn Schmiedebergs Arch Pharmacol. 2024; 397: 2145-2157. doi: 10.1007/s00210-023-02744-7. 

Khosravi MA, Seifert R. Clinical trials on curcumin in relation to its bioavailability and effect on malignant diseases: critical analysis. Naunyn Schmiedebergs Arch Pharmacol. 2024; 397: 3477-3491. doi: 10.1007/s00210-023-02825-7. 

Kuschel K, Seifert R. Advertisements for prescription-free drugs and dietary supplements in the Deutsche Apotheker Zeitung (German Pharmacist Journal). Naunyn Schmiedebergs Arch Pharmacol. 2024. doi: 10.1007/s00210-024-03401-3. Epub ahead of print.

Kyriazi D, Voth L, Bader A, Ewert W, Gerlach J, Elfrink K, Franz P, Tsap MI, Schirmer B, Damiano-Guercio J, Hartmann FK, Plenge M, Salari A, Schöttelndreier D, Strienke K, Bresch N, Salinas C, Gutzeit HO, Schaumann N, Hussein K, Bähre H, Brüsch I, Claus P, Neumann D, Taft MH, Shcherbata HR, Ngezahayo A, Bähler M, Amiri M, Knölker HJ, Preller M, Tsiavaliaris G.An allosteric inhibitor of RhoGAP class-IX myosins suppresses the metastatic features of cancer cells. Nat Commun. 2024 Nov 16;15(1):9947. doi: 10.1038/s41467-024-54181-6.

Leemhuis H, Seifert R. Prescriptions of homeopathic remedies at the expense of the German statutory health insurance from 1985 to 2021: scientific, legal and pharmacoeconomic analysis. Naunyn Schmiedebergs Arch Pharmacol. 2024; 397: 6135-6152,doi: 10.1007/s00210-024-03005-x. 

Ludwig L, Seifert R. How does pharmacological and toxicological knowledge evolve? A case study on hydrogen cyanide in German pharmacology and toxicology textbooks from 1878 to 2020. Naunyn Schmiedebergs Arch Pharmacol. 2024 Jun 20. doi: 10.1007/s00210-024-03227-z. Epub ahead of print.

Ludwig L, Seifert R. The decline in the clinical relevance of pilocarpine and physostigmine monitored in pharmacology textbooks from 1878 to 2023: nine take-home messages for future (pharmacology) textbook authors. Naunyn Schmiedebergs Arch Pharmacol. 2024 Nov 12. doi: 10.1007/s00210-024-03558-x. Epub ahead of print.

Misera N, Seifert R. Presentation of the obsolete drug reserpine in three German-language pharmacology textbooks. Naunyn Schmiedebergs Arch Pharmacol. 2024; 397:4381-4401, doi: 10.1007/s00210-023-02877-9. 

Mispagel M, Seifert R. Scientific, bibliometric and biographical analysis of 71 Jewish and dissident pharmacologists persecuted in Germany between 1933 and 1945. Naunyn Schmiedebergs Arch Pharmacol. 2024 Dec 18. doi: 10.1007/s00210-024-03645-z. Epub ahead of print.

Möller IH, Seifert R. Presentation of pharmacological content in crime novels between 1890 and 2023. Naunyn Schmiedebergs Arch Pharmacol. 2024 Apr 21. doi: 10.1007/s00210-024-03103-w. Epub ahead of print.

Obst CS, Seifert R. Updated analysis of the prescription and evaluation of protein kinase inhibitors for oncology in Germany. Naunyn Schmiedebergs Arch Pharmacol. 2024 Aug 23. doi: 10.1007/s00210-024-03377-0. Epub ahead of print. PMID: 39177786.

Philipp M, Seifert R. Legal and scientific deficiencies of drug advertisements on German television. Naunyn Schmiedebergs Arch Pharmacol. 2024 Nov 15. doi: 10.1007/s00210-024-03604-8. Online ahead of print.

Rathmann AM, Seifert R. Vitamin A-containing dietary supplements from German and US online pharmacies: market and risk assessment. Naunyn Schmiedebergs Arch Pharmacol. 2024 Mar 28. doi: 10.1007/s00210-024-03050-6. Epub ahead of print. 

Ricke JN, Seifert R. Disinformation on dietary supplements by German influencers on Instagram. Naunyn Schmiedebergs Arch Pharmacol. 2024 Nov 25. doi: 10.1007/s00210-024-03616-4. Epub ahead of print.

Schröder L, Seifert R. The 10 top prescribed medicines in Germany from 1985 to 2022: pharmacological analysis. Naunyn Schmiedebergs Arch Pharmacol. 2024 Nov 21. doi: 10.1007/s00210-024-03615-5. Epub ahead of print.

Seifert R, Schirmer B, Seifert J. How pharmacology can aid in the diagnosis of mental disorders. Naunyn Schmiedebergs Arch Pharmacol. 2024 Sep 4. doi: 10.1007/s00210-024-03413-z. Epub ahead of print. PMID: 39230588.

Specht T, Seifert R. Repurposing of H1-receptor antagonists (levo)cetirizine, (des)loratadine, and fexofenadine as a case study for systematic analysis of trials on clinicaltrials.gov using semi-automated processes with custom-coded software. Naunyn Schmiedebergs Arch Pharmacol. 2024; 397: 2995-3018. doi: 10.1007/s00210-023-02796-9. 

Tiligada E, Stefanaki C, Ennis M, Neumann D. Opportunities and challenges in the therapeutic exploitation of histamine and histamine receptor pharmacology in inflammation-driven disorders. Pharmacol Ther. 2024 Nov;263:108722. doi: 10.1016/j.pharmthera.2024.108722. Epub 2024 Sep 19.

Trabert M, Seifert R. Critical analysis of ginkgo preparations: comparison of approved drugs and dietary supplements marketed in Germany. Naunyn Schmiedebergs Arch Pharmacol. 2024; 397:451-461.; doi: 10.1007/s00210-023-02602-6. 

Wittau J, Celik S, Kacprowski T, Deserno TM, Seifert R. Fake paper identification in the pool of withdrawn and rejected manuscripts submitted to Naunyn-Schmiedeberg's Archives of Pharmacology. Naunyn Schmiedebergs Arch Pharmacol. 2024; 397: 2171-2181 doi: 10.1007/s00210-023-02741-w. 

Wittau J, Seifert R. Metadata analysis of retracted fake papers in Naunyn-Schmiedeberg's Archives of Pharmacology. Naunyn Schmiedebergs Arch Pharmacol. 2024; 397:3995-4011. doi: 10.1007/s00210-023-02850-6. Epub ahead of print. 

Wittau J, Seifert R. How to fight fake papers: a review on important information sources and steps towards solution of the problem. Naunyn Schmiedebergs Arch Pharmacol. 2024 Dec;397(12):9281-9294. doi: 10.1007/s00210-024-03272-8.

Zöllner H, Seifert R. How do German pharmacologists publish in the non-peer-reviewed science magazine Biospektrum? Naunyn Schmiedebergs Arch Pharmacol. 2024; 397:1889-1900. doi: 10.1007/s00210-023-02740-x. 

2023

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA, Annett S, Boison D, Burns KE, Dessauer C, Gertsch J, Helsby NA, Izzo AA, Ostrom R, Papapetropoulos A, Pyne NJ, Pyne S, Robson T, Seifert R, Stasch JP, Szabo C, van der Stelt M, van der Vliet A, Watts V, Wong SS. The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 2023 Oct;180 Suppl 2:S289-S373. doi: 10.1111/bph.16181. 

Arning A, Seifert R. Computer-Assisted Analysis of the Intelligibility of Package Inserts. Dtsch Arztebl Int. 2023; 120: 601-602. doi: 10.3238/arztebl.m2023.0153. 

Borchert M, Seifert R. Systematic analysis of the pharmacological content of the Tatort (scene of crime) TV series from 2019 to 2021. Naunyn Schmiedebergs Arch Pharmacol. 2023; 96:1957-1975, doi: 10.1007/s00210-023-02427-3.

Covaleda-Cortés G, Mechaly A, Brissac T, Baehre H, Devaux L, England P, Raynal B, Hoos S, Gominet M, Firon A, Trieu-Cuot P, Kaminski PA. The c-di-AMP-binding protein CbpB modulates the level of ppGpp alarmone in Streptococcus agalactiae. FEBS J. 2023; 290: 2968-2992, doi: 10.1111/febs.16724.

Dats LB, von Haugwitz F, Seifert R. Bibliometric development of Naunyn-Schmiedeberg's Archives of Pharmacology. Naunyn Schmiedebergs Arch Pharmacol 2023; 396: 43-61, doi: 10.1007/s00210-022-02307-2.  

Dats LB, von Haugwitz F, Seifert R. Correction to: Bibliometric development of Naunyn-Schmiedeberg's Archives of Pharmacology. Naunyn Schmiedebergs Arch Pharmacol 2023; 396: 171, doi: 10.1007/s00210-022-02335-y. 

Hattori Y, Seifert R. Reflections on the 150th anniversary of Naunyn-Schmiedeberg's Archives of Pharmacology: past, challenges, and future. Naunyn Schmiedebergs Arch Pharmacol. 2023; 396:1-3. doi: 10.1007/s00210-022-02321-4.

Obst CS, Seifert R. Critical analysis of the prescription and evaluation of protein kinase inhibitors for oncology in Germany. Naunyn Schmiedebergs Arch Pharmacol. 2023; 96:2529-2543; doi: 10.1007/s00210-023-02475-9. 

Philippu A, Seifert R. History of pharmacology: 1 - The Department of Pharmacology of the University of Tartu (Dorpat): genealogy and biographies. Naunyn Schmiedebergs Arch Pharmacol 2023; 396: 5-17, doi: 10.1007/s00210-022-02328-x. 

Philippu A, Seifert R. History of pharmacology: 2 - The Institute of Pharmacology of the University of Strasbourg: genealogy and biographies. Naunyn Schmiedebergs Arch Pharmacol 2023; 396:19-33; doi: 10.1007/s00210-022-02336-x. 

Schrammel JC, König M, Frommer M, Andersen KS, Kirsten M, Seifert R, Neumann D, Schirmer B. Histamine H1- and H4-receptor expression in human colon-derived cell lines. Naunyn Schmiedebergs Arch Pharmacol 2023; 396:3683-3693. doi: 10.1007/s00210-023-02565-8. 

Seifert R, Bugert JJ. cCMP and cUMP phosphodiesterases in viral infections. Trends Biochem Sci 2023; 48: 835-838. doi: 10.1016/j.tibs.2023.05.013.

2022

Bense S, Witte J, Preuße M, Koska M, Pezoldt L, Dröge A, Hartmann O, Müsken M, Schulze J, Fiebig T, Bähre H, Felgner S, Pich A, Häussler S. Pseudomonas aeruginosa post-translational responses to elevated c-di-GMP levels. Mol Microbiol 2022; 117:1213-1226. doi: 10.1111/mmi.14902.  

Chen F, Elgaher WAM, Winterhoff M, Büssow K, Waqas FH, Graner E, Pires-Afonso Y, Casares Perez L, de la Vega L, Sahini N, Czichon L, Zobl W, Zillinger T, Shehata M, Pleschka S, Bähre H, Falk C, Michelucci A, Schuchardt S, Blankenfeldt W, Hirsch AKH, Pessler F. Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism. Nat Metab 2022; 4: 534-546. doi: 10.1038/s42255-022-00577-x. 

Cohen H, Adani B, Cohen E, Piscon B, Azriel S, Desai P, Bähre H, McClelland M, Rahav G, Gal-Mor O. The ancestral stringent response potentiator, DksA has been adapted throughout Salmonella evolution to orchestrate the expression of metabolic, motility, and virulence pathways. Gut Microbes 2022; 14:1997294. doi: 10.1080/19490976.2021.1997294. 

Ding J, Schuergers N, Baehre H, Wilde A. Enzymatic properties of CARF-domain proteins in Synechocystis sp. PCC 6803. Front Microbiol. 2022 Nov 7;13:1046388. doi: 10.3389/fmicb.2022.1046388. 

Ellerbeck R, Seifert R. Poisoning cases in the German crime series Tatort (crime scene) from 1974 to 2022. Naunyn Schmiedebergs Arch Pharmacol. 2022; 395:1419-1440. doi: 10.1007/s00210-022-02281-9. 

Gruenwald M, Chen F, Bähre H, Pessler F. Itaconate Isomers in Bread. Antioxidants (Basel) 2022; 11: 1382. doi: 10.3390/antiox11071382. 

Kaya-Zeeb S, Engelmayer L, Straßburger M, Bayer J, Bähre H, Seifert R, Scherf-Clavel O, Thamm M. Octopamine drives honeybee thermogenesis. Elife 2022; 11:e74334. doi: 10.7554/eLife.74334. 

Kircher B, Woltemate S, Gutzki F, Schlüter D, Geffers R, Bähre H, Vital M. Predicting butyrate- and propionate-forming bacteria of gut microbiota from sequencing data. Gut Microbes 2022; 14: 2149019. doi: 10.1080/19490976.2022.2149019. 

Koska M, Kordes A, Erdmann J, Willger SD, Thöming JG, Bähre H, Häussler S. Distinct Long- and Short-Term Adaptive Mechanisms in Pseudomonas aeruginosa. Microbiol Spectr 2022; 10: e0304322; doi: 10.1128/spectrum.03043-22.

Li F, Cao L, Bähre H, Kim SK, Schroeder K, Jonas K, Koonce K, Mekonnen SA, Mohanty S, Bai F, Brauner A, Lee VT, Rohde M, Römling U. Patatin-like phospholipase CapV in Escherichia coli - morphological and physiological effects of one amino acid substitution. NPJ Biofilms Microbiomes 2022; 8: 39. doi: 10.1038/s41522-022-00294-z. 

Mederacke I, Filliol A, Affo S, Nair A, Hernandez C, Sun Q, Hamberger F, Brundu F, Chen Y, Ravichandra A, Huebener P, Anke H, Shi H, Martínez García de la Torre RA, Smith JR, Henderson NC, Vondran FWR, Rothlin CV, Baehre H, Tabas I, Sancho-Bru P, Schwabe RF. The purinergic P2Y14 receptor links hepatocyte death to hepatic stellate cell activation and fibrogenesis in the liver. Sci Transl Med 2022; 14: eabe5795. doi: 10.1126/scitranslmed.abe5795. 

Moradali MF, Ghods S, Bähre H, Lamont RJ, Scott DA, Seifert R. Atypical cyclic di-AMP signaling is essential for Porphyromonas gingivalis growth and regulation of cell envelope homeostasis and virulence. NPJ Biofilms Microbiomes. 2022; 8: 53. doi: 10.1038/s41522-022-00316-w. 

Nakane D, Enomoto G, Bähre H, Hirose Y, Wilde A, Nishizaka T. Thermosynechococcus switches the direction of phototaxis by a c-di-GMP-dependent process with high spatial resolution. Elife 2022; 11: e73405. doi: 10.7554/eLife.73405.

Naasner L, Froese N, Hofmann W, Galuppo P, Werlein C, Shymotiuk I, Szaroszyk M, Erschow S, Amanakis G, Bähre H, Kühnel MP, Jonigk DD, Geffers R, Seifert R, Ricke-Hoch M, Wende AR, Blaner WS, Abel ED, Bauersachs J, Riehle C. Vitamin A preserves cardiac energetic gene expression in a murine model of diet-induced obesity. Am J Physiol Heart Circ Physiol 2022; 323: H1352-H1364. doi: 10.1152/ajpheart.00514.2022. 

Oberkampf M, Hamiot A, Altamirano-Silva P, Bellés-Sancho P, Tremblay YDN, DiBenedetto N, Seifert R, Soutourina O, Bry L, Dupuy B, Peltier J. c-di-AMP signaling is required for bile salt resistance, osmotolerance, and long-term host colonization by Clostridioides difficile. Sci Signal 2022;15: eabn8171. doi: 10.1126/scisignal.abn8171. 

Rick T, Kreiling V, Höing A, Fiedler S, Glatter T, Steinchen W, Hochberg G, Bähre H, Seifert R, Bange G, Knauer SK, Graumann PL, Thormann KM. GGDEF domain as spatial on-switch for a phosphodiesterase by interaction with landmark protein HubP. NPJ Biofilms Microbiomes. 2022; 8: 35. doi: 10.1038/s41522-022-00297-w. 

Riehle C, Sieweke JT, Bakshi S, Ha CM, Junker Udesen NL, Møller-Helgestad OK, Froese N, Berg Ravn H, Bähre H, Geffers R, Seifert R, Møller JE, Wende AR, Bauersachs J, Schäfer A. miRNA-200b-A Potential Biomarker Identified in a Porcine Model of Cardiogenic Shock and Mechanical Unloading. Front Cardiovasc Med 2022; 9:881067. doi: 10.3389/fcvm.2022.881067. 

Schirmer B, Giehl K, Kubatzky KF. Report of the 24th Meeting on Signal Transduction 2021. Int J Mol Sci 2022; 23: 2015. doi: 10.3390/ijms23042015.

Seifert R, Alexander S. Perspective article: A proposal for rational drug class terminology. Br J Pharmacol. 2022; 179(17):4311-4314. doi: 10.1111/bph.15916.

Seifert R, Schirmer B. cCMP and cUMP come into the spotlight, finally. Trends Biochem Sci 2022; 47: 461-463. doi: 10.1016/j.tibs.2021.12.008. 

Sohail A, Iqbal AA, Sahini N, Chen F, Tantawy M, Waqas SFH, Winterhoff M, Ebensen T, Schultz K, Geffers R, Schughart K, Preusse M, Shehata M, Bähre H, Pils MC, Guzman CA, Mostafa A, Pleschka S, Falk C, Michelucci A, Pessler F. Correction: Itaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection. PLoS Pathog 2022; 18:e1011002. doi: 10.1371/journal.ppat.1011002. Erratum for: PLoS Pathog. 2022; 18: e1010219. 

Sohail A, Iqbal AA, Sahini N, Chen F, Tantawy M, Waqas F, Winterhoff M, Ebensen T, Schultz K, Geffers R, Schughart K, Preusse M, Shehata M, Bähre H, Pils MC, Guzman CA, Mostafa A, Pleschka S, Falk C, Michelucci A, Pessler F. Itaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection. PLoS Pathog 2022; 18: e1010219. doi: 10.1371/journal.ppat.1010219. 

Tantawy E, Schwermann N, Ostermeier T, Garbe A, Bähre H, Vital M, Winstel V. Staphylococcus aureus Multiplexes Death-Effector Deoxyribonucleosides to Neutralize Phagocytes. Front Immunol. 2022; 13:847171.
doi: 10.3389/fimmu.2022.847171. 

Zehetbauer R, von Haugwitz F, Seifert R. Gender-specific analysis of the authors and the editorial board of Naunyn-Schmiedeberg's Archives of Pharmacology from 2000 to 2020. Naunyn Schmiedebergs Arch Pharmacol 2022; 395: 39-50. doi: 10.1007/s00210-021-02166-3

2021

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Davies JA, Boison D, Burns KE, Dessauer C, Gertsch J, Helsby NA, Izzo AA, Koesling D, Ostrom R, Pyne NJ, Pyne S, Russwurm M, Seifert R, Stasch JP, van der Stelt M, van der Vliet A, Watts V, Wong SS. THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol 2021; 178 Suppl 1:S313-S411. doi: 10.1111/bph.15542.

Andersen JB, Hultqvist LD, Jansen CU, Jakobsen TH, Nilsson M, Rybtke M, Uhd J, Fritz BG, Seifert R, Berthelsen J, Nielsen TE, Qvortrup K, Givskov M, Tolker-Nielsen T. Identification of small molecules that interfere with c-di-GMP signaling and induce dispersal of Pseudomonas aeruginosa biofilms. NPJ Biofilms Microbiomes 2021; 7:59. doi: 10.1038/s41522-021-00225-4.

Braun F, Recalde A, Bähre H, Seifert R, Albers SV. Putative Nucleotide-Based Second Messengers in the Archaeal Model Organisms Haloferax volcanii and Sulfolobus acidocaldarius. Front Microbiol 2021; 12:779012. doi: 10.3389/fmicb.2021.779012.

Bünsow D, Tantawy E, Ostermeier T, Bähre H, Garbe A, Larsen J, Winstel V. Methicillin-resistant Staphylococcus pseudintermedius synthesizes deoxyadenosine to cause persistent infection. Virulence 2021; 12: 989-1002. doi: 10.1080/21505594.2021.1903691.

Cohen H, Adani B, Cohen E, Piscon B, Azriel S, Desai P, Bähre H, McClelland M, Rahav G, Gal-Mor O. The ancestral stringent response potentiator, DksA has been adapted throughout Salmonella evolution to orchestrate the expression of metabolic, motility, and virulence pathways. Gut Microbes. 2022; 14: 1997294. doi: 10.1080/19490976.2021.1997294. 

Dorado-Morales P, Martínez I, Rivero-Buceta V, Díaz E, Bähre H, Lasa I, Solano C. Elevated c-di-GMP levels promote biofilm formation and biodesulfurization capacity of Rhodococcus erythropolis. Microb Biotechnol 2021; 14: 923-937. doi: 10.1111/1751-7915.13689.

Durán V, Grabski E, Hozsa C, Becker J, Yasar H, Monteiro JT, Costa B, Koller N, Lueder Y, Wiegmann B, Brandes G, Kaever V, Lehr CM, Lepenies B, Tampé R, Förster R, Bošnjak B, Furch M, Graalmann T, Kalinke U. Fucosylated lipid nanocarriers loaded with antibiotics efficiently inhibit mycobacterial propagation in human myeloid cells. J Control Release 2021; 334: 201-212. doi: 10.1016/j.jconrel.2021.04.012. 

Fortuna A, Bähre H, Visca P, Rampioni G, Leoni L. The two Pseudomonas aeruginosa DksA stringent response proteins are largely interchangeable at the whole transcriptome level and in the control of virulence-related traits. Environ Microbiol 2021; 3: 5487-5504. doi: 10.1111/1462-2920.15693

Harloff M, Prüschenk S, Seifert R, Schlossmann J. Activation of soluble guanylyl cyclase signalling with cinaciguat improves impaired kidney function in diabetic mice. Br J Pharmacol 2022; 179: 2460-2475.. doi: 10.1111/bph.15425. 

Krishnan SM, Nordlohne J, Dietz L, Vakalopoulos A, Haning P, Hartmann E, Seifert R, Hüser J, Mathar I, Sandner P. Assessing the Use of the sGC Stimulator BAY-747, as a Potential Treatment for Duchenne Muscular Dystrophy. Int J Mol Sci 2021; 22: 8016. doi: 10.3390/ijms22158016.

Krüger L, Herzberg C, Wicke D, Bähre H, Heidemann JL, Dickmanns J, Schmitt K, Ficner R, Stülke J.. A meet-up of two second messengers: the c-di-AMP receptor DarB controls (p)ppGpp synthesis in Bacillus subtilis. Nat Commun. 2021; 12: 1210. 

Neumann J, Grobe JM, Weisgut J, Schwelberger HG, Fogel WA, Marušáková M, Wache H, Bähre H, Buchwalow IB, Dhein S, Hofmann B, Kirchhefer U, Gergs U. Histamine can be Formed and Degraded in the Human and Mouse Heart. Front Pharmacol. 2021; 12: 582916. doi: 10.3389/fphar.2021.582916.

Neumann D, Seifert R. Probiotics in Naunyn-Schmiedeberg's Archives of Pharmacology. Naunyn Schmiedebergs Arch Pharmacol 2021; 394:1595-1597. doi: 10.1007/s00210-021-02110-5. 

Oeser S, Wallner T, Nils S, Bučinská L, Sivabalasarma S, Bähre H, Albers SV, Wilde A. Minor pilins are involved in motility and natural competence of the cyanobacterium Synechocystis sp. PCC 6803. Mol Microbiol 2021; 116: 743-765. doi: 10.1111/mmi.14768. 

Ostrom KF, LaVigne JE, Brust TF, Seifert R, Dessauer CW, Watts VJ, Ostrom RS. Physiological Roles of Mammalian Transmembrane Adenylyl Cyclase Isoforms. Physiol Rev 2022; 102: 815-857. 
DOI: 10.1152/physrev.00013.2021. DOI: 10.1152/physrev.00013.2021

Perduns R, Volk J, Plum M, Jochums A, Gutzki F, Kaever V, Geurtsen W. Camphorquinone alters the expression of extracellular proteases in a 3D co-culture model of the oral mucosa. Dent Mater 2021; 37: 236-248. doi: 10.1016/j.dental.2020.11.005.

Ring J, Beyer K, Biedermann T, Bircher A, Fischer M, Fuchs T, Heller A, Hoffmann F, Huttegger I, Jakob T, Klimek L, Kopp MV, Kugler C, Lange L, Pfaar O, Rietschel E, Rueff F, Schnadt S, Seifert R, Stöcker B, Treudler R, Vogelberg C, Werfel T, Worm M, Sitter H, Brockow K. Guideline (S2k) on acute therapy and management of anaphylaxis: 2021 update: S2k-Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the Medical Association of German Allergologists (AeDA), the Society of Pediatric Allergology and Environmental Medicine (GPA), the German Academy of Allergology and Environmental Medicine (DAAU), the German Professional Association of Pediatricians (BVKJ), the Society for Neonatology and Pediatric Intensive Care (GNPI), the German Society of Dermatology (DDG), the Austrian Society for Allergology and Immunology (ÖGAI), the Swiss Society for Allergy and Immunology (SGAI), the German Society of Anaesthesiology and Intensive Care Medicine (DGAI), the German Society of Pharmacology (DGP), the German Respiratory Society (DGP), the patient organization German Allergy and Asthma Association (DAAB), the German Working Group of Anaphylaxis Training and Education (AGATE). Allergo J Int 2021; 30:20-49. doi: 10.1007/s15007-020-4750-0.

Ring J, Beyer K, Biedermann T, Bircher A, Fischer M, Fuchs T, Heller A, Hoffmann F, Huttegger I, Jakob T, Klimek L, Kopp MV, Kugler C, Lange L, Pfaar O, Rietschel E, Rueff F, Schnadt S, Seifert R, Stöcker B, Treudler R, Vogelberg C, Werfel T, Worm M, Sitter H, Brockow K. Guideline (S2k) on acute therapy and management of anaphylaxis: 2021 update: S2k-Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the Medical Association of German Allergologists (AeDA), the Society of Pediatric Allergology and Environmental Medicine (GPA), the German Academy of Allergology and Environmental Medicine (DAAU), the German Professional Association of Pediatricians (BVKJ), the Society for Neonatology and Pediatric Intensive Care (GNPI), the German Society of Dermatology (DDG), the Austrian Society for Allergology and Immunology (ÖGAI), the Swiss Society for Allergy and Immunology (SGAI), the German Society of Anaesthesiology and Intensive Care Medicine (DGAI), the German Society of Pharmacology (DGP), the German Respiratory Society (DGP), the patient organization German Allergy and Asthma Association (DAAB), the German Working Group of Anaphylaxis Training and Education (AGATE). Allergo J Int. 30:1-25 (2021)

Ring J, Beyer K, Biedermann T, Bircher A, Fischer M, Fuchs T, Heller A, Hoffmann F, Huttegger I, Jakob T, Klimek L, Kopp MV, Kugler C, Lange L, Pfaar O, Rietschel E, Rueff F, Schnadt S, Seifert R, Stöcker B, Treudler R, Vogelberg C, Werfel T, Worm M, Sitter H, Brockow K. Messages for patients and relatives from the 2021 update of the guideline on acute therapy and management of anaphylaxis. Allergo J Int 2021 Sep 27:1-6. doi: 10.1007/s40629-021-00185-3. 

Ring J, Beyer K, Bircher A, Biedermann T, Fischer M, Fuchs T, Heller AR, Hoffmann F, Huttegger I, Jakob T, Klimek L, Kopp MV, Kugler C, Lange L, Pfaar O, Rietschel E, Ruëff F, Schnadt S, Seifert R, Stöcker B, Treudler R, Vogelberg C, Werfel T, Worm M, Sitter H, Brockow K. Kurzfassung der Leitlinie "Akuttherapie und Management der Anaphylaxie - Update 2021" für Patienten und Angehörige. Allergo J. 2021; 30: 24-31. doi: 10.1007/s15007-021-4907-5. 

Rodriguez-Garcia E, Zabaleta N, Gil-Farina I, Gonzalez-Aparicio M, Echeverz M, Bähre H, Solano C, Lasa I, Gonzalez-Aseguinolaza G, Hommel M. AdrA as a Potential Immunomodulatory Candidate for STING-Mediated Antiviral Therapy That Required Both Type I IFN and TNF-α Production. J Immunol 2021; 206: 376-385. doi: 10.4049/jimmunol.2000953.

Sabel BA, Seifert R. How criminal science publishing gangs damage the genesis of knowledge and technology-a call to action to restore trust. Naunyn Schmiedebergs Arch Pharmacol 2021; 394: 2147-2151. doi: 10.1007/s00210-021-02158-3.

Schirmer B, Neumann D. The Function of the Histamine H4 Receptor in Inflammatory and Inflammation-Associated Diseases of the Gut. Int J Mol Sci 2021; 22: 6116. doi: 10.3390/ijms22116116.

Seifert R. How Naunyn-Schmiedeberg's Archives of Pharmacology deals with fraudulent papers from paper mills. 
Naunyn-Schmiedeberg's Arch Pharmacol 2021; 394:431-436. doi: 10.1007/s00210-021-02056-8.

Seifert R, Schirmer B. Why Naunyn-Schmiedeberg's Archives of Pharmacology abandons traditional names of drug classes. Naunyn-Schmiedeberg's Arch Pharmacol 2021; 394:1321-1325. doi: 10.1007/s00210-021-02111-4.

Seifert R, Schirmer B. A case to stop the use of the term 'antibiotics'. Trends Microbiol 29: 963-966. doi: 10.1016/j.tim.2021.03.017.

Seifert R, Schirmer B. Problems associated with the use of the term “antibiotics”. Naunyn-Schmiedeberg's Arch Pharmacol  2021; 394: 2153-2166. doi.org/10.1007/s00210-021-02144-9. 

Selim KA, Haffner M, Burkhardt M, Mantovani O, Neumann N, Albrecht R, Seifert R, Krüger L, Stülke J, Hartmann MD, Hagemann M, Forchhammer K. Diurnal metabolic control in cyanobacteria requires perception of second messenger signaling molecule c-di-AMP by the carbon control protein SbtB. Sci Adv. 2021; 7: eabk0568. doi: 10.1126/sciadv.abk0568.  

Slavik KM, Morehouse BR, Ragucci AE, Zhou W, Ai X, Chen Y, Li L, Wei Z, Bähre H, König M, Seifert R, Lee ASY, Cai H, Imler JL, Kranzusch PJ. cGAS-like receptors sense RNA and control 3'2'-cGAMP signaling in Drosophila. Nature 2021; 597: 109-113. doi: 10.1038/s41586-021-03743-5. 

Winterhoff M, Chen F, Sahini N, Ebensen T, Kuhn M, Kaever V, Bähre H, Pessler F. Establishment, Validation, and Initial Application of a Sensitive LC-MS/MS Assay for Quantification of the Naturally Occurring Isomers Itaconate, Mesaconate, and Citraconate. Metabolites 2021; 11: 270. doi: 10.3390/metabo11050270.

Worm M, Ring J, Klimek L, Jakob T, Lange L, Treudler R, Beyer K, Werfel T, Biedermann T, Bircher A, Fischer M, Fuchs T, Heller AR, Hoffmann F, Huttegger I, Kopp MV, Kugler C, Lommatzsch M, Pfaar O, Rietschel E, Ruëff F, Schnadt S, Seifert R, Stöcker B, Vogelberg C, Sitter H, Gieler U, Brockow K. Management des Anaphylaxie-Risikos bei Covid-19-Impfung. HNO Nachr 2021; 51:18-21. doi: 10.1007/s00060-021-7480-3.

Worm M, Ring J, Klimek L, Jakob T, Lange L, Treudler R, Beyer K, Werfel T, Biedermann T, Bircher A, Fischer M, Fuchs T, Heller AR, Hoffmann F, Huttegger I, Kopp MV, Kugler C, Lommatzsch M, Pfaar O, Rietschel E, Rueff F, Schnadt S, Seifert R, Stöcker B, Vogelberg C, Sitter H, Gieler U, Brockow K. Covid-19 vaccination and risk of anaphylaxis - Recommendations for practical management. MMW Fortschr Med 2021; 163:48-51

Zhu S, Stanslowsky N, Fernández-Trillo J, Mamo TM, Yu P, Kalmbach N, Ritter B, Eggenschwiler R, Ouwendijk WJD, Mzinza D, Tan L, Leffler A, Spohn M, Brown RJP, Kropp KA, Kaever V, Ha TC, Narayanan P, Grundhoff A, Förster R, Schambach A, Verjans GMGM, Schmidt M, Kispert A, Cantz T, Gomis A, Wegner F, Viejo-Borbolla A. Generation of hiPSC-derived low threshold mechanoreceptors containing axonal termini resembling bulbous sensory nerve endings and expressing Piezo1 and Piezo2. Stem Cell Res 2021; 56: 102535. doi: 10.1016/j.scr.2021.102535.

2024

Masterarbeiten

Herbig, Franziska (M.Sc. Biomedizin): Klonierung und Charakterisierung von humanen Glucocorticoid Rezeptor Isoformen

Bosse, Annika (M.Sc. Molekulare Mikrobiologie): Optimierung und Charakterisierung eines Resonanz-Energie-Transfer (RET)-basierten Indikators für 3‘,5‘-cUMP

Bachelorarbeiten

Ballhause, Anna (B.Sc. Biochemie): Grundlegende Charakterisierung der Nukleotidylzyklaseaktivität von PycC aus Escherichia coli

2023

Masterarbeiten

Hoppe, Daniel (M.Sc. Biochemie): Biochemische Analyse der Interaktion des Histamin-Rezeptors mit dem G-Protein-gekoppelten einwärtsgleichrichtenden Kalium-Kanal

Bachelorarbeiten

Bertram, Tim (B.Sc. Biochemie): Klonierung, Expression in HEK293 Zellen und erste funktionelle Charakterisierung von humanen Histamin H1 und H2 Rezeptoren

Bakker, Alina Doreen (B.Sc. Biochemie): Analyse des Histamin-induzierten Metaboloms in HL-60 Zellen

2022

Experimentelle Doktorarbeiten

Hasan, Alan (Dr. med.): Rolle der löslichen Adenylylzyklase in der Regulation zellulärer zyklischer 3’,5’ – Nukleotidmonophosphate

Kaiser, Christian (Dr. med.): Analysis of the effects of 3', 5'-cyclic pyrimidin nucleotides in T cells.

Stelzer, Tane (Dr. med.): Pseudomonas aeruginosa Effektorprotein ExoY ist eine Cytidylyl- und Uridylylzyklase in vivo.

Masterarbeiten

Dolgner, Tim (M.Sc. Biomedizin): Herstellung und Validierung eines cUMP-BRET-Sensors

Hagel, Sebastian (M.Sc. Biochemie): Aufreinigung und Charakterisierung der PycC Uridylylcyclase aus Pseudomonas aeruginosa

Kirsten, Marla (M.Sc. Biomedizin): Reguliert Histamin über den Histamin H₁-Rezeptor die Produktion entzündungsfördernder Mediatoren in humanen Colonepithelzellen?

2021

Experimentelle Doktorarbeit

Silchmüller, Marc Phillipp (Dr. med.): Der Effekt des H4R auf die chronisch TNBS-induzierte Colitis im Mausmodell

Masterarbeiten

Postels, Anna Michaela (M.Sc. Biomedizin): Analyse molekularer Mechanismen von zyklischen Pyrimidin- und Purinnukleotiden in Ovarialkarzinomzelllinien

Schrammel, Jasper (M.Sc. Biochemie): CRISPR/Cas-basierte Etablierung von HCT116-Zellkulturmodellen zur Analyse von Histaminrezeptoreffekten

Bachelorarbeiten

Bessert, Linda (B.Sc. Biochemie): Analyse der physikalischen Interaktionen der Histamin-H1- und Histamin-H4-Rezeptoren mithilfe des bipartiten sfGFP-Expressionssystems

Hübner, Angelina (B.Sc. Biologie): Einfluss von JNK1, JNK2, p38 und p65 auf die Proliferation muriner embryonaler Fibroblasten durch zyklische Nukleotide

Kelpe, Johannes (B.Sc. Biochemie): Analyse des Effekts von Histamin auf das Metabolom der promyelozytären Zelllinie HL 60

Klemann, Mika (B.Sc. Biochemie): Analyse des Einflusses von Histamin auf die Proliferation und Apoptose der humanen Darmkrebszellline HCT-116